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EFFECT OF COMBINED MIXTURE OF FOUR MINOR MILLETS ON BLOOD GLUCOSE, SERUM LIPIDS AND OXIDATIVE STRESS IN OVARIECTOMISED WISTAR ALBINO RATS AN ANIMAL MODEL FOR MENOPAUSAL COMPLICATIONS
Diabetes mellitus, coronary artery disease and oxidative stress are some of the important complications encountered by women during menopause due to decrease in estrogen levels. Food intake has a strong impact on menopausal women and a well balanced diet is important for good health and to combat some of the complications of menopause to certain extent. Minor millets has much health benefits and h...
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SIMULTANEOUS ESTIMATION AND ANALYTICAL METHOD DEVELOPMENT, VALIDATION FOR THE TENELIGLIPTIN AND METFORMIN BY RP-UFLC
The study aims to develop an analytical method for the simultaneous estimation of Teneligliptin and Metformin using RP-UFLC. A simple, sensitive and accurate method was developed for Teneligliptin and Metformin using the chromatographic conditions of C18 Phenomenex Kinetex (250 mm × 4.6 mm i.e., 5 μm particle size) column in gradient elution mode with the mobile phase consisting of methanol, ace...
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ANALYSIS OF VARIOUS METAL IONS IN SOME MEDICINAL PLANTS USING ATOMIC ABSORPTION SPECTROPHOTOMETER
Metal ions such as iron , lead, copper, nickel, cadmium , chromium and zinc were investigated in medicinally important plants Alstonia scholaris, Tabernaemontana coronariae, Asparagus racemosus, Mimosa pudica, Leucas aspera and Adhatoda vasica applying atomic absorption spectrophotometer techniques. The purpose of this study was to standardize various metal ion Contamination in indigenous me...
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STUDY OF ANTIDEPRESSANT ACTIVITY OF CHRONIC ADMINISTRATION OF TRAMADOL AND WHEN IT IS CO-ADMINISTERED WITH FLUOXETINE IN LOW DOSES IN SWISS ALBINO MICE USING DESPAIR SWIM TEST
Objective- To evaluate the antidepressant activity of chronic administration of Tramadol alone and when combined with Fluoxetine in low doses in albino mice. Methods- The antidepressant effect was determined by recording the immobility time in Despair Swim Test. The mice were randomized into seven groups, with six mice in each group. Group 1 mice were given normal saline (10 ml/kg) which served as...
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IN-VITRO LOUSCIDAL AND ACARICIDAL ACTIVITIES OF ALKALOID OF CALPURNIA AUREA EXTRACTS AGAINST LINOGNATHUS OVILLUS AND AMBLYOMMA VARIEGATUM
The study was designed to evaluate the louscidal, and acaricidal activities of alkaloids of Calpurnia aurea leaves extracts. Alkaloid of C. area leaves extract at concentrations of 200, 100, 50, 25, 12.5 and 6.25 mg/ml were used for in-vitro adult immersion test of ticks and lice, which they were monitored for their mortality rates for 24 h. The activities of test substances were evaluated against...
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COMPARATIVE SYNTHESIS AND PHYSICOCHEMICAL CHARACTERIZATION OF SUBSTITUTED 2-METHYLQUINOLIN- 4(1H)-ONE BY VARIOUS CONVENTIONAL AND MICROWAVE METHODS
In the present work various conventional methods and microwave method for synthesis of substituted quinolone reported. Substituted anilines were taken as a starting material and reacted with ethyl acetoacetate in presence of catalytic amount of acid and cyclized by various cyclisation agents that give the title compounds which differ in its color intensity, reaction time as well in %yield. Based o...
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EFFECT OF Di-n-BUTYL PHTHALATE ON THE EPIDIDYMAL ANTIOXIDANT SYSTEM OF WISTAR RATS
The study evaluates the effect of di-n-butyl phthalate (DBP), a ubiquitous environmental contaminant, on epididymal antioxidant system of Wistar rats. Adult Wistar rats were orally administered DBP (500, 1000 and 1500 mg/ kg b.wt) for 7 days. Body weight increased significantly while caput and cauda epididymal weight decreased. Significant reduction in total protein concentration, lipid soluble an...
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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING SPECTRO-PHOTOMETRIC METHOD FOR THE ESTIMATION OF RIZATRIPTAN BENZOATE IN BULK AND PHARMACEUTICAL DOSAGE FORM
A simple, accurate and rugged stability indicating UV Spectrophotometric method was developed using methanol as the solvent to determine Rizatriptan Benzoate content in pharmaceutical dosage forms. The UV Spectrophotometric method for Rizatriptan Benzoate was determined at λmax 278nm and the drug proved linear in the range of 10-80μg/ml, with a good correlation coefficient of 0.9997. Percentage ...
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EFFECT OF SOLVENT EXTRACTION SYSTEM ON THE ANTIOXIDANT ACTIVITY OF SOME SELECTED WILD LEAFY VEGETABLES OF MEGHALAYA STATE IN INDIA
The antioxidant activities of five wild leafy vegetables e.g. Allium porrum, Carpesium cernuum, Tricyrtis pilosa, Spilanthes acmella, and Leea sambucina collected from Meghalaya state in India were determined by using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, reducing power ability, estimation of total phenolic content, flavonoid content and flavonol content.. The result...
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VIRTUAL SCREEENING AND PHARMACOLOGICAL EVALUATION OF NEWER BTK INHIBITIORS AS POTENT ANTI-RHEUMATOID ARTHRITIC AGENTS
Rheumatoid arthritis is a chronic autoimmune disease affecting 1% of the world wide population. Recent researches suggested that the need for discovery of new therapeutic disease modifying anti-rheumatoid arthritis drugs (DMARD’s). BTK (Bruton’s tyrosine kinase) is cytoplasmic, non receptor tyrosine kinase and it is efficient target for the treatment of rheumatoid arthritis. This encouraged us...
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