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ISOLATION AND CHARACTERIZATION OF NATURAL PRODUCT COMPOUNDS FROM RHIZOMES OF CYPERUS ROTUNDUS LINN.
Background: Cyperus rotundus Linn. is a traditional medicinal plant appearing among Indian, Chinese and Japanese natural drugs, used for the treatment of spasms stomach disorder and also used as anti-inflammatory, antimalarial, hypotensive, antipyretic, anthelmintic, hepatoprotective agent. Rhizomes of C. rotundus have been used in ancient medicine in India for fever, dysentery, pruritis, pain, vo...
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BIOAVALIBILITY ENHANCEMENT OF RESVERATROL USING SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM DEVELOPED APPLYING CENTRAL COMPOSITE DESIGN
The objective of current study was to develop self-nanoemulsifying drug delivery systems using long-chain triglycerides of resveratrol to enhance its bioavailability. Solubility studies performed in different lipids, surfactants and cosurfactants. Phase diagrams constructed to select areas of nanoemulsion. SNEDDS formulation optimized using 33 central composite design (CCD) considering lipid (X1),...
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STUDY OF FORCED DEGRADATION BEHAVIOUR OF A NOVEL PROTEASOME-INHIBITING ANTICANCER DRUG BY LC-MS AND DEVELOPMENT OF A VALIDATED STABILITY-INDICATING ASSAY METHOD
In the present study, comprehensive stress testing of Carfilzomib, a newly approved proteasome-inhibiting anticancer drug was carried out according to ICH guideline Q1A (R2). The drug was subjected to acid (0.1N HCl), neutral and alkaline (0.1N NaOH) hydrolytic conditions at 70 ºC, as well as to oxidative decomposition at room temperature. Photolysis was carried out in 0.1N HCl, water and 0.1N Na...
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ASSESSMENT OF ANTIDIABETIC POTENTIAL OF CAESALPINIA DIGYNA ROTTLER ROOT EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS
This study was undertaken to investigate the antidiabetic activity effect of repeated oral administration of the methanolic extract of Caesalpinia digyna (Family: Leguminosae) in normal and streptozotocin induced diabetic rats, respectively. The effect of repeated oral administration of methanolic extract on serum lipid profile in diabetic rats was also examined. The doses, viz. 250 and 500mg/kg b...
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A VALIDATED STABILITY INDICATING RP-UPLC METHOD FOR DETERMINATION OF ERYTHROMYCIN ESTOLATE IN PHARMACEUTICAL FORMULATION
A novel, sensitive and selective stability-representing RP-UPLC method was developed and validated for the quantitative determination of Erythromycin estolate in Erythromycin 250 mg capsules. The chromatographic separation was achieved on BEH C18; 50 × 2.1 mm; 1.7 µm column by using mobile phase containing a mixture of 0.002M di-potassium hydrogen phosphate and acetonitrile 53:47 v/v at a flow r...
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NOVEL PROPENYL FLAVONOIDS GLYCOSIDE AND ANTIOXIDANT ACTIVITY OF EGYPTIAN BAUHINIA RETUSA
Column chromatography of ethyl acetate of Bauhinia retusa afforded a novel flavonoid identified as [ rhamnetin-3-O-α- L-rhamnopyranosyl-3’-O-(prop-1-enyl)], in addition to kaempferol, isorhamnetin-3-α-rhamnoside, qurcitrin, quercetin 3-O-β-D-glucopyranosyl-β-D-glucopyranoside, and quercetin 3,7-di-o- β-D-glucoside have been isolated for the first time. Their structures were established ...
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EFFECTS OF GLYCOSMIS PENTAPHYLLA LEAF POWDER AGAINST CHRONIC ARSENICOSIS IN RATS
The present study was undertaken to evaluate the effects of Glycosmis pentaphylla (GP) leaf powder against sodium arsenite (NaAsO2) induced toxicosis in adult albino rats. Forty eight albino rats having body weight 150-200 gm of either sex were randomly divided (equally) into four groups viz., I0, I1, I2, I3. Sodium arsenite was administered at 4mg/kg body weight daily in drinking water for 90 day...
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A COMPREHENSIVE PHARMACOGNOSTIC REVIEW: MANILKARA HEXANDRA (ROXB.) DUBARD
The aim of this review paper is to provide throughout the information of Manilkara hexandra (Roxb.) Dubard, used as a Khirni or Rayon in most of the tropical regions of India. It is native to India, mainly distributed as a wild tree in the southern part and North-central part of India. It is widely spread in Gujarat, Rajasthan, Madhya Pradesh, Andhra Pradesh, Kerala and Maharashtra our efforts are...
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SYNTHESIS, CHARACTERIZATION, DNA-BINDING, PHOTOCLEAVAGE AND ANTI-MICROBIAL STUDIES OF COMPLEX [Ru(4-ETHYL- PYRIDINE)4(DPPZ)]2+
The new Ru (II) complex [Ru(4-Et-py)4(dppz)]2+ (dppz = dipyrido phenazine) have been synthesized and characterized by different analytical techniques like elemental analysis, LC-MS, 1H NMR , 13C NMR. The interaction of this complex with calf thymus DNA has been explored by U.V. absorption spectroscopy, Fluorescence measurements, and viscosity measurements. Their photocleavage behavior towards ...
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IMPACT OF TEACHING CLINICAL ASPECTS OF CARDIOVASCULAR PHARMACOLOGY AT BEDSIDE
Introduction: Medical students of present era have to prove their efficiency in every step of life. To do so one has to become a competent doctor. This is possible only with the proper knowledge and application of the rational therapeutics in clinical practice. This can happen when the students are motivated and taught medicine in such a way that can produce better learning. The clinical aspect of...
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