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STUDY OF POTENTIAL TO INHIBIT HEMOZOIN FORMATION OF SOME NOVEL AMINOPROPANOLS
One of the factors responsible for malaria pathogenesis is the suppression of host immune responses. This suppression enhances parasitemia and diminishes the host immune response to malaria-expressed proteins and other pathogens. Hemozoin is a key metabolite associated with severe malaria anemia (SMA), immunosuppression, and cytokine dysfunction. Targeting of this pigment may be necessary in the d...
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SCREENING OF ANTICANCER AND ANTI-OXIDANT ACTIVITY OF LEAVES OF ANNONA RETICULATA ON EAC INDUCED SOLID TUMOR
Objective: The objective of the study was to evaluate the in-vivo anticancer and antioxidant activity of methanolic extract of leaves of Annona reticulata Linn. on EAC induced solid tumor. Methodology: Tumor cells (1 × 106 cells/mice/I.M.) were injected into the hind limb for solid tumor formation, and the treatment started from day 1 for 14 days. Group 1 served as a Normal control, Group 2 serve...
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PRODUCTION AND PURIFICATION STRATEGIES FOR LACCASE
Laccase belongs to polyphenol oxidases, which is a very wide family of copper-containing atoms in the center, which serves as the catalytic site. It is biochemically a glycoprotein with molecular mass being between 50kda to 130kda and 30% carbohydrate content, in addition to this it has three types of copper atoms. It is one of the most important enzymes due to its role in the food industry. It ac...
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COMPARATIVE ANTIOXIDANT ACTIVITY AND BRINE SHRIMP LETHALITY BIOASSAY OF DIFFERENT PARTS OF THE PLANT- ACACIA AURICULIFORMIS
The present study was undertaken to evaluate and compare the antioxidant activity and brine shrimp lethality bioassay of different parts (leaf and bark) of the plant Acacia auriculiformis. DPPH radical scavenging and NO scavenging capacity were measured for the determination of antioxidant activity. Ethyl acetate fraction of bark was found to possess highest DPPH radical scavenging activity with I...
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SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-ARYLQUINOXALIN-2-AMINES BEARING BENZIMIDAZOLE DERIVATIVES
In the present study reports synthesis and development of 3-Chloro – N - ((5-chloro-1-tosyl-1H-benzo [d] imidazol – 2 - yl) methyl) - N arylquinoxalin-2-amines (5a-e) from 3-chloro-N-p-tolyl quinoxalin -2-amine (3) condensed with proporgyl bromide followed by adding 4-chloro-N1-tosylbenzene-1,2-diamine,by adopting simple procedure. All titled compounds were screened for their anti bacterial ac...
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PHARMACOGNOSTIC CHARACTERIZATION OF STEM AND ROOT OF ADHATODA ZEYLANICA MEDICUS
Adhatoda zeylanica Medicus is a well-known plant drug in Ayurvedic, Unani-Tibbi, Siddha, Allopathic, Homeopathic, Naturopathic & Home Remedies. The present communication deals with the pharmacognostic evaluation on the stem and root of Adhatoda zeylanica Medicus (Acanthaceae). Macroscopic and microscopic examinations of the different organ, observations, and differential microchemical test has...
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PRIMITIVE NEUROECTODERMAL TUMOR PRESENTING AS QUADRI-PARESIS: A RARE OCCURRENCE
Primary spinal cord presentation of Primitive neuroectodermal tumors (PNET) is a rare occurrence and carries poor prognosis. A 13-year-old boy presented with pain in neck region, bilateral upper and lower limb weakness and bladder and bowel dysfunction. Neurological examination revealed the marked paresis with hyporeflexia of both the upper and lower extremities. Preoperative MRI of spine revealed...
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STUDY OF ANTIDEPRESSANT ACTIVITY OF CHRONIC ADMINISTRATION OF TRAMADOL AND WHEN IT IS CO-ADMINISTERED WITH FLUOXETINE IN LOW DOSES IN SWISS ALBINO MICE USING DESPAIR SWIM TEST
Objective: To evaluate the antidepressant activity of chronic administration of Tramadol alone and when combined with Fluoxetine in low doses in albino mice. Methods: The antidepressant effect was determined by recording the immobility time in Despair Swim Test. The mice were randomized into seven groups, with six mice in each group. Group 1 mice were given normal saline (10 ml/kg) which served as...
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LIPOPOLYSACCHARIDE (LPS) AND MURAMYL DIPEPTIDE (MDP) INDUCED CHRONIC LIVER INJURY IN HIGH FAT DIET FED RAT–A POSSIBLE MODEL FOR NON ALCOHOLIC FATTY LIVER DISEASE
Liver defend the PAMPs or DAMPs via regulation of innate immunity through modulation of “TOLL LIKE RECEPTORS and NOD LIKE RECEPTORS” A breakdown of tolerance may induce in appropriate immune response leads to acute and chronic liver diseases like NASH/NAFLD thus considered as disorders of immune response. HFD is itself a basic component for generating metabolic disorders and major source for f...
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INFUSION OF ADRENOMEDULLIN-2 ANTAGONIST INDUCES APOPTOSIS AND CHANGES m-RNA EXPRESSION LEVELS OF ADM2 RECEPTORS IN PLACENTA OF PREGNANT RATS DURING LATE GESTATION AND CAUSES FETOPLACENTAL GROWTH RESTRICTION
Adrenomedullin-2 or Intermedin (ADM2/IMD) is newly identified novel hormone belongs to peptide family like AM, calcitonin, CGRP, amylin and it is widely distributed in various tissues including ovaries, uterus & placenta. The aim of present study was to investigate the role endogenous ADM2 in fetoplacental development in pregnant rats during late gestation period through infusion of ADM2 antag...
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