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EFFECTS OF JUSSIAEA REPENS L ON SPERM DNA INTEGRITY IN MALE ALBINO RATS
Fertility control is an issue of global challenge. Researchers are trying to develop male herbal contraceptives from natural sources. Jussiaea repens L (JR) is such an herb which is reported to have non toxic antigonadal activity in male rats. The present study has designed to evaluate whether crude queous extract of JR affects the DNA integrity of spermatozoa and also to study whether its actions...
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ISOLATION AND CHARACTERIZATION OF NATURAL PRODUCT COMPOUNDS FROM RHIZOMES OF CYPERUS ROTUNDUS LINN.
Background: Cyperus rotundus Linn. is a traditional medicinal plant appearing among Indian, Chinese and Japanese natural drugs, used for the treatment of spasms stomach disorder and also used as anti-inflammatory, antimalarial, hypotensive, antipyretic, anthelmintic, hepatoprotective agent. Rhizomes of C. rotundus have been used in ancient medicine in India for fever, dysentery, pruritis, pain, vo...
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FABRICATION AND COMPARATIVE EVALUATION OF CURCUMIN AND PACLITAXEL- LOADED SOLID LIPID NANOPARTICLE; THE PATHWAY OF EFFECTIVE CANCER THERAPY
The objective of the present study is to develop, evaluate and compare potent phytoconstituents of curcumin loaded solid lipid nanoparticles (CUR-SLN) and Paclitaxel loaded solid lipid nanoparticles (PTX-SLN) for the treatment of malignancy. Curcumin is an active phenolic compound of Curcuma longa as a promising phytoconstituent has been extensively studied over the past several years. The result ...
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FUNCTIONAL GENOMICS OF MYCOBACTERIUM TUBERCULOSIS
Mycobacterium tuberculosis is a deadly infectious disease, there is rising death of humans every year because of this disease, availability of genome sequences of Mycobacterium tuberculosis has provided tremendous amount of information that can be useful in drug target and new vaccine development. Sequence similarity provides accurate annotation for genes in newly sequenced genomes. In this pres...
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PHYTO-FABRICATION OF SILVER NANOPARTICLES BY DIFFERENT PHYSICO-CHEMICAL PARAMETRES USING PETREA VOLUBILIS L. LEAF BROTH AND EVALUATION OF THEIR ANTI-MICROBIAL ACTIVITY
The present study instantiates the phyto-fabrication of silver nanoparticles by utilizing Petrea volubilis L. leaf broth which were instantaneously synthesised, eco-friendly, and cost-effective. The influence of physico-chemical parameters viz. contact time, leaf broth quantity, pH, temperature, and silver nitrate concentration were investigated and optimised to engineer infinitesimal nanopartic...
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STUDIES ON MICROBIALLY TRIGGERED ENTERIC COATED TABLETS FOR COLON TARGETED DELIVERY OF MESALAMINE
Objective: This study aims to develop an enteric coated (coated with Eudragit S-100) matrix tablet of Mesalamine to improve the bioavailability by targeting the drug to the colon for the treatment of ulcerative colitis. Materials and Methods: Matrix tablets were prepared by wet granulation technique by applying 32 full factorial designs for optimization. The independent variables used were the amo...
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DMSO INDUCED PRODUCT RECOVERY OF BACOSIDE A IN CELL SUSPENSION CULTURE OF BACOPA MONNIERI LINN.
Bacopa monnieri Linn. is an important medicinal plant belonging to family scrophulariaceae. Bacopa is a neurotonic, immuno-modulator, tranquilizing, memory and learning enhancing, cerebral activator, anti-ulcer, antispasmodic, anti-asthmatic. It is also used in Epilepsy, anxiety and depression. Major component of Bacopa are saponins Bacoside A and Bacoside B. The cell suspension culture of BacopaÂ...
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ELECTROCHEMICAL BEHAVIOR OF MANIDIPINE AND ITS VOLTAMMETRIC DETERMINATION IN PHARMACEUTICAL FORMULATIONS
The electrochemical behavior of Manidipine is studied by employing cyclic voltammetry (CV) and Differential Pulse Polaro graphy (DPP) in universal buffers of PH ranging from 2.0 to 12.0. The kinetic parameters, such as transfer co-efficient, diffusion co-efficient, and heterogeneous forward rate constant values are evaluated by employing these techniques. Differential Pulse Polarography is emp...
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TO INVESTIGATE THE EFFECT OF GINGER (ZINGIBER OFFICINALE ROSCOE) ON PENDULAR INTESTINE MOTILITY OF RAT
To investigate the effects of ginger-juice (Zingiber Officinale Roscoe) on rat’s intestinependular motility. Methods: Albino rats were sacrificed to isolate intestine. Concentration of ginger is expressed in term of mg/ml of ginger rhizome. It is based on preparation of ginger-juice as detailed in material and methods section. 150 ml of filtrate used in the isolated experiment represented 500 gm...
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NITRIC OXIDE: A NOVEL THERAPEUTIC TARGET
Nitric oxide (NO), the most potent natural vasorelaxant, has close relation to cardiovascular physiology, inspite of its complex chemistry; it is a signal-transducing radical. Aspects of NO biology critical to gastrointestinal health and, consequently, nutritional status are increasingly being recognized. Cross-talk between NO and micronutrients within and outside the gastrointestinal system affec...
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