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EFFECTIVENESS OF DIPEPTIDYL PEPTIDASE – 4 INHIBITORS IN STREPTOZOTOCIN INDUCED NEURODEGENERATIVE MICE
Introduction: Neurodegenerative diseases are incurable and debilitating condition that results in progressive degeneration and / or death of nerve cells. Anti-oxidants, Antihyper-glycemics and insulin sensitizing agents are reported for reducing cognitive dysfunction in diabetes. Decreasing GLP-1 degradation using Dipeptidyl Peptidase-4 (DPP-4) inhibitors has been shown to be effective for treatin...
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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING SPECTRO-PHOTOMETRIC METHOD FOR THE ESTIMATION OF RIZATRIPTAN BENZOATE IN BULK AND PHARMACEUTICAL DOSAGE FORM
A simple, accurate and rugged stability indicating UV Spectrophotometric method was developed using methanol as the solvent to determine Rizatriptan Benzoate content in pharmaceutical dosage forms. The UV Spectrophotometric method for Rizatriptan Benzoate was determined at λmax 278nm and the drug proved linear in the range of 10-80μg/ml, with a good correlation coefficient of 0.9997. Percentage ...
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PREVALENCE OF SERUM THYROID HORMONES AND MENSTRUAL IRREGULARETIES WITH INFERTILITY IN UTTAR PRADESH, INDIA
It is important to predict the serum thyroid hormones level in females during infertility to prevent its occurrence later on. In this study, we studied serum thyroid hormones and menstrual irregularities during infertility. A case control study was performed in 75 infertile patients with menstrual irregularities and 50 healthy matched women. Three biochemical parameters were measured in serum, hor...
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COMPARATIVE STUDIES ON BIOCHEMICAL, HISTOPATHOLOGICAL AND FTIR-ATR SPECTRAL STUDIES OF HYPERLIPIDEMIA INDUCED BY CHOLESTEROL-RICH DIET IN RATS
Objective: To compare the routine biochemical and histological techniques with FTIR-ATR spectroscopic methods in diagnosing hyperlipidemia. Materials: Compositional changes in the serum and tissues reflects the healthy and pathological status of animals. FTIR-ATR was attempted as an additional tool for evaluating the composition in the serum as well as in tissues materials. To achieve this Wistar ...
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EFFECT OF FUROSEMIDE (LOOP DIURETIC) ON INGESTIVE BEHAVIOR, BODY WEIGHT AND CERTAIN HEMATOLOGICAL PARAMETERS IN ADULT WISTAR RATS
The present experiment was aimed to examine the effect of furosemide (loop diuretic) on ingestive behavior & some hematological parameters. The adult Wistar rats (n=6/ group) were divided into control group (n =6; Group I) and experimental group (n =6; Group II). The experimental group received furosemide intraperitonially (40mg/kg BW) for a duration of 30 days. The control group of rats was...
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ANTI-INFLAMMATORY AND ANTIHYPERCHOLESTEROLEMIC ACTIVITY OF ROSA CENTIFOLIA, CORIANDRUM SATIVUM AND CYNODON DACTYLON
Hypercholesterolemia is one of the major conditions that are prevalent in today’s world, the significant causes being unhealthy food habits and lifestyle or abnormal genetic conditions. HMG CoA reductase is an important rate-limiting enzyme in the mevalonate pathway that synthesizes cholesterol. Biosynthesis of cholesterol in the liver can be reduced significantly by inhibiting HMG CoA reductase...
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ANTIBACTERIAL AND FREE RADICAL SCAVENGING ACTIVITY OF DURANTA PLUMIERI, LINN.
The antibacterial properties of methanol leaf extract of Duranta plumieri wasdeterminedagainst Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis and Bacillus subtilis as test organisms using the agar disc diffusion method. The minimum inhibitory concentrations were determined using the microbroth dilution method. The methanol extract was subj...
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EFFECT OF VERMICOMPOST ON BIOCHEMICAL CONTENT OF TWO INDIAN GREEN LEAFY VEGETABLES
Nowadays, the organic way of farming gains much more important and the people believe that the production of plants with organic farming has more nutrients and a lot of health benefits. In this, the green leafy vegetables occupy an important place among the food crops as they provide an adequate number of vitamins and minerals for humans. Solanum nigrum L. and Trigonella foenum-graecum L. are comm...
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PREPARATION & PHYSICOCHEMICAL CHARACTERIZATION OF POORLY WATER SOLUBLE DRUG BY USING SPRAY DRYING AND SOLVENT EVAPORATION METHODS
Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. The various preparation techniques for solid dispersion and compiles some of the recent technology transfers. This research article investigates enhancement of the dissolution profile of atorvastatin using solid dispersion wit...
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POTENTIAL LARVICIDES IN NIGERIAN HERBAL RECIPES
Investigations into the larvicidal potential of crude extracts of ten Nigerian plants were carried out against the fourth instar larvae of Anopheles gambiae mosquito. The phytochemical screening revealed that both anthraquinones and cyanogenic glycosides were absent in all the plants. However, alkaloids, saponins, tannins, cardiac glycosides, terpenes and flavonoids were either present or absent. ...
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