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DIRECT SPECTROPHOTOMETRIC DETERMINATION OF SATRANIDAZOLE
A direct spectrophotometric method was developed by the authors for the detection and determination of satranidazole in pure form as well in pharmaceutical formulations in the form of tablets and capsules. The method was based on the formation of a reddish-purple color dye, due to the diazotization reaction between the nitro group of the drug sample, sulphanilamide and NEDA. The drug sample dissol...
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A STABILITY INDICATING RP-LC METHOD FOR THE DETERMINATION OF STRYCHNINE IN KRIMIMUDGARA RASA
A reliable, rapid, simple and accurate high-performance liquid chromatography method with UV detection was developed for the simultaneous quantitative determination of strychnine in a polyherbal formulation prepared from Nux Vomica. Krimimudgara rasa, a herbal dosage form containing Strychnos nux vomica, Apium graveolens, Embellia ribes, Butea monosperma in combination. Separation of the strychnin...
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IN-VITRO AND IN-VIVO ANIMAL MODEL FOR SCREENING ANTI-DIABETIC ACTIVITY OF HELLENIA SPECIOSA (J. KOENIG) S. R. DUTTA
Diabetes mellitus is one of the most common endocrine disorder which causes microvascular and macrovascular complications. Herbal medicines derived from plant extracts are used to treat various diseases because of its fewer side effects. The present investigation includes a screening of phytochemicals and evaluation of the in-vitro and in-vivo anti-diabetic activity of Hellenia speciosa leaves ext...
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HYPOLIPIDEMIC ACTIVITY OF PANCHATIKTA GHRITA PREPARED BY A MURCHITA AND MURCHITA GHRITA
In Ayurveda, ghrita (ghee) and taila (oil) are commonly used for treatment either internally or externally. It is commonly believed that by consumption of oil or ghee will lead to hyperlipidemia. Hyperlipidemia is an ailment of lipid metabolism produced by an increase of plasma concentration of the various lipid and lipoprotein, which cause cardiac disease, premature coronary artery disease, strok...
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A CASE ON KAWASAKI SYNDOME IT’S DIAGNOSIS AND MANAGEMENT
Kawasaki Syndrome (KS) can be a widespread vasculitis affecting many systems, and some of the other recognized complications are discussed, including those affecting the skin, nervous system, gastrointestinal tract, musculo-skeletal system, kidneys, lungs, eyes and haematological effects. There is no specific diagnostic test or pathognomonic clinical features; those previously mentioned clinical c...
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ANIMAL MODELS USED IN THE SCREENING OF ANTIEPILEPTIC DRUGS
Epilepsy is a disorder of episodic brain dysfunction characterized by recurrent unprovoked spontaneous seizures. Epilepsy is the second most common neurological disorder after stroke. Antiepileptic drug discovery in animal models starts with the assumption that the experimental seizure model mimics human seizure. The identification of potential therapeutic agents for the treatment of epilepsy requ...
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1915
ANTI-OXIDATIVE, ANTIBACTERIAL ACTIVITY AND PHYTOCHEMICAL SCREENING OF ARTOCARPUS HETEROPHYLLUS SEED EXTRACTS
Artocarpus heterophyllus is an evergreen tree cultivated and consumed throughout Nepal; however, its seed has been neglected as compared to the fruit. The sample was screened for phytochemical evaluation, and general tests, DPPH activity, antibacterial activity, and total flavonoid content was also measured. Also, the potential of its use as functional food was highlighted. Phytochemical analysis ...
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MODELING OF BAKER TRIAZINE DERIVATIVES AS DHFR INHIBITORS USING QUANTUM CHEMICAL DESCRIPTORS
DHFR being involved in many important cell processes, its inhibition has long been an attractive goal for the development of chemotherapeutic agents. In present work, efforts have been made to model the DHFR inhibitory activity of a series of 4,6-diamino-2,2-dimethyl-1,2-dihydro-1,3,5-triazine derivatives to identify the structural requirements for the binding affinity between the receptor and Tri...
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CHARACTERIZATION AND CYTOTOXICITY EVALUATION OF SUPERPARAMAGNETIC NANOPARTICLES BIOSYNTHESIZED BY FUSARIUM OXYSPORUM SK
Superparamagnetic iron oxide nanoparticles have been used for various industrial and clinical applications. In the present study, biosynthesis of superparamagnetic Fe3O4 nanoparticles was carried out using a fungal isolate. The fungal isolate was identified as Fusarium oxysporum SK through 18S ribosomal DNA sequence analysis. The synthesized magnetic nanoparticles were subjected to Transmission El...
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ANALYSIS OF THE CHANGES IN PRICING REGULATION ON LEADING ANALGESICS MEDICINES PRICES AND UTILIZATION IN BULGARIA
In 2004, the new pricing regulation was enforced in Bulgaria. It liberates the OTC medicines pricing procedure from reference pricing to registration according to marketing authorization holder proposal. The goal is to analyse the changes in the pricing regulations concerning OTC and its impact on prices and utilization of analgesic medicines. Two main hypotheses are tested in the study. H1: The ...
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