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MINOCYCLINE DECREASES ACETYLCHOLINESTRASE ACTIVITY IN INTRA-CEREBROVENTRICULAR STREPTOZOTOCIN INFUSED RATS
Alzheimer’s disease, a synonym for life threatening dementias is characterized by oxidative stress and neuroinflammation induced neuronal loss, impaired energy metabolism, and cholinergic deficit leading to severe cognitive impairments and other abnormal neuropsychiatric changes. Cholinergic hypothesis is the most accepted theory explaining pathology of AD and Acetylcholinestrase inhibitors are ...
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EFFECT OF METHYL PARATHION (AN ORGANOPHOSPHATE) ON BIOCHEMICAL CONTENTS OF FRESH WATER CAT FISH HETEROPNEUSTES FOSSILIS (BLOCH)
The present work was planned to study the effect of methyl parathion an organophosphate compound (OP) on biochemical contents of fresh water cat fish Heteropneustis fossilis. The exposure of fish to the sub-lethal concentrations of the toxicant methyl parathion was investigated and the variations were observed in biochemical contents in different tissues of the fish i.e. gill, liver, intestine, mu...
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IN-VITRO LOUSCIDAL AND ACARICIDAL ACTIVITIES OF ALKALOID OF CALPURNIA AUREA EXTRACTS AGAINST LINOGNATHUS OVILLUS AND AMBLYOMMA VARIEGATUM
The study was designed to evaluate the louscidal, and acaricidal activities of alkaloids of Calpurnia aurea leaves extracts. Alkaloid of C. area leaves extract at concentrations of 200, 100, 50, 25, 12.5 and 6.25 mg/ml were used for in-vitro adult immersion test of ticks and lice, which they were monitored for their mortality rates for 24 h. The activities of test substances were evaluated against...
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COMPARISON OF ANTI-OXIDANT COMPOUNDS AND ANTIOXIDANT ACTIVITY OF NATIVE AND DUAL MODIFIED RICE FLOUR
Rice (Oryza sativa L.) is one of the most important cereal crops consumed in Asia and the primary staple food being consumed by nearly half of the world’s population. Black rice is getting popular recently and is consumed as a functional food. Black rice contains relatively high anthocyanin in the pericarp layer which gives the dark purple color. Black rice has a higher content of phenolic compo...
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LEAD FINDING FROM WHOLE PLANT OF CURCUMA LONGA WITH OXIDATIVE POTENTIAL
The present study deals with the antioxidant activity, drug likeness score and bioactivity score of the compounds isolated from Curcuma longa and search lead antioxidant compound through molinspiration software. We have taken ten compounds from this plant. All the compounds were further subjected to molecular properties prediction and drug likeness by Molinspirstion and found in compliance with ...
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EFFECT OF SOLVENT EXTRACTION SYSTEM ON THE ANTIOXIDANT ACTIVITY OF SOME SELECTED WILD LEAFY VEGETABLES OF MEGHALAYA STATE IN INDIA
The antioxidant activities of five wild leafy vegetables e.g. Allium porrum, Carpesium cernuum, Tricyrtis pilosa, Spilanthes acmella, and Leea sambucina collected from Meghalaya state in India were determined by using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, reducing power ability, estimation of total phenolic content, flavonoid content and flavonol content.. The result...
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EFFECT OF COMBINED MIXTURE OF FOUR MINOR MILLETS ON BLOOD GLUCOSE, SERUM LIPIDS AND OXIDATIVE STRESS IN OVARIECTOMISED WISTAR ALBINO RATS AN ANIMAL MODEL FOR MENOPAUSAL COMPLICATIONS
Diabetes mellitus, coronary artery disease and oxidative stress are some of the important complications encountered by women during menopause due to decrease in estrogen levels. Food intake has a strong impact on menopausal women and a well balanced diet is important for good health and to combat some of the complications of menopause to certain extent. Minor millets has much health benefits and h...
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SYNTHESIS AND CHARACTERIZATION OF GRAPHENE-USNIC ACID CONJUGATE MICROSPHERES AND ITS ANTIBACTERIAL ACTIVITY AGAINST STAPHYLOCOCCUS AUREUS
In response to the spacious propagation of bacterial contamination stimulated by pathogens, the evolution of novel therapeutics with eminent antibacterial action is of avid concern. When the skin unity is ruptured accidentally or intentionally, its natural defenses will thus be vitiated, and topical medication may be prescribed. Topical medicaments are designed to either obliterate or inhibit the ...
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ASSESSMENT OF THE PRESCRIPTION PATTERN OF ORAL HYPOGLYCEMIC DRUGS IN UNCOMPLICATED DIABETES MELLITUS PATIENTS AT TERTIARY CARE HOSPITAL
Aim and Objective: Drug utilization research help in identification of the clinical use of drugs in population and its impact on health care system and to evaluate the rational drug usage. To study prescription pattern, to evaluate the adherence to treatment guidelines in diabetic patients attending the medical outpatient department in a tertiary care teaching hospital. Drug utilization research h...
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SYNTHESIS OF 4-(4-DI SUBSTITUTED AMINO(PHENYL) METHYL)1-3-HYDROXY NAPHTHALEN -2-OL)DIZENYL
The reaction between 2-naphthol, aryl aldehydes and ammonia or amines yields aminobenzyl naphthols in process known as Betti reaction; this procedure can be interpreted as extension of the Mannich condensation, with formaldehyde replaced by aromatic aldehydes, secondary amine by ammonia and the C – H acid by an electron-rich aromatic compound such as 2-naphthol. 1,3-Disubstituted-2,3-dihydro-1H-...
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