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DEVELOPMENT AND VALIDATION OF STABILITY – INDICATING RP-HPLC CHROMATOGRAPHIC METHOD BY FORCED DEGRADATION STUDIES FOR AZATHIOPRINE BY RELATED SUBSTANCES
Simple, rapid and reproducible stability-indicating methods were established for quantitative determination of azathioprine using a, phenomenex 250 mm × 4.9 mm C18, 5 µm, inertsil and UV detection at 240 nm. The isocratic elution was used to quantify the analyte and the mobile phase was acetate buffer: acetonitrile: methanol (30: 35: 35) was pumped at 1.0 mL/min. The method was linear between 10...
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ANTI- DIABETIC ACTIVITY OF BRUGUIERA GYMNORHIZA ROOT
The different extracts of the roots of Bruguiera gymnorhiza (Family- Rhizophoraceae) were tested for anti-diabetic activity, by glucose tolerance test in normal rats and alloxan induced diabetic rats. Aqueous ethanol and butanol extracts had shown significant protection and lowered the blood glucose levels to normal in glucose tolerance test. In alloxan induced diabetic rats the maximum reduction ...
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PEROXYNITRITE SCAVENGING AND TOXICITY POTENTIAL OF DIFFERENT FRACTIONS OF THE AERIAL PARTS OF BACOPA MONNIERA LINN.
Bacopa monniera is locally referred as Brahmi Shak, has been reputed to use in the Ayurvedic system of medicine for centuries. In our ongoing study to identify the scavenger of ONOO- from natural sources, the aerial parts of Bacopa monniera Linn. was evaluated to scavenge authentic peroxynitrites (ONOO-) and to inhibit total reactive oxygen species (ROS) generation, in kidney homogenates using 2',...
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EVALUATION OF ANTI-TUSSIVE ACTIVITY OF ROSA CENTIFOLIA
Aim of study is to evaluate the potential anti-tussive activity in a mouse model induced by sulphur dioxide gas of ethanolic extract of “Rosa centifolia”. The ethanol extract of Rosa centifolia (250mg/kg 500 mg/g p.o) showed significant anti-tussive activity, the cough inhibition (35% and 57% respectively) and being comparable to that of 10-20mg/kg of codeine phosphate (41 and 64% respectively...
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COMPARATIVE EVALUATION OF THE EFFECT OF STANNOUS CHLORIDE (SnCl2) AND DIMETHYLTIN DICHLORIDE (DMTC) ON DIAZOTROPHIC GROWTH AND NITROGEN METABOLISM OF NOSTOC MUSCORUM
Stannous chloride (SnCl2), an inorganic salt and Dimethyltin dichloride (DMTC), the organic species were found to influence the survival and nitrogen assimilatory system of Nostoc muscorum. A difference in the survival fractions suggested for differential susceptibility of the strain to the toxic effects of the either tin species. Growth of the Nostoc muscorum cells, measured as a function of grad...
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STUDY OF THE ANTICONVULSANT ACTIVITY OF ETHANOLIC EXTRACT OF RHIZOMES OF ZINGIBER OFFICINALE IN EXPERIMENTAL ANIMALS
Objective: To evaluate the anticonvulsant property of Zingiber officinale as well as its interaction with conventional anticonvulsant drug using Maximal electroshock seizures (MES) model and to evaluate possible mechanism involved in its action. Method: The present study was done after getting ethical clearance. The rhizomes of ginger were authenticated and extraction of dried rhizomes was done by...
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STUDY OF STRUCTURE BASED DESIGN FOR SULFONES AS ENOYL-ACP REDUCTASE INHIBITORS
Mycobacterium leprae, the causative agent of the disease, leprosy develops resistance against most of the drugs, so novel drug targets are required to design new drugs. Present work is aimed at understanding the inhibition of enoyl-acyl carrier protein reductase (Enoyl-ACP reductase), which is one of the receptor proteins used in drug discovery for screening anti-leprosy agents by virtually design...
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A COMPREHENSIVE PHARMACOGNOSTIC REVIEW: MANILKARA HEXANDRA (ROXB.) DUBARD
The aim of this review paper is to provide throughout the information of Manilkara hexandra (Roxb.) Dubard, used as a Khirni or Rayon in most of the tropical regions of India. It is native to India, mainly distributed as a wild tree in the southern part and North-central part of India. It is widely spread in Gujarat, Rajasthan, Madhya Pradesh, Andhra Pradesh, Kerala and Maharashtra our efforts are...
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INCIDENCE AND COMPARATIVE ANALYSIS OF ADVERSE DRUG REACTIONS IN DOTS
To assess the adverse drug reactions (ADRs) induced by antitubercular drugs used in Directly Observed Treatment Short Course (DOTS) from previously reported 8 articles from referred sources. Articles related to adverse drug reactions induced by first line anti- tuberculosis drugs in DOTS therapy published during 2002 to 2012 were searched. The incidence rate of each type of ADR from entire ADRs we...
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NEW APPROACHES OF 4-ARYL-2-HYDRAZINOTHIAZOLE DERIVATIVES SYNTHESIS, MOLECULAR DOCKING, AND BIOLOGICAL EVALUATIONS
In the field of the preparation of chemotherapeutic agents with new mechanism distinct from currently approved drugs is important. However, the clinically effective approved small inhibitor molecule is still lacking. Previous reports indicated that 4-aryl-2-hydrazinothiazole derivatives provided a useful start point to develop HAT inhibitors (histone acetyltransferase). Consequently, preparation a...
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