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ROLE OF SOLVENT ACCESSIBLE SURFACE AREA (ASA+) AND BALABEN 3D INDEX (J3D) IN BINDING AFFINITY OF TIBO DERIVATIVES
In present QSAR study of TIBO derivatives, aim of the author is to analysis some different 3D parameter in order to get best QSAR model, which enhance the binding affinity of TIBO derivatives. Solvent accessible surface area (3D) of all atoms with positive partial charge (strictly greater than 0) and Balaben 3D index plays vital role in this concern. This study focuses on some important and differ...
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PREVALENCE AND RISK FACTORS OF METABOLIC SYNDROME IN ADULT TUNISIAN PATIENTS
Background: Metabolic syndrome (MetS) is a cluster of diseases, including hypertension, obesity, dyslipidemia, and hyperglycemia. We therefore aimed to estimate MetS prevalence and to determine risk factors for MetS. Methods: In the present study, we recruited 209 adult Tunisian MetS patients (57 males and 152 females, mean age 58.9±10.7 years) matched by gender and ethnic origin to 193 healthy i...
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ENHANCED HUMAN EXPOSURE TO RADIATIONS, ROLE OF PHYTOCHEMICALS AS POTENTIAL RADIO-PROTECTANTS: A REVIEW
Science and technology have greatly contributed to man’s never-ending quest for quality improvement in different domains of life. But in the process of development, the usage of radiation-based technologies has considerably increased in the fields of medicine, agriculture, aviation, space, warfare, food processing, electronic and communication systems, nuclear-power generation and other industri...
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COMPARATIVE STUDIES ON BIOCHEMICAL, HISTOPATHOLOGICAL AND FTIR-ATR SPECTRAL STUDIES OF HYPERLIPIDEMIA INDUCED BY CHOLESTEROL-RICH DIET IN RATS
Objective: To compare the routine biochemical and histological techniques with FTIR-ATR spectroscopic methods in diagnosing hyperlipidemia. Materials: Compositional changes in the serum and tissues reflects the healthy and pathological status of animals. FTIR-ATR was attempted as an additional tool for evaluating the composition in the serum as well as in tissues materials. To achieve this Wistar ...
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PROTECTIVE ROLE OF GYMNEMIC ACID IN CURBING HIGH FAT DIET AND HIGH FRUCTOSE INDUCED PANCREATIC OXIDATIVE STRESS MEDIATED TYPE-2 DIABETES IN WISTAR RATS
High fat diet and High fructose intake is the predominant lifestyle change that increased the epidemic of type-2 diabetes. HFD+HF feeding leads to oxidative stress mediated T2D through production of free radicals and decrement of antioxidant enzymes. Our present study focussed on the curbing effect of gymnemic acid on high fat diet and high fructose feeding induced oxidative stress mediated Type 2...
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CLINICAL EVALUATION OF T-AYU-HMTM IN THE MANAGEMENT OF SICKLE CELL ANEMIA
Sickle cell anemia is a hemoglobin disorder, which is an autosomal recessive type affects millions of children of underprivileged and tribal area every year. Because of its devastating complications sickle cell is considered a major health problem in India and the entire world. Since many years, majority of the tribal population in the South Gujarat region are suffering from this lifelong disorder...
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ANTIDIABETIC ACTIVITY OF HYDROETHANOLIC LEAF EXTRACT OF GYMNEMA HIRSUTUM WIGHT & ARN IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
The present study has investigated the hypoglycaemic effect of oral administration of 50% ethanolic leaf extract of G. hirsutum Wight & Arn in normal and Streptozotocin–induced diabetic rats. Albino Wistar rats (190 to 220 gm) were induced diabetic condition by administration of Streptozotocin (STZ) (55 mg/kg bw) intraperitoneally. 50% ethanolic extract of G. hirsutum Wight & Arn l...
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SYNTHESIS OF SOME NOVEL OXADIAZOLE BASED CHALCONE DERIVATIVES AS ANTI-BACTERIAL AGENTS
A series of 1, 3, 4-oxadiazole derivatives were designed and out of which six compounds have been synthesized via four step synthetic scheme and evaluated for antibacterial activity using cup plate method. The compounds were previously characterized by IR, 1H-NMR spectral analysis. The compounds with hydroxyl and methoxy substituted phenyl rings showed higher activity than the chloro substituted d...
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SYNTHESIS AND EVALUATION OF SOME ALDEHYDE DERIVATIVES OF 1, 4 DI-HYDRO PYRIDINE AND THEIR BIOLOGICAL EVALUVATION
Synthesis of some aldehyde derivatives of 1, 4 di- hydro pyridine has been done. The entire synthesized compounds were characterized by UV, IR and 1HNMR spectroscopy. The anticonvulsant and antimicrobial activity were also evaluated. The present investigation deals with the synthesized compounds possessing good anticonvulsant, analgesic and antimicrobial activity. Synthesized compounds like PNH, P...
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EFFICACY OF GRIFFITHSIA PACIFICA KYLIN ON IN VIVO ANTI DIABETIC AND ALTERATIONS IN ENZYMATIC ACTIVITIES OF STZ INDUCED RATS
In recent years there is more research work taken in Marine sources for its pharmaceutically valuable compounds and active medicines for anticancer, anti diabetic, anti oxidant, antimicrobial, and anti-inflammatory. The present study investigated for the medicinal value of red algae Griffithsia pacifica Kylin (GPK) and its alterations in enzymatic activity of STZ induced diabetic rats. The resul...
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