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DESIGN AND CHARACTERIZATION OF PULSATILE DRUG DELIVERY SYSTEM OF LERCANIDIPINE
The purpose of the present investigation is to formulate and evaluate Lercanidipine pulsatile drug delivery system by press coating method. The inner core tablets were prepared by using direct compression method by using cross-carmellose sodium (Ac-Di-Sol), sodium starch glycolate, crospovidone as super disintegrants. The drug polymer interaction was investigated by FTIR and their results directed...
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EVALUATION OF WOUND HEALING ACTIVITY OF ZIZIPHUS XYLOPYRUS (RETZ) WILLD LEAVES EXTRACT IN WISTAR ALBINO RATS
Aim: The present study provides a scientific evaluation for the wound healing activity of methanolic extract of Ziziphus xylopyrus (Retz) Willd leaves (MEZX). Methods: Incision and excision wound models were used to evaluate the wound healing activity of MEZX on Wistar rats. In each model, animals were divided into four groups of 6 animals each. In both model, Group I was assigned as control (oint...
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DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF DORZOLAMIDE HCl IN BULK AND PHARMACEUTICAL DOSAGE FORMS
Three Simple, precise, accurate and economical UV methods have been developed and validated for the quantitative estimation of Dorzolamide HCl in bulk and pharmaceutical dosage form. Dorzolamide HCl has the absorbance maxima at 253 nm in zero order spectra (Method A). In the first order derivative spectra, showed absorbance maxima at 238 nm (Method B) and in the second order derivative spectra, sh...
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ADVANCED INOPERABLE URINARY BLADDER ADENOCARCINOMA: A CASE REPORT
Aim: Primary urinary bladder adenocarcinoma is a rare entity. This is a clinical case presentation with review of the literature on this topic. Primary adenocarcinoma of the urinary bladder has shown a poor response to radiation or chemotherapy individually. Therefore, combination chemotherapy with radical EBRT is the effective therapeutic approach for inoperable cases. Method: A 58 year o...
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EVALUATION OF ANTIOXIDANT POTENTIALS OF SELECTED INDIAN MEDICINAL PLANTS
Oxidative stress is found to be one of the major causes of health hazards in the present global scenario. The traditional herbs and medicinal plants have been investigated for the presence of natural antioxidants, which have incredible effects in the prevention of various oxidative stress associated diseases. The objective of present investigation is to assess the antioxidant capacity and phytoche...
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DESIGN AND EVALUATION OF DILTIAZEM HYDROCHLORIDE LOADED BUCCAL PATCH
The purpose of this study was to develop and optimise the formulation of mucoadhesive patches of Diltiazem hydrochloride using chitosan as base matrix. The patches were prepared by solvent casting method. PVP (K30) and propylene glycol were introduced into the patches formulae to improve the filming properties. The patches were found to be smooth in appearance, uniform in thickness, weight, and ...
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RIFAMPICIN AND ISONIAZID MICROCAPSULES FOR TREATMENT OF TUBERCULOSIS
Rifampicin and Isoniazid microcapsules were prepared by phase seperation coacervation method for inclusion in suspension formulations. Ethyl cellulose was used as the coating material for microencapsulation. Developed microcapsules were characterized for visual appearance, photomicrography, sieve analysis, drug content, bulk density, ethyl cellulose content and drug release studies. Microcapsules ...
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EVALUATION OF EFFICACY AND SAFETY OF GEMIFLOXACIN IN CHRONIC BRONCHITIS PATIENTS
The study aimed to assess the efficacy and safety of Amoxicillin/Clavulanate 625 mg and Amoxicillin/Clavulanate 1 gram in chronic bronchitis patients. Chronic bronchitis, a type of COPD defined by a productive cough that lasts for 3 months or more for at least 2 years, other symptoms include wheezing and breathlessness, upon exertion. It is caused by recurring irritation to the epithelium of bronc...
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HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACTS OF NARINGI CRENULATA (ROXB) NICOLSON AGAINST CCl4 INDUCED HEPATOTOXICITY IN RATS
The present study was designed to screen and evaluate the hepatoprotective and antioxidant activity of ethanol extracts of leaf and bark of Naringi crenulata (Roxb) Nicolson (NCL, NCB) against CCl4 induced hepatotoxicity in rats. Liver functions were assessed by the activities of liver marker enzymes, SGOT, SGPT, ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubin...
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SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 2-SUBSTITUTED BENZOTHIAZOLE DITHIOMIDOCARBONATE DERIVATIVES
A series of novel 2- substituted benzothiazole dithiomidocarbonate derivatives were synthesized by the reaction of 2-amino benzothiazole with various halides. The test compounds were screened for their antimicrobial activity (antibacterial and antifungal) by disc diffusion method and the results of the microbial activity indicates that the test compounds exhibited varying degree of antimicrobial a...
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