Most Popular
PLACKETT-BURMAN SCREENING OF OLMESARTAN MEDOXOMIL LIQUISOLID TABLETS: QUALITY BY DESIGN APPROACH
Solubility is considered as the important parameters to achieve desired concentration of drug in systemic circulation for achieving required pharmacological response. Olmesartan medoxomil (OLM) is poorly soluble belongs to BCS class II. The drug is rapidly absorbed following oral administration, with a bioavailability approximately 26%. Liquisolid technique was used to enhance the aqueousÂ...
3795
2504
MINOCYCLINE DECREASES ACETYLCHOLINESTRASE ACTIVITY IN INTRA-CEREBROVENTRICULAR STREPTOZOTOCIN INFUSED RATS
Alzheimer’s disease, a synonym for life threatening dementias is characterized by oxidative stress and neuroinflammation induced neuronal loss, impaired energy metabolism, and cholinergic deficit leading to severe cognitive impairments and other abnormal neuropsychiatric changes. Cholinergic hypothesis is the most accepted theory explaining pathology of AD and Acetylcholinestrase inhibitors are ...
3794
1775
LEAD FINDING FROM WHOLE PLANT OF CURCUMA LONGA WITH OXIDATIVE POTENTIAL
The present study deals with the antioxidant activity, drug likeness score and bioactivity score of the compounds isolated from Curcuma longa and search lead antioxidant compound through molinspiration software. We have taken ten compounds from this plant. All the compounds were further subjected to molecular properties prediction and drug likeness by Molinspirstion and found in compliance with ...
3793
1687
FORMULATION AND EVALUATION OF STOMACH – SPECIFIC NOVEL GASTRO-RETENTIVE FORMULATIONS OF 5-FLUOROURACIL FOR TARGETING GASTRIC CANCER
Intravenous administration of 5-Fluorouracil (5FU) produces severe systemic, dose-related side effects due to its cytotoxic nature, additionally, 5FU is rapidly absorbed from the stomach after oral administration. Therefore a combined floating-bioadhesive tablet (FBT) of 5FU has been developed in order to reduce the dose and associated side effects in other sites of the body. The tablets were prep...
3793
1507
SYNTHESIS AND CHARACTERIZATION OF [16]- MEMBERED DIOXA DIAZA NAPTHALDEHYDE BASED MACROCYCLIC LIGAND AND ITS COMPLEXES OF Co(III), Ni(II) AND Cu(II) PERCHLORATE IONS
An hitherto new unreported [16]-membered dioxadiazanapthaldehyde based macrocyclic ligand (L) 2,11-dioxa-23,30-diaza heptacyclo [30.4.0.04,9.012,21.014,19.024,29.034,39] -tetraconta-12,14,16, 18,20,22, 24,26,28,30,32,34,36,38,40-pentadecaene, has been synthesized by two different synthetic routes each involving two stages. 2-Hydroxy-1-Napthaldehyde in the presence of potassium carbonate was trea...
3792
1777
A STUDY ON PHYSICAL, CHEMICAL, AND ANTIOXIDANT PROPERTIES OF ESSENTIAL OIL SEPARATED FROM FRESH BERRIES OF CINNAMOMUM RIPARIUM BY STEAM DISTILLATION TECHNIQUE
Cinnamomum riparium Gamble belongs to the family Lauraceae is a red listed species by the International Union for Conservation of Nature (IUCN). It is a tree growing in evergreen forests and traditionally used for treating conditions like wound healing, fever, intestinal worms, headache, inflammations, menstrual problems etc. According to tribal’s, this activity is mainly due to the volatile oil...
3792
1474
PHARMACOLOGICAL EVALUATION OF ANTI-ULCER EFFECTS OF COMBINED DOSES OF ALOE VERA AND VITAMIN-E AGAINST INDOMETHACIN INDUCED PEPTIC ULCER MODEL
Peptic Ulcer Disease (PUD) is one of the most prevalent pathogenic conditions which affects around 5-10% of the global population. Helicobacter pylori infection and the use of Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are two of the most common etiological causes in the PUD pathogenesis. First line treatment for PUD involves use of drugs which cause acid suppression or target against the erad...
3792
1463
EVALUATION OF BINDING EFFECT OF PROSOPIS CINERARIA LEAF AND STEM BARK EXTRACTS WITH CALF THYMUS DNA
The present research aimed to evaluate the binding effect of hydroalcoholic extracts of leaf and Stem bark of Prosopis cineraria (PCL and PCB) with Calf Thymus (CT) DNA. The interaction of the PCL and PCB with Calf Thymus (CT) DNA has been studied using absorption spectra, viscosity measurements and cyclic voltammetry methods. It was observed that the PCL and PCB exhibited hypochromic and bathochr...
3791
1806
PULSATILE DRUG DELIVERY OF CANDESARTAN CILEXETIL FOR CARDIOVASCULAR COMPLICATIONS
The aim of current investigation was to formulate and evaluate an oral time controlled drug delivery system to achieve timed release of Candesartan cilexetil for the treatment of cardiovascular complications. Blood pressure rises early in the morning which can leads to hypertension and congestive cardiac failure. Attempt has been made to develop a drug delivery which releases the drug based on cha...
3791
1629
IN-SILICO DEVELOPMENT OF EFFICIENT L-ASPARAGINASE ENZYME FOR ACUTE LYMPHOBLASTIC LEUKAEMIA THERAPY
L-asparaginase has been accepted clinically as an anti-tumour agent for the effective treatment of acute lymphoblastic leukaemia and lymphosarcoma. This enzyme also possesses L-glutaminase activity and causes immunological problems. Hence, efforts have been made to develop mutants with lower or no glutaminase activity. In the present study, a homology model of L-asparaginase obtained from Pectobac...
3791
1497