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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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29.

DETECTION OF ANTI-QUORUM SENSING ACTIVITY OF ROSEMARINUS OFFICINALIS AND VALERIANA OFFICINALIS USING MICROBIAL BIOSENSOR STRAIN

Quorum-sensing is a phenomenon in which bacteria exhibit several density dependent phenotypes. Quorum-sensing is achieved through production of auto - inducer which on acquiring a threshold concentration, activates the genes, bringing into effect the concerned phenotypes. Ayurvedic medicinal plant extracts are being used to treat a plethora of infectious disease and are known to be rich in phytoch...

P. Biswas* and A. Lokur

Department of Microbiology, Ramnarain Ruia College, Matunga, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(12).5205-14

5205-5214

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46.

CARBOHYDRATE METABOLISM AND THE STATE OF THE PRO-ANTIOXIDANT SYSTEM IN THE PANCREAS OF RATS WITH EXPERIMENTALLY INDUCED DIABETES AND THE RELEASE OF VANADIUM CITRATE

We investigated the effect of vanadium citrate in the amounts of 0.125, 0.5, and 2.0 µg/mL of water on the enzymatic activity of carbohydrate metabolism, antioxidant system, and the level of lipid peroxide oxidation products in the pancreas of rats with alloxan-induced diabetes. Diabetes was detected at a glucose level of 15.14 mmol/L by measuring glucose level in the blood collected from the tai...

O. Sushko *, G. Klumets and R. Iskra

Laboratory of Biochemistry Adaptation and Ontogenesis of Animals, Institute of Animal Biology NAAS, V. Stusa Street, Lviv, Ukraine.

DOI: 10.13040/IJPSR.0975-8232.9(12).5382-87

5382-5387

3854

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4.

KANENGISER’S EVALUATION METHOD: AN EFFICIENT METHOD FOR DETERMINING OCULAR IRRITANT POTENTIAL IN COSMETICS

A growing interest in usage of cosmetics has created the need for greater precision in evaluation and has stimulated research into cosmetic medicine. Ocular irritation testing represents an important step in the safety evaluation of cosmetic products.  The objective of this study was to introduce a method of assessing ocular irritancy in human subjects and to illustrate the significance of a new ...

Swapnil S. Khadke* and Swapnil D. Mahajan

Department of Pharmacology, JSPM’s Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(4).742-47

742-747

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26.

IN- VITRO ANTIOXIDANT ACTIVITY OF HYDROETHANOLIC EXTRACT OF STEM BARK OF OUGEINIA OOJEINENSIS (ROXB.) HOCHR (LEGUMINOSAE)

Safer antioxidants suitable for long term use are needed to prevent or stop the progression of free radical mediated disorders. In this study, the antioxidant activity of hydroethanolic extract of stem bark of Ougeinia oojeinensis (Roxb.) (HEBO) was studied using various in vitro assays. The antioxidant activity of the extract was evaluated by using the free radical scavenging activity assay (DPPH...

P. P. Shinde*, Y. M. Joshi and V. J. Kadam

Department of Pharmacology, Bharati Vidyapeeth’s College of Pharmacy, Sector 8, CBD, Belapur, Navi Mumbai - 400614, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3207-09

3207-3209

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6.

AN ANALYSIS OF PHARMACOLOGICAL ACTIVITIES OF PORTULACA OLERACEA

Portulaca oleracea belonging to the family Portulacaceae has a wide occurrence throughout the World. It has numerous nutritional and medicinal benefits to humans because it is a good source of many minerals, vitamins, fatty acids, alkaloids, flavonoids, aspartic acid, coumarins, glutathione, etc. It is used in the traditional system of medicine in many countries like India, Nigeria, Palestine, Chi...

H. Kaur

Department of Botany, Government College for Girls, Patiala, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).5995-04

5995-6004

3853

1629

50.

INCIDENCE AND COMPARATIVE ANALYSIS OF ADVERSE DRUG REACTIONS IN DOTS

To assess the adverse drug reactions (ADRs) induced by antitubercular drugs used in Directly Observed Treatment Short Course (DOTS) from previously reported 8 articles from referred sources. Articles related to adverse drug reactions induced by first line anti- tuberculosis drugs in DOTS therapy published during 2002 to 2012 were searched. The incidence rate of each type of ADR from entire ADRs we...

Amitkumar Anandrao Khade* and Vishal Janu Gothal

Government College of Pharmacy, Karad, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3641-44

3641-3644

3851

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55.

CHEMICAL PROFILING, ADME PREDICTION OF BOERHAVIA DIFFUSA LINN. AND CRATEVA NURVALA BUCH. HAM IN THE MANAGEMENT OF UROLITHIASIS

Background: This study was carried out to investigate qualitative and quantitative phytochemical analysis and free radical scavenging activity of Boerhavia diffusa (root) and Crateva nurvala (bark) along with certain computational ADME (Absorption, Distribution, Metabolism, Excretion) parameters of compounds analyzed from Boerhavia diffusa (root) and Crateva nurvala (bark). Methods: The dried powd...

S. R. Gophane * and C. N. Khobragade

School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).890-16

890-916

3851

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7.

SCREENING OF ANTICANCER AND ANTI-OXIDANT ACTIVITY OF LEAVES OF ANNONA RETICULATA ON EAC INDUCED SOLID TUMOR

Objective: The objective of the study was to evaluate the in-vivo anticancer and antioxidant activity of methanolic extract of leaves of Annona reticulata Linn. on EAC induced solid tumor. Methodology: Tumor cells (1 × 106 cells/mice/I.M.) were injected into the hind limb for solid tumor formation, and the treatment started from day 1 for 14 days. Group 1 served as a Normal control, Group 2 serve...

P. K. M. Nagarathna, K. Yadav *, D. M. M. Lou and G. T. Bhutia

Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4868-80

4868-4880

3851

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1.

POSSIBLE MECHANISMS OF METABOLIC CHANGES OF BIOCHEMICAL METABOLISM IN THE CONDITIONS OF EXPERIMENTAL ALLOXAN-INDUCED DIABETES MELLITUS (DM)

Alloxan diabetes mellitus (DM) simulates acute metabolic stress in a different direction, whose starting point is primary lysis of β-cells in the pancreas. Disorders in the system of the major insulin-induced regulatory mechanism occur, initiating imbalance in the system of a living organism generally. Primary changes occur on the level of metabolic ways of the cells of the pancreas and liver: re...

O. G. Chernyukh *, M. V. Dikal and V. Gerushi

Department of Bioorganic and Biological Chemistry and Clinical Biochemistry, Bukovinian State Medical University, Ukraine.

DOI: 10.13040/IJPSR.0975-8232.10(11).4806-17

4806-4817

3851

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25.

AN IN SILICO STUDY ON HIV-1 PROTEASE WILD-TYPE AND MUTANT WITH INHIBITORS FROM ANNONA SQUAMOSA

Human immunodeficiency virus (HIV) is a lent virus that cause acquired immunodeficiency syndrome (AIDS), a state in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV Wild type ...

Lisina KV* and Shanmughavel Piramanayagam

Department of Bioinformatics, Computational Biology Lab, DBT Bioinformatics Centre, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1811-18

1811-1818

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