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ANTIOXIDANT EFFECT OF THE STEM AND LEAVES OF HIBISCUS ESCULENTUS LINN.
The ethanol extract of Hibiscus esculentus Linn roots inhibited the formation of oxygen derived free radicals were screened for their in vitro antioxidant activity. Stems leaves and root of selected plants were dried at 45°C and powdered for extraction. Extraction was performed with methanol. By employing DPPH (2, 2-diphenyl-1picrylhydrazyl radical) scavenging assays, it was shown that all the et...
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AN IN SILICO STUDY ON HIV-1 PROTEASE WILD-TYPE AND MUTANT WITH INHIBITORS FROM ANNONA SQUAMOSA
Human immunodeficiency virus (HIV) is a lent virus that cause acquired immunodeficiency syndrome (AIDS), a state in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV Wild type ...
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DEVELOPMENT AND CHRACTERIZATION OF SELF ASSEMBELED NANOPARTICLES: A REVIEW
Various types of lipid based vesicular systems have been developed in controlled and targeted drug delivery. Self assembled nanoparticles (SAN) has advantages over traditional colloidal vesicular systems and also avoids some of their major disadvantages. SAN made of solid lipids are submicron colloidal carriers (50-1000nm). These consist of a solid hydrophobic core having a monolayer of phospholip...
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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING SPECTRO-PHOTOMETRIC METHOD FOR THE ESTIMATION OF RIZATRIPTAN BENZOATE IN BULK AND PHARMACEUTICAL DOSAGE FORM
A simple, accurate and rugged stability indicating UV Spectrophotometric method was developed using methanol as the solvent to determine Rizatriptan Benzoate content in pharmaceutical dosage forms. The UV Spectrophotometric method for Rizatriptan Benzoate was determined at λmax 278nm and the drug proved linear in the range of 10-80μg/ml, with a good correlation coefficient of 0.9997. Percentage ...
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DESIGN, FORMATION AND EVALUATION OF A CO-DRIED DIRECTLY COMPRESSIBLE EXCIPIENT “TSAG-15” AND ITS UTILIZATION IN THE FORMULATION OF A RAPID RELEASE-MOUTH DISINTEGRATING ASCORBIC ACID TABLETS
A research was conducted to design a directly compressible filler binder characterized with rapid release and mouth disintegrating. Acacia gum was obtained from local source and was purified using a standard method. Tapioca starch was also extracted from cassava tuber using a standard method. Both primary excipients were evaluated for power properties and coprocessed at varying concentration using...
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DEVELOPMENT AND VALIDATION OF A SENSITIVE AND SPECIFIC HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR ASSAY OF A BINARY MIXTURE OF PANTOPRAZOLE AND DOMPERIDONE IN ORAL SOLID DOSAGE FORMULATIONS
A simple new rapid, accurate, robust, and specific HPLC method was developed for the assay of pantoprazole and domperidone from the oral solid dosage pharmaceutical formulations. The reverse-phase chromatographic method was developed on an RP C8 column (250 mm × 4.6 mm, 5 µm) using a mixture of 25 mM sodium dihydrogen phosphate solution of pH 6.8 and methanol in the ratio 40:60 v/v as mobile pha...
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ANTI-LIPID PEROXIDATION ACTIVITY OF ALLMANIA NODIFLORA (L.) R. BR.: A TRADITIONAL LEAFY VEGETABLE
Allmania nodiflora (L.) R. Br. is a diffuse herb, belongs to family Amaranthaceae. Fresh leaves used as a green leafy vegetable, which is rich in vitamins and iron. The present aim of this work is to evaluate the phytochemical composition and antioxidant activity of ethanol and water extracts of A. nodiflora leaves. The results on the phytochemical composition of the water and ethanol extracts of ...
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INVESTIGATION FOR POTENTIAL EFFECT OF NYCTANTHES ARBORTRISTIS IN EXPERIMENTALLY INDUCED ASTHMA
Aim of study: In this study, we investigate the potential effect of Nyctanthes arbortristis leaf extract in experimentally induced asthma in rats. The leaf has shown the prominent effect against the inflammation. Materials and methods: Asthma was induced experimentally in rats using Sephadex and in another model croton oil was applied on ear of rats; this model also mimics the biological event ...
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SYNTHESIS AND BIOLOGICAL ASSESMENT OF QUINAZOLONE BASED AMIDE LINKAGE CONTAINING THIAZOLIDINONE AND THEIR DERIVATIVES
A number of substituted quinazolones are well known for their pharmacological activities like anti-inflammatory, antibacterial and analgesic etc. The present work deals with synthesis of quinazolone based thiazolidinone in order to enhance the biological properties. A Series of (2-(substituted phenyl)-4-oxothiazolidin-3-yl) -4- (4-oxo-2-phenyl quinazolin-3(4H)-yl) benzamide (6a-6h) were synthesi...
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MODELING OF BAKER TRIAZINE DERIVATIVES AS DHFR INHIBITORS USING QUANTUM CHEMICAL DESCRIPTORS
DHFR being involved in many important cell processes, its inhibition has long been an attractive goal for the development of chemotherapeutic agents. In present work, efforts have been made to model the DHFR inhibitory activity of a series of 4,6-diamino-2,2-dimethyl-1,2-dihydro-1,3,5-triazine derivatives to identify the structural requirements for the binding affinity between the receptor and Tri...
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