Most Popular
ON SOME TOPOLOGICAL INDICES OF TRIANGULAR SILICATE AND TRIANGULAR OXIDE NETWORKS
A topological index is a numeric quantity from the structural graph of a molecule. It has become a very useful tool in the prediction of pharmacological, toxicological and physico - chemical properties of a compound. In this paper, we have computed some topological indices of triangular silicate TsL (n) and triangular oxide TOL (n) networks....
2663
983
VIRTUAL TOXICITY STUDIES OF NOVEL SPIROAZETIDIN-2-ONES TETHERED WITH FURANS
Background and aim: Spiroazetidin-2-ones and furans are commonly used as anti-bacterial, anti-fungal, anti-inflammatory, cardiovascular activities, anticancer, antiparkinson agents etc. The purpose of this study was to perform virtual toxicity studies of the synthesized compounds 1-(substitutedphenyl)-3-chloro-5,9-bis(furan-2-ylmethylidene)-1-azaspiro[3.5]nonan-2-ones (3a-3h). Materials and method...
2662
1067
ANALYSIS OF LIVER FUNCTION TESTS AND RENAL FUNCTION TESTS IN MAJOR DEPRESSIVE PATIENTS ON IMIPRAMINE, SERTRALINE AND ESCITALOPRAM THERAPY: AN OBSERVATIONAL STUDY IN A TERTIARY CARE HOSPITAL, AJMER, RAJASTHAN
Depression is the major cause of disability Worldwide. Antidepressant medications remain a mainstay of treatment for major depressive disorder. Our aim in this study was to analyze the LFT & RFT in patients of major depressive disorder taking imipramine, sertraline and escitalopram. A total of 810 such patients meeting the inclusion and exclusion criteria were randomly divided into three group...
2662
1025
IN VITRO ANTIMICROBIAL SCREENING OF MEDICINAL PLANTS AGAINST CLINICAL AND PHYTOPATHOGENIC BACTERIA AND FUNGI
The positive results of screening medicinal plants for antimicrobial activity forms primary platform for phytochemical and pharmacological studies in future. The work was undertaken to evaluate the antimicrobial activity of four medicinal plants viz., Sesbania grandiflora, Epiphyllum oxypetalum, Nyctanthes arbor-tristis, and Vetiveria zizanioides. Leaves were extracted using water and ethanol as s...
2661
1085
FORMULATION AND CHARACTERIZATION OF NUTRACEUTICAL NECTAR BASED ON ORANGE JUICE AND GREEN TEA
Green tea represents a popular beverage worldwide due to its high polyphenol and antioxidant activity. It is commonly brewed along with vitamin C source which plays a positive role in maintaining its antioxidant potential. Orange juice can serve as an excellent medium for supplementation of green tea for the formulation of nutraceutical nectar by enriching drink with vitamin C and overcoming the a...
2661
861
SYNTHESIS OF FUSED [1, 4] DIAZEPINES BY BASE CATALYSED CONDENSATION OF 1, 2-DIAMINES WITH CARBONYL COMPOUNDS
Based on the principle of base catalyzed condensation reaction of 1, 2-diamines with carbonyl compounds, an efficient method for the synthesis of fused 1, 4-diazepines was developed. High yields were obtained for both electron-releasing as well as electron-withdrawing substituted 1, 4-diazepine derivatives by the mentioned method...
2660
1547
COMPARATIVE MODELING OF INACTIVE UBIQUITIN THIOESTERASE FAM105A AND MOLECULAR DOCKING STUDIES OF SYNTHESIZED BENZIMIDAZOLE DERIVATIVES
In this study, homology modeling and molecular docking studies were performed to explore structural features and binding mechanism of synthesized benzimidazole derivatives as ubiquitin inhibitors. A homology modeling procedure was employed to construct a 3D model of ubiquitin protein by using MODELLER9.15. For this procedure, the X-ray crystal structure of Gumby / fam105b in Complex with linear Di...
2659
1191
DETECTING MEDICATION ERRORS FROM ADVERSE DRUG REACTION MONITORING CENTRE DATABASE – A RETROSPECTIVE ANALYSIS
Introduction: Despite the traditional focus on adverse drug reactions, pharmacovigilance centres have recently been identified as a potentially rich and important source of medication error (ME) data. The aim of this study is to identify ME from adverse drug reaction (ADRs) reports. Materials and methods: A retrospective analysis of ADR reports notified to adverse drug reaction monitoring centre o...
2659
1109
POTENTIAL LARVICIDES IN NIGERIAN HERBAL RECIPES
Investigations into the larvicidal potential of crude extracts of ten Nigerian plants were carried out against the fourth instar larvae of Anopheles gambiae mosquito. The phytochemical screening revealed that both anthraquinones and cyanogenic glycosides were absent in all the plants. However, alkaloids, saponins, tannins, cardiac glycosides, terpenes and flavonoids were either present or absent. ...
2658
2122
STANDARDIZATION, FORMULATION & ANTIMICROBIAL ACTIVITY OF CASSIA TORA
Incidence of fungal infections is increasing at an alarming rate, presenting an enormous challenge to healthcare professionals. Despite advances in preventive, diagnostic, and therapeutic interventions, the invasive fungal infection causes significant morbidity and mortality in immunocompromised patients. An effective alternative to conventional synthetic antifungal agents can be the use of medici...
2656
957