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DESIGN OF EXPERIMENT UTILIZATION TO DEVELOP AND VALIDATE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY TECHNIQUE FOR ESTIMATION OF SERTACONAZOLE NITRATE
A novel method of estimation and validation of Sertaconazole nitrate (SER) by Reverse Phase-High Performance Liquid Chromatography coupled with Ultra-violet detection was developed which had high potential in determining drug concentration with more precision and high accuracy. The process of elution was conducted using Phenomenex C18 (250 mm × 4.6 mm i.d., 5.0 μm) using 0.01M monobasic sodium p...
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DESIGN, SYNTHESIS AND CYTOTOXIC ACTIVITY OF SOME NOVEL FLAVONES
A series of flavones (5-15) weresynthesized from resorcinolvia Baker-Venkataraman transformation, characterized and evaluated for their cytotoxicity against human cervical cell line (HeLa) by MTT assay method. The result of preliminary MTT cytotoxicity studies shown that the compounds 5, 9 and 10 were found to be most potent against HeLa cells; IC50 values were of 0.22, 0.88 and 1.26 µM respect...
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SYNTHESIS, SPECTRAL CHARACTERIZATION AND PHARMACEUTICAL IMPORTANCE OF NOVEL 4H-1, 4-BENZOTHIAZINES, AND THEIR SULFONE ANALOGUES
In recent years, synthesis and biological evaluation of novel 4H-1, 4-benzothiazines and their sulfone analogues have gained momentum due to their medicinal and industrial importance. The present article describes the synthesis of new 4H-1, 4-benzothiazines via condensation and oxidative cyclization of substituted 2-aminobenzenethiols with compounds containing active methylene groups. It is believ...
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IN-VIVO STUDY OF ORODISPERSIBLE TABLET OF PRIMAQUINE
The main objective of the study is to evaluate orodispersible tablets of primaquine with different in-vivo parameters. Sharma P et al., (2015), in-vitro study was based on various evaluation parameters of orodispersible tablets of primaquine. From their study results, we have selected formula-6 of orodispersible tablets of primaquine for in-vivo study. Taste masking evaluation was performed on fiv...
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IN-SILICO STUDY OF TOXICITY MECHANISMS FOR METABOLITES OF PHYTO-COMPOUNDS FROM MUSA SP. COMPARED TO SYNTHETIC MEDICINE RANITIDINE
An in-silico attempt to predict rat oral acute toxicity, hepatotoxicity, immunotoxicity, genetic toxicity endpoints, nuclear receptor (NR) signaling, and stress response (SR) pathways of metabolites of synthetic medicine Ranitidine and flavonoids of Musa sp. The metabolites of common flavonoids and synthetic medicine were taken from literature, and the prediction was done by using ProTox-II webser...
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ANTIBACTERIAL ACTIVITY OF HEXANIC EXTRACT OF RUTA GRAVEOLENS ON KLEBSIELLA PNEUMONIAE- A COMMON POST- ORTHOPEDIC SURGERY INFECTION
Introduction: Klebsiella pneumoniae is one of the most frequent infection organism following orthopedic surgeries and specifically total hip arthroplasty. Recently, attitude toward herbal medicine is being popular both in people and health care systems. Ruta graveolens is a traditional herbal remedy Iranian medicine and some other countries with a wide spectrum of therapeutic utilities. Our purpos...
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A NOVEL APPROACHES FOR DRUG DEVELOPMENT AND PHARMACOLOGICAL STUDY OF HERBAL PLANT
From ancient times, herbal medicines are in use to cure the diseases due to their impending and less side effects. But complications in identification, processing, standardizing, extracting of herbal drugs, it seldom attracts scientists towards the development of novel delivery systems for herbal drugs. During drug development, the complete knowledge of novel scientific approaches like toxicity st...
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ADVERSE DRUG INTERACTIONS IN ELDERLY HOSPITALIZED PATIENTS: A PROSPECTIVE ANALYSIS
Objective: To determine the incidence, characteristics, predictors and cost associated with the management of adverse drug interactions (ADIs) in elderly population. Methods: The prospective, intensive and interventional study included all patients taking at least two medications who were elderly admitted to medicine or surgery wards of a tertiary care hospital and were followed untill discharge. ...
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IN-VITRO STUDIES ON OIL DEGRADING BACTERIA ISOLATED FROM OIL CONTAMINATED SOIL OF VANIYAMBADI AND AMBUR AREAS OF VELLORE DISTRICT
The oil polluted soil has many hydrocarbons which can be degraded by microbes. These oil degrading microbes were isolated from the oil contaminated soil through plate and dilution technique. The oil contaminated soils were collected from the oil spilled places of Vaniyambadi and Ambur areas of Vellore District, Tamil nadu, India. Through the biochemical tests, the isolated bacterial strains were i...
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ACU-TENS STIMULATION AT BILATERAL ZUSANLI (ST36) ACUPOINT IN STREPTOZOTOCIN INDUCED DIABETIC RATS
The ancient medicine acupuncture was used to treat the diabetes and its complications. Our study was aimed to find out the hypoglycemic effect of Acu-TENS electrical stimulation at bilateral Zusanli (ST36) acupoint in streptozotocin (45 mg/kg/body weight/IP) induced diabetic rats. Diabetes was induced in male albino wistar rats with the administration of single dose of streptozotocin(45mg/kg/body ...
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