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ANTIHYPERGLYCEMIC, ANTIOXIDANT AND ANTIDYSLIPIDEMIC PROPERTIES OF HEMIDESMUS INDICUS ROOT EXTRACT STUDIED IN ALLOXAN-INDUCED EXPERIMENTAL DIABETES IN RATS
Diabetes mellitus is a chronic metabolic disorder associated with hyperglycemia, oxidative stress and dyslipidemia. Hemidesmus indicus is employed as an indigenous medicine for a variety of ailments from earlier days. The present study was aimed to evaluate the role of Hemidesmus indicus in alloxan-induced experimental diabetic rats. The effect of oral administration of Hemidesmus indicus root ext...
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NOVEL AMORPHOUS SOLID DISPERSIONS OF CANAGLIFLOZIN HEMIHYDRATE IN EUDRAGIT® E PO
The purpose of this research was to develop novel solid dispersions (SDs) of BCS class IV drug, canagliflozin hemihydrate (CFZ) using Eudragit® E PO (EE PO) as a carrier, to enhance its solubility and dissolution rate. Solvent evaporation technique was used to prepare SDs. The SDs were evaluated for saturated solubility, in-vitro dissolution study, solid-state characterization using FTIR, DSC, XR...
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SERUM ELECTROLYTES CHANGES WITH ATHEROGENIC INDEX OF PLASMA IN HYPOTHYROID DIABETIC (TYPE-2) YOUNG MALES
Background: Atherogenic index of plasma, a newly emerging lipid parameter, has been employed only in a few studies of diabetics and not at all in hypothyroid type -2 diabetic young males with electrolytes imbalance. Methods: Association between diabetic hypothyroid and electrolytes with atherogenic index of plasma in 50 subjects and aged (25-45 years) matched healthy controlled were studied ret...
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SYNTHESIS AND CYTOPROTECTIVE EFFICACY EVALUATION OF NEW DRDE-07 ANALOGUES AGAINST SULPHUR MUSTARD TOXICITY
Sulfur mustard is well known as toxic Chemical warfare agent and on contact with skin it produces blisters as well as systemic toxicity. In this study we have evaluated the efficacy of few analogues of S-2(2-amino-ethylamino) ethyl phenyls sulphide (DRDE-07) and a known radioprotector amifostine against SM induced toxicity in mouse. We have selected seven newly synthesized analogues of DRDE-07 for...
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GROUNDWATER ARSENIC (As) CONTAMINATION AND SIMPLE LOW COST ARSENIC REMOVAL PROCESSES IN TRIPURA
Arsenic (As) is a metalloid. It occurs in almost every fraction of the environment. It is moving in each and every corner of our environment. Levels of arsenic (As) in the environment have become a global concern due to its toxicity and adverse effects on human health and other living beings. It is highly toxic even at low concentrations. It is also carcinogenic. Although, its natural sources are...
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DEVELOPMENT OF FELODIPINE LOADED SMEDDS FOR IMPROVING ORAL BIOAVAILABILITY
Felodipine is a poorly water soluble drug having 15% oral bioavailability. In the present study Self micro emulsifying drug delivery system of felodipine was developed to improve its solubility and bioavailability. SMEDDS were prepared by phase titration method and ternary phase diagram was constructed using Chemix software. Based on solubility of drug in the excipients, capmul MCM, oleic acid, Tw...
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A STUDY ON FEASIBILITY OF OPTIMIZATION TECHNIQUE IN FORMULATION OF DISPERSIBLE TABLETS BY FACTORIAL DESIGN
In the present research work an attempt was made to study the effect of formulation variables in the development of dispersible tablet by using various super disintegrants. Instead of normal trial and error method an optimization technique was adapted. Amount of Crosscarmellose sodium, SSG and MCC were included as independent variables and hardness, percentage friability, disintegration time and w...
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EVALUATION OF WOUND HEALING ACTIVITY OF ZIZIPHUS XYLOPYRUS (RETZ) WILLD LEAVES EXTRACT IN WISTAR ALBINO RATS
Aim: The present study provides a scientific evaluation for the wound healing activity of methanolic extract of Ziziphus xylopyrus (Retz) Willd leaves (MEZX). Methods: Incision and excision wound models were used to evaluate the wound healing activity of MEZX on Wistar rats. In each model, animals were divided into four groups of 6 animals each. In both model, Group I was assigned as control (oint...
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EVALUATION OF ANTI-INFLAMMATORY ACTIVITY AND DETERMINATION OF TOTAL FLAVONOIDS AND TANNIN CONTENTS OF LAGENARIA SICERARIA ROOT
The crude ethanolic extract of the root of Lagenaria siceraria (Molina) Standley (Family: Cucurbitaceae), was evaluated for its possible anti-inflammatory activity and determination of total flavonoids and tannin contents growing in Bangladesh. The anti-inflammatory activity was studied using carrageenan and histamine-induced rat paw edema test at different doses (200 and 400 mg/kg body weight) of...
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CARDIOPROTECTIVE EFFECT OF CASSIA AURICULATA LINN., PETAL EXTRACT ON ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN MALE ALBINO RATS
Protective effect of Cassia auriculata Linn., floral extract was examined against Isoproterenol induced Myocardial infarction in male albino rats. The oral administration of aqueous extract of Cassia auriculata, afforded protection against Isoproterenol induced alterations in Cholesterol, LDL, HDL, TG, Protein, AST, ALT, LDH, Catalase and GPx. The protective effect was further supported by t...
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