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NITRIC OXIDE: A NOVEL THERAPEUTIC TARGET
Nitric oxide (NO), the most potent natural vasorelaxant, has close relation to cardiovascular physiology, inspite of its complex chemistry; it is a signal-transducing radical. Aspects of NO biology critical to gastrointestinal health and, consequently, nutritional status are increasingly being recognized. Cross-talk between NO and micronutrients within and outside the gastrointestinal system affec...
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RAPID CHROMATOGRAPHIC AND SPECTROPHOTOMETRIC DETERMINATION OF CITALOPRAM IN RELEVANCE TO PHARMACEUTICAL ANALYSIS
This paper describes the study to measure the sensitivity and accuracy of two techniques, chromatography and spectrophotometry for the direct determination of citalopram in pharmaceutical formulations. Chromatography was performed on SE-30 column (1 m × 3 mm i.d) using Nitrogen as a carrier gas (flow rate of 40 ml/min), having retention time of 12.8 min. Calibration curve was found linear in the ...
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CYCLODEXTRIN GLYCOSYLTRANSFERASE PRODUCTION BY ALKALIPHILIC BACILLUS SP. ISOLATED FROM RICE CULTIVATED SOIL AND MEDIA OPTIMIZATION USING TAGUCHI METHOD
A Cyclodextrin glycosyltransferase (CGTase) producer was isolated from soil obtained from rice fields using alkaline Horikoshi II medium. The alkaliphile was characterized microscopically, biochemically and confirmed by 16S rRNA analysis as Bacillus oshimensis. CGTase production is dependent on the strain, medium composition and culture conditions; hence media optimization studies were carried out...
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INFLUENCE OF VERAPAMIL ON PHARMACOKINETICS OF PIOGLITAZONE IN NORMAL AND DIABETIC RATS
The study was undertaken to find out the pharmacokinetic drug interaction of verapamil on pioglitazone in normal and alloxan induced diabetic rats following single and multiple dose treatment. Human oral therapeutic doses of pioglitazone and verapamil were extrapolated to rats based on their body surface area. The serum pioglitazone concentrations were estimated by a sensitive reverse phase – hi...
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A SIMPLE METHOD FOR SYNTHESIS OF AMANTADINE HYDROCHLORIDE
Amantadine hydrochloride (1) is an antiviral drug currently used to treat certain influenza infections (type A). It is also used as an anti-dyskinetic agent to treat Parkinson’s disease. Several methods for the preparation of amantadine hydrochloride (1) were reported, these procedures started from adamantane (2), using procedure four reaction steps to obtain amantadine hydrochloride with an ove...
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ALLEVIATION OF ARSENIC INDUCED LUNG TOXICITY BY OCIMUM SANCTUM IN MURINE MODEL
Arsenic is a well known pulmonary irritant and has been found associated with lung cancer in smelter workers exposed to arsenic via inhalation. The recent findings suggest the involvement of reactive oxygen species (ROS), generated during arsenic metabolism in inducing arsenic toxicity. Thus present work was designed to establish a correlation between arsenic induced oxidative stress, histopatholo...
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COMPARATIVE ANALYSIS OF MOLECULAR INTERACTIONS BETWEEN DRUGS OF AQUEOUS PROPYLENE GLYCOL WITH CERTAIN ALCOHOLS AT 308.15K: AN INSIGHT FROM DENSITY AND VISCOSITY STUDIES
Density, ρ and viscosity, η of drug of aqueous solution of propylene glycol (PG) (3 m and 7 m) with tert-butanol/2-propanol have been measured over the entire composition range of alkanols at 308.15 K. From this experimental data, excess molar volume, , deviation in viscosity, Δη, and excess Gibbs free energy of activation of viscous flow, ΔG*E have been determined. Positive values of Δη, ...
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NANOEMULSION: A NOVEL TRAIT IN THE TREATMENT OF SKIN AGEING
Nanoemulsion system is a promising vehicle due to the powerful ability to deliver the drug through the skin. Researchers have been conducted to prove its potential for the delivery of the drugs used in many skin disorders. Skin is the largest organ and acts as the first line of defense of our body. After a certain period of time, our skin loses tone and elasticity which is called aging. It is the ...
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ANTI-MICROBIAL AND ANTI ADHESIVE PROPERTIES OF LACTOBACILLUS AND BACILLUS SP.
The aim of this study was to determine the anti-microbial and anti-adhesive properties of a Lactobacillus and Bacillus, against several micro-organisms, including Gram-positive and Gram-negative bacteria. Biofilm producing micro- organisms were isolated from different samples. The isolated micro-organism were characterized and identified. The anti-microbial and anti-adhesive activities were determ...
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ASSESSMENT OF POTENTIAL EFFECT OF ANTIEPILPETIC DRUGS ON LIPID PROFILE AND C-REACTIVE PROTEIN AS PREDICTORS OF VASCULAR DISEASE IN EPILEPSY PATIENTS
Epilepsy is a neurological disorder which often requires lifelong treatment with antiepileptic drugs (AEDs). Prolonged use of AEDs is associated with changes in vascular risk markers. Hence, the study was designed to evaluate the effect of older generation AEDs (carbamazepine and phenytoin) and newer generation AED (levetiracetam) monotherapy on the markers of vascular risk in epilepsy patients. T...
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