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SAFETY AND ADVERSE EVENTS OF PROPHYLACTIC HPV VACCINES AMONG HEALTHY WOMEN: A SYSTEMATIC REVIEW & META ANALYSIS
Cervical cancer (CaCx) is the third most common female cancer worldwide with an estimated 5, 27, 624 new cases and 2, 65, 653 deaths in 2014. We conducted a systematic review and meta- analysis to assess safety of prophylactic HPV vaccines compared against placebo. Four unique trials were included out of 607 publications. The total patient data evaluated was 1427(852 in vaccinated arm; 575 in the ...
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VIRTUAL TOXICITY STUDIES OF NOVEL SPIROAZETIDIN-2-ONES TETHERED WITH FURANS
Background and aim: Spiroazetidin-2-ones and furans are commonly used as anti-bacterial, anti-fungal, anti-inflammatory, cardiovascular activities, anticancer, antiparkinson agents etc. The purpose of this study was to perform virtual toxicity studies of the synthesized compounds 1-(substitutedphenyl)-3-chloro-5,9-bis(furan-2-ylmethylidene)-1-azaspiro[3.5]nonan-2-ones (3a-3h). Materials and method...
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THE EFFECT OF DI-BUTYL PHTHALATES (DBP) AND DI (2-ETHYLHEXYL) PHTHALATES (DEHP) ON FEMALE RATS FERTILITY
Phthalate esters are industrial chemicals widely used in cosmetics, plastics bottles and medical devices, and the risk of exposure to phthalates is on the increase. In recent years, many studies have been carried out on the possible health hazards of phthalates, including the effect on reproduction. In this studyrats were injected twice weekly with Di-butyl Phthalates (DBP) or Di (2-Ethylhexyl) ...
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ON SOME TOPOLOGICAL INDICES OF TRIANGULAR SILICATE AND TRIANGULAR OXIDE NETWORKS
A topological index is a numeric quantity from the structural graph of a molecule. It has become a very useful tool in the prediction of pharmacological, toxicological and physico - chemical properties of a compound. In this paper, we have computed some topological indices of triangular silicate TsL (n) and triangular oxide TOL (n) networks....
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EFFECT OF NIMODIPINE ON NOCICEPTIVE PAIN AND ITS INTERACTION WITH OPIOID ANALGESICS IN RATS
Objective: To explore the effect of nimodipine on nociception and on opioid-induced antinociception in rats by using the tail-flick method. Method: Sixty albino rats were used for the study. The tail-flick method was used to induce nociception in rats. Analgesic effect of nimodipine was evaluated by using three graded doses (200 mcg/kg, 400 mcg/kg, and 800 mcg/kg). To study the effect of nimodipin...
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COMPARATIVE MODELING OF INACTIVE UBIQUITIN THIOESTERASE FAM105A AND MOLECULAR DOCKING STUDIES OF SYNTHESIZED BENZIMIDAZOLE DERIVATIVES
In this study, homology modeling and molecular docking studies were performed to explore structural features and binding mechanism of synthesized benzimidazole derivatives as ubiquitin inhibitors. A homology modeling procedure was employed to construct a 3D model of ubiquitin protein by using MODELLER9.15. For this procedure, the X-ray crystal structure of Gumby / fam105b in Complex with linear Di...
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DETECTING MEDICATION ERRORS FROM ADVERSE DRUG REACTION MONITORING CENTRE DATABASE – A RETROSPECTIVE ANALYSIS
Introduction: Despite the traditional focus on adverse drug reactions, pharmacovigilance centres have recently been identified as a potentially rich and important source of medication error (ME) data. The aim of this study is to identify ME from adverse drug reaction (ADRs) reports. Materials and methods: A retrospective analysis of ADR reports notified to adverse drug reaction monitoring centre o...
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TOPSIS ANALYSIS FOR THE PREDICTION OF DIABETES BASED ON GENERAL CHARACTERISTICS OF HUMANS
Worldwide diabetic patients are very common. This paper studies spread of diabetes in human living in Lahore, Pakistan. Data is collected from two local hospitals of Lahore and TOPSIS is applied to draw the results of the study. The study points out the people who are more likely to have diabetes due to various parameters like age, weight, height, body mass index (BMI), systolic blood pressure (SB...
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IN-VITRO LOUSCIDAL AND ACARICIDAL ACTIVITIES OF ALKALOID OF CALPURNIA AUREA EXTRACTS AGAINST LINOGNATHUS OVILLUS AND AMBLYOMMA VARIEGATUM
The study was designed to evaluate the louscidal, and acaricidal activities of alkaloids of Calpurnia aurea leaves extracts. Alkaloid of C. area leaves extract at concentrations of 200, 100, 50, 25, 12.5 and 6.25 mg/ml were used for in-vitro adult immersion test of ticks and lice, which they were monitored for their mortality rates for 24 h. The activities of test substances were evaluated against...
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EVALUATION OF ANTIOXIDANT POTENTIALS OF SELECTED INDIAN MEDICINAL PLANTS
Oxidative stress is found to be one of the major causes of health hazards in the present global scenario. The traditional herbs and medicinal plants have been investigated for the presence of natural antioxidants, which have incredible effects in the prevention of various oxidative stress associated diseases. The objective of present investigation is to assess the antioxidant capacity and phytoche...
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