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REVIEW ON HETEROCYCLIC COMPOUNDS SYNTHESIS AND EVALUATION
Among all the organic compounds, heterocyclic compounds are the most common and varied class. It has been possible to synthesis a considerable number of heterocyclic molecules thus far. Heterocyclic compounds are getting more and more prevalent due to extensive synthetic study and their synthetic utility. In the realm of medical chemistry, these molecules are useful in several ways. Some common us...
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SYNTHESIS OF N-(ALKYL OR ARYL)-2-(1H-BENZOTRIAZOL-1-YL)-ACETAMIDES AS SELECTIVE COX-2 INHIBITOR
Microwave assisted organic synthesis (MAOS) has emerged as frontier in pharmaceutical research for synthesis of newer drugs and implementing GREEN chemistry. Arylacetamides are pharmaceutically interesting as they show various biological activities such as analgesic, local anesthetic, antiarthritic, antiarrhythmic activities, etc. In arylacetamides the nature of aromatic ring and its substituent i...
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COMPUTATIONAL UNDERSTANDING OF SELECTIVE MMP INHIBITORS IN COPD
Chronic Obstructive Pulmonary Diseases (COPD) refers to multiple lung diseases, is the occurrence of chronic bronchitis and emphysema, a pair of commonly co-existing diseases of the lungs in which the airways become narrowed because of inflammatory cells like neutrophils, CD8 cells and macrophages. These cells produce the Matrix metalloproteinases (MMPs), cathapsins and other proteinase enzymes. I...
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FORMULATION DEVELOPMENT AND EVALUATION OF MUCOADHESIVE FILMS OF ZOLMITRIPTAN
Formulation development for new drugs, an extension of formulations, finding an alternative to conventional dosage forms for better therapeutic response are some of the research impetus in Pharmaceutical F and D. The new -untried routes of administration are also an avenue that can be explored. Under this research zolmitriptan, an antimigraine, BCS class II drug is formulated into mucoadhesive fil...
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MICROWAVE ASSISTED SYNTHESIS & QSAR STUDY OF SOME NOVEL PYRAZOLYL THIAZINE DERIVATIVES
This work involves synthesis of pyrazolyl thiazine derivatives from different chalcones [1(a-b)] synthesized from substituted acetophenones and different aromatic aldehydes in basic medium by Claisen-Schmidt reaction. These chalcones [1(a-b)] on condensation with different hydrazides [2(a-b)] and isothiocyanates [3(a-b)] when irradiated with microwaves (20%, 140watts) in scientific microwave o...
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SYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLES BY JUSTICIA GENDARUSSA BURM F. LEAF EXTRACT
The unusual physio and chemical properties of gold nanoparticles are found to have more advantage in the field of medicine, diagnostics and biosensors. In the present document, it is reported that Justicia gendarussa leaf extract mediated synthesis of gold nanoparticles by the reduction of gold ions. Three different phytochemical fractions were prepared from methanolic leaf extract by liquid-l...
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SIMULTANEOUS ESTIMATION OF PARACETAMOL AND TAPENTADOL IN COMBINED DOSAGE FORM BY DERIVATIVE METHOD
Two simple, rapid, precise and accurate spectrophotometric methods have been developed for simultaneous analysis of Paracetamol (PCM) and Tapentadol (TAP) in their combined dosage form. Method A, First order derivative method involves measurement of absorbance at 257.060 nm (for TAP) and 289.406 nm (for PCM) in first order derivative spectra. Method B, Second order derivative method involves measu...
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HYPERDENSE INTRACRANIAL VESSELS IN NON-CONTRAST COMPUTED TOMOGRAPHY SCAN OF BRAIN-A CASE REPORT
A 20-year-old male patient reported to ophthalmology outpatient department with complaint of loss of vision in right eye since childhood and diminished vision in left eye for 1month of duration. Funduscopy revealed right side optic atrophy and left sided vitreous hemorrhage. Non-contrast computed tomography study of head showed hyperdense circle of Willis and cerebral venous sinuses. No contrast w...
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EVALUATION OF A DESIGNED COMMUNITY-BASED POST -DISCHARGE WARFARIN MANAGEMENT PROTOCOL ON IRAQI PATIENTS
Introduction: The warfarin management programs include mainly routine INR measurement, dosing protocols, clinical management protocols for excessive anticoagulation, and patient education. There have been numerous investigations to explore the most appropriate model for outpatients, accordingly different Anticoagulation Management Programs have been emerged in practice. Aims and objectives: This s...
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NOVEL PARAMETERS TO DEFINE BIO-EFFICACY OF SHILAJIT RESIN AND ITS VALIDATION
Shilajit, a herbo-mineral blackish brown resin, extracted from humic rocks, is attributed to several therapeutic claims in Ayurveda like antiaging, health-promoter, immune- booster, urogenital problems and bio-enhancer. The lack of strong parameters for its quality control and standardization; and the knowledge gap to explain its mechanism of action are the important factors behind its restricted ...
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