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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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46.

CARBOHYDRATE METABOLISM AND THE STATE OF THE PRO-ANTIOXIDANT SYSTEM IN THE PANCREAS OF RATS WITH EXPERIMENTALLY INDUCED DIABETES AND THE RELEASE OF VANADIUM CITRATE

We investigated the effect of vanadium citrate in the amounts of 0.125, 0.5, and 2.0 µg/mL of water on the enzymatic activity of carbohydrate metabolism, antioxidant system, and the level of lipid peroxide oxidation products in the pancreas of rats with alloxan-induced diabetes. Diabetes was detected at a glucose level of 15.14 mmol/L by measuring glucose level in the blood collected from the tai...

O. Sushko *, G. Klumets and R. Iskra

Laboratory of Biochemistry Adaptation and Ontogenesis of Animals, Institute of Animal Biology NAAS, V. Stusa Street, Lviv, Ukraine.

DOI: 10.13040/IJPSR.0975-8232.9(12).5382-87

5382-5387

3858

1459

26.

IN- VITRO ANTIOXIDANT ACTIVITY OF HYDROETHANOLIC EXTRACT OF STEM BARK OF OUGEINIA OOJEINENSIS (ROXB.) HOCHR (LEGUMINOSAE)

Safer antioxidants suitable for long term use are needed to prevent or stop the progression of free radical mediated disorders. In this study, the antioxidant activity of hydroethanolic extract of stem bark of Ougeinia oojeinensis (Roxb.) (HEBO) was studied using various in vitro assays. The antioxidant activity of the extract was evaluated by using the free radical scavenging activity assay (DPPH...

P. P. Shinde*, Y. M. Joshi and V. J. Kadam

Department of Pharmacology, Bharati Vidyapeeth’s College of Pharmacy, Sector 8, CBD, Belapur, Navi Mumbai - 400614, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3207-09

3207-3209

3856

1676

13.

DIETARY HYPERCHOLESTEROLEMIA INDUCES OXIDATIVE STRESS CHALLENGING SPERMATOGENESIS IN RAT MODEL: A LINK TO POSSIBLE INFERTILITY

Background: Hypercholesterolemia is rapidly becoming a worldwide epidemic that affects children and adults. Some attempt had made to generalize a relationship between hypercholesterolemia and infertility, but until now it remains scanty. Thus, the aim of the present study was initiated. Methods: Male Wistar rats were divided into four groups of six each (n=6). The first group was control and secon...

A. Biswas*, U. J. A. D’souza and S. Bhat

Department of Physiology, Faculty of Medicine, Mahsa University, Kuala Lumpur, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.8(12).5065-71

5065-5071

3856

1806

55.

CHEMICAL PROFILING, ADME PREDICTION OF BOERHAVIA DIFFUSA LINN. AND CRATEVA NURVALA BUCH. HAM IN THE MANAGEMENT OF UROLITHIASIS

Background: This study was carried out to investigate qualitative and quantitative phytochemical analysis and free radical scavenging activity of Boerhavia diffusa (root) and Crateva nurvala (bark) along with certain computational ADME (Absorption, Distribution, Metabolism, Excretion) parameters of compounds analyzed from Boerhavia diffusa (root) and Crateva nurvala (bark). Methods: The dried powd...

S. R. Gophane * and C. N. Khobragade

School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).890-16

890-916

3856

1592

4.

KANENGISER’S EVALUATION METHOD: AN EFFICIENT METHOD FOR DETERMINING OCULAR IRRITANT POTENTIAL IN COSMETICS

A growing interest in usage of cosmetics has created the need for greater precision in evaluation and has stimulated research into cosmetic medicine. Ocular irritation testing represents an important step in the safety evaluation of cosmetic products.  The objective of this study was to introduce a method of assessing ocular irritancy in human subjects and to illustrate the significance of a new ...

Swapnil S. Khadke* and Swapnil D. Mahajan

Department of Pharmacology, JSPM’s Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(4).742-47

742-747

3855

1615

1.

POSSIBLE MECHANISMS OF METABOLIC CHANGES OF BIOCHEMICAL METABOLISM IN THE CONDITIONS OF EXPERIMENTAL ALLOXAN-INDUCED DIABETES MELLITUS (DM)

Alloxan diabetes mellitus (DM) simulates acute metabolic stress in a different direction, whose starting point is primary lysis of β-cells in the pancreas. Disorders in the system of the major insulin-induced regulatory mechanism occur, initiating imbalance in the system of a living organism generally. Primary changes occur on the level of metabolic ways of the cells of the pancreas and liver: re...

O. G. Chernyukh *, M. V. Dikal and V. Gerushi

Department of Bioorganic and Biological Chemistry and Clinical Biochemistry, Bukovinian State Medical University, Ukraine.

DOI: 10.13040/IJPSR.0975-8232.10(11).4806-17

4806-4817

3855

1887

6.

AN ANALYSIS OF PHARMACOLOGICAL ACTIVITIES OF PORTULACA OLERACEA

Portulaca oleracea belonging to the family Portulacaceae has a wide occurrence throughout the World. It has numerous nutritional and medicinal benefits to humans because it is a good source of many minerals, vitamins, fatty acids, alkaloids, flavonoids, aspartic acid, coumarins, glutathione, etc. It is used in the traditional system of medicine in many countries like India, Nigeria, Palestine, Chi...

H. Kaur

Department of Botany, Government College for Girls, Patiala, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).5995-04

5995-6004

3854

1630

27.

FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF FAST DISSOLVING POLYMERIC FILMS OF OLANZAPINE FOR THE MANAGEMENT OF PANIC ATTACK OF SCHIZOPHRENIA

Schizophrenia is a severe and disabling disorder which needs immediate administration of a suitable drug. Olanzapine, a BCS class II atypical antipsychotics drug of thienobenzodiazepine class is frequently prescribed to treat schizophrenia. The aim of the present investigation was to formulate mouth dissolving films of Olanzapine to improve its solubility and patient compliance. An inclusion compl...

M. Momin *, S. Lalka, S. Mhatre and S. Mistry

Department of Pharmaceutics, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mithibai Campus, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(4).1765-74

1765-1774

3853

1670

7.

SCREENING OF ANTICANCER AND ANTI-OXIDANT ACTIVITY OF LEAVES OF ANNONA RETICULATA ON EAC INDUCED SOLID TUMOR

Objective: The objective of the study was to evaluate the in-vivo anticancer and antioxidant activity of methanolic extract of leaves of Annona reticulata Linn. on EAC induced solid tumor. Methodology: Tumor cells (1 × 106 cells/mice/I.M.) were injected into the hind limb for solid tumor formation, and the treatment started from day 1 for 14 days. Group 1 served as a Normal control, Group 2 serve...

P. K. M. Nagarathna, K. Yadav *, D. M. M. Lou and G. T. Bhutia

Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4868-80

4868-4880

3853

1709

25.

AN IN SILICO STUDY ON HIV-1 PROTEASE WILD-TYPE AND MUTANT WITH INHIBITORS FROM ANNONA SQUAMOSA

Human immunodeficiency virus (HIV) is a lent virus that cause acquired immunodeficiency syndrome (AIDS), a state in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV Wild type ...

Lisina KV* and Shanmughavel Piramanayagam

Department of Bioinformatics, Computational Biology Lab, DBT Bioinformatics Centre, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1811-18

1811-1818

3852

2214