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DEVELOPMENT AND EVALUATION OF SOLID SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM OF POORLY SOLUBLE OLMESARTAN MEDOXOMIL BY USING ADSORPTION ON TO SOLID CARRIER TECHNIQUE
Olmesartan medoxomil (OLM) is an angiotensin II receptor blocker antihypertensive agent. It is a highly lipophilic (log p (octanol / water) 5.55), poorly water soluble drug with absolute bioavailability of 26%.The present work aimed at formulating a solid self Nano emulsifying drug delivery system (solid-SNEDDS) for Olmesartan medoxomil with the objective of improving the aqueous solubility, disso...
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ANTHROPOMETRIC AND BIOCHEMICAL ANALYSIS OF NORMAL AND OBESE SUBJECTS ON AN INDIAN POPULATION
Obesity is a very serious health problem worldwide. Obesity depends on several physical and bio-chemicals parameters that are discussed in this work, i.e., BMI, cholesterol level that includes Total cholesterol (TC), High density lipoprotein concentration (HDL-c), Low density lipoprotein (LDL-c), Triglycerides level (TG), Glucose level, Postprandial glucose level. The present study throws light on...
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TRACE LEVEL QUANTIFICATION OF CYPIONYL CHLORIDE IN TESTOSTERONE CYPIONATE BY PRE COLUMN DERIVATIZATION WITH 2-BUTANOL BY GAS CHROMATOGRAPHY WITH ELECTRON IMPACT IONIZATION DETECTOR
The author has been proposed the precolumn derivatization method for the trace level quantification of cypionyl chloride in testosterone cypionate, it maybe potential impurity in the testosterone cypionate, it has to quantify in the testosterone drug Substance. The method development of cypionyl chloride has been started with gas chromatography with FID detector. The detection of cypionyl chloride...
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TASKS OF COMPLIMENTARY AND FUNCTIONAL TRIO-MINERALS IN HYPERTENSION
Micronutrient deficiencies such as potassium, magnesium and calcium are very common in the general population and it is more predominantly present in the individuals with hypertension and cardiovascular patients. These deficiencies will have a massive impact on present and future cardiovascular health outcomes such as hypertension, myocardial infarction, stroke, etc. Recent efforts to reduce the p...
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COMPUTER AIDED DESIGN OF SELECTIVE CALCIUM CHANNEL BLOCKERS: USING PHARMACOPHORE – BASED AND DOCKING SIMULATIONS
In the present study, 3-D QSAR analysis was performed on the previously synthesized and evaluated derivatives of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers. Calcium Channel blockers is the molecular target responsible for the treatment of neuropathic and inflammatory pain. The 3D-QSAR study based on the principle of the alignment of pharmacophoric features b...
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PREVALENCE & ANTIBACTERIAL RESISTANCE OF ESBLs AMONG PREGNANT WOMEN WITH UTI
Urinary tract infection (UTI) remains the common infections diagnosed in outpatients as well as in hospitalized patients. Worldwide data show that there is an increasing resistance among urinary tract pathogens to conventional drugs. Extended spectrum beta lactamases (ESBL) hydrolyse expanded spectrum cephalosporins like ceftazidime, cephotaxime which are used in the treatment of UTI. ESBL-pro...
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FATTY ACIDS OF HIPPOCRATEA AFRICANA ROOT: ANTIOXIDANT AND ANTI-MICROBIAL ACTIVITY
In this study, the fatty acid content, antioxidant activities and antimicrobial potential of oil obtained from the root of Hippocratea africana was investigated. Results showed that the oil was characterized by oleic acid (65.73%), palmitic acid (20.34%) and linoleic acid (6.90%) as the most abundant fatty acids with a oleic acid/linoleic acid ratio of 9.52. The oil possessed potent antioxidant ac...
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PREGNANE – A PARENT OF PROGESTERONE FROM TRIGONELLA FOENUM – GRAECUM LINN.
There are some herbal contraceptives that have the property to avoid the embryo implantation. Trigonella foenum-graecum Linn. is used in folk medicine as alcoholic and aqueous preparations for prevention of pregnancy. Pregnane- progesterone is one of the important steroid has direct connection with contraceptive activity. Pregnane is a C21 steroid and indirectly, a parent of progesterone. The ...
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FORMULATION DEVELOPMENT AND EVALUATION OF CANDESARTAN BUCCAL TABLETS
Buccal tablets are prepared by direct compression method using different polymers like carbopol, hydroxypropyl methylcellulose and sodium alginate. Nine formulations were prepared while (F1) to (F3) were prepared by taking individual concentrations whereas all the remaining formulations were prepared by taking combinations of polymers. Aim of study is to develop and optimize mucoadhesive buccal ta...
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A STUDY OF ANTIMICROBIAL PRESCRIPTION PATTERN IN THE EAR, NOSE AND THROAT INFECTIONS AT A TERTIARY CARE TEACHING HOSPITAL, RAJKOT
Introduction: The ear, nose and throat (ENT) infections can be caused by a variety of microorganisms such as bacteria, fungi and viruses. Their treatment involves the use of appropriate antimicrobial agents and inappropriate use is closely linked to antibiotic resistance. Hence, present study was planned to evaluate the prescribing pattern of antimicrobials in the ENT outpatient department of a te...
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