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RP-HPLC METHOD FOR QUANTIFICATION OF OROTIC ACID IN CAPSULE FORMULATION
A simple, sensitive and specific RP-HPLC method was developed and validated for the determination of Orotic acid in bulk and capsule dosage form. Chromatography was carried out on an Enable C18G (250 × 4.6 mm i.d.,5µ) column using filtered and degassed mixture of acetonitrile and methanol in the ratio of 60:40% v/v as mobile phase at a flow rate of 1 ml/min and effluent was monitored at 280 nm. ...
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RAS GTPase AS THE DRUG TARGET FOR ANTI-CANCER DESIGNING OF DRUG FROM TEMPLATE
Ras proteins in association with GTP and GDP act as a bio-molecular switch for signaling cell growth, cell survival and signal transduction. The presence of mutated Ras proteins is found to vary in different cancer types and the highest occurrence of about 90% is observed in pancreatic cancer. The Ras GTPase binding site is mainly involved in signal cell proliferation. Hence, this binding site h...
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COLON SPECIFIC DRUG DELIVERY SYSTEM: REVIEW ON NOVEL APPROACHES
Article reviews the research focus on potential opportunities and challenges available in new area of colon targeted drug delivery system. Colon was considered as “BLACK BOX” as, most of drugs are absorbed from upper part of GIT tract. Targeted drug delivery to the colon would ensure direct treatment at the disease site, lowering of dose and lesser systemic side effects. In addition, the colon...
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SCREENING OF ANTI-INFLAMMATORY POTENTIAL OF CISSAMPELOS PAREIRA LINN LEAVES EXTRACT IN ALBINO RATS
Anti-inflammatory activity of the ethanolic extract of the Cissampelos pariera Linn leaves was studied in albino wistar rats using the carrageenan induced rat paw edema model. The ethanolic extract of Cissampelos pariera (400 mg/kg p.o.) inhibited carrageenan induced rat paw edema. The extract was also studied for its preliminary phytochemical screening and acute toxicity studies. The result indic...
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COMPERATIVE STUDY OF RIVEA HYPOCRATERFORMIS, CYNODON DACTYLONE AND BALANITE AEGYPTICAE USING ANTILITHIATIC ACTIVITY IN VITRO
Ethanolic extracts of Rivea hypocraterformis, Methanolic extract of Cynodon dactylone and Water extract of Balanite aegypticae were tested for their in vitro antilithiatic /anticalcification activity by the homogenous precipitation method. The extracts were compared with an aqueous extract of cystone (a marketed preparation) for their activities. Extracts of Rivea hypocraterformis showed activity ...
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DASHAMULARISHTA: PHYTOCHEMICAL AND ANTIMICROBIAL SCREENING AGAINST EFFECT OF ENVIRONMENTAL POLLUTION
Pollution have a serious impact on human health and environment. The incidences of various diseases are becoming prominent with the increase in rate of population. The diseases mainly include respiratory disorders, cardiovascular disorders, throat inflammation, skin infections etc. In the present study, widely claimed crude drug Dashamularishta, have been screened for their antibacterial activit...
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AN EVALUATION ON GRAIN QUALITY UNDER POST HARVEST STORAGE IN SELECTED INDIAN WHEAT VARIETIES
Wheat belongs to the genus Triticum of the grass family, Poaceae. This genus is originated in tropical South west Asia, where it occurs in wild as well as in cultivated forms. Man has depended upon the wheat plant for thousands of years. Wheat (the Triticum spp.) is cultivated worldwide. The grain production varies from year to year and hence the grains should be stored strategically from years of...
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BIOCHEMICAL CHARACTERIZATION OF PROTEASE FROM ZINGIBER OFFICINALE RHIZOME BY USING NEURAL NETWORKING APPROACH
Biochemical characterization of enzyme is the most fundamental aspects of enzymology from industrial point, as it is desirable to choose an enzyme which will have the fastest reaction rate per unit amount of enzyme which indicates the maximum effect for the minimum amount of added catalyst. In this study, Protease enzyme was extracted from Z. officinale and purified by using various down streaming...
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SYNTHESIS, EXPERIMENTAL STUDIES OF THE ANTIMICROBIAL POTENTIAL OF SOME NOVEL 1, 5- BENZO THIAZEPINE DERIVATIVES
Optically active 1, 5- benzothiazepines belong to the well known benzothiazepine type substances. Some of them possess important bioactivities. In this article, optically active 2, 3-dihydro-1, 5-benzothiazepine derivatives are synthesized by the reaction of new α-β unsaturated carbonyl compounds with 2-aminothiophenol under mild conditions in the presence of silver sulphate in acetonitrile in s...
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MITIGATING POTENTIAL OF ALLLIUM SATIVUM ON ARTESUNATE INDUCED RENAL TOXICITY IN MALE MICE
In recent times, the use of natural antioxidants as ameliorative agents has become the focus of basic research. Allium sativum (garlic) is one such agent which has been proven to have antibacterial, antiseptic, antifungal, antiparasitic, anticoagulant and antitumor properties. The present investigation deals with the ameliorative effects of Allium sativum on the induced renal toxicity of the antim...
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