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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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10.

CANDIDATURE OF THE SYNTHETIC CASPASE INHIBITORS AS NEW ANTI-SARS-COV-2 DRUG DISCOVERY, IN-SILICO MOLECULAR DOCKING

The new pandemic virus identified as severe acute respiratory syndrome Coronavirus 2 is the etiological agent responsible for the pneumonia outbreak that ended with respiratory failure. The main protease (MPRO) is a key enzyme for SARS-CoV-2, which plays a pivotal role in mediating viral replication and transcription, making it an attractive drug target for this virus. Here, we determine the mech...

A. M. M. Zaki *, Y. M. Ahmed and E. M. N. Abdelhafez

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt.

DOI: 10.13040/IJPSR.0975-8232.12(1).104-19

104-119

3698

2872

1.

THEPESIA POPULNEA FOR THE MANAGEMENT OF DIVERSE DISEASES: AN OVERVIEW

Thespesia populnea Linn., a member of the Malvaceae family also known as Portia tree, a plant commonly found in coastal and tropical regions of India. Its therapeutic properties have been recognized in ayurvedic medicine, which has been validated by modern scientific research. This paper highlights the chemical constituents and pharmacological profile of Thespesia populnea. The plant has shown rem...

Dipti Pal, Smita Suthar, Aman Naskar and Sanmati K. Jain *

Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.15(4).990-05

990-1005

3698

3027

25.

SYNTHESIS OF NEFOPAM ANALOGUES AND CHARACTERISATION

Modified Benzoxazocine moiety of Nefopam with N-Protected-ethanolamine, fluorobenzene benzylbromide, 2,3-dimethyl-benzene, naphthalene, fluro-naphthalene. In these modification Friedel Craft alkylation plays vital role with using grignard reagent and aluminum chloride with the starting phthalic anhydride to form acid compound and was converted to amide compound with using of thionyl chloride, N-Pr...

K. Srinivasachary *, S. Tiwari, Y. S. Somannavar and B. Ramadevi

Chemical Research and Development, APL Research Centre-II, Aurobindo Pharma Ltd., Indrakaran, Sangareddy, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4613-35

4613-4635

3694

2284

9.

NON ALCOHOLIC FATTY LIVER DISEASE: A BRIEF OVERVIEW

The occurrence of non-alcoholic fatty liver disease (NAFLD) is around 20-30% in the general population. NAFLD is usually asymptomatic, although a minority of patients may present with evidence of progressive liver injury with complications of cirrhosis, liver failure, and hepatocellular carcinoma. In spite of being common and potentially serious, relatively little is known about the natural histor...

J.A. Ansari*, K. Shakil and A. Rashid

Department of Pharmacology, MESCO College of Pharmacy , Mustaidpura, Hyderabad-500006, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3598-02

3598-3602

3693

1821

26.

APPLICATION AND COST-EFFECTIVENESS OF LAMP (LOOP-MEDIATED ISOTHERMAL AMPLIFICATION) TECHNOLOGY FOR AUTHENTICATION OF MEDICINAL PLANTS PODOPHYLLUM HEXANDRUM ROYLE

We have developed a novel LAMP-based molecular marker for easy and fast identification of Podophyllum hexandrum Royle (Indian May apple). It is an important medicinal plant valued all over the world. It have both anti-cancer (pro-oxidant ability) and radioprotective (antioxidant ability) effects respectively. The LAMP-based molecular was constructed based on genomic DNA of P. hexandrum that amplif...

Waleed M. Al-Shaqha , Mohsin Khan , Arezki Azzi and Anis Ahmad Chaudhary *

College of Medicine Al-Imam Muhammad Ibn Saud Islamic University (IMSIU), Riyadh-13317-7544, Kingdom of Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.6(5).2035-41

2035-41

3693

1553

42.

EFFECT OF PH & TEMPERATURE VARIATIONS ON PHAGE STABILITY – A CRUCIAL PREREQUISITE FOR SUCCESSFUL PHAGE THERAPY

Phage therapy has become a successful alternative to conventional antibiotic therapy due to the increasing number of multidrug-resistant bacteria in most clinical settings. Various factors like phage adsorption to the host site and phage neutralization by the host determine the efficacy of phage treatment. However, external factors like temperature and pH are critical in deciding the success of us...

A. N. Pradeep, S. Ramasamy, J. K. Veniemilda and C. S. Vinod Kumar *

Department of Microbiology, S. S. Institute of Medical Sciences & Research Centre, Davangere, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5178-82

5178-5182

3693

1218

41.

PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL ACTIVITY ON THE FRUITS OF HUGONIA MYSTAX L. (LINACEAE)

An ethnomedicinal plant, Hugonia mystax L., was examined for preliminary phytochemical screening and antimicrobial activity. Preliminary phytochemical screening showed the presence of various classes of secondary metabolites such as flavonoids, phenols, saponins, steroids, tannins and terpenoids.  Antimicrobial activity of petroleum ether, chloroform, ethanolic and aqueous fruits extracts showed ...

A. Vimalavady*, K. Kadavul and A. C. Tangavelou

Department of Botany, Kanchi Mamunivar Centre for Post Graduate Studies, Lawspet, Puducherry- 605008, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(4).1178-83

1178-1183

3692

1671

20.

COMPUTER AIDED DESIGN OF SELECTIVE CALCIUM CHANNEL BLOCKERS: USING PHARMACOPHORE – BASED AND DOCKING SIMULATIONS

In the present study, 3-D QSAR analysis was performed on the previously synthesized and evaluated derivatives of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers. Calcium Channel blockers is the molecular target responsible for the treatment of neuropathic and inflammatory pain. The 3D-QSAR study based on the principle of the alignment of pharmacophoric features b...

Reetu* and Vipin Kumar

Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(3).805-10

805-810

3691

1640

10.

CRYONICS: A REVIEW

Tissues can be preserved for centuries under the conditions of extremely cold temperatures along with the neurological functions of the human brain. It is possible with the process of vitrification; here the cells of the brain are cooled to the cryogenic temperature without the formation of ice. Damage caused due to this process is theoretically reversible as like before, but practically, rejuvena...

Pavankumar Krosuri *, K. Madhavi, J. Sunayana and M. Sai Ganesh

Department of Pharmaceutics, Santhiram College of Pharmacy, Nandyal, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).95-100

95-100

3691

1389

31.

TOXICITY STUDIES OF AQUEOUS EXTRACT OF BRIDELIA MICRANTHA STEM ADMINISTERED ON MICE AND RATS

The World Health Organization (WHO) defines traditional medicine as “the health practices, approaches, knowledge and beliefs incorporating plants, animals and mineral-based medicines, spiritual therapies, manual techniques and exercises, applied singularly or in combination to treat, diagnose and prevent illness or maintain wellbeing. Various compounds have been isolated from Bridelia micrantha ...

E.O. Oshomoh*, M. Idu and D. Uwaya

Department of Plant Biology and Biotechnology, Faculty of Life Sciences, University of Benin, Benin city, Edo State. Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(6).2856-65

2856-2865

3689

1654