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COMPARISON OF ALCOHOLIC AND AQUEOUS EXTRACT OF ROOT OF AERVA JAVANICA FOR ITS NEPHRO-PROTECTIVE EFFECT IN CISPLATIN-INDUCED RENAL TOXICITY
Aerva javanica belonging to family (Amaranthaceae) roots and flowers are reported to possess medicinal properties against rheumatism and kidney problems. The present work is to evaluate the nephroprotective effect of Aerva javanica by cisplatin induced renal toxicity in adult male albino rats of Wistar strain. The effect ofalcoholic extract and aqueous extract were evaluated at 200 mg/kg and 400 m...
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PREVALENCE OF CHRONIC PERIODONTITIS AMONG POST MENOPAUSAL WOMEN- HORMONE REPLACEMENT THERAPY A REMEDY?
Menopause is a stage which every woman has to pass through. Menopausal stage brings physical changes as well as microbial changes in the oral cavity. The latter change is often left unnoticed, or it is neglected. The important feature during menopause is a rapid decline in the level of the hormone estrogen. Due to the gradual to a rapid drop in the level of the hormone, there is a lower absorption...
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IN SILICO PHARMACOLOGICAL AND IN VITRO BIOLOGICAL STUDY OF NOVEL ORGANOTINSORBATE
In this research work, a well established method was used to synthesize of stannane of 2, 4-hexadienoic acid and its characterization was carried using ultraviolet (UV)-visible and 1H NMR (nuclear magnetic resonance). Our research aimed at developing a potent multi-target drug which could act as antibacterial agent and also peroxisome proliferator-activated receptor gamma (PPAR γ) agonists that i...
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EFFECT OF TRANS – ESTERIFICATION OF OIL ON NANOEMULSION GEL FOR TOPICAL DRUG DELIVERY
The research investigated the modification of nano-emulsion by using transesterfied soyabean oil, to enhanced solubility and diffusion of voriconazole. Ternary phase diagrams of soyabean oil, acid / base esters of soyabean oil, Tween 80: PEG 400 (S/CoS) and water were developed. Ester value of soyabean oil increased from 214.04 to 261.5mg KOH/1g for acid ester and 293.58mg KOH/1g for base ester co...
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TRENDS IN ANTIEPILEPTIC DRUGS PRESCRIPTION PATTERN AMONG PATIENTS VISITING A TERTIARY CARE CENTER
The objectives were to observe the drug pattern of epileptic patients with their seizure type, to analyze the type of therapy received by the patients, to observe if epileptic patients are receiving an appropriate dose, to identify the side effects in epileptic patients associated with drug treatment and to observe the cost of conventional and newer antiepileptic drugs (AED’s). This was a cross-...
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ANTICONVULSANT AND SEDATIVE EFFECTS OF LEAF EXTRACT OF SOLANUM PUBESCENS
The herbal preparation of the leaves of Solanum pubescens Pers (Solanaceae) is used in traditional medicine for the treatment of Epilepsy and febrile convulsions. A pilot study has confirmed the potency of the leaf of Solanum pubescens in the control of seizure in mice. The current study was aimed to identify the active phytochemical responsible for the activity. Results indicated that methanolic ...
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EVALUATION OF ANTIDIABETIC ACTIVITY OF PELTOPHORUM PTEROCARPUM ON ALLOXAN AND GLUCOSE INDUCED DIABETIC MICE
The present study was designed to determine the antidiabetic activity of the methanol: ethyl acetate (1:9) extract of flower buds of Peltophorum pterocarpum on alloxen and glucose indueced diabetic mouse model. The extract was given intraperitonially at a dose of 200 mg/kg body weight and the hypoglycemic effects compared with metformin, a standard drug. The extract reduced blood glucose level in ...
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SEMI-BATCH AND CONTINUOUS CARBOCHLORINATION OF ZIRCONIA IN A PILOT PLANT FLUIDIZED BED REACTOR: OPTIMIZATION OF OPERATING CONDITIONS VIA RESPONSE SURFACE METHODOLOGY
Zirconium tetrachloride was produced in a pilot plant fluidized bed reactor via the carbochlorination reaction of zirconia. Minitab software 17 was used for the design of experiment with response surface methodology (RSM) for both semi batch and continuous processes. The operating temperature (800-1200 °C), reaction time (30-90 min) and mean particle size (MPS) (70-130µm) were chosen as the rang...
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KANENGISER’S EVALUATION METHOD: AN EFFICIENT METHOD FOR DETERMINING OCULAR IRRITANT POTENTIAL IN COSMETICS
A growing interest in usage of cosmetics has created the need for greater precision in evaluation and has stimulated research into cosmetic medicine. Ocular irritation testing represents an important step in the safety evaluation of cosmetic products. The objective of this study was to introduce a method of assessing ocular irritancy in human subjects and to illustrate the significance of a new ...
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EFFECT OF NATURAL AND ARTIFICIAL SUPERDISINTEGRANTS IN THE FORMULATION OF FAST DISSOLVING DICLOFENAC TABLET
FDTs are designed to disintegrate rapidly on contact with saliva and enables oral administration without water or chewing, these formulations offer increased convenience and ease of administration with the potential to improve patient compliance, particularly in certain populations, where swallowing of conventional solid oral dosage forms presents difficulties. In the present study, the effect of ...
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