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COMPARISON OF DIFFERENT CLASSES OF ORAL ANTIDIABETIC DRUGS IN COMBINATION WITH METFORMIN ON COGNITIVE FUNCTIONS
Type 2 diabetes mellitus is associated with cognitive impairment. The antidiabetic treatment found to delays the impairment. However, the benefit is due to antidiabetic drugs, or control of blood sugar is debatable. Most of the drug-based studies used monotherapy, which contradicts the clinical practice. This study aims to assess cognitive function in type-2 diabetes mellitus patients on metformin...
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BIOSYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLE FROM COCCINIA GRANDIS AND ITS CATALYTIC ACTIVITY
The fabrication of spherical gold nanoparticles (AuNPs) using the reducing agent and stabilizing agent Coccinia grandis is reported here. Irradiation of the reaction mixture under a domestic microwave oven enabled the formation of gold nanoparticles. The successful formations of AuNPs were characterized by UV-Visible spectroscopy (UV-Vis), Fourier transforms infrared spectroscopy (FTIR), X-ray pow...
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FLAVONOIDS IMPACT ON PREVENTION AND TREATMENT OF OBESITY AND RELATED METABOLIC RISK FACTORS
Metabolic syndrome, the most prevailing health concern worldwide, and their incidences are increasing at a very high rate, resulting in enormous social costs. Obesity is a measure risk factor for non-communicable disease such as cardiovascular diseases, diabetes, cancer, and inflammation-based diseases. Therapeutic strategies for managing this syndrome include synthetic drugs and surgery, which en...
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VASORELAXANT AND ANTIHYPERTENSIVE EFFECTS OF RHUS PENTAPHYLLA (SEARSIA PENTAPHYLLA)
Rhus pentaphylla (Jacq.) Desf. (Searsia pentaphylla (Jacq.) FA. Barkley) is used for its colorant and tanning properties by the local population. The bark, leaves, roots, and fruits are employed in Moroccan traditional medicine to treat gastrointestinal disorders and diarrhea. Nevertheless, the pharmacological properties of R. pentaphylla on cardiovascular diseases have not yet been presented. Thi...
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NANOEMULSION: A NOVEL TRAIT IN THE TREATMENT OF SKIN AGEING
Nanoemulsion system is a promising vehicle due to the powerful ability to deliver the drug through the skin. Researchers have been conducted to prove its potential for the delivery of the drugs used in many skin disorders. Skin is the largest organ and acts as the first line of defense of our body. After a certain period of time, our skin loses tone and elasticity which is called aging. It is the ...
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ANTI-OXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF SYNTHESIZED 3(SUBSTITUTED) CHROMEN-2-ONE
This study was designed to investigate the in vitro anti-oxidant and in vitro anti-inflammatory potential of synthesized 3(Substituted) Chromen-2-one. Anti-oxidant activity has done by DPPH, NO and H2O2 free radical scavenging activity, ascorbic acid was used as a standard. Anti-inflammatory activity has done by membrane stabilization method; aceclofenac sodium was used as standard. The presence o...
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HETEROLEPTIC MONONUCLEAR RUTHENIUM(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES
Mononuclear ruthenium(II) complexes of the type [Ru(bpy)2(L)] (PF6)2, where L=4,5-bis(4-dimethyaminophenyl)-1H, 1 'H-2,2'-biimidazole (1) and 4,5-bis (4-fluorophenyl) - 1H, 1' H-2,2'-biimidazole (2) have been synthesized and characterized by elemental analyses and spectroscopic techniques such as UV-visible, IR and ESI-MS. The redox behavior of the complexes has been studied by cyclic and differ...
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FORMULATION AND EVALUATION OF DILTIAZEM HCl FAST DISSOLVING TABLETS USING DIFFERENT CO-PROCESSED EXCIPIENTS BY DIRECT COMPRESSION METHOD
The aim of present work was to prepare Diltiazem HCl Fast Dissolving tablets by Direct compression method because of their convenience in administration and suitability for patients having dysphagia using Co-processed excipients - Disintequik MCC25, Disintequik MCC, Lubritose MCC, Lubritose SD, Lubritose AN, NF Fast flo Lactose Monohydrate modified spray dried. The Prepared powdered blend and tabl...
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PHARMACOLOGICAL ACTIVITY OF SILVER NANOPARTICLES SYNTHESIZED USING STEMODIA VISCOSA AQUEOUS EXTRACT
The Pharmacological effects of silver nanoparaticle of Stemodia viscosa aqueous plant extract on albino wistar rats was explored. The plant extract 40 ml was added to 10 ml of 10mM silver nitrate aqueous solution and kept at room temperature for synthesizing silver nanoparaticle. Diabetes was induced in overnight fasted mice by single intra-peritoneal injection of 55 mg/kg of Streptozotozin (STZ),...
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DETERMINATION OF As, Hg, Pb, Cd AND Al IN THE LIPSTICKS IN THE KINGDOM OF SAUDI ARABIA
Using inductively coupled plasma optical emission spectroscopy (ICP–OES) I determined the concentrations of heavy metals, arsenic (As), mercury (Hg), lead (Pb), cadmium (Cd) and aluminum (Al) element after digestion using microwave pressure for 32 different types from the most popular and widely sold lipsticks in Riyadh markets. Analysis was conducted for the samples of expensive and cheap brand...
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