Most Popular
EFFECTIVENESS OF DIPEPTIDYL PEPTIDASE – 4 INHIBITORS IN STREPTOZOTOCIN INDUCED NEURODEGENERATIVE MICE
Introduction: Neurodegenerative diseases are incurable and debilitating condition that results in progressive degeneration and / or death of nerve cells. Anti-oxidants, Antihyper-glycemics and insulin sensitizing agents are reported for reducing cognitive dysfunction in diabetes. Decreasing GLP-1 degradation using Dipeptidyl Peptidase-4 (DPP-4) inhibitors has been shown to be effective for treatin...
3820
1602
LANDFILL LEACHATE DEGRADATION USING ZINC OXIDE UNDER DIRECT SUNLIGHT
There has been a significant increase in the generation of MSW (Municipal Solid Waste) in India over the last few decades. The degradation of persistent organic pollutant using advanced oxidation processes with sunlight as energy source have a great advantage at lower costs. Pallikaranai wetland is a freshwater marsh in the city of Chennai, India. Pallikaranai marshland is the only surviving wetla...
3819
1616
SPECTROPHOTOMETRIC DETERMINATION OF MEBENDAZOLE THROUGH CHARGE TRANSFER INTERACTIONS
This article presents the development of a direct, simple and sensitive spectrophotometric method for the quantitative analysis of mebendazole (MBz), an anthelmintic medication in its pure and pharmaceutical forms. The method is based on the charge transfer (CT) interactions between MBz, an electron donor, and chloranilic acid (CA), 3,5-dinitrosalicylic acid (DNSA), and picric acid (PA), (all of w...
3819
1535
A GREENER CHEMISTRY APPROACH FOR SYNTHESIS OF 4-(4-HYDROXYPHENYL)-6-METHYL-2-OXO-1,2,3,4 TETRAHYDROPYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
The objective of present research work is to provide green technique for synthesis of 4-(4-Hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester. Pyrimidine derivatives are well known in the pharmaceutical industry and exhibit to possess a broad spectrum of biological activities. Highly efficient and simple methods complying with principle of Green chemistry have...
3818
3149
HIGH FRUCTOSE INDUCED ADIPOGENESIS AND INHIBITORY POTENTIAL OF TRIGONELLINE ON MURINE MESENCHYMAL STEM CELLS: A MORPHOLOGICAL STUDY
Regular intake of carbohydrate diet containing high fructose or sucrose increases adipogenesis resulting in conditions like weight gain, high blood pressure, elevated blood glucose levels, insulin resistance, raised triglycerides, low HDL cholesterol, with metabolic syndrome as a leading consequence. Since intricacies of adipogenesis are of major relevance to human health; present study aimed to e...
3818
1669
ANTI-INFLAMMATORY AND ANTIHYPERCHOLESTEROLEMIC ACTIVITY OF ROSA CENTIFOLIA, CORIANDRUM SATIVUM AND CYNODON DACTYLON
Hypercholesterolemia is one of the major conditions that are prevalent in today’s world, the significant causes being unhealthy food habits and lifestyle or abnormal genetic conditions. HMG CoA reductase is an important rate-limiting enzyme in the mevalonate pathway that synthesizes cholesterol. Biosynthesis of cholesterol in the liver can be reduced significantly by inhibiting HMG CoA reductase...
3818
1714
PREPARATION & PHYSICOCHEMICAL CHARACTERIZATION OF POORLY WATER SOLUBLE DRUG BY USING SPRAY DRYING AND SOLVENT EVAPORATION METHODS
Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. The various preparation techniques for solid dispersion and compiles some of the recent technology transfers. This research article investigates enhancement of the dissolution profile of atorvastatin using solid dispersion wit...
3817
1881
DOCKING, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL QUINOLINE CONTAINING SCHIFF BASES FOR ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES
Quinolines bears a very good synthon so that a variety of novel heterocyclic with good pharmaceutical profile can be designed. There are various biological activities for quinolones such as antibacterial, antimalarial and various drugs possessing quinolone as nucleus are ciprofloxacin (Cipro), lomefloxacin (Maxaquin), norfloxacin (Noroxin), ofloxacin (Floxin), moxifloxacin (Avelox) and levofloxaci...
3817
1627
NOVEL PROPENYL FLAVONOIDS GLYCOSIDE AND ANTIOXIDANT ACTIVITY OF EGYPTIAN BAUHINIA RETUSA
Column chromatography of ethyl acetate of Bauhinia retusa afforded a novel flavonoid identified as [ rhamnetin-3-O-α- L-rhamnopyranosyl-3’-O-(prop-1-enyl)], in addition to kaempferol, isorhamnetin-3-α-rhamnoside, qurcitrin, quercetin 3-O-β-D-glucopyranosyl-β-D-glucopyranoside, and quercetin 3,7-di-o- β-D-glucoside have been isolated for the first time. Their structures were established ...
3816
1593
A STUDY OF CARDIOVASCULAR AND ANTIMICROBIAL EFFECTS OF TINOSPORA CORDIFOLIA
Tinospora cordifolia is known for a wide range of medicinal properties. In this study, cardiovascular and antimicrobial properties of aqueous and ethanolic extracts of Tinospora cordifolia were evaluated. Dose dependent negative ionotropic and chronotropic effects were observed with both aqueous and ethanolic extracts. The effects were antagonized by atropine indicating involvement of muscarinic r...
3816
1379