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EVALUATION OF PREVALENCE, KAP AND PRESCRIBING PATTERN OF DRUGS TO TYPE 2 DIABETIC PATIENTS AND ASSESSMENT OF RISK FACTORS AMONG THE NON-DIABETIC PATIENTS IN A TERTIARY CARE HOSPITAL IN SOUTHERN KERALA
A prospective, observational study was conducted among the 100 diabetic and 100 non-diabetic patients for a period of six months for the evaluation of prevalence, KAP (Knowledge, Attitude and Practice) and prescribing pattern of drugs to type 2 diabetic patients and to assess the risk factors of prevalence of diabetes among the non-diabetic patients. All information relevant to the study was colle...
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METHOD DEVELOPMENT, VALIDATION AND STABILITY INDICATING ASSAY ON GLIMEPIRIDE IN TABLET DOSAGE FORM BY RP-UFLC
The study aimed to develop a specific, exact, selective, precise and accurate Reversed-Phase Stability Indicating Ultra-fast Liquid Chromatography (RP-UFLC) strategy is created and validated for the determination of glimepiride in the tablet dosage form. The method showed an adequate separation for glimepiride from their degradation products. The optimum separation was achieved by using 250 mm × ...
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IN VITRO COMPARATIVE STUDY OF MEMBRANE STABILIZATION CAPACITY OF DIFFERENT EXTRACTS OF BLEPHARIS MADERASPATENSIS (L.) HEYNE EX ROTH. AND BLEPHARIS MOLLUGINIFOLIA PERS. GROWN IN THE REGION OF MYSORE, KARNATAKA
Blepharis is a genus belonging to family Acanthaceae. It is an Afro-asiatic genus comprising 129 species which occur in arid and semi-arid habitats. They are used for the treatment of a number of ailments. Anti-inflammatory activity was performed based on the folk lore information. The present study is aimed at the evaluation ofanti-inflammatory property of the petroleum ether, ethyl acetate and e...
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MOLECULAR DOCKING AND MOLECULAR DYNAMICS STUDIES OF QUASSINOIDS AS HIV-1 TAT INHIBITORS
TAT (Trans-activator-Transcription Protein) is a viral protein encoded by the TAT gene in HIV-1-which is a lethal subtype of HIV (Human immunodeficiency Virus). It is vital for transcription of the viral genome. Previous studies show that in Human, TAT is a toxin-producing protein allowing cell death in obtained from QSAR studies, best quassinoid compounds were used to find the highest binding aff...
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IMPAIRMENT OF OVARIAN BIOCHEMICAL CONTENTS AND ENZYMES ACTIVITIES DURING POTASSIUM BROMATE (KBRO3-) INTOXICATION IN ALBINO MICE MUS MUSCULUS
Potassium bromate (KBrO3-) is a chemical compound commonly used as a oxidizing agent that has been used as a food additive for baking of white bread, bun, pav and pizza bread. Potassium bromate (KBrO3-) is mainly known to generate free radicals, which cause oxidative damage to essential cellular macro molecules, leading to cause nephrotoxicity in experimental animals. In this part of experiment bi...
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A STABILITY INDICATING RP-LC METHOD FOR THE DETERMINATION OF STRYCHNINE IN KRIMIMUDGARA RASA
A reliable, rapid, simple and accurate high-performance liquid chromatography method with UV detection was developed for the simultaneous quantitative determination of strychnine in a polyherbal formulation prepared from Nux Vomica. Krimimudgara rasa, a herbal dosage form containing Strychnos nux vomica, Apium graveolens, Embellia ribes, Butea monosperma in combination. Separation of the strychnin...
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WOUND HEALING POTENCY OF ETHANOLIC EXTRACT OF LEUCAS URTICIFOLIA IN EXPERIMENTAL ANIMALS
The present study was planned to investigate the effect of ethanolic extract of Leucas Urticifolia on resutured incision, excision and burn wounds in Wistar rats. Resutured incision, excision and dead space wounds were inflicted under light ether anaesthesia aseptically. In incision wound model the control animals receive only distilled water and all test animals were treated with different doses ...
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VIABILITY OF ADIPOSE-DERIVED STEM CELLS (ASCs) ON POROUS CHITOSAN SCAFFOLD
Background: Stem cells have great potential in regenerative medicine due to their multipotentiality. Treatments involving cell sheets for tissue reconstruction require a large number of cells to repair the tissue damage, and the cells are fragile. Combined with a porous chitosan scaffold (PCS), adipose-derived stem cells (ASCs), which are ubiquitous, can be delivered to a target tissue in vivo. Th...
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IMMUNOLOCALIZATION OF METALLOTHIONEIN IN DIFFERENT TISSUES OF FRESH WATER CATFISH, CLARIAS GARIEPINUS ON EXPOSURE TO CADMIUM
Metallothionein (MT) is a cysteine-rich protein that binds to heavy metals, and it is induced by them. The objective of this study to identify the MT protein induction/expression and localization in liver and kidney tissues (treated with 20 mg/L of CdCl2 for 72 hours) by immunohistochemical techniques and Western Blotting methods in the fresh water catfish, Clarias gariepinus. MT expression (MT-I ...
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MINOCYCLINE DECREASES ACETYLCHOLINESTRASE ACTIVITY IN INTRA-CEREBROVENTRICULAR STREPTOZOTOCIN INFUSED RATS
Alzheimer’s disease, a synonym for life threatening dementias is characterized by oxidative stress and neuroinflammation induced neuronal loss, impaired energy metabolism, and cholinergic deficit leading to severe cognitive impairments and other abnormal neuropsychiatric changes. Cholinergic hypothesis is the most accepted theory explaining pathology of AD and Acetylcholinestrase inhibitors are ...
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