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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-(2′-HYDROXY-3′-NITRO-5′-METHYLPHENYL)-5-(ARYL/HETERYL) PYRAZOLES
Heterocyclic compounds are well known for their different biological activities like anti-inflammatory, antibacterial, antifungal, anticancer, insecticidal, pecticidal, antibiotic, etc. the versatile applications of oxygen, nitrogen and sulphur containing heterocyclic compounds have made this area of extensive research. The present study deals with the synthesis of some new 3-(2'-hydroxy-3'-nitro-...
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IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF POLYALTHIA LONGIFOLIA (SONN.) THWAITE SEEDS
The present study is designed to evaluate the in vitro antioxidant and in-vivo anti-inflammatory activities of Polyalthia longifolia (Sonn.) Thwaite seeds. Initially, the extracts (Nonpolar to polar) were screened for in-vitro antioxidant activity by DPPH, nitric oxide radical, hydroxyl radical, and superoxide radical considering ascorbic acid as standard. Among the extracts the ethyl acetate and ...
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PROTECTIVE ROLE OF MELATONIN AND TAURINE AGAINST TOXICITY INDUCED BY CAFFEINE IN BRAIN BY ABROGATION OF OXIDATIVE STRESS, DECREASE APOPTOSIS, AND ALTERS CEREBRAL MONOAMINE NEUROTRANSMITTERS IN MALE ALBINO RATS
The current study aimed to investigate the protective effects of taurine and melatonin against caffeine-induced brain damage in rats. 36 male albino rats were divided into 6 groups: Group I: control, group II: Rats received 20 mg/kg melatonin for 28 days. Group III: Rats received 50 mg/kg taurine dissolved in distilled water daily for 28 days. Group IV: Rats received 50 mg/kg caffeine dissolved in...
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REAL PICTURE OF CANCER IN BANGLADESH, A DEVELOPING SOUTH ASIAN COUNTRY: A SURVEY STUDY
Cancer - one of the most pervasive diseases, thus far mostly in affluent countries - is fast raising its ugly head in the developing world. This is a survey work on cancer due to recent increasing of the number of cancer patients in Bangladesh. This study was carried out in Ahsania Mission Cancer Hospital, Dhaka Bangladesh as this is the biggest missionary hospital in this country, From 13 Febru...
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ANTI ULCER ACTIVITY OF HELIOTRPIUM INDICUM LEAVES EXTRACT
The objective of present study is to evaluate the anti ulcer activity of ethanol extract of leaves of Heliotropium indicum. The ethanol extract of H. indicum was investigated for its anti ulcer activity against Aspirin plus pylorus ligation induced gastric ulcer in rats, HCl –Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats. The antiulcer activity was assessed by de...
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EVALUATION OF IN VITRO ANTIOXIDANT CAPACITY OF AQUEOUS AND ETHANOLIC EXTRACTS OF EIGHT DIFFERENT PLANTS MATERIALS
The plants and their materials have been utilized for treatment of various diseases in human and animals which are rich source of antioxidants due to presence of phytonutrients such as vitamins (alpha- tocopherol, Ascorbate, carotenoid) or minerals (zinc, selenium) and flavanoid, polyphenols and flavoproteins which exert their action through scavenging free radicals in vivo system. Hence search ...
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THERAPEUTIC APPLICATIONS OF MUSHROOMS AND ITS COMPOSITIONAL ANALYSIS BY HIGH THROUGHPUT SCREENING TECHNIQUES
Mushrooms can be considered as a prolific resource for drugs as per previous literature surveys. Their constituent bioactive components are broadly classified such as phenols, flavonoids, triterpenoids, saponins. Whole mushrooms or mainly fruiting bodies extracts and compounds isolated from their mycelium are of immense pharmacological importance. Extraction employing suitable solvents leads to th...
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DESIGN, SYNTHESIS AND ANTIVIRAL ACTIVITY OF 2-{[(2E)-3-(3, 4, 5-MONO/DI/TRI HYDROXYPHENYL) PROP-2-ENOYL] SULFANYL/AMINO} PROPANOIC ACIDS IN HUMAN PLASMA BY ROTOR GENE-Q (5 PLEX) REAL TIME PCR METHOD
Halfmer of chicoric acid derivatives in two series were planned to synthesized and evaluated for their capacity to reduce the viral load in the human plasma by ROTOR GENE-Q (5 Plex) Real Time PCR method to check their biological activity. Different substituted hydroxy cinnamic acids has been conjugated with different amino acid in N-series and in K-Series same substituted hydroxy cinnamic acids ha...
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MICROWAVE IRRADIATED SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDIES OF 3-((SUBSTITUTED-BENZO[D]THIAZOL-2-YLAMINO)METHYL)-5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOLE-2(3H)-THIONE
A series of new Mannich base derivatives were designed, synthesized by conventional and non-conventional microwave method, compared and evaluated for their antimicrobial and anti-mycobacterial activity. Structures of the newly synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral studies. The bioactive assay showed that Mannich base derivativ...
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PREPARATION AND EVALUATION OF ANTIMICROBIAL HERBAL FORMULATION OF PTEROSPERMUM ACERIFOLIUM WILLD.
The present work deals with formulation of topical gels containing aqueous extract of P. acerifolium seeds and also to evaluate the prepared gels against some Gram-positive and Gram-negative bacteria. The antibacterial activity of various P. acerifolium seed extracts was measured through determining minimum inhibitory concentration (MIC) by cube dilution method and zone of inhibition by disc diffu...
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