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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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62.

ANTI-INFLAMMATORY AND ANTIHYPERCHOLESTEROLEMIC ACTIVITY OF ROSA CENTIFOLIA, CORIANDRUM SATIVUM AND CYNODON DACTYLON

Hypercholesterolemia is one of the major conditions that are prevalent in today’s world, the significant causes being unhealthy food habits and lifestyle or abnormal genetic conditions. HMG CoA reductase is an important rate-limiting enzyme in the mevalonate pathway that synthesizes cholesterol. Biosynthesis of cholesterol in the liver can be reduced significantly by inhibiting HMG CoA reductase...

A. Thilagavathy *, S. Dsouza, A. Shriraksha and K. G. Singh

Department of Biochemistry, Mount Carmel College, Autonomous, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).966-72

966-972

3779

1688

53.

IN-VITRO PROPAGATION OF TYLOPHORA OVATA (LIND.) HOOK. EX. STEUD – AN IMPORTANT MEDICINAL PLANT

Efficient in-vitro propagation of Tylophora ovata (Lind.) Hook. Ex. Steud was carried out in this present investigation.  Nodal segments from the healthy grown plants were used as explants for culturing.  Explants were cultured on standard Murashige and Skoog (MS) medium supplemented with different concentration of benzyl amino purine (BAP) and naphthalene acetic acid (NAA) for primary shoot pro...

R. Jeyachandran* and M. Bastin

Department of Botany, St. Joseph’s College (Autonomous), Tiruchirappalli – 620 002, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1083-86

1083-1086

3777

1350

53.

PHYSIOCHEMICAL MICROBIAL AND PHARMACOLOGICAL STUDIES OF Zn (II) – 6- THIGUANINE DRUG COMPLEX

A new complex has been synthesized of Zn (II) complex with 6-thioguanine and physicochemical characterized by amperometry, polarography elemental analysis, UV and IR spectroscopy. After Synthesis of metal complex, it was evaluated it for antibacterial activities against various pathogenic microorganisms such as; Streptococcus aureus, Proteus. M., klebsiella pneumonia and Asperginus Niger, Nigrospo...

Agrawal Shuchita * and Jain Sanchita

Department of Chemistry, Mewar University, Chittorgarh Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(6).2678-83

2678-83

3777

1517

42.

SYNTHESIS, CHARACTERISATION AND BIOLOGICAL SCREENING OF Cu (II) COMPLEXES OF PINCER LIGANDS

The ligands bis-(benzimidazolyl)pyridine (BBIP) and bis-(benzimidazolyl)benzene (BBIB) have been used to synthesize Copper(II) complexes [Cu(BBIP)2]Cl2 and [Cu(BBIB)2]Cl2 respectively. The complexes are characterized by analytical and spectral (FTIR, 1H NMR and electronic) techniques. IR spectra of complexes show that the tertiary nitrogens in the ligand are involved in the co-ordination to the me...

Ramya Ayyasamy *, Parameswari Kandasamy and Subramanian Chitra

Department of Chemistry, PSGR Krishnammal College for women, Peelamedu, Coimbatore - 641004, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.6(6).2594-00

2594-00

3776

1572

47.

ENHANCEMENT OF SOLUBILITY OF POORLY SOLUBLE DRUG BY INCLUSION COMPLEXATION WITH γ-CYCLODEXTRIN

Candesartan is an angiotensin receptor blocker, used as an anti-hypertensive drug. It is available in the salt form of cilexetil i.e.; Candesartan cilexetil belongs to class II of the Biopharmaceutical classification system. It is a poorly soluble drug, and the bioavailability is 15%. The intention of the study is to improve the solubility of the poorly soluble drug, Candesartan cilexetil using th...

B. Radha Madhavi *, B. Divya, K. Anusha, G. Tejaswi, G. Yamini Divya Teja and K. Kiran Kumar Reddy

Department of Pharmaceutics, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, West Godavari, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6593-99

6593-6599

3775

977

22.

ASSESSMENT OF NUTRITIONAL CONSTITUENTS AND IN VITRO ANTIOXIDANT CAPACITY OF METHANOLIC STEM EXTRACT OF CARALLUMA ATTENUATA

The main objective of the present study includes the assessment of nutritional constituents and anti-oxidant activity of methanolic stem extract of Caralluma attenuata by in-vitro methods. In the present investigation the author has identified the phytochemical constituents which have nutritional importance by specific chemical tests, thin layer chromatography, atomic absorption spectroscopy for C...

P. Mounika, M. Vijaya Jyothi *, Y. Rajendra Prasad, C. Naresh Babu and S. Triveni

Department of Pharmaceutical Chemistry, Raghavendra Institute of Pharmaceutical Education and Research, K.R. Palli cross, Ananthapuramu, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(7).2910-15

2910-2915

3774

1514

27.

STUDY OF ANTIULCER ACTIVITY OF ANGIOTENSIN RECEPTOR ANTAGONISTS IN EXPERIMENTALLY INDUCED GASTRIC ULCERS IN RATS

Background: Peptic ulcer is one of the common diseases affecting the mankind. Many studies reveal co-occurrence of both peptic ulcer and hypertension in humans. So, it might be beneficial to choose an optimal drug that will target both these conditions. The role of renin-angiotensin system in the pathogenesis of peptic ulcer is well known. AT receptor antagonists which prevent binding of AT-II to ...

Suvarna S. Rathod *, Vijay M. Motghare and Vinod S. Deshmukh

Flat no 17, Laxmikantam Apartment, Tirupati Nagar, Warje, Pune-411052, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(2).502-07

502-507

3773

1604

12.

STUDY OF THE INVOLVEMENT OF ADIPONECTIN AND HOMA-IR IN TUNISIAN SUBJECTS WITH METABOLIC SYNDROME

Metabolic syndrome (MS) is a multi-factorial disorder with insulin resistance as a major characteristic. Adiponectin, an adipocyte derived cytokine, can regulate glucose levels and lipid homeostasis by its insulin sensitizer properties. Low circulating levels of serum adiponectin has been reported as a risk factor for the development of MS. The aim of this case control study was to investigate the...

Sondes Sahli *, Abir Jaballah, Latifa Khlifi, Henda Chahed, Salima Ferchichi and Abedelhedi Miled

Biochemistry Laboratory CHU Farhat HACHED, Sousse, Tunisia

DOI: 10.13040/IJPSR.0975-8232.7(10).4022-27

4022-27

3773

1541

39.

METHOD DEVELOPMENT, VALIDATION AND STABILITY INDICATING ASSAY ON GLIMEPIRIDE IN TABLET DOSAGE FORM BY RP-UFLC

The study aimed to develop a specific, exact, selective, precise and accurate Reversed-Phase Stability Indicating Ultra-fast Liquid Chromatography (RP-UFLC) strategy is created and validated for the determination of glimepiride in the tablet dosage form. The method showed an adequate separation for glimepiride from their degradation products. The optimum separation was achieved by using 250 mm × ...

R. Maruthi * and R. S. Chandan

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(9).4345-53

4345-4353

3773

1229

29.

CARDIOPROTECTIVE EFFECT OF CASSIA AURICULATA LINN., PETAL EXTRACT ON ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN MALE ALBINO RATS

Protective effect of Cassia auriculata Linn., floral extract was examined against Isoproterenol induced Myocardial infarction in male albino rats.  The oral administration of aqueous extract of Cassia auriculata, afforded protection against Isoproterenol induced alterations in Cholesterol,  LDL, HDL, TG, Protein, AST, ALT, LDH, Catalase and GPx.  The protective effect was further supported by t...

S. Manimegalai and P. Venkatalakshmi

Assistant Professor, Department Of Biochemistry, S.T.E.T.Women’s College, Sundarakottai, Mannargudi 614001, Thiruvarur District, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(3).848-52

848-852

3772

1273