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PHYTOCHEMICAL EVALUATION OF HYDROXY CITRIC ACID, CATECHINS AND CALCIUM PANTOTHENATE PRESENT IN HERBAL FORMULATION
The analytical method for the estimation of phytochemical active ingredients present in Garginia combogia extract, Green tea extract with calcium pantothenate for herbal formulations are evaluated for it’s Assay content and dissolution release. This herbal formulation with slim formula consists of several active ingredients such as Hydroxy Citric acid, catechins and calcium pantothenate. The HPL...
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COMPARATIVE ANTIOXIDANT ACTIVITY AND BRINE SHRIMP LETHALITY BIOASSAY OF DIFFERENT PARTS OF THE PLANT- ACACIA AURICULIFORMIS
The present study was undertaken to evaluate and compare the antioxidant activity and brine shrimp lethality bioassay of different parts (leaf and bark) of the plant Acacia auriculiformis. DPPH radical scavenging and NO scavenging capacity were measured for the determination of antioxidant activity. Ethyl acetate fraction of bark was found to possess highest DPPH radical scavenging activity with I...
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A GREENER CHEMISTRY APPROACH FOR SYNTHESIS OF 4-(4-HYDROXYPHENYL)-6-METHYL-2-OXO-1,2,3,4 TETRAHYDROPYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
The objective of present research work is to provide green technique for synthesis of 4-(4-Hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester. Pyrimidine derivatives are well known in the pharmaceutical industry and exhibit to possess a broad spectrum of biological activities. Highly efficient and simple methods complying with principle of Green chemistry have...
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DRUG UTILIZATION PATTERN IN CARDIOLOGY INTENSIVE CARE UNIT IN A TERTIARY HEALTH CARE INSTITUTION
Aims and Objectives: To evaluate the current prescription pattern of drug utilization in patients admitted in cardiology intensive care unit (ICU) and to find out drug use indicators. Methods: It was a retrospective, observational hospital based study which was done for 6 months after obtaining permission from the institutional human ethics committee. The prescriptions of both genders and of any a...
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QUALITY BY DESIGN: A PRE-REQUISITE FOR PHARMACEUTICAL DEVELOPMENT
Quality by Design (QbD) is an essential part of modern pharmaceutical development. QbD is a requisite for the design and development process for the pharmaceutical industry. QbD assists and encourages both the industries and FDA to inculcate a proactive, scientific and risk-based approach in the process and product development. It is based on a concept of building quality right from the start of t...
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THE MOST RELIABLE APPROCH TO DEFEAT ‘A SILENT KILLER’
Yoga and exercise are an efficient way of declining patients of hypertension in present and in future. However it has been shown that Non-pharmacological intervention prevent the rising blood pressure and reduce it up to maximum extent, near to the normal. This experiment was designed to determine effectiveness of Yoga and exercises therapies to control blood pressure of hypertension patients. The...
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COMPARATIVE STUDIES ON BIOCHEMICAL, HISTOPATHOLOGICAL AND FTIR-ATR SPECTRAL STUDIES OF HYPERLIPIDEMIA INDUCED BY CHOLESTEROL-RICH DIET IN RATS
Objective: To compare the routine biochemical and histological techniques with FTIR-ATR spectroscopic methods in diagnosing hyperlipidemia. Materials: Compositional changes in the serum and tissues reflects the healthy and pathological status of animals. FTIR-ATR was attempted as an additional tool for evaluating the composition in the serum as well as in tissues materials. To achieve this Wistar ...
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EFFECT OF PHARMACEUTICAL CARE TRAINING ON KNOWLEDGE ATTITUDE AND PRACTICES OF PHARMACISTS IN MAHARASHTRA
The objective of the study was to assess the effect of Pharmaceutical care training on Knowledge, Attitude and Practices of Pharmacists from various settings. In this prospective interventional study, a validated Knowledge, Attitude and Practice questionnaire was administered, before and after an educational training to the pharmacists belonging to hospital, community and corporate settings of Pun...
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ANALYSIS OF VARIOUS METAL IONS IN SOME MEDICINAL PLANTS USING ATOMIC ABSORPTION SPECTROPHOTOMETER
Metal ions such as iron , lead, copper, nickel, cadmium , chromium and zinc were investigated in medicinally important plants Alstonia scholaris, Tabernaemontana coronariae, Asparagus racemosus, Mimosa pudica, Leucas aspera and Adhatoda vasica applying atomic absorption spectrophotometer techniques. The purpose of this study was to standardize various metal ion Contamination in indigenous me...
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QUERCETIN AMELIORATES OXIDATIVE STRESS, NEURAL DAMAGE OF BRAIN AND BEHAVIORAL IMPAIRMENT OF RAT WITH FLUORIDE EXPOSURE
Excess fluoride causing fluorosis, can enter in to brain, disturb oxidative status and induce neural damage. Quercetin, antioxidant flavonoid stabilizes oxidative milieu of brain by quenching free radicals. The present study aimed to report ameliorative effect of quercetin on NaF induced oxidative stress, histological alterations in the brain and behavioural changes of rats. Rats were divided into...
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