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ANTI-INFLAMMATORY ACTIVITY OF ETHANOL EXTRACTS OF LEAF AND BARK OF NARINGI CRENULATA (ROXB.) NICOLSON
Ethanol extracts of Naringi crenulata leaf and bark were evaluated for its anti-inflammatory activity at the dose levels of 250mg kg-1 and 500mg kg-1 body weight using a Carrageenan induced paw oedema method (acute inflammation). Results showed that both leaf and bark ethanol extracts had potent and significant anti-inflammatory activity. These results were also comparable with reference drug ...
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GC-MS ANALYSIS OF ANTI-MICROBIAL COMPOUNDS FROM ANTHERAEA MYLITTA COCOONS
The architecture of cocoons and the chemical compounds present in the cocoons play crucial role to provide protection of the pupae during metamorphosis. Insects spin a silk web as cocoon to facilitate protection and ensuring proper inner environment inside the cocoon during the metamorphosis. Such cocoons are equipped with a variety of chemical compounds which include antibacterial, antifungal, in...
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ISOLATION OF ACAULOSPORA SPECIES FROM JATROPHA CURCAS L AND PONGAMIA PINNATA PIERRE
Jatropha curcas L. and P. pinnata Pierre is gaining importance as biodiesel crop in India. Jatropha curcas L. a member of the family Euphorbiacea and Pongamia pinnata, a member of the family Leguminoseae. A study was conducted to identify common arbuscular mycorrhizal fungi present in its rhizosphere from different regions of India viz., Jodhpur (Rajasthan), Hissar (Haryana), Jhansi and Lalitpur (...
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A STUDY ON THE EFFECT OF ISOBARIC HYPOXIA ON ANTIOXIDANT ENZYME ACTIVITY AND LIPID PEROXIDATION IN RAT BRAIN
In the present work, an attempt was made to study the effect of isobaric hypoxic hypoxia (10%) on rat brain. Since literatures support generation of free radicals during post ischemic/hypoxic period, here hypoxia followed by reoxygenation is dealt with as the single problem. Subsequently, as brain shows regional variations in its function and metabolic activities an attempt was made to study effec...
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SYNTHESIS, CHARACTERISATION AND ANTIFUNGAL STUDIES OF Cu (II) HALIDE COMPLEXES OF SOME STERYL DERIVATIVES OF SUBSTITUTED BENZIMIDAZOLES
Complexes of Copper (II) halides with steryl derivative of 2- methylbenzimidazole (stmbz), 2-ethylbenzimidazole (stebz) and 2-benzylbenzimidazole (stbbz) of composition CuL2X2 (L = stmbz, stebz and stbbz and X = Cl, Br) have been prepared and characterised. The magnetic susceptibility e.p.r. data, electronic absorption pattern and i.r. spectral studies of complexes indicated distorted octahedral e...
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THE EFFECT OF HYRDRAZIDE GROUP ON THE OXYDATION OF FERROCENE AT TWO DIFFERENT ELECTRODES USING ROTATING DISK ELECTRODE (RDE) IN ORGANIC MEDIUM
Through this work we adopted Rotating Disk Electrode (RDE) Voltammetry to study the kinetics of oxidation and the effect of hydrazide group on ferrocene in organic medium. Thus, two different electrodes (Pt and Gc) were used in ordre to determine this latter. According to the ferrocene taken as a witness the hydrazide group related to the ferrocene made oxydation more difficult. This ferrocenic de...
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ANTICONVULSANT STUDIES ON LEAF EXTRACT OF ERYTHRINA INDICA LAM.
To determine the anticonvulsant activity of the leaf extract of Erythrina Indica in mice and rats, and in order to verify the traditional use of the plant in the treatment of epilepsy. The pentyleneterazole (PTZ) and the maximal electroshock seizure (MES) models were used for assessing the anticonvulsant effects of the chloroform leaf extract in mice and rats. The chloroform extract (500 mg/kg p.o...
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EFFECT OF GALANTAMINE WITH NEUROPHARMACOLOGICAL BENEFITS IN WISTAR RATS MODELS OF EPILEPSY AND BEHAVIOUR
Involvements of oxidative damage, deficiency of acetylcholine and cognitive impairment have been reported in the pathophysiology of epilepsy. It has been demonstrated that cholinesterase is degranulated at the site of a lesion it cause brain disorder leading to epilepsy. Cholinesterase inhibitor (Galantamine) inhibits the release of cholinesterase thus it benefits in epilepsy. So the aim of the st...
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TARGETED DELIVERY OF CATALASE TO MACROPHAGES BY USING SURFACE MODIFICATION OF BIODEGRADABLE NANOPARTICLE
Reactive oxygen species (ROS) produced by activated macrophages play a major role in causing liver disorders. Small antioxidants and scavengers are protective only at very high concentrations and they poorly detoxify toxic ROS. Catalase (CAT) is an antioxidant enzyme that scavenges ROS and has great potential for treating liver disorders. In the present research work, gelatin nanoparticles bearing...
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ANTIDIABETIC ACTIVITY OF HEARTWOOD OF TECOMELLA UNDULATA SEEM. AND HISTOLOGY OF ORGANS IN STREPTOZOTOCIN-NICOTINAMIDE INDUCED DIABETES MELLITUS IN EXPERIMENTAL RATS
Objective: The main objective of the present work was to analyze the therapeutic potential of various fractions of ethanolic extract of Tecomella undulata Seem. heartwood in streptozotocin - nicotinamide (STZ-NA) induced diabetes in experimental rats. Materials and methods: Diabetes was induced in the experimental rats by injecting nicotinamide and streptozotocin intraperitonealy at an interval of...
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