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FABRICATION AND COMPARATIVE EVALUATION OF CURCUMIN AND PACLITAXEL- LOADED SOLID LIPID NANOPARTICLE; THE PATHWAY OF EFFECTIVE CANCER THERAPY
The objective of the present study is to develop, evaluate and compare potent phytoconstituents of curcumin loaded solid lipid nanoparticles (CUR-SLN) and Paclitaxel loaded solid lipid nanoparticles (PTX-SLN) for the treatment of malignancy. Curcumin is an active phenolic compound of Curcuma longa as a promising phytoconstituent has been extensively studied over the past several years. The result ...
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DEVELOPMENT AND EVALUATION OF ORAL COLON TARGETED KETOROLAC TROMETHAMINE CAPSULE
The present endeavour was directed towards fabrication of the novel colon drug delivery system of ketorolac tromethamine capsule. Hard gelatin Capsules were fabricated using combination of both microflora activated natural polysaccharide (guar gum) and pH-dependent polymer (cellulose acetate phthalate). In vitro drug release studies revealed that Ketorolac tromethamine granules bearing hard gelati...
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A CASE CONTROL STUDY OF ANTIOXIDANT AND OXIDANT STATUS IN TUNISIAN RHEUMATOID ARTHRITIS PATIENTS
Rheumatoid arthritis is a chronic inflammatory disease with several triggers such as oxidative stress. The aim of this study was to assess the antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase), the total antioxidant status, lipid peroxidation (malondialdehyde) and homocysteine levels in patients with rheumatoid arthritis. The study pop...
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A RETROSPECTIVE STUDY OF PRESCRIBING PATTERN FOR ACUTE RESPIRATORY INFECTIONS IN CHILDERN IN A TERTIARY CARE TEACHING HOSPITAL
Objective: To study prescribing pattern for acute respiratory infections in children attending outpatient department of Paediatrics, J.L.N. Hospital, Ajmer, Rajasthan. Material and Method: The study was carried out retrospectively by analyzing the copies of prescriptions of patients who had visited the O.P.D. of the paediatrics department of J.L.N. Hospital Ajmer. A total of 350 prescriptions havi...
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FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF FAST DISSOLVING POLYMERIC FILMS OF OLANZAPINE FOR THE MANAGEMENT OF PANIC ATTACK OF SCHIZOPHRENIA
Schizophrenia is a severe and disabling disorder which needs immediate administration of a suitable drug. Olanzapine, a BCS class II atypical antipsychotics drug of thienobenzodiazepine class is frequently prescribed to treat schizophrenia. The aim of the present investigation was to formulate mouth dissolving films of Olanzapine to improve its solubility and patient compliance. An inclusion compl...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF METOPROLOL, TELMISARTAN AND CLINIDIPINE IN TABLET
RP-HPLC method has been developed for separation and quantification of Metoprolol succinate, Telmisartan, and Clinidipine using Phenomenex Luna C18 column (150 mm × 4.6 mm, 5 µm) as a stationary phase with security guard cartridge C18 (4 × 3 mm) and acetonitrile: methanol: phosphate buffer pH 7.5 (45:30:25) as a mobile phase by isocratic elution at the flow rate of 1.0 ml/min. The detection was...
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SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF LAMIVUDINE AND ABACAVIR IN THE MIXTURE
A novel, simple, rapid and sensitive spectrophotometer method has been developed for simultaneous estimation of Lamivudine and Abacavir. The method employs formation and solving of simultaneous equation using 280 nm and 297 nm as two analytical wavelengths. Both the drugs obey Beer’s Law in the concentration ranges employed for this method. Accuracy and reproducibility of the proposed method was...
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EVALUATION OF ANTI-INFLAMMATORY ACTIVITY AND DETERMINATION OF TOTAL FLAVONOIDS AND TANNIN CONTENTS OF LAGENARIA SICERARIA ROOT
The crude ethanolic extract of the root of Lagenaria siceraria (Molina) Standley (Family: Cucurbitaceae), was evaluated for its possible anti-inflammatory activity and determination of total flavonoids and tannin contents growing in Bangladesh. The anti-inflammatory activity was studied using carrageenan and histamine-induced rat paw edema test at different doses (200 and 400 mg/kg body weight) of...
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THE QUALITY ASSESSMENT OF ONCOLOGICAL PAIN MANAGEMENT CLINICAL TRIALS IN THE CONTEXT OF A LIMITED NUMBER OF META-ANALYSIS OF OPIOID FORMULATIONS
Treatment ofcancer painis mainly based on the use of opioidanalgesics.This study includes opioids commonly used in Polish clinical practice, such as: dihydrocodeine, tramadol, buprenorphine, morphine, fentanyl, oxycodone and methadone. The purpose of our research is performing a quality assessment of the available clinical trials concerning opioids efficacy and an evaluation of the cause of the li...
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IN SILICO CHARACTERISATION AND COMPUTATIONAL MODELLING OF NEURO-TOXINS OF INDIAN COBRA
Snake venom is cocktail of various enzymes, toxins. Snake venom components have major role as therapeutics application in current drug industry. Snake venom toxins plays vital role as one of the major component in case of bite and most of the toxins are lethal which are of various types such as cardio-toxins, myotoxins and neurotoxins etc. The Indian Cobra neurotoxins sequences were retrieved form...
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