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EFFICACY OF GRIFFITHSIA PACIFICA KYLIN ON IN VIVO ANTI DIABETIC AND ALTERATIONS IN ENZYMATIC ACTIVITIES OF STZ INDUCED RATS
In recent years there is more research work taken in Marine sources for its pharmaceutically valuable compounds and active medicines for anticancer, anti diabetic, anti oxidant, antimicrobial, and anti-inflammatory. The present study investigated for the medicinal value of red algae Griffithsia pacifica Kylin (GPK) and its alterations in enzymatic activity of STZ induced diabetic rats. The resul...
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PRELIMINARY PHYTOCHEMICAL SCREENING AND GC MS ANALYSIS OF CHLOROFORM EXTRACT OF KANDELIA CANDEL (L.) DRUCE
The aim of the present study is to screen the phytochemicals present in the leaf extract of Kandelia candel and further analysis of the bioactive components present in it by Gas chromatography - Mass spectrometry (GC-MS) analysis. Carbohydrates, proteins, amino acids, Saponins, flavonoids, terpenoids, glycosides, tannins, alkaloids, and phenols were present in the sample. The percentage yield of p...
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A COMPREHENSIVE PHARMACOGNOSTIC REVIEW: MANILKARA HEXANDRA (ROXB.) DUBARD
The aim of this review paper is to provide throughout the information of Manilkara hexandra (Roxb.) Dubard, used as a Khirni or Rayon in most of the tropical regions of India. It is native to India, mainly distributed as a wild tree in the southern part and North-central part of India. It is widely spread in Gujarat, Rajasthan, Madhya Pradesh, Andhra Pradesh, Kerala and Maharashtra our efforts are...
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SOLUBILITY ENHANCEMENT OF BCS CLASS II DRUGS
One of the major barriers in the development of oral dosage form is poor solubility. Poor water solubility obstructs drug bioavailability and decreases its pharmaceutical development. Many drugs are in the pipeline to enhance solubility to formulate dosage form to be taken by the most preferred route of administration that is the oral route. Etodolac is nonsteroidal anti-inflammatory drug having a...
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DETECTION OF PORIN ANTIGEN IN SERUM FOR EARLY DIAGNOSIS OF TYPHOID INFECTION
Typhoid fever is serious public health problem in many parts of the world.Typhoid fever, also known as enteric fever, is an illness caused by the bacterium, Salmonella typhi. The immunology of typhoid fever in man has been the subject of a recent review. The diagnosis and subsequent treatment could reduce infection complication towards acute illness. It is difficult at present time, to diagnose ...
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MODULATORY ROLE OF WITHENIA SOMNIFERA ROOT EXTRACT MIXED PELLETED FEED ON PESTICIDE INDUCED HEPATIC ANOMALIES’ IN FRESH WATER CATFISH CLARIAS BATRACHUS (LINN.)
The pharmacological activity of Withenia somnifera commonly called Ashwagandha, a herb having multi-medicinal properties, was investigated against carbofuran exposed hepatic anomalies in the air breathing fish Clarias batrachus. Fishes were exposed to 1 mg/L carbofuran for three weeks to induce the toxic effects. These fishes were then fed with Withenia somnifera root extract mixed pelleted fe...
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EVALUATION OF ANTI-DIABETIC POTENTIAL OF CYPERUS PANGOREI ROTTB. ETHYLACETATE SUBFRACTIONS
A study was undertaken to fractionate and characterize the antidiabetic potential of Cyperus pangorei rhizomes. The column chromatography and HPTLC study was performed on ethyl acetate fraction and five sub-fractions were separated and subjected for the evaluation of antidiabetic potential in streptozotocin induced diabetic rats. The experimental data indicated that the ethyl acetate sub-fractio...
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DEVELOPMENT AND EVALUATION OF ELASTIC NOISOMAL FORMULATION FOR MIGRAINE TREATMENT USING TRNA APPROACH
The approach of site specific topical delivery of Rizatriptan Benzoate (RBZ), used for migraine using the elastic carrier at posterior cervical region for sustained action was attempted in the present study. RBZ-entrapped elastic niosomes were prepared using the modified mechanical stirring method. The formulation was optimized using 23 full factorial designs. The type of edge activator (EA), Twee...
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BENEFICIAL EXPLORATION OF NATURAL PESTICIDES FROM HIGHER PLANT
The methanolic extract (MeOH) of the bark of Holoptelea integrifolia (Roxb.) Planch and its partitions namely n-hexane (Hx), ethyl acetate (EtOAC), butanol (BuOH) and water (H2O) was screened for various in vitro biological activities including general cytotoxicity (brine shrimp lethality assay), phytotoxicity (lemna minor bioassay), nematicidal and insecticidal (Tribolium castaneum H., Rhyzoperth...
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IN VITRO SUSCEPTIBILITY OF PLASMODIUM FALCIPARUM TO LUMEFANTRINE AND ANALYSIS OF POLYMOPHYSIMS IN PFMDR-1 GENE ISOLATES FROM ABIDJAN (CÔTE D’IVOIRE)
Context: Malaria endemic disease remains the most common tropical parasitic disease in the world. According to the World Health Organization (WHO), malaria is the first endemic disease of which humanity is paying a heavy price. Malaria is a major public health problem in Côte d'Ivoire. Objective: To evaluate the in vitro chemosensitivity to Lumefantrine (LUM) and analyze Pfmdr-1gene polymorphism ...
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