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REVIEW ON HETEROCYCLIC COMPOUNDS SYNTHESIS AND EVALUATION
Among all the organic compounds, heterocyclic compounds are the most common and varied class. It has been possible to synthesis a considerable number of heterocyclic molecules thus far. Heterocyclic compounds are getting more and more prevalent due to extensive synthetic study and their synthetic utility. In the realm of medical chemistry, these molecules are useful in several ways. Some common us...
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DEVELOPMENT OF QUALITY CONTROL PARAMETERS FOR THE STANDARDIZATION OF AEGLE MARMELOS (ROXB.) SEED
The present investigation was undertaken to determine the requisite pharmacognostic standards for evaluating the plant material. The macroscopic, microscopic, powder study, physicochemical, qualitative phytochemical and florescence analysis of the seed were carried out. The microscopic study showed abundant large parenchymatous cells with aleurone grains, calcium oxalate crystals, lignified tricho...
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EVALUATION OF ANTIDIABETIC ACTIVITY OF PELTOPHORUM PTEROCARPUM ON ALLOXAN AND GLUCOSE INDUCED DIABETIC MICE
The present study was designed to determine the antidiabetic activity of the methanol: ethyl acetate (1:9) extract of flower buds of Peltophorum pterocarpum on alloxen and glucose indueced diabetic mouse model. The extract was given intraperitonially at a dose of 200 mg/kg body weight and the hypoglycemic effects compared with metformin, a standard drug. The extract reduced blood glucose level in ...
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EFFECT OF ETANERCEPT AGAINST MYOCARDIAL ISCHEMIA/REPERFUSION INJURY IN MALE MICE
Objective: This study was undertaken to investigate the potential role of etanercept in amelioration of myocardial I/R injury induced by ligation of coronary artery in a mice model. Materials & methods: Adult male Swiss Albino mice were randomized into 4 equal groups. Group (1) sham group: mice underwent the same anesthetic and surgical procedure as the control group except ligation of LAD cor...
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A RETROSPECTIVE STUDY OF PRESCRIBING PATTERN FOR ACUTE RESPIRATORY INFECTIONS IN CHILDERN IN A TERTIARY CARE TEACHING HOSPITAL
Objective: To study prescribing pattern for acute respiratory infections in children attending outpatient department of Paediatrics, J.L.N. Hospital, Ajmer, Rajasthan. Material and Method: The study was carried out retrospectively by analyzing the copies of prescriptions of patients who had visited the O.P.D. of the paediatrics department of J.L.N. Hospital Ajmer. A total of 350 prescriptions havi...
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CHARACTERIZATION OF ENDOGLIN GENE USING IN SILICO TOOLS
Diabetic retinopathy (DR) is a micro vascular disorder affecting the retina of the eye. Many genes have been identified for its pathogenesis. Endoglin (ENG) is one of the candidate gene involved in DR. Several literature studies helped us understand that the in vitro and in vivo studies of these candidate genes had demonstrated the role of a new gene called endoglin (ENG) capable of inhibiting ang...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF METOPROLOL, TELMISARTAN AND CLINIDIPINE IN TABLET
RP-HPLC method has been developed for separation and quantification of Metoprolol succinate, Telmisartan, and Clinidipine using Phenomenex Luna C18 column (150 mm × 4.6 mm, 5 µm) as a stationary phase with security guard cartridge C18 (4 × 3 mm) and acetonitrile: methanol: phosphate buffer pH 7.5 (45:30:25) as a mobile phase by isocratic elution at the flow rate of 1.0 ml/min. The detection was...
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SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF SOME SUBSTITUTED 2, 3-SUBSTITUTED QUINAZOLINONE ANALOGS
In recent years, there is a tremendous increase of drug resistant pathogens, leading to the design and development of newer antitubercular agents. A series of 2-(substituted-phenyl)-1,3-benzoxazin-4-ones and 3-amino-2-(substituted-phenyl)quinazolin-4(3H)-ones were synthesized by the reaction of substituted benzoyl chloride with anthranilic acid and 2- (substituted phenyl)-1,3-benzoxazin-4-one wi...
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DEVELOPMENT AND VALIDATION OF RP-HPLC AND SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND AMLODIPINE IN PHARMACEUTICAL DOSAGE FORMS
A simple, rapid, precise, accurate, sensitive and time consuming reverse phase high performance liquid chromatography (RP-HPLC) and spectrophotometric method for simultaneous estimation of atorvastatin and amlodipine in pharmaceutical dosage forms have been developed and validated. Drug was resolved on a C18 column (Phenomenex phenyl hexyl column, 250mm* 4.6mm i.d, 5um). Utilizing mobile phase of ...
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FORMULATION AND CHARACTERIZATION OF NUTRACEUTICAL NECTAR BASED ON ORANGE JUICE AND GREEN TEA
Green tea represents a popular beverage worldwide due to its high polyphenol and antioxidant activity. It is commonly brewed along with vitamin C source which plays a positive role in maintaining its antioxidant potential. Orange juice can serve as an excellent medium for supplementation of green tea for the formulation of nutraceutical nectar by enriching drink with vitamin C and overcoming the a...
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