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PERFORMANCE OF ASSOCIATION RULES FOR DENGUE VIRUS TYPE1 AMINO ACIDS USING AN INTEGRATION OF TRANSACTION REDUCTION AND RANDOM SAMPLING (TRRS) ALGORITHM
Association rule mining is the recent research area in data mining. Frequent Itemset Mining techniques is one of the prominent techniques in pattern mining. In this system frequent itemset mining is used to find the frequent amino acids patterns in Dengue Virus Type1 data set. This system uses an integration of Transaction Reduction and Random Sampling (TRRS) approach to identify the frequent patt...
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FABRICATION, CHARACTERIZATION AND PHARMACOLOGICAL ACTIVITY OF USNIC ACID LOADED NANOPARTICLES
Usnic acid is lichen metabolite. Lichen species are the source of usnic acid. It has Antitumor and Anti-proliferation activity. Usnic acid is poorly water soluble drug. So its dissolution and bioavailability is poor. To enhance dissolution and bioavailability of usnic acid nanotechnology has been adopted. So in this study usnic acid powder was formulated as a nanoparticle with the help of PLGA pol...
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IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF POLYALTHIA LONGIFOLIA (SONN.) THWAITE SEEDS
The present study is designed to evaluate the in vitro antioxidant and in-vivo anti-inflammatory activities of Polyalthia longifolia (Sonn.) Thwaite seeds. Initially, the extracts (Nonpolar to polar) were screened for in-vitro antioxidant activity by DPPH, nitric oxide radical, hydroxyl radical, and superoxide radical considering ascorbic acid as standard. Among the extracts the ethyl acetate and ...
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TOXICOLOGICAL STUDY ON THE EGFR PROTEIN INHIBITOR (IRESSA 1) USING TOPKAT
The epidermal growth factor receptor (EGFR) pathway has emerged as a key target in non-small-cell lung cancer. EGFR inhibition in non-small-cell lung cancer is achieved via small molecular tyrosine kinase inhibitors, such as erlotinib or Iressa (gefitinib), or monoclonal antibodies such as cetuximab. The EGFR is under investigation as a therapeutic target for cancers. Lung cancer cell lines are va...
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PREPARATION AND EVALUATION OF ANTIMICROBIAL HERBAL FORMULATION OF PTEROSPERMUM ACERIFOLIUM WILLD.
The present work deals with formulation of topical gels containing aqueous extract of P. acerifolium seeds and also to evaluate the prepared gels against some Gram-positive and Gram-negative bacteria. The antibacterial activity of various P. acerifolium seed extracts was measured through determining minimum inhibitory concentration (MIC) by cube dilution method and zone of inhibition by disc diffu...
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ENHANCEMENT OF SOLUBILITY OF POORLY SOLUBLE DRUG BY INCLUSION COMPLEXATION WITH γ-CYCLODEXTRIN
Candesartan is an angiotensin receptor blocker, used as an anti-hypertensive drug. It is available in the salt form of cilexetil i.e.; Candesartan cilexetil belongs to class II of the Biopharmaceutical classification system. It is a poorly soluble drug, and the bioavailability is 15%. The intention of the study is to improve the solubility of the poorly soluble drug, Candesartan cilexetil using th...
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PROTECTIVE EFFECT OF COCCINIA INDICA LEAF EXTRACT AGAINST ALCOHOL COMBINED WITH CARBON TETRACHLORIDE AND PARACETAMOL INDUCED LIVER DAMAGE IN RATS
Liver is a major metabolic organ affected by various toxins and chemicals. So the potential therapeutic agent is needed for the treatment of liver diseases. Natural products are the best source of remedies for the treatment of all diseases.The aim of our study was to investigate the effect of leaf extract of Coccinia indica against Alcohol combines with CCl4 and Paracetamol induced hepatotox...
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EMBLICA OFFICINALIS ENHANCES CARDIAC TISSUE REGENERATION IN TADPOLES OF THE FROG RANA CYANOPHLYCTIS (SCHNEIDER)
Emblica officinalis and its derivative (Ascorbic acid) have profound effect on development and regeneration and are widely used in the Indian System of medicine for the treatment of different type of disease. Here, we discussed the comprehensive account of the effect of aqueous extract of the fruit of E.officinalis with special reference to cardiac tissue regeneration in frog tadpoles. E.officinal...
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EFFECT OF COMBINED VITAMIN E SUPPLEMENTATION AND TREADMILL EXERCISE ON SPECIFIC HAEMATOLOGICAL PARAMETERS OF THE SEDENTARY UNIVERSITY STUDENTS
Background: Hemoglobin in the blood carries oxygen from the respiratory organs (lungs or gills) to the rest of the body (i.e. the tissues). There it releases the oxygen to permit aerobic respiration to provide energy to power the functions of the organism in the process called metabolism. Several research studies have pointed out the role of vitamin supplementation and amelioration from exercise i...
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PHYTO-FABRICATION OF SILVER NANOPARTICLES BY DIFFERENT PHYSICO-CHEMICAL PARAMETRES USING PETREA VOLUBILIS L. LEAF BROTH AND EVALUATION OF THEIR ANTI-MICROBIAL ACTIVITY
The present study instantiates the phyto-fabrication of silver nanoparticles by utilizing Petrea volubilis L. leaf broth which were instantaneously synthesised, eco-friendly, and cost-effective. The influence of physico-chemical parameters viz. contact time, leaf broth quantity, pH, temperature, and silver nitrate concentration were investigated and optimised to engineer infinitesimal nanopartic...
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