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IN VITRO EVALUATION FOR CYTOTOXIC ACTIVITY OF THREE FERULA SPECIES
To study the effect of herbal materials as anti-cancer agents, the first step is to evaluate their cytotoxic activity; thus in the present study, the cytotoxic activity of the extracts and fractions of Ferula szowitsiana, F. hirtella and F. oopoda in MCF-7, HT-29, A-549 and HepG-2 cells have been investigated through MTT assay. The result showed that the n-hexane and chloroform fractions of F. szo...
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ANTIOXIDANT POTENTIAL FRACTIONATION FROM METHANOL EXTRACT OF AERIAL PARTS OF RUELLIA PROSTRATA POIR (ACANTHACEAE)
Aerial parts of Ruellia prostrata were subjected to extraction and further fractionation to obtain antioxidant rich fraction. Different concentrations of methanolic extract and its n-butanolic fraction were subjected to antioxidant assay by DPPH method, Nitric oxide scavenging activity and reducing power assay. The fractions showed dose dependent free radical scavenging property in all the models....
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ADVANCED INOPERABLE URINARY BLADDER ADENOCARCINOMA: A CASE REPORT
Aim: Primary urinary bladder adenocarcinoma is a rare entity. This is a clinical case presentation with review of the literature on this topic. Primary adenocarcinoma of the urinary bladder has shown a poor response to radiation or chemotherapy individually. Therefore, combination chemotherapy with radical EBRT is the effective therapeutic approach for inoperable cases. Method: A 58 year o...
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FATTY ACIDS OF HIPPOCRATEA AFRICANA ROOT: ANTIOXIDANT AND ANTI-MICROBIAL ACTIVITY
In this study, the fatty acid content, antioxidant activities and antimicrobial potential of oil obtained from the root of Hippocratea africana was investigated. Results showed that the oil was characterized by oleic acid (65.73%), palmitic acid (20.34%) and linoleic acid (6.90%) as the most abundant fatty acids with a oleic acid/linoleic acid ratio of 9.52. The oil possessed potent antioxidant ac...
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VIRTUAL SCREENING OF NOVEL HIV-RT NNRT INHIBITORS USING ZINC DATABASE
Non-nucleoside reverse transcriptase inhibitors (NNRTI) are a group of small hydrophobic compounds with diverse structure that specifically inhibit HIV-1 reverse transcriptase (RT) by allosteric bind to change its conformation. NNRTIs interact with HIV-1 RT by binding to a single site on the p66 subunit of the p66/p51 heterodimeric enzyme, termed the NNRTI-binding pocket (NNRTI-BP), binding intera...
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PREVALENCE OF DIETARY SUPPLEMENTS AND AYURVEDIC MEDICINES’ INTAKE BY PATIENTS TAKING PRESCRIBED ALLOPATHIC MEDICINES AT LUCKNOW
Aim: Present study was done to know the prevalence of the use of dietary supplements and ayurvedic drugs by patients taking allopathic drugs. Introduction: Allopathic drugs are likely to act with ayurvedic drugs and dietary supplements and concurrently used. This concept is usually not recognized by the patients and physicians. Sometimes this may prove dangerous. Present study was done to find ...
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SYNTHESIS, CHARACTERIZATION AND COMPARATIVE STUDY OF CERTAIN METAL-1, 3-DIKETONATES
A substantial interest in rational design of novel transition metal complexes which bind and cleaves duplex DNA has been a motivation of the present investigation. This DNA adhesion of metal complex which targets bacterial DNA and cleaves it thereby results in an effective antibacterial agent. In the present work two series of metal diketonates were prepared by using diketones like acetyl acetone ...
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VARIATIONS IN PHENOLICS, ANTIOXIDANT AND PHYTOCHEMICAL COMPOSITION OF SALVADORA PERSICA IN TWO LOCATIONS
Phenolic extracts of crude oil and methanol extracts of defatted seed cake were used to evaluate total phenolics, flavonoids content and antioxidant activity for two locations. The seeds were evaluated for their proximate composition while oils were subjected to chemical analysis. Salvadora persica had highest phenolics ranged from 12.3 ± 0.3 to 22.3 ± 0.3mg GAE/g and flavonoids content 3.7 ± 0...
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PLANT REGENERATION FROM THE NODAL PART OF CITRULLUS COLOCYNTHIS (L.) SCHARD.
Citrullus colocynthis, belonging to the family of cucurbitaceae. It is a xerophytic desert plant, widely used for its medicinal purpose. In tribal areas it is used for the treatment of constipation, oedema, bacterial infection, cancer, diabetes and abortifacient. Present study is based on developing a protocol for plantlet regeneration from the nodal segment. The sterilized explants were inoculate...
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DOCKING, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL QUINOLINE CONTAINING SCHIFF BASES FOR ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES
Quinolines bears a very good synthon so that a variety of novel heterocyclic with good pharmaceutical profile can be designed. There are various biological activities for quinolones such as antibacterial, antimalarial and various drugs possessing quinolone as nucleus are ciprofloxacin (Cipro), lomefloxacin (Maxaquin), norfloxacin (Noroxin), ofloxacin (Floxin), moxifloxacin (Avelox) and levofloxaci...
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