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EVALUATION OF PROTECTIVE EFFICACY OF PUNICA GRANATUM ON SHORT TERM Β-CYFLUTHRIN TOXICITY ON REPRODUCTIVE TISSUE OF MALE MICE
Pyrethroids are among the most extensively used insecticide. The widespread use of these synthetic pesticides has stimulated research into the possible existence of adverse effects related to reproductive activity. The present study was, therefore, undertaken to assess the effects of β- Cyfluthrin, a type II synthetic pyrethroid on testes, the main organ of male reproduction. Animals were divided...
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QUALITY BY DESIGN: A PRE-REQUISITE FOR PHARMACEUTICAL DEVELOPMENT
Quality by Design (QbD) is an essential part of modern pharmaceutical development. QbD is a requisite for the design and development process for the pharmaceutical industry. QbD assists and encourages both the industries and FDA to inculcate a proactive, scientific and risk-based approach in the process and product development. It is based on a concept of building quality right from the start of t...
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COMPARATIVE ANTIOXIDANT ACTIVITY AND BRINE SHRIMP LETHALITY BIOASSAY OF DIFFERENT PARTS OF THE PLANT- ACACIA AURICULIFORMIS
The present study was undertaken to evaluate and compare the antioxidant activity and brine shrimp lethality bioassay of different parts (leaf and bark) of the plant Acacia auriculiformis. DPPH radical scavenging and NO scavenging capacity were measured for the determination of antioxidant activity. Ethyl acetate fraction of bark was found to possess highest DPPH radical scavenging activity with I...
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PURIFICATION AND BIOCHEMICAL CHARACTERIZATION OF NOVEL FIBRINOLYTIC PROTEASE PRODUCED BY MESOPHILIC BACILLUS CIRCULANS GD25
A novel fibrinolytic protease from Bacillus circulansGD25 was isolated and characterized for the fibrinolytic activity. The fibrinolytic protease was purified by ammonium sulphate fractionation (70%) and subjected to chromatographic methods like Sephadex G-50, DEAE –Sephadex A-50 columns. The purified enzyme has an approximately 38 kDa in size by SDS-PAGE and gel filtration. Optimum activity was...
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COMPARATIVE STUDIES ON BIOCHEMICAL, HISTOPATHOLOGICAL AND FTIR-ATR SPECTRAL STUDIES OF HYPERLIPIDEMIA INDUCED BY CHOLESTEROL-RICH DIET IN RATS
Objective: To compare the routine biochemical and histological techniques with FTIR-ATR spectroscopic methods in diagnosing hyperlipidemia. Materials: Compositional changes in the serum and tissues reflects the healthy and pathological status of animals. FTIR-ATR was attempted as an additional tool for evaluating the composition in the serum as well as in tissues materials. To achieve this Wistar ...
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DRUG UTILIZATION PATTERN IN CARDIOLOGY INTENSIVE CARE UNIT IN A TERTIARY HEALTH CARE INSTITUTION
Aims and Objectives: To evaluate the current prescription pattern of drug utilization in patients admitted in cardiology intensive care unit (ICU) and to find out drug use indicators. Methods: It was a retrospective, observational hospital based study which was done for 6 months after obtaining permission from the institutional human ethics committee. The prescriptions of both genders and of any a...
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ANALYSIS OF VARIOUS METAL IONS IN SOME MEDICINAL PLANTS USING ATOMIC ABSORPTION SPECTROPHOTOMETER
Metal ions such as iron , lead, copper, nickel, cadmium , chromium and zinc were investigated in medicinally important plants Alstonia scholaris, Tabernaemontana coronariae, Asparagus racemosus, Mimosa pudica, Leucas aspera and Adhatoda vasica applying atomic absorption spectrophotometer techniques. The purpose of this study was to standardize various metal ion Contamination in indigenous me...
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QUERCETIN AMELIORATES OXIDATIVE STRESS, NEURAL DAMAGE OF BRAIN AND BEHAVIORAL IMPAIRMENT OF RAT WITH FLUORIDE EXPOSURE
Excess fluoride causing fluorosis, can enter in to brain, disturb oxidative status and induce neural damage. Quercetin, antioxidant flavonoid stabilizes oxidative milieu of brain by quenching free radicals. The present study aimed to report ameliorative effect of quercetin on NaF induced oxidative stress, histological alterations in the brain and behavioural changes of rats. Rats were divided into...
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PHYTOCHEMICAL EVALUATION OF HYDROXY CITRIC ACID, CATECHINS AND CALCIUM PANTOTHENATE PRESENT IN HERBAL FORMULATION
The analytical method for the estimation of phytochemical active ingredients present in Garginia combogia extract, Green tea extract with calcium pantothenate for herbal formulations are evaluated for it’s Assay content and dissolution release. This herbal formulation with slim formula consists of several active ingredients such as Hydroxy Citric acid, catechins and calcium pantothenate. The HPL...
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NOVEL PROPENYL FLAVONOIDS GLYCOSIDE AND ANTIOXIDANT ACTIVITY OF EGYPTIAN BAUHINIA RETUSA
Column chromatography of ethyl acetate of Bauhinia retusa afforded a novel flavonoid identified as [ rhamnetin-3-O-α- L-rhamnopyranosyl-3’-O-(prop-1-enyl)], in addition to kaempferol, isorhamnetin-3-α-rhamnoside, qurcitrin, quercetin 3-O-β-D-glucopyranosyl-β-D-glucopyranoside, and quercetin 3,7-di-o- β-D-glucoside have been isolated for the first time. Their structures were established ...
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