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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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24.

ANTI ULCER ACTIVITY OF HELIOTRPIUM INDICUM LEAVES EXTRACT

The objective of present study is to evaluate the anti ulcer activity of ethanol extract of leaves of Heliotropium indicum. The ethanol extract of H. indicum was investigated for its anti ulcer activity against Aspirin plus pylorus ligation induced gastric ulcer in rats, HCl –Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats. The antiulcer activity was assessed by de...

Ashoka M. Shenoy* and Shashidhar C. Shastry

Department of Pharmacology, Srinivas College of Pharmacy, Mangalore- 574143, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(10).2651-54

2651-2654

3831

1570

53.

EVALUATION OF IN VITRO ANTIOXIDANT CAPACITY OF AQUEOUS AND ETHANOLIC EXTRACTS OF EIGHT DIFFERENT PLANTS MATERIALS

The plants and their materials have been utilized for treatment of various diseases in human and animals which are rich source of antioxidants due to presence of phytonutrients such as vitamins  (alpha- tocopherol, Ascorbate, carotenoid) or minerals (zinc, selenium) and flavanoid, polyphenols and flavoproteins which exert their action through scavenging free radicals in vivo system. Hence search ...

D. K. Sharma *, V. K. Gupta, D. B. Mondal, Mamta Singh, R.S.K. Mandal and R. Raguvaran

Division of Medicine, Indian Veterinary Research Institute, Bareilly (UP), Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(9).4086-91

4086-91

3831

2072

50.

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-(2′-HYDROXY-3′-NITRO-5′-METHYLPHENYL)-5-(ARYL/HETERYL) PYRAZOLES

Heterocyclic compounds are well known for their different biological activities like anti-inflammatory, antibacterial, antifungal, anticancer, insecticidal, pecticidal, antibiotic, etc. the versatile applications of oxygen, nitrogen and sulphur containing heterocyclic compounds have made this area of extensive research. The present study deals with the synthesis of some new 3-(2'-hydroxy-3'-nitro-...

S. B. Borul * and S. V. Agarkar

Department of Chemistry , Late Ku. Durga K. Banmeru Science College, Lonar, M.S. India

DOI: 10.13040/IJPSR.0975-8232.7(5).2663-66

2663-66

3831

1701

53.

MICROWAVE IRRADIATED SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDIES OF 3-((SUBSTITUTED-BENZO[D]THIAZOL-2-YLAMINO)METHYL)-5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOLE-2(3H)-THIONE

A series of new Mannich base derivatives were designed, synthesized by conventional and non-conventional microwave method, compared and evaluated for their antimicrobial and anti-mycobacterial activity. Structures of the newly synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral studies. The bioactive assay showed that Mannich base derivativ...

V. M. Patel and N. B. Patel*

Department of Chemistry, Veer Narmad South Gujarat University, Surat, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).4021-33

4021-4033

3831

1701

2.

THERAPEUTIC APPLICATIONS OF MUSHROOMS AND ITS COMPOSITIONAL ANALYSIS BY HIGH THROUGHPUT SCREENING TECHNIQUES

Mushrooms can be considered as a prolific resource for drugs as per previous literature surveys. Their constituent bioactive components are broadly classified such as phenols, flavonoids, triterpenoids, saponins. Whole mushrooms or mainly fruiting bodies extracts and compounds isolated from their mycelium are of immense pharmacological importance. Extraction employing suitable solvents leads to th...

D. Chatterjee *, S. Das and D. Halder

Department of Food Technology and Biochemical Engineering, Jadavpur University, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3508-18

3508-3518

3831

1821

47.

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEW CHALCONES USING ANHYDROUS POTASSIUM CARBONATE AS AN EFFICIENT BASIC CATALYST BY CONVENTIONAL AND MICROWAVE ASSISTED TECHNIQUES

A series of novel 3-(substituted aryl)-1-(5-methylfuran-2-yl)prop-2-en-1-one derivatives (3a-k) were synthesized from commercially available 2-acetyl-5-methylfuran and various substituted aromatic aldehydes in presence of anhydrous potassium carbonate in ethanol solution and by microwave irradiation method with good yield compared to conventional method.  Anhydrous potassium carbonate has been ut...

S. Kulathooran and M. Dhamodaran *

Department of Chemistry, Perunthalaivar Kamarajar (Govt.) Institute of Engineering and Technology, Karaikal, Karaikal India

DOI: 10.13040/IJPSR.0975-8232.6(7).3027-33

3027-33

3830

1692

32.

FUNCTIONAL GENOMICS OF MYCOBACTERIUM TUBERCULOSIS

Mycobacterium tuberculosis is a deadly infectious disease, there is rising death of humans every year because of this disease, availability of genome sequences of Mycobacterium tuberculosis has provided tremendous amount of  information that can be useful in drug target and new vaccine development. Sequence similarity provides accurate annotation for genes in newly sequenced genomes. In this pres...

Anitha Jabamalai Raj , Sangilimuthu Algar Yadav , Velliyur Kanniappan Gopalakrishnan , Akila Selvaraj and Sudarsanam Dorairaj*

Department Advanced Zoology and Biotechnology, Medical lab Technology & Biomedical Instrumentation ScienceLoyola College, Chennai-600034, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(7).1793-98

1793-1798

3829

1601

37.

A COMPARATIVE GROUP-QSAR AND MOLECULAR DOCKING STUDIES OF 4 -THIAZOLIDINONE CONTAINING INDOLIN-2-ONE MOIETY AS VGEFR INHIBITORS

Vascular endothelial growth factor receptors (VEGFR) are kinase based receptors reported as a promising target in anti tumour therapy. VGEFR inhibitors are being investigated which can have important contribution in anti-angiogenic therapy for treatment of cancer. In the present study, an attempt has been made to develop a site-specific QSAR model in order to explore the definite sites of substitu...

Pragya Nayak * and Monica Kachroo

Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1796-05

1796-1805

3829

1659

7.

ROLE OF POLYMERS IN SUSTAINED RELEASED MICROBEADS FORMULATION: A REVIEW

The aim of this article is to provide a wide-angle prospect of the detailed information of pharmaceutical polymers in sustained released micro-beads dosage forms. Polymers have played an integral role in the advanced drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and constant release of both hydrophilic and hydroph...

M. Bhupathyraaj *, S. Pole and R. Vijayarani

College of Pharmacy, National University of Science and Technology, Muscat, Oman.

DOI: 10.13040/IJPSR.0975-8232.12(1).76-84

76-84

3829

1637

53.

ISOLATION AND CHARACTERIZATION OF NATURAL PRODUCT COMPOUNDS FROM RHIZOMES OF CYPERUS ROTUNDUS LINN.

Background: Cyperus rotundus Linn. is a traditional medicinal plant appearing among Indian, Chinese and Japanese natural drugs, used for the treatment of spasms stomach disorder and also used as anti-inflammatory, antimalarial, hypotensive, antipyretic, anthelmintic, hepatoprotective agent. Rhizomes of C. rotundus have been used in ancient medicine in India for fever, dysentery, pruritis, pain, vo...

T. C. Sharma, A. K. Sharma *, S. K. Meena, M. P. Dobhal and M. C. Sharma

Department of Chemistry, Jagan Nath University, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.9(7).3024-28

3024-3028

3828

1661