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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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22.

EFFECTIVENESS OF DIPEPTIDYL PEPTIDASE – 4 INHIBITORS IN STREPTOZOTOCIN INDUCED NEURODEGENERATIVE MICE

Introduction: Neurodegenerative diseases are incurable and debilitating condition that results in progressive degeneration and / or death of nerve cells. Anti-oxidants, Antihyper-glycemics and insulin sensitizing agents are reported for reducing cognitive dysfunction in diabetes. Decreasing GLP-1 degradation using Dipeptidyl Peptidase-4 (DPP-4) inhibitors has been shown to be effective for treatin...

R. J. Vaidya*, N. H. Chauhan, B. A. Vyas and S. A. Shah

Maliba Pharmacy College, Ukatarsadia University, Tarsadi, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1044-50

1044-1050

3785

1577

41.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING SPECTRO-PHOTOMETRIC METHOD FOR THE ESTIMATION OF RIZATRIPTAN BENZOATE IN BULK AND PHARMACEUTICAL DOSAGE FORM

A simple, accurate and rugged stability indicating UV Spectrophotometric method was developed using methanol as the solvent to determine Rizatriptan Benzoate content in pharmaceutical dosage forms. The UV Spectrophotometric method for Rizatriptan Benzoate was determined at λmax 278nm and the drug proved linear in the range of 10-80μg/ml, with a good correlation coefficient of 0.9997. Percentage ...

Uttam Prasad Panigrahy* and M. Divya Swetha

Department of Pharmaceutical Analysis and Quality Assurance, Malla Reddy College of Pharmacy, Secunderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).4046-50

4046-4050

3784

1547

76.

PREVALENCE OF SERUM THYROID HORMONES AND MENSTRUAL IRREGULARETIES WITH INFERTILITY IN UTTAR PRADESH, INDIA

It is important to predict the serum thyroid hormones level in females during infertility to prevent its occurrence later on. In this study, we studied serum thyroid hormones and menstrual irregularities during infertility. A case control study was performed in 75 infertile patients with menstrual irregularities and 50 healthy matched women. Three biochemical parameters were measured in serum, hor...

Neha Sharma* and Simant Baliar Singh

Department of Biochemistry, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly- 243 202, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3454-57

3454-3457

3784

1631

48.

COMPARATIVE STUDIES ON BIOCHEMICAL, HISTOPATHOLOGICAL AND FTIR-ATR SPECTRAL STUDIES OF HYPERLIPIDEMIA INDUCED BY CHOLESTEROL-RICH DIET IN RATS

Objective: To compare the routine biochemical and histological techniques with FTIR-ATR spectroscopic methods in diagnosing hyperlipidemia. Materials: Compositional changes in the serum and tissues reflects the healthy and pathological status of animals. FTIR-ATR was attempted as an additional tool for evaluating the composition in the serum as well as in tissues materials. To achieve this Wistar ...

S. Khatheeja *, A. Safiullah, M. Alsawalha, A. R. Prabhakaran, V. P. Veeraraghavan and S. K. Mohan

Department of Physics, Justice Basheer Ahmed Sayeed College for Women, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).836-45

836-845

3784

1614

21.

EFFECT OF FUROSEMIDE (LOOP DIURETIC) ON INGESTIVE BEHAVIOR, BODY WEIGHT AND CERTAIN HEMATOLOGICAL PARAMETERS IN ADULT WISTAR RATS

The present experiment was aimed to examine the effect of furosemide (loop diuretic) on ingestive behavior & some hematological parameters.  The adult Wistar rats (n=6/ group) were divided into control group (n =6; Group I) and experimental group (n =6; Group II). The experimental group received furosemide intraperitonially (40mg/kg BW) for a duration of 30 days. The control group of rats was...

Venkappa S. Mantur , N. A. Vinodini*, A. K. Nayanatara , A. V. Ranade , C. Ramaswamy , Pratik K. Chatterjee and K. Kishan

Associate Professor in Physiology, Department of Physiology, Center for Basic Sciences, Kasturba Medical College, Bejai, Mangalore- 575004, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(3).811-14

811-814

3783

1760

62.

ANTI-INFLAMMATORY AND ANTIHYPERCHOLESTEROLEMIC ACTIVITY OF ROSA CENTIFOLIA, CORIANDRUM SATIVUM AND CYNODON DACTYLON

Hypercholesterolemia is one of the major conditions that are prevalent in today’s world, the significant causes being unhealthy food habits and lifestyle or abnormal genetic conditions. HMG CoA reductase is an important rate-limiting enzyme in the mevalonate pathway that synthesizes cholesterol. Biosynthesis of cholesterol in the liver can be reduced significantly by inhibiting HMG CoA reductase...

A. Thilagavathy *, S. Dsouza, A. Shriraksha and K. G. Singh

Department of Biochemistry, Mount Carmel College, Autonomous, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).966-72

966-972

3783

1689

9.

ANTIBACTERIAL AND FREE RADICAL SCAVENGING ACTIVITY OF DURANTA PLUMIERI, LINN.

The antibacterial properties of methanol leaf extract of Duranta plumieri wasdeterminedagainst Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis and Bacillus subtilis as test organisms using the agar disc diffusion method. The minimum inhibitory concentrations were determined using the microbroth dilution method. The methanol extract was subj...

Vishnukanta* and A. C. Rana

Department of Pharmaceutics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

DOI: 9. http://dx.doi.org/10.13040/IJPSR.0975-8232.2(2).282-87

282-287

3782

1570

52.

EFFECT OF VERMICOMPOST ON BIOCHEMICAL CONTENT OF TWO INDIAN GREEN LEAFY VEGETABLES

Nowadays, the organic way of farming gains much more important and the people believe that the production of plants with organic farming has more nutrients and a lot of health benefits. In this, the green leafy vegetables occupy an important place among the food crops as they provide an adequate number of vitamins and minerals for humans. Solanum nigrum L. and Trigonella foenum-graecum L. are comm...

A. Vijayalakshmi and R. Karthiyayini *

Department of Botany, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(10).4446-50

4446-4450

3782

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48.

PREPARATION & PHYSICOCHEMICAL CHARACTERIZATION OF POORLY WATER SOLUBLE DRUG BY USING SPRAY DRYING AND SOLVENT EVAPORATION METHODS

Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. The various preparation techniques for solid dispersion and compiles some of the recent technology transfers. This research article investigates enhancement of the dissolution profile of atorvastatin using solid dispersion wit...

Sunita S. Shinde*, Amol S. Shete , Manisha V. Patil , Sharad Salunkhe and Deepak Indapure

Department of Pharmaceutics, Tatayasaheb Kore College of Pharmacy, Warananagar, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1035-44

1035-1044

3781

1865

33.

POTENTIAL LARVICIDES IN NIGERIAN HERBAL RECIPES

Investigations into the larvicidal potential of crude extracts of ten Nigerian plants were carried out against the fourth instar larvae of Anopheles gambiae mosquito. The phytochemical screening revealed that both anthraquinones and cyanogenic glycosides were absent in all the plants. However, alkaloids, saponins, tannins, cardiac glycosides, terpenes and flavonoids were either present or absent. ...

Olawale H. Oladimeji*, Leonard Ani and Emmanuel Nyong

Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3783-87

3783-3787

3781

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