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1-[3/-(SUBSTITUTED PHENYL) -5/- (AMINO PYRIMIDINE)]- 3- (4/-NITRO PHENYL) 5-(SUBSTITUTED PHENYL)- 2-PYRAZOLINES: SYNTHESIS, CHRACTERISATION AND ANTIMICROBIAL SCREENING
In the present study eight novel 2-pyrazoline - amino pyrimidine hybrids have been synthesized in order to search new chemical entities with increased pharmacological properties. The targeted analogues were synthesized in four steps; Claisen-schmidt condensation of 4-nitro acetophenone with different benzaldehydes in basic medium to yield precursor chalcone which was cyclised using hydrazine hydra...
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PHYTOCHEMICAL INVESTIGATION AND HEPATOPROTECTIVE EFFECT OF SCOPARIA DULCIS AGAINST CARBON TETRACHLORIDE INDUCED LIVER DAMAGE IN RATS
The objective of the present study is to carry out the photochemical investigation and hepatoprotective activity study of different extracts of Scoparia dulcis. Scoparia dulcis Linn. belongs to the family Scrophulariaceae and have ruminate medicinal properties. The different extracts of this plant were prepared by successive extraction with petroleum ether, chloroform and ethanol. These extracts (...
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COMPERATIVE STUDY OF RIVEA HYPOCRATERFORMIS, CYNODON DACTYLONE AND BALANITE AEGYPTICAE USING ANTILITHIATIC ACTIVITY IN VITRO
Ethanolic extracts of Rivea hypocraterformis, Methanolic extract of Cynodon dactylone and Water extract of Balanite aegypticae were tested for their in vitro antilithiatic /anticalcification activity by the homogenous precipitation method. The extracts were compared with an aqueous extract of cystone (a marketed preparation) for their activities. Extracts of Rivea hypocraterformis showed activity ...
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ASSESSMENT OF COMPLIANCE TO TREATMENT AMONG AMBULATORY ASTHMATIC PATIENTS IN A SECONDARY HEALTH CARE FACILITY IN NIGERIA
This study assessed the level of compliance using three different methods: pill count, self report and peak expiratory flow rate, in asthmatic patients attending a secondary health care facility. Self report (using a pre-tested structured questionnaire), peak expiratory flow rate and pill count were used to assess patient’s compliance and identify the factors which may be responsible for non com...
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THE HEATH RELATED QUALITY OF LIFE (HRQOL) FOR HYPERTENSIVE PATIENTS IN EASTERN PROVINCE IN SAUDI ARABIA: CROSS SECTIONAL STUDY
Background: Hypertension is associated with the flow of blood under high pressures, and is a risk factor for coronary heart disease. Methodology: We designed a prospective observational study that included 280 participants to investigate the effect of hypertension on the health-related quality of life (HRQOL) for hypertensive patients in the eastern province of KSA. To measure HRQOL, this study us...
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SCREENING OF ANTI-INFLAMMATORY POTENTIAL OF CISSAMPELOS PAREIRA LINN LEAVES EXTRACT IN ALBINO RATS
Anti-inflammatory activity of the ethanolic extract of the Cissampelos pariera Linn leaves was studied in albino wistar rats using the carrageenan induced rat paw edema model. The ethanolic extract of Cissampelos pariera (400 mg/kg p.o.) inhibited carrageenan induced rat paw edema. The extract was also studied for its preliminary phytochemical screening and acute toxicity studies. The result indic...
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A SHORT PERIOD STUDY ON VELLORE ENRICHED SOILS – A SOURCE FOR POTENTIAL MICROBIAL ENZYMES WHICH DEGRADES THE WASTE GENERATED FROM VARIOUS INDUSTRIES AND BYPRODUCTS CAN BE USED IN PHARMACEUTICALS
Waste is anything, which is not used by any owner, producer and processor, even though it has always been a part of the earth’s ecosystem. Enriched Soil is a good source for the isolation of power full and potential microorganisms which produces specific enzymes which target the waste and in turn produces pharmacologically viable products; Microbes hold this prominent position because of their d...
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IN VITRO EFFECT OF SOME IRANIAN MEDICINAL PLANTS ON THE HISTOMONAS MELEAGRIDIS PARASITE
Objective: This study aimed to investigate the in vitro effect of the extracts of five Iranian medicinal herbs on Histomonas meleagridis protozoan parasite. Methods: This study was conducted in the following three phases in Khorramabad, Iran, in 2016: 1) preparing and extracting the 5 medicinal herbs Dracocephalum kotschyi, Satureja khuzestanica, Pulicaria gnaphalodes, Olea europaea, and Echinopho...
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CONSERVED WATER MIMIC INHIBITOR DESIGN FOR hIMPDH (INOSINE MONOPHOSPHATE DEHYDROGENASE): MD SIMULATION AND DOCKING STUDIES OF IMP-ANALOGS
Inosine Monophosphate Dehydrogenase (IMPDH) plays a very important role in Guanosine Monophosphate (GMP) biosynthesis. Type I hIMPDH is expressed at lower levels in all cells, whereas type II is especially observed in acute myelogenous leukemia, chronic myelogenous leukemia cancer cells, so it is thought to be an active target for leukemic drug design. MD-simulation studies of the solvated modeled...
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A PRELIMINARY EVALUATION OF ANTIBACTERIAL AND TOXIC POTENTIALS OF P. GUINEENSE SWARTZ. FRUIT PULP FROM DIFFERENT STAGES OF RIPENESS
Psidium guineense Swartz is a shrub native to Brazil. It is consumed in natura or in the form of pulp, which presents a high content of C vitamin and proteins. The chemical prospection of the aqueous extracts from unripe and mature pulp revealed the presence of tannins and flavonoids. The extracts demonstrated moderate antibacterial activity against the most of strains tested, and the best result ...
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