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SIMULTANEOUS ESTIMATION AND ANALYTICAL METHOD DEVELOPMENT, VALIDATION FOR THE TENELIGLIPTIN AND METFORMIN BY RP-UFLC
The study aims to develop an analytical method for the simultaneous estimation of Teneligliptin and Metformin using RP-UFLC. A simple, sensitive and accurate method was developed for Teneligliptin and Metformin using the chromatographic conditions of C18 Phenomenex Kinetex (250 mm × 4.6 mm i.e., 5 μm particle size) column in gradient elution mode with the mobile phase consisting of methanol, ace...
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IN VIVO AND IN VITRO ANTIOXIDANT ACTIVITIES OF COUMARIN ON CHEMICAL INDUCED HYPERGLYCEMIC RATS
The present study was aimed at investigating the antioxidant activities of coumarin in streptozotocin (STZ)-nicotinamide (NA) induced type 2 diabetic rats. Diabetes was induced in experimental rats by a single intraperitoneal (i.p.) injection of STZ (45 mg/kg body weight (b.w.)), 15 min after the i.p. administration of NA (110 mg/kg b.w.). Diabetic rats were administered coumarin intragastrically ...
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ANALYSIS OF LIVER FUNCTION TESTS AND RENAL FUNCTION TESTS IN MAJOR DEPRESSIVE PATIENTS ON IMIPRAMINE, SERTRALINE AND ESCITALOPRAM THERAPY: AN OBSERVATIONAL STUDY IN A TERTIARY CARE HOSPITAL, AJMER, RAJASTHAN
Depression is the major cause of disability Worldwide. Antidepressant medications remain a mainstay of treatment for major depressive disorder. Our aim in this study was to analyze the LFT & RFT in patients of major depressive disorder taking imipramine, sertraline and escitalopram. A total of 810 such patients meeting the inclusion and exclusion criteria were randomly divided into three group...
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GREEN SYNTHESIS OF SILVER NANOPARTICLE BY USING TINOSPORA CORDIFOLIA LEAF EXTRACT AND ITS ANTIMICROBIAL PROPERTY
Tinospora cordifolia is one of the best medicinal plants holds most prominent place in Ayurveda Rasayana herbs and it also known as “rejuvenate herbs” because of its medicinal properties. It has been found to exhibit anti-microbial properties, its anti-microbial feature found in root, stem, and leaf extracts on pathogenic micro-organisms. Green synthesis of AgNPs can potentially eliminate chem...
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USE OF ATENOLOL AND OLMESARTAN AS AN ADD-ON THERAPY WITH CALCIUM CHANNEL BLOCKER IN HEMODIALYSIS PATIENTS FOR HYPERTENSION
Background: Management of hypertension in hemodialysis patients was never the same in all and tends to involve a various classes of drugs with respect to their disease conditions, response to drug therapy, medication adherence, and many more. Atenolol and Olmesartan can be used as add-on therapy in managing hypertension with calcium channel blockers. Methodology: Blood pressure was monitored using...
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SYSTEMATIC REVIEW OF CLINICAL TRIALS AND PROSPECTIVE COHORTS: FOLLOW UP METHODS IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA TREATED WITH DASATINIB
Chronic myeloid leukemia (CML) is a malignancy of hematopoietic stem cells associated with a t(9;22) translocation that forms the Philadelphia chromosome and creates a novel fusion gene, BCR-ABL. For those who are resistant or intolerant to imatinib, second-generation tirosino-kinase inhibitor, as dasatinib, has been shown to be efficacious in all phases of the disease. Once dasatinib is taken ora...
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ANTIMICROBIAL ACTIVITY OF 2, 2-BIPYRIDINEDICHLOROPLATINUM (II), C10H8CL2N2Pt
Antimicrobial activity of compound (2) was investigated against pathogenic microorganisms: Staphylococcus aureus (Gram (+), Escherichia coli (Gram (-) and fungal strain, Candida albicans using the Well Diffusion and the Poison plate methods. Compound (2) was shown to inhibit pathogenic growth, and judging from the area of the zone of inhibition, the susceptibility of the microorganism against co...
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IN-VITRO EVALUATION OF ANTIBACTERIAL ACTIVITY AND CYTOTOXICITY EFFECT OF CHEMICALLY SYNTHESIZED ZnO NANOPARTICLE
Nanoparticles, generally considered as particle with a size of upto 100nm, exhibit completely new or improved properties as compared to the larger particles of the bulk material that they are composed of based on specific characteristics such as size, distribution and morphology. In this study ZnO nanoparticle was synthesized by a simple and easy chemical method from ZnCl2. The synthesized nanopar...
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BENEFICIAL EXPLORATION OF NATURAL PESTICIDES FROM HIGHER PLANT
The methanolic extract (MeOH) of the bark of Holoptelea integrifolia (Roxb.) Planch and its partitions namely n-hexane (Hx), ethyl acetate (EtOAC), butanol (BuOH) and water (H2O) was screened for various in vitro biological activities including general cytotoxicity (brine shrimp lethality assay), phytotoxicity (lemna minor bioassay), nematicidal and insecticidal (Tribolium castaneum H., Rhyzoperth...
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ANTI-DIABETIC ACTIVITY OF PSORALIA CORYLIFOLIA SEED EXTRACT IN ALLOXAN INDUCED DIABETIC RATS
Psoralia corylifolia commonly known as Babchi, Bavachi in Hindi, is a well known herb in Indian system of medicine to treat various disorders including diabetes mellitus without any scientific evidences. Therefore this study was designed to investigate in vivo hypoglycemic and antidiabetic potential of methanolic extract of seeds of Psoralia corylifolia in glucose loaded animals and alloxan induce...
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