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STUDIES ON VIBURNUM NERVOSUM HOOK CHEMISTRY AND SPECTROSCOPY OF BERGENIN AND ITS DERIVATIVES
Bergenin is reported to occur in Viburnum nervosum (Capprifoliaceae). This is the first report of its occurrence in genus Viburnum. Derivative of Bergenin viz Bergenin diethyl ether, its penta acetate and diethyl ether triacetate have been prepared. Their method of preparation and characterization by spectroscopy is reported for the first time....
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THE MOST RELIABLE APPROCH TO DEFEAT ‘A SILENT KILLER’
Yoga and exercise are an efficient way of declining patients of hypertension in present and in future. However it has been shown that Non-pharmacological intervention prevent the rising blood pressure and reduce it up to maximum extent, near to the normal. This experiment was designed to determine effectiveness of Yoga and exercises therapies to control blood pressure of hypertension patients. The...
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NATURE AND CAUSE OF TAKING PSYCHOTROPIC DRUGS: A CROSS-SECTIONAL HEALTH SURVEY IN NORTHERN REGIONS OF BANGLADESH
A health study was conducted in Northern Region of Bangladesh to determine the prevalence and cause of taking psychotropic drugs. The health survey was involved 615 patients who are taking psychotropic drugs and found 63.58% patient is male and 36.42% is female. The majority of patients are student (45.65%), housewife (19.02%) and service holder (13.33%). The age of patients is 15 - 24 years 35.93...
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OPTIMIZATION OF EFFECT OF SUPERDISINTEGRANTS AND SUBLIMING AGENT ON ORODISPERSIBLE TABLET OF ONDANSETRON RESINATE
Ondansetron is a serotonin 5HT3 antagonist; anti emetic drug. Bitter taste of the ondansetron is a major problem in ensuring patient compliance. Resinates of ondansetron were prepared with Indion 234 and loading process was optimized. A 3² factorial design was used for formulation development of orodispersible tablet of these taste masked resinates. The amount of subliming agent (camphor) and sup...
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DEVELOPMENT AND EVALUATION OF A DIRECTLY COMPRESSIBLE CO-PROCESSED MULTIFUNCTION SUSTAINED RELEASE AGENT FOR ISOSORBIDE MONONITRATE SUSTAINED RELEASE TABLETS
Directly compressible co-processed sustained release multifunction agent [DCCSRA] comprising povidone and glyceryl behenate in the ratio of 1:1, 1:2 and 1:3 were prepared and evaluated for formulation of sustained release tablets of isosorbide mononitrate. The DCCSRA exhibited good flow and compressibility. The DCCSRA, prepared by hot melting method and co-precipitation method served as a retardan...
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DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ABACAVIR AND LAMIVUDINE IN COMBINED TABLET DOSAGE FORM USING MULTICOMPONENT MODE
A simple, accurate, precise, economical analytical method has been developed for the simultaneous estimation of abacavir and lamivudine in pure bulk drug and in combined tablet dosage form by UV spectrophotometry in multicomponent mode. The standard solutions of abacavir and lamivudine in mixture of acetonitrile and methanol were diluted with distilled water individually to get the concentration o...
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RELATIVE EXPLORATION OF IN-VITRO ANTI- INFLAMMATORY ACTIVITIES OF DIFFERENT ARTOCARPUS SEED EXTRACTS
The study was undertaken to investigate and compare in vitro anti inflammatory activities of five varieties of hexane and methanol seed extracts each, specifically Artocarpus heterophyllus, Artocarpus integrifolia, Artocarpus hirsitus, Artocarpus inciscus and Artocarpus integer of Artocarpus species belonging to the family Moraceae by means of most prominent membrane stability assay. Results revea...
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SYNTHESIS OF NOVEL IMIDAZO [1, 2-a] PYRIDINE FOR THEIR POTENT ANTI-CONVULSANT ACTIVITY
Synthesis of a Derivatives of imidazo[1,2-a]pyridines with potent activity. Synthetic approaches allowing for variation of the 2-Amino Pyridines as well as other imidazopyridine substituents are outlined and resulting effects on anticonvulsant activity are highlighted. An experimental evaluation of anticonvulsant activity of synthesized Imidazo[1,2-a]pyridine derivatives by Maximal Electro Shock (...
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HEMAGGLUTININ PROTEIN 35.7 kDA ACTS AS AN ADHESION MOLECULE IN THE OUTER MEMBRANE PROTEIN (OMP) OF SHIGELLA DYSENTERIAE
Shigellosis becomes a major health problem of developing countries. It is caused by Shigella spp. Shigella dysenteriae causes the most severe; prolonged and fatal Shigellosis by its ability in producing Shigatoxin (Stx). Unfortunately, there has not been any effective vaccine available in worldwide and using antibiotic is no longer effective. Adhesion molecule of bacteria can be used as component ...
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DIETHYLSTILBESTROL (DES) INDUCED ENDOMETRIOSIS IN BALB/C MICE TREATED WITH MMP-2 AND 9 INHIBITORS-I
Diethylstilbestrol (DES) is an endocrine disturbing compound it can mimic and perform like a natural hormone, which mimics estradiol by binding to the estrogen receptor. This compound mainly reproductive target, so in this study used to induce endometriosis. Endometriosis is an estrone dependent constant gynaecological disorder. Here it, intends to induce endometriosis and treated by the MMP inhib...
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