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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF HEPATOCYTES REGENERATOR POTENTIALITY OF SOME NOVEL OXADIAZOLE DERIVATIVES FOLLOWED BY MOLECULAR DOCKING AGAINST NF-KB
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases and improper immune development. The main objective of the present research work was the synthesis of N-(4-{[5-(substituted phenyl)-1,3,4...
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MICROWAVE ASSISTED SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING AND ANTIMICROBIAL EVALUATION OF 4-NITROCINNAMIDE ANALOGUES
A series of novel 2-Benzamido-3-(4-nitrophenyl)-N’-(substituted) benzylidene-acrylohydrazide (4a-l) analogues were designed by incorporating the few pharmacophoric fragments to enhance the activity profile of molecules. Title compounds were synthesized by the microwave irradiation of α-Benzamido-(4-nitro)-cinnamahydrazide (3) reveals with aromatic/ heteroaromatic aldehydes under acidic conditio...
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SPIRULINA PLATENSIS AT TENUATES STRESS-INDUCED PHYSICAL AND BIOCHEMICAL CHANGES IN RATS
The aim of present study on Spirulina platensis (Spirulina) was to evaluate the anti-stress activity. The anti-stress activity was assessed by tail suspension method andcold immobilization induced change of biochemical parameters. Acute toxicity (LD50) of Spirulina platensis values was also studied. Duration of immobilization time and cold immobilization induced alteration of biochemical parameter...
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ASSESMENT OF CYTOTOXIC EFFECT OF METHANOLIC CRUDE EXTRACTS OF AZADIRACTA INDICA
The aim of the research is to observe the cytotoxic activity of methanolic crude extracts of Azadirachta indica, a plant belonging to the family Meliaceae. The root of Azadirachta indica was extracted with organic solvent and the extracts were fractionated by using three fractions (n-hexane, ethyl acetate and chloroform). The crude extracts were screened for antitumor properties using brine shrimp...
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CURCUMIN CONSUMPTION AND COGNITIVE FUNCTION IN ELDERLY
Cognitive impairment in elderly is a growing public health concern, and is mainly caused by dementia of various etiologies. Hence, it is important to explore possible measures to mitigate the risk of dementia. Curcumin, active ingredient of turmeric (Curcuma longa) is used in curry and has shown protective effect on cognition. This study aims to explore the association between curcumin consumption...
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CANDIDATURE OF THE SYNTHETIC CASPASE INHIBITORS AS NEW ANTI-SARS-COV-2 DRUG DISCOVERY, IN-SILICO MOLECULAR DOCKING
The new pandemic virus identified as severe acute respiratory syndrome Coronavirus 2 is the etiological agent responsible for the pneumonia outbreak that ended with respiratory failure. The main protease (MPRO) is a key enzyme for SARS-CoV-2, which plays a pivotal role in mediating viral replication and transcription, making it an attractive drug target for this virus. Here, we determine the mech...
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HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACTS OF NARINGI CRENULATA (ROXB) NICOLSON AGAINST CCl4 INDUCED HEPATOTOXICITY IN RATS
The present study was designed to screen and evaluate the hepatoprotective and antioxidant activity of ethanol extracts of leaf and bark of Naringi crenulata (Roxb) Nicolson (NCL, NCB) against CCl4 induced hepatotoxicity in rats. Liver functions were assessed by the activities of liver marker enzymes, SGOT, SGPT, ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubin...
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EFFECT OF ORAL ADMINISTRATION OF VITAMIN A ON BLOOD GLUCOSE LEVEL IN RABBITS AND ITS POSSIBLE INTERACTIONS WITH COMMONLY USED ORAL ANTIDIABETIC AGENTS
In diabetes mellitus antioxidant vitamins are commonly employed to prevent or mitigate the long term complications of the disorder. Diabetic retinopathy, nephropathy, coronary and cerebral vascular insufficiency are examples of such complications. They are more common in Type 2 diabetes mellitus. The present study was conducted to observe the effect of Vit A on blood glucose level and its possible...
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IN VIVO EVALUATION OF THE ANTICANCER ACTIVITY OF A WATER-IN-GARLIC OIL NANOEMULSION LOADED WITH DOCETAXEL
Docetaxel (Doc) is an antitumor drug used to treat various types of cancers. However, it has certain limitations in clinical use due to its side effects. The major objective of this study was to assess the antitumor activity and cardiotoxicity of the Doc loaded in a nanoemulsion formulated with the garlic oil (Doc-NEGO) in Ehrlich ascites carcinoma (EAC)-bearing mice. One hundred mice were split i...
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METHOD DEVELOPMENT, VALIDATION AND STABILITY INDICATING ASSAY ON GLIMEPIRIDE IN TABLET DOSAGE FORM BY RP-UFLC
The study aimed to develop a specific, exact, selective, precise and accurate Reversed-Phase Stability Indicating Ultra-fast Liquid Chromatography (RP-UFLC) strategy is created and validated for the determination of glimepiride in the tablet dosage form. The method showed an adequate separation for glimepiride from their degradation products. The optimum separation was achieved by using 250 mm × ...
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