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GLOBAL PERSPECTIVES ON MEDICAL DEVICE REGULATIONS: A COMPARATIVE STUDY OF US, CANADA, EUROPE, INDIA, AND JAPAN
This review paper compares medical device regulations across the United States (US), Canada, Europe, India, and Japan. It offers an understanding of the many regulatory frameworks that control the approval processes for medical devices, the Competent Authorities, the rules and regulations, the licensing or registration processes, the classification systems for devices, and the quality management/G...
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DEVELOPMENT OF ECONOMIC TRANSDERMAL PATCHES CONTAINING LORNOXICAM FOR TREATMENT OF ACUTE AND CHRONIC INFLAMMATORY MODELS IN ALBINO RATS (A PRECLINICAL STUDY)
Objective: To formulate economic transdermal patch of lornoxicam (LX) and to study its anti-inflammatory activity on acute and chronic inflammatory in rat models. Method: Three LX transdermal patches (F1, F2, and F3) consist of Eudragit RL-100, and RS-100 in three different ratios (1:2, 1:1 and 2:1) were prepared respectively by the solvent evaporation technique. All formulations contain diethyl p...
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NON-INFERIORITY OF NEBULIZED COLISTIN COMPARED WITH CONVENTIONAL SYSTEMIC ANTIBIOTICS FOR THE TREATMENT OF VENTILATOR-ASSOCIATED PNEUMONIA
Background: In the present study, our objective was to determine whether nebulized colistin as an adjunctive therapy to conventional intravenous antibiotics of Ventilator-associated pneumonia (VAP) caused by multi-drug resistant (MDR) was safe and beneficial in critically ill patients. Methods: A prospective matched case-control study was performed at the ICUs of the University Hospital of Isfahan...
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STUDY OF THE EFFECT OF MELATONIN ON RETENTION OF CONDITIONED AVOIDANCE RESPONSE AND ON ENHANCEMENT OF SEROTONIN MEDIATED BEHAVIOURAL RESPONSES AFTER ELECTROCONVULSIVE SHOCK (ECS) ADMINISTRATION IN RATS
Objectives: To obtain the data regarding the effects of melatonin on retention of conditioned avoidance response (CAR) and on enhancement of serotonin mediated behavioural responses after electroconvulsive shock (ECS) administration in rats. Methods: Forty rats after training for conditioned avoidance response by using Cook’s pole climbing apparatus were divided in four groups with ten rats in e...
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ROSMARINIC ACID ENHANCES CISPLATIN CYTOTOXICITY IN HEPG2 CELL LINE AND ATTENUATES ITS NEPHROTOXICITY IN MICE
The present study aimed to investigate the anticancer effect of rosmarinic acid (RA), both alone and in combination with cisplatin (cis). Also, the potential nephroprotective effects of RA against cis-induced nephrotoxicity in mice and the possible mechanisms underlying this protection were explored. Treatment of HepG2 cells with RA produced a significant decline in cellular proliferation. RA indu...
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A STUDY OF ETHNOMEDICINAL PLANT DIVERSITY OF SACRED NATURAL SITES OF PANCHKOSHI PILGRIMAGE OF VARANASI, UTTAR PRADESH INDIA
Introduction: Medicinal plants have always played a major role in primary health care system since time immemorial. Sacred natural sites is the prime place to encompass large medicinal plant with wide range of natural resources. It potentially conserves plant biodiversity with inclusion of sacred places and sacred water bodies. Apart from social and religious importance it, regulate air and water ...
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PATIENT- REPORTED ADVERSE EFFECTS TO ANTI RETROVIRAL DRUGS IN A SPECIALIST HOSPITAL, NORTH WEST NIGERIA
Patients experiencing adverse effects are less likely than those not experiencing it to adhere to treatment. However little is known about the adverse drug reactions to many HIV programme in developing countries, indicating the need for Antiretroviral (ART) safety surveillance. The study is a retrospective analysis of records of adverse reactions by patients initiated on ART. A total of 1870 patie...
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GENE THERAPY, RECENT DEVELOPMENT AND FUTURE PROSPECTS IN GASTROINTESTINAL ONCOLOGY: A REVIEW ARTICLE
The introduction of nucleic acids into cells has as a purpose of medical condition or disease. Currently, gene therapy studies a broad range of potential therapeutic interventions, including the body's immune reaction to tumours, new blood vessels in the heart to alleviate heart attacks and to stop HIV-replication in patients with AIDS1 .There is also renewed emphasis on the gene therapy of geneti...
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SYNTHESIS AND SPECTROSCOPIC STUDIES OF COBALT (II) COMPLEXES WITH NITROGEN- OXYGEN AND NITROGEN SULPHUR DONOR LIGANDS
CoII complexes of ligands pyridine3carboxamide thiosemicarbazone (L1), pyridine 3 carboxamide semicarbazone (L2), pyridine2carboxamide thiosemicarbazone (L3) and pyridine 2 carboxamide semicarbazone (L4) have been synthesized. The ligands were characterized based on elemental analyses, IR, 1HNMR studies while the complexes were characterized by elemental analyses, molar conductance, magnetic momen...
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IMMUNOMODULATORY ACTIVITY OF LEAVES OF RUMEX VESICARIUS LINN. AND SYMPLOCOS RACEMOSA ROXB.
Objective: To determine the immunomodulatory activity of leaves of Rumex vesicarius Linn. and Symplocos racemosa Roxb. Methods: The ethyl acetate and ethanolic extract of Rumex Vesicarius Linn. and ethanolic and N-hexane extract of Symplocos racemosa Roxb. were administered orally at the dosage level of 200 mg/kg/day and 400 mg/kg/day each according to the body weight of Rat. The assessments of im...
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