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FORCED DEGRADATION STUDY – A NEW APPROACH FOR STRESS TESTING OF DRUG SUBSTANCES AND DRUG PRODUCTS
Forced degradation studies are a vital tool in pharmaceutical research and development to predict long-term stability. Stress studies should be performed in method development to know drug behavior but can also be performed with method validation for regulatory filling predict stability, and measure impurities. It is especially valuable when little data is free about potential degradation products...
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INCREASING COMPLEX FORMATION OF WEAK ACID DRUG WITH ION EXCHANGE RESIN
Functionality of Ion Exchange Resin (IER) mainly depends on solubility and degree of ionization and molecular weight of drug. For this reason the application of IER is limited to only strong acidic and basic drugs or drug existing as salt; not for weak acidic and weak basic drugs due to their low ionization properties. If we increase the ionization of weak acid and bases, then application of IER w...
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EFFECT OF IVNT ON OVARIAN WEIGHT, FOLLICLE NUMBER, ESTRUS FREQUENCY AND REVERSIBILITY OF REPRODUCTIVE CYCLE IN ALBINO RAT
The cyclic albino rats of body weight group (120-130 gm.) were intravaginally treated with single dose (0.1 ml) neem oil at various durations to study its anti-fertility efficiency. It was observed that a significant increase in ovarian weight in weekly three months treated rat group to control and a significant decrease in follicle numbers in single ovary in weekly and fortnightly one and three ...
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DETERMINATION OF DRUG SUSCEPTIBILITY PATTERN AGAINST NOSOCOMIAL INFECTION
Nosocomial infections even in this modern era antibiotics, continue to remain an important and formidable consequence of hospitalization. Our aim of the study was to investigate the antimicrobial susceptibility against hospital-associated infecting microorganisms. 30 Clinical samples were taken from OPD of GMC Hospital, Bhopal (MP), India. Among 30 clinical isolates we identified bacterial pathoge...
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EFFECT OF VERMICOMPOST ON BIOCHEMICAL CONTENT OF TWO INDIAN GREEN LEAFY VEGETABLES
Nowadays, the organic way of farming gains much more important and the people believe that the production of plants with organic farming has more nutrients and a lot of health benefits. In this, the green leafy vegetables occupy an important place among the food crops as they provide an adequate number of vitamins and minerals for humans. Solanum nigrum L. and Trigonella foenum-graecum L. are comm...
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MICROARRAY BASED IDENTIFICATION REVEALS ARTERIAL ANGIOTENSIN SYSTEM EXPRESSION IN HUMAN
Purpose: We studied by microarray analysis the tissue angiotensin system organization. We elucidated the expression of chymase, cathepsins D, G and angiotensin-converting enzyme (ACE), potentially involved in intraparietal angiotensin II formation and atheroma. Methods: mRNA gene expression was measured by an Affymetrix Gene Chip Human Gene 1.0 ST arrays (Affymetrix, Santa Clara, CA, USA) using RN...
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TWO ALGAE FROM OMAN SEA: THE IN VITRO BIOLOGICAL EFFECTS
Algae are extensively used in cosmetics, supplements and pharmaceutical industries. Researches support their hypotensive, cytotoxic, anti-inflammatory and many other biologic effects. In the present study, the cytotoxic, antioxidant and acetylcholinesterase inhibitory activities of two brown algae, Padina tetrastromatica and P. australis, have been evaluated. Total extract was prepared using metha...
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SEROPREVALENCE OF TYPHOID FEVER IN CHILDREN OF DIFFERENT ETHNIC GROUPS OF BALOCHISTAN
In present study total 2352 samples were collected out of that 21.04% were positive for Typhoid fever while 78.95% were negative. The sex wise distribution results showed male are more effected (12.71%) as compare to female (8.33%). However, the age wise distribution showed that 10.45% in 6-10 years, 6.54% in 3-6 years and 4.03% in 1-3 years. Moreover, the Typhoid fever cases were significantly hi...
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CONCEPTS OF ANTI-HIV THERAPY & ITS APPLICATIONS IN RESOURCE POOR SETTINGS
HIV since its invention has become global burden. In last two decades of the HIV prevalence many anti-retroviral drugs have been developed. Poor countries like India have started central government funded programmes to tackle the menace of the HIV. These programmes have been started because many people cannot afford costly ART drugs. In this review article, we have discussed current ART regimens a...
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SYNTHESIS OF FUSED [1, 4] DIAZEPINES BY BASE CATALYSED CONDENSATION OF 1, 2-DIAMINES WITH CARBONYL COMPOUNDS
Based on the principle of base catalyzed condensation reaction of 1, 2-diamines with carbonyl compounds, an efficient method for the synthesis of fused 1, 4-diazepines was developed. High yields were obtained for both electron-releasing as well as electron-withdrawing substituted 1, 4-diazepine derivatives by the mentioned method...
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