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TRIDAX PROCUMBENS ATTENUATES ACETAMINOPHEN – INDUCED FREE RADICAL REACTION AND CELL NECROSIS IN CULTURED MOUSE HEPATOCYTES
Drug-induced hepatotoxicity represents a major clinical problem and an impediment to new medicine development. In vitro evaluation of hepatotoxicity is an essential stage in the research and development of new pharmaceuticals as the liver is one of the most commonly impacted organs during preclinical toxicity studies. The effect of an aqueous leaf extract of Tridax procumbens was evaluated...
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1521
DETECTION OF PORIN ANTIGEN IN SERUM FOR EARLY DIAGNOSIS OF TYPHOID INFECTION
Typhoid fever is serious public health problem in many parts of the world.Typhoid fever, also known as enteric fever, is an illness caused by the bacterium, Salmonella typhi. The immunology of typhoid fever in man has been the subject of a recent review. The diagnosis and subsequent treatment could reduce infection complication towards acute illness. It is difficult at present time, to diagnose ...
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1410
DIFFERENT TYPE OF CELL DEATH INDUCTION BY CURCUMIN, ARSENIC TRIOXIDE AND DEGRASYN (WP1130) IN HUMAN MULTIPLE MYELOMA CELLS
Curcumin has been shown to inhibit the activation of nuclear factor-κB (NF-κB), which is closely linked to chemo-resistance, in multiple myeloma cells. Malignant cells of this kind typically develop progressive multidrug resistance. Our aim was to investigate new possibilities for overcoming this resistance by suppressing cell signaling pathways. MTT-dye reduction assay was used to evaluate the ...
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1541
SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND CLOPIDOGREL BY SIMULTANEOUS EQUATION METHOD IN CAPSULE DOSAGE FORM
The current work is intended towards the development of a simple, rapid and precise UV-Visible spectrophotometric method for the simultaneous estimation of Atorvastatin (ATR) and Clopidogrel (CP) present in the marketed formulation using UV simultaneous equation. Methanol was used as a solvent and the absorbance of the drug was measured at the absorbance maxima (λmax) of Atorvastatin & Clopid...
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1628
NEW POTENTIAL ALLELOCHEMICALS FROM AERIAL PARTS OF INDIGOFERA TRIFOLIATA LINN.
Two new potential allelochemicals were isolated from ethanolic extract of the aerial parts of Indigofera trifoliata Linn. Along with three known compounds Tricin (3), Taraxerol (4) and 5-hydroxy-3, 4′, 7-trimethoxyflavone (5). The structures of new allelochemicals were characterized as 6, 3′, 4′-trihydroxy-5, 7, 8-trimethoxyflavanone-4′-O-α-L-rhamnopyranosyl-(1→4)-O-β-D-xylopyranosyl...
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DEVELOPMENT OF ONDANSETRON HCL FAST DISINTEGRATING TABLETS USING 32 FULL FACTORIAL DESIGN
The present investigation was carried out to study the disintegrant property of Plantago ovata and Ocimum basilicum mucilages. The objective of the work was to develop Fast disintegrating tablets of Ondansetron HCl with a view to enhance patient compliances and dissolution rate by direct compression method using 3² full factorial design. Plantago ovata (2-10% w/w), Ocimum basilicum (4-8%w/w) muci...
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ANTIMICROBIAL POTENTIAL OF SOME INDIAN MEDICINAL PLANTS AGAINST DRUG-RESISTANT PATHOGENS
Many infectious diseases are known to be treated with herbal remedies throughout the history of mankind. Even today, plant materials continue to play a major role in primary health care as therapeutic remedies in many developing countries. Traditional system of medicine is found to have utilities as many accounts. Due to population rise adequate supply of drug and high cost of treatment in side ef...
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1671
ASSESSMENT OF FOOD, ETHNOBOTANICAL AND ANTIBACTERIAL ACTIVITY OF TRICHOSANTHES CUCUMIRINA L.
Trichosanthes cucumirina L., locally known as “Chachindra” among the tribal and rural mass of Similipal Biosphere Reserve (SBR) forest. Plant parts are used as ethnomedicine among inhabitants of SBR. They use the fruits, leaves, and roots against various diseases and traditional practices are continuing since long. Leaves are used against microbial infections, roots against diabetic and fruits...
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1321
EVALUATION OF ANTIMICROBIAL ACTIVITIES AND DNA-BINDING PROPERTIES OF MOLYBDENUM COMPLEXES
Molybdenum is a trace element distributed widely in nature which plays an important role in plant and animal nutrition and in our industrial society. Molybdenum is essentially present in the enzymes nitrogenase, Xanthine-oxidase, sulphite oxidas, nitrate reductase, formate dehydrogenase and aldehyde oxidase. These enzymes are responsible for a number of catalytic reactions of redox nature. M...
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1584
MORPHOMETRY OF THE THYROID GLAND IN DIFFERENT AGE GROUPS IN NORTH INDIAN POPULATION: A CADAVERIC STUDY
Aims and Objectives: The present study was conducted to find out morphometry of thyroid gland in different age groups. Material and Methods: The study was conducted on 60 human thyroid glands in the Department of Anatomy, Pt. B. D. Sharma, PGIMS, Rohtak in North Indian population. Results: In present study, mean length of right and left lobe of thyroid gland was found to be 29.88±7.03 mm and 29.4...
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