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INCIDENCE AND PATTERN OF ADVERSE DRUG REACTIONS (ADRs) IN PATIENTS TREATED FOR TUBERCULOSIS UNDER DOTS AT A TERTIARY CARE HOSPITAL OF NORTHERN INDIA
Background: WHO statistics for 2015 give an estimated incidence figure of 2.2 million cases of TB for India out of a global incidence of 9 million thus making India accountable for almost one-third of the global TB burden. The first-line antitubercular drugs include H (Isoniazid), R (Rifampicin), Z (Pyrazinamide), E (Ethambutol) and S (Streptomycin). The treatment of tuberculosis being of longer d...
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USHIRASAVA-PHYSICOCHEMICAL STANDARDIZATION AND QUANTITATIVE ESTIMATION OF SOME BIOACTIVES
Ushirasava is a commonly used ayurvedic formulation reported to be effective in Raktapitta (Bleeding disorders), Pandu (Anaemia), Kustha (Skin diseases), Prameha (Urinary disorders), Arsa (piles), Krmi (Worm infestation) and Sotha (Inflammatory diseases). It is a polyherbal hydroalcoholic product comprising of more than twenty-five ingredients. An exhaustive literature survey revealed that standar...
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IN VITRO AND IN VIVO ANTIHEPATOTOXIC ACTIVITY OF OROXYLUM INDICUM AGAINST CARBON-TETRACHLORIDE INDUCED HEPATIC DAMAGE
Evaluation of the anti-hepatotoxic activity of methanol-dichloromethane (MDM) extract of Oroxylum indicum (OI) whole plant on carbon tetrachloride (CCl4)- induced hepatotoxicity in rat liver explant cultures (in-vitro) and chronic liver damage in rats (in-vivo). In toxicant (CCl4) treated explants culture set (in-vitro), the marker enzymes GOT, GPT and ALP level increased significantly (p<0.001...
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DEVELOPMENT OF A NEW ADDITIONAL METHOD TO DISTINGUISH THE INVALID DRUGS AND DETECT DRUG VALIDITY
The threats and risks of the invalid drugs as expired, counterfeit (cheated drugs), Substandard, spurious, falsely labeled, falsified) .The risks and threats of the invalid drugs are many and wide vary, and the countries are trying to prevent these threats by some efforts as the regulatory institution's efforts and the recorded expire date on the drug container, but that are not enough to prevent ...
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CARBOHYDRATE METABOLISM AND THE STATE OF THE PRO-ANTIOXIDANT SYSTEM IN THE PANCREAS OF RATS WITH EXPERIMENTALLY INDUCED DIABETES AND THE RELEASE OF VANADIUM CITRATE
We investigated the effect of vanadium citrate in the amounts of 0.125, 0.5, and 2.0 µg/mL of water on the enzymatic activity of carbohydrate metabolism, antioxidant system, and the level of lipid peroxide oxidation products in the pancreas of rats with alloxan-induced diabetes. Diabetes was detected at a glucose level of 15.14 mmol/L by measuring glucose level in the blood collected from the tai...
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PHARMACOGNOSTICAL STANDARDIZATION OF PLANT CRYPTOLEPIS BUCHANANI ROEM. & SCHULT. AERIAL PART
Cryptolepis buchanani Roem. & Schult. (Family: Asclepiadaceae) commonly-known as Wax leaved climber, Kali Sariva in English and Sanskrit. It is broadly used in Ayurveda as a remedy of ailment. Though, its diverse medicinal aspects, no detail pharmacognostical study is available till date. The present study is to investigate the pharmacognostical characteristics of C. buchanani aerial part. The...
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IN SILICO PHARMACOLOGICAL AND IN VITRO BIOLOGICAL STUDY OF NOVEL ORGANOTINSORBATE
In this research work, a well established method was used to synthesize of stannane of 2, 4-hexadienoic acid and its characterization was carried using ultraviolet (UV)-visible and 1H NMR (nuclear magnetic resonance). Our research aimed at developing a potent multi-target drug which could act as antibacterial agent and also peroxisome proliferator-activated receptor gamma (PPAR γ) agonists that i...
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CHITOSAN-BASED INTRATUMORAL INJECTABLE NANOPARTICLES FOR GENE DELIVERY TO PANCREATIC CANCER CELLS
One of the obstacles to effective intratumoral gene delivery lies in low transfection efficiency of non-viral vectors. Thus, in this study we evaluate the application of Diethyl methyl chitosan (DEMC) in intratumoral gene delivery of pancreatic cancer. DEMC/ pEGFP nanoparticles are prepared by polyelectrolyte complexation. After nanoparticle characterization via atomic force microscopy (AFM), in i...
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EFFECTIVENESS OF DIPEPTIDYL PEPTIDASE – 4 INHIBITORS IN STREPTOZOTOCIN INDUCED NEURODEGENERATIVE MICE
Introduction: Neurodegenerative diseases are incurable and debilitating condition that results in progressive degeneration and / or death of nerve cells. Anti-oxidants, Antihyper-glycemics and insulin sensitizing agents are reported for reducing cognitive dysfunction in diabetes. Decreasing GLP-1 degradation using Dipeptidyl Peptidase-4 (DPP-4) inhibitors has been shown to be effective for treatin...
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HIGH FRUCTOSE INDUCED ADIPOGENESIS AND INHIBITORY POTENTIAL OF TRIGONELLINE ON MURINE MESENCHYMAL STEM CELLS: A MORPHOLOGICAL STUDY
Regular intake of carbohydrate diet containing high fructose or sucrose increases adipogenesis resulting in conditions like weight gain, high blood pressure, elevated blood glucose levels, insulin resistance, raised triglycerides, low HDL cholesterol, with metabolic syndrome as a leading consequence. Since intricacies of adipogenesis are of major relevance to human health; present study aimed to e...
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