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SPECTROPHOTOMETRIC DETERMINATION OF MEBENDAZOLE THROUGH CHARGE TRANSFER INTERACTIONS
This article presents the development of a direct, simple and sensitive spectrophotometric method for the quantitative analysis of mebendazole (MBz), an anthelmintic medication in its pure and pharmaceutical forms. The method is based on the charge transfer (CT) interactions between MBz, an electron donor, and chloranilic acid (CA), 3,5-dinitrosalicylic acid (DNSA), and picric acid (PA), (all of w...
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METHOD DEVELOPMENT, VALIDATION AND STABILITY INDICATING ASSAY ON GLIMEPIRIDE IN TABLET DOSAGE FORM BY RP-UFLC
The study aimed to develop a specific, exact, selective, precise and accurate Reversed-Phase Stability Indicating Ultra-fast Liquid Chromatography (RP-UFLC) strategy is created and validated for the determination of glimepiride in the tablet dosage form. The method showed an adequate separation for glimepiride from their degradation products. The optimum separation was achieved by using 250 mm × ...
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DIURETIC ACTIVITY OF METHANOLIC RHIZOME EXTRACT OF PICRORRHIZA KURROA ROYLE EX. BENTH.
Kidneys are the excretory organs of our body that serves the important functions such as elimination of waste products, regulation of fluid volume and electrolyte content of the extracellular fluid. Picrorrhiza kurroa (Scrophulariaceae) is a small perennial herb growing in the hilly parts of the north-Western Himalayas region in India and Nepal. The objective of the present study was to evaluate a...
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CARDIOPROTECTIVE EFFECT OF CASSIA AURICULATA LINN., PETAL EXTRACT ON ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN MALE ALBINO RATS
Protective effect of Cassia auriculata Linn., floral extract was examined against Isoproterenol induced Myocardial infarction in male albino rats. The oral administration of aqueous extract of Cassia auriculata, afforded protection against Isoproterenol induced alterations in Cholesterol, LDL, HDL, TG, Protein, AST, ALT, LDH, Catalase and GPx. The protective effect was further supported by t...
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DEVELOPMENT AND EVALUATION OF VERAPAMIL HYDROCHLORIDE XANTHAN GUM MICROCAPSULES AS CONTROLLED DRUG DELIVERY SYSTEM
In the present study, the microspheres containing Verapamil hydrochloride xanthan complexes encoated with ethyl cellulose by emulsion solvent evaporation method. DSC shown absence of any new endothermic peak, disappearance of no shift of endothermic peak confirmed that there is no any interaction between drug, excipients and the drug was thermally stable. Drug polymer ratio was altered while the o...
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STUDY OF THE INVOLVEMENT OF ADIPONECTIN AND HOMA-IR IN TUNISIAN SUBJECTS WITH METABOLIC SYNDROME
Metabolic syndrome (MS) is a multi-factorial disorder with insulin resistance as a major characteristic. Adiponectin, an adipocyte derived cytokine, can regulate glucose levels and lipid homeostasis by its insulin sensitizer properties. Low circulating levels of serum adiponectin has been reported as a risk factor for the development of MS. The aim of this case control study was to investigate the...
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ADVANCED INOPERABLE URINARY BLADDER ADENOCARCINOMA: A CASE REPORT
Aim: Primary urinary bladder adenocarcinoma is a rare entity. This is a clinical case presentation with review of the literature on this topic. Primary adenocarcinoma of the urinary bladder has shown a poor response to radiation or chemotherapy individually. Therefore, combination chemotherapy with radical EBRT is the effective therapeutic approach for inoperable cases. Method: A 58 year o...
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SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF COPPER(II), COBALT(II) AND ZINC(II) COMPLEXES OF 6-METHOXY-3-FORMYLCHROMONE
A new series of Cu(II), Zn(II) and Co(II) complexes have been synthesized from 6-Methoxy-3-phenyliminomethyl-chromen-4-one, a Schiff base derived from 6-Methoxy-4-oxo-4H-chromene-3-carbaldehyde and aniline. The nature of bonding and the structure of the complexes have been deduced from IR, UV, 1H NMR spectroscopy. The biological activity of the ligand and metal complexes have been examined against...
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SELF-REPORTED CHRONIC ILLNESSES AND USE OF PRESCRIPTION MEDICINES (PM) AMONG ELDERLY MALAYS- A COMMUNITY BASED STUDY
This study explored self-reported chronic illnesses and use of prescription medicines (PM) by elderly Malays in the community. The study was a population based cross sectional study conducted among 490 Malay subjects aged ≥ 60 years in the semi-urban and rural areas in Perak, Malaysia. The study was conducted using pre-validated questionnaires after getting informed consent from the study partic...
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GENERAL CONSIDERATION OF GUILLIAIN BARRE SYNDROME
Guillain-Barré syndrome is a rare but important disease that can lead to life threatening respiratory failure. This review summarises the verified consideration of Guillain-Barré syndrome (GBS) which are thought to be caused by direct autoimmune attack on peripheral nerves. Aim- Nerve conduction study helps differentiate the heterogeneous subtypes of GBS. Patients exhibit a progressive paralysis...
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