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DOCKING, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL QUINOLINE CONTAINING SCHIFF BASES FOR ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES
Quinolines bears a very good synthon so that a variety of novel heterocyclic with good pharmaceutical profile can be designed. There are various biological activities for quinolones such as antibacterial, antimalarial and various drugs possessing quinolone as nucleus are ciprofloxacin (Cipro), lomefloxacin (Maxaquin), norfloxacin (Noroxin), ofloxacin (Floxin), moxifloxacin (Avelox) and levofloxaci...
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LANDFILL LEACHATE DEGRADATION USING ZINC OXIDE UNDER DIRECT SUNLIGHT
There has been a significant increase in the generation of MSW (Municipal Solid Waste) in India over the last few decades. The degradation of persistent organic pollutant using advanced oxidation processes with sunlight as energy source have a great advantage at lower costs. Pallikaranai wetland is a freshwater marsh in the city of Chennai, India. Pallikaranai marshland is the only surviving wetla...
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A NEW, SIMPLE, SENSITIVE, ACCURATE & RAPID ANALYTICAL METHOD DEVELOPMENT & VALIDATION FOR SIMULTANEOUS ESTIMATION OF LAMIVUDINE, ABACAVIR & ZIDOVUDINE IN TABLET DOSAGE FORM BY USING UPLC
The present work was undertaken to develop and validate a rapid and consistent UPLC method in which the peaks will appear in a short period as per ICH Guidelines. The UPLC separation was achieved on a Symmetry C18 (2.1 × 100mm, 1.7mm, Make: BEH) or equivalent in an Isocratic Mode. The mobile phase was composed of Phosphate Buffer (60%) [pH 3.0] & Methanol (40%) [UPLC Grade] The flow rate was ...
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MOLECULAR DOCKING STUDIES OF NOVEL IMIDAZOLE ANALOGS AS HIV-1-RT INHIBITORS
Molecular docking studies of 102 newly designed N-substituted imidazoles was performed in the non nucleoside inhibitory binding pocket of reverse transcriptase enzyme of wild type as well as resistant strains of HIV-1 virus with PDB ID 1RT2, 1JLB, 3BGR and 1FK9 respectively by using Glide 5.0 to carry out a binding mode analysis of the designed imidazoles. Results generated from this study indicat...
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METAL COMPLEXES OF RIBAVIRIN; SYNTHESIS, CHARACTERIZATION AND IN-VITRO BIOLOGICAL SCREENING
Medicinal applications of metals and its compound were reported centuries ago but it gained huge appreciation after the discovery of anticancer activity of metal based drug cisplatin. After cisplatin discovery many medicinal synthetic chemist moved into the field of organometallics for combating diseases and investigating the excellent pharmaceutical potential of metal complexes, giving birth to m...
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FORMULATION AND EVALUATION OF MICROSPHERES BASED ORO-DISPERSIBLE ROXITHROMYCIN TABLETS USING CENTRAL COMPOSITE DESIGN
The aim of this study was to develop microspheres based orodispersible tablets of roxithromycin using the solvent evaporation technique. The microspheres were formulated in to orodispersible tablets using direct compression technique by central composite design. The objective of the study was to analyze the effect of concentration of eudragit RS100 (X1) and concentration of polyvinyl alcohol (X2),...
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A REVIEW OF LIPID-POLYMER HYBRID NANOPARTICLES AS A NEW GENERATION DRUG DELIVERY SYSTEM
Lipid–polymer hybrid nanoparticles (LPNs) are next-generation core-shell nanoparticle structures comprising polymer cores and lipid/lipid–PEG shells, which produce complementary characteristics of both polymeric nanoparticles and liposomes, specifically in terms of their physical stability and biocompatibility. Recently the LPNs have been shown to have superior in vivo cellular delivery effica...
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MYELOPEROXIDASE AS A POTENTIAL BIOMARKER IN DIFFERENT STAGES OF KNEE OSTEOARTHRITIS
Osteoarthritis (OA) is disabling condition leading to loss of articular cartilage. Etiology of OA is not clearly understood and diagnosis of early stages of OA is difficult due to lack of specific markers. Recent literature suggest that elevation of Myeloperoxidase (MPO) levels in synovial fluid in early stages of OA as compared to controls and late stage OA. Presence of MPO in blood and Urine sam...
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ANTIDIABETIC ACTIVITY OF BARK AND ROOT OF CAESALPINIA BONDUE
The different extracts of the roots of Caesalpinia Bondue (Family- Fabeaccae) were tested for anti-diabetic activity, by glucose tolerance test in normal rats and alloxan induced diabetic rats. Aqueous ethanol and chloroform extracts had shown significant protection and lowered the blood glucose levels to normal in glucose tolerance test. In alloxan induced diabetic rats the maximum reduction in b...
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SYNTHESIS OF WATER SOLUBLE CROSSLINKED N- ACYL DERIVATIVE OF CHITOSAN AND ITS ASSESSMENT FOR ANTIMICROBIAL ACTIVITIES IN VITRO
Currently, natural polysaccharides are being utilized increasingly in the markets because they exhibit biodegradability, biocompatibility, versatility, and are found abundant in nature. Chitosan is a natural polysaccharide that possesses excellent biological properties. It has been recognized for its antibacterial activity, in that it is destructive towards the bacterium Escherichia coli (E. coli)...
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