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FABRICATION, CHARACTERIZATION AND PHARMACOLOGICAL ACTIVITY OF USNIC ACID LOADED NANOPARTICLES
Usnic acid is lichen metabolite. Lichen species are the source of usnic acid. It has Antitumor and Anti-proliferation activity. Usnic acid is poorly water soluble drug. So its dissolution and bioavailability is poor. To enhance dissolution and bioavailability of usnic acid nanotechnology has been adopted. So in this study usnic acid powder was formulated as a nanoparticle with the help of PLGA pol...
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ACNE VULGARIS: AN INSIGHT
Context: Acne vulgaris, a very common malady of adolescents, is well known and easily recognized. Acne is a “polymorphic” disorder which exhibits series of widespread and diverse lesions. Four key factors have been identified in the etiology of acne: increased sebum production, follicular hyperkeratinization, colonization of the pilosebaceous unit with Propioni bacterium acnes and the producti...
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PROTECTIVE ROLE OF MELATONIN AND TAURINE AGAINST TOXICITY INDUCED BY CAFFEINE IN BRAIN BY ABROGATION OF OXIDATIVE STRESS, DECREASE APOPTOSIS, AND ALTERS CEREBRAL MONOAMINE NEUROTRANSMITTERS IN MALE ALBINO RATS
The current study aimed to investigate the protective effects of taurine and melatonin against caffeine-induced brain damage in rats. 36 male albino rats were divided into 6 groups: Group I: control, group II: Rats received 20 mg/kg melatonin for 28 days. Group III: Rats received 50 mg/kg taurine dissolved in distilled water daily for 28 days. Group IV: Rats received 50 mg/kg caffeine dissolved in...
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META-ANALYSIS OF HERBAL CURE FOR PITYRIASIS VERSICOLOR: A CASE REPORT
Background: Pityriasis Versicolor (PV) is a cutaneous fungal infection of the skin revealed by changes in skin pigmentation due to colonization by a dimorphic lipophilic fungus of the skin, known as Malassezia furfur. There is an impact on the psychological status of patients resulting in anxiety or depression. This disease is predominant in warm and hot climates. Currently, no ideal drug of choic...
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SEASONAL COMPARATIVE STUDY OF KANOI PAPER MILL EFFLUENT IN REFERENCE OF PHYSICO-CHEMICAL AND HEAVY METALS
In order to ascertain the degree of various pollutants in Kanoi Paper mill effluent of Bilaspur district (C.G.) India. We have taken minor research project. For attained to this purpose, we have selected eight sampling sites; Four SW and four GW sources. Collected samples (Premonsoon, Monsoon and Postmonsoon 2012) were analyzed for physico-chemical special chloride and phenolic compounds and heavy...
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DEVELOPMENT AND IN-VITRO EVALUATION OF FLOATING MICROSPHERES OF 5-FLUOROURACIL
Objective of the present study was to prepare and evaluate floating Microspheres using different ratio of ethylcellulose to control the release rate of 5-Fluorouracil (5-Fu) which was taken as a model drug. The microspheres were prepared by the modified emulsion solvent diffusion technique using different ratio of ethanol (ETN) and acetone (ACTN) as solvent system. To study the morphology of micro...
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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF 3-(5- SUBSTITUTED PHENYL- 1, 3, 4 – OXADIAZOL- 2 – YL) PYRIDINES
A series of 3- (5- substituted phenyl- 1, 3, 4- Oxadiazol- 2- yl) pyridines was designed, synthesized and characterized for evaluation of potential antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella species and antifungal activity against Candida albicans. Structure-activity relationship led to the conculsion that compound IVb, and IVe exhibited g...
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IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF POLYALTHIA LONGIFOLIA (SONN.) THWAITE SEEDS
The present study is designed to evaluate the in vitro antioxidant and in-vivo anti-inflammatory activities of Polyalthia longifolia (Sonn.) Thwaite seeds. Initially, the extracts (Nonpolar to polar) were screened for in-vitro antioxidant activity by DPPH, nitric oxide radical, hydroxyl radical, and superoxide radical considering ascorbic acid as standard. Among the extracts the ethyl acetate and ...
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IDENTIFICATION OF HEAVY METAL TOXICITY INDUCED BIOMARKERS AND THE PROTECTIVE ROLE OF ASCORBIC ACID SUPPLEMENTATION IN CHANNA PUNCTATUS
Arsenic and mercury are presently the most common pollutants of freshwater bodies. There is a continuous increase in the toxic level of these pollutants with some seasonal changes, affecting the aquatic biota. The present study aimed to identify cellular biomarkers of arsenic and mercury toxicity in freshwater fish Channa punctatus. Antioxidant defense like catalase (CAT), superoxide dismutase (SO...
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REAL PICTURE OF CANCER IN BANGLADESH, A DEVELOPING SOUTH ASIAN COUNTRY: A SURVEY STUDY
Cancer - one of the most pervasive diseases, thus far mostly in affluent countries - is fast raising its ugly head in the developing world. This is a survey work on cancer due to recent increasing of the number of cancer patients in Bangladesh. This study was carried out in Ahsania Mission Cancer Hospital, Dhaka Bangladesh as this is the biggest missionary hospital in this country, From 13 Febru...
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