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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NEW BAYLIS-HILLMAN DERIVED NITRO METHYLENE IMIDAZOLE DERIVATIVES AS INSECTICIDAL AGENTS
A series of Baylis-Hillman derived N-cinnamyl substituted nitro methylene imidazole derivatives 4a-swere synthesizedfrom Baylis-Hillman acetates and nitro methylene imidazole compoundsand characterised by 1H NMR, IR, Mass and HRMS spectroscopy. Their insecticidal activities were evaluated against T. Castaneum and compared with a standard insecticide Permethrane. Preliminary biological activity tes...
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INVESTIGATION OF SELECTED HERBOMINERAL FORMULATION T-AYU-H & T-AYU-HM™ PREMIUM AS AN ANTISICKLING AGENT FOR SICKLE CELL ANEMIA
Sickle cell anaemia is a genetic blood disorder that is caused by a mutation in the gene that encoded b-globin of haemoglobin, which results as the presence of abnormal haemoglobin HbS in the RBC. Presently, there is no universal cure for sickle cell anaemia Herbomineral formulations were standardized for organoleptic properties (colour, odour and taste), physiochemical properties, total ash value...
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NON-PROLIFERATIVE ACTIVITY OF SAPONINS ISOLATED FROM THE LEAVES OF GYMNEMA SYLVESTRE AND ECLIPTA PROSTRATA ON HEPG2 CELLS- IN VITRO STUDY
The non-proliferative activity of isolated saponins, gymnemagenol (C30H50O4) from Gymnema sylvestre and dasyscyphin C (C28H40O8) from Eclipta prostrata leaves were tested under on HepG2 cells under in vitro conditions. Both gymnemagenol and dasyscyphin C exhibited non-proliferative activity on HepG2 cells at 24 h with the IC50 value of 18.5 and 23.5μg/ml respectively. 5-Fluorouracil (5FU) a posit...
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STRUCTURAL DYNAMICS OF LACTOBACILLUS RHAMNOSUS PROTEINS UNDER COPPER SULPHATE AND ZINC CHLORIDE STRESS
Lactobacillus rhamnosus plays an important role as probiotic often associated with beneficial health effects. Although copper and zinc are trace metals, they are toxic at high concentrations. In this paper, bioinformatic tools and molecular modeling approach was adopted to explore the structure of L. rhamnosus under copper sulfate and zinc chloride stress. The differentially expressed proteins un...
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NON ALCOHOLIC FATTY LIVER DISEASE: A BRIEF OVERVIEW
The occurrence of non-alcoholic fatty liver disease (NAFLD) is around 20-30% in the general population. NAFLD is usually asymptomatic, although a minority of patients may present with evidence of progressive liver injury with complications of cirrhosis, liver failure, and hepatocellular carcinoma. In spite of being common and potentially serious, relatively little is known about the natural histor...
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ANTIOXIDANT AND LIPID LOWERING EFFECTS OF ELAEOCARPUS GANITRUS IN CHOLESTEROL FED RABBITS
Elaeocarpus ganitrus Roxb. is reported to exhibit multifarious pharmacological activities. However no scientific study has been conducted to evaluate antiatherosclerotic /lipid lowering activity of E. ganitrus Roxb. The present study was designed to investigate the antihyperlipidaemic and antioxidant activity of 70% ethanolic extract of E. ganitrus seed (EGEE) in cholesterol fed hyperlipidaemic ra...
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DETECTING MEDICATION ERRORS FROM ADVERSE DRUG REACTION MONITORING CENTRE DATABASE – A RETROSPECTIVE ANALYSIS
Introduction: Despite the traditional focus on adverse drug reactions, pharmacovigilance centres have recently been identified as a potentially rich and important source of medication error (ME) data. The aim of this study is to identify ME from adverse drug reaction (ADRs) reports. Materials and methods: A retrospective analysis of ADR reports notified to adverse drug reaction monitoring centre o...
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TOXICITY STUDIES OF AQUEOUS EXTRACT OF BRIDELIA MICRANTHA STEM ADMINISTERED ON MICE AND RATS
The World Health Organization (WHO) defines traditional medicine as “the health practices, approaches, knowledge and beliefs incorporating plants, animals and mineral-based medicines, spiritual therapies, manual techniques and exercises, applied singularly or in combination to treat, diagnose and prevent illness or maintain wellbeing. Various compounds have been isolated from Bridelia micrantha ...
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STUDY OF THE EFFECT OF SODIUM VALPROATE ON ENHANCEMENT OF MONOAMINE MEDIATED BEHAVIOURAL RESPONSES AFTER ELECTROCONVULSIVE SHOCK (ECS) ADMINISTRATION IN RATS
Objectives: To obtain the data regarding the effects of sodium valproate on enhancement of monoamines mediated behavioural responses following administration of ECS for ten days to rats. Methods: Forty rats were selected for the study in which tonic-clonic seizures were developed fully after giving single maximal electroconvulsive shock (150V, 210mA). Four groups (n= ten in each) were received dif...
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EFFECTS OF GLYCOSMIS PENTAPHYLLA LEAF POWDER AGAINST CHRONIC ARSENICOSIS IN RATS
The present study was undertaken to evaluate the effects of Glycosmis pentaphylla (GP) leaf powder against sodium arsenite (NaAsO2) induced toxicosis in adult albino rats. Forty eight albino rats having body weight 150-200 gm of either sex were randomly divided (equally) into four groups viz., I0, I1, I2, I3. Sodium arsenite was administered at 4mg/kg body weight daily in drinking water for 90 day...
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