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ANALGESIC, ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITY OF TRICHOSANTHES DIOICA ROXB. LEAF EXTRACTS
Aim of the study: This study evaluates the analgesic, anti-inflammatory and antipyretic activities of the aqueous, methanol and n-hexane extracts of Trichosanthes dioica Roxb. to provide experimental evidence for its traditional use such as fever, pain and inflammation. Materials and methods: Investigations on the analgesic effects of Trichosanthes dioica Roxb. was carried out by acetic acid-induc...
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NON-TARGETED ANALYSIS AND CYTOTOXIC ACTIVITY OF HAMELIA PATENS JACQ.
In the present study we have done non-targeted analysis of extract from Hamelia patens Jacq. by GC/MS and estimated the inhibitory concentration (IC50) of the extract in three human tumor cell lines MCF-7, H-460 and SF-268. Hamelia patens is an herbaceous perennial plant of family Rubiaceae. Parts of the plant are used in Peruvian and Mexican folk-medicine. Dried leaves of Hamelia patens were extr...
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ASSESSMENT OF OXIDATIVE STRESS, ANTIOXIDANT ENZYMES AND LIPID PROFILE IN THE SUBJECTS OF CORONARY ARTERY DISEASE (CAD)
Coronary artery disease (CAD) is the major cause of mortality and morbidity worldwide. The incident of CAD is rising and they are predicted to be the biggest causes of death by 2020 in India. Therefore, the aim of the present study was to assess the association of oxidative stress, antioxidant enzyme and lipid status parameters in CAD patients and to compare the results age- sex matched healthy co...
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STUDIES ON LINEARTY AND ASSAY USING RP-HPLC AND UV-VISIBLE SPECTROSCOPY FOR THE DRUGS OXCARBAZEPINE AND PIOGLITAZONE BEFORE AND AFTER EXPIRY PERIOD
The standard for stability and quality of drugs for approval of marketing, are assured by testing and systematic evaluation using different analytical techniques. The drugs are tested in pharma analytical lab involving analysts associated spectra, chromatogram etc , and the results are analyzed leading to fixation of expiry dates. Once the drug crosses its expiry period, its potency is lost and it...
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STATUS OF DIABETIC HYPERTENSION IN KANPUR CITY AND ROLE OF PHARMACIST AS A HEALTHCARE PROFESSIONAL IN TREATMENT AND CONTROL OF DIABETIC HYPERTENSION
Pharmacists in all practice settings are in a key position to start providing care to people, who have diabetes or are at risk of developing it, or to expand and improve their care. Pharmacy programs for patients with diabetes involve activities ranging from identifying and referring at-risk patients, to supporting American Diabetes Association recognized multi-disciplinary diabetes care programs....
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PHARMACOGNOSTIC AND PHYTOCHEMICAL INVESTIGATION OF POTENTIALLY IMPORTANT PLANTS OF WESTERN GHATS, INDIA
Objective: The Indian traditional system of medicine, namely Ayurveda and Siddha, are primarily based on the use of the whole plant or different parts of plant singly or in combination to make multifactorial formulations. The use of plant drugs, however, demands correct identification of species and the characterization of phytoconstituents. Materials and Methods: The plants reported for their wou...
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STUDIES ON FORMULATION AND EVALUATION OF BILAYERED TABLETS OF CURCUMIN
Bilayer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of the successful drug delivery system. Bilayer tablets can be a primary option to avoid chemical incompatibilities between API by physical separation and to enable the development of different drug release profiles. The bi-layered tablet is a very different asp...
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PHYTOCHEMICAL ANALYSIS OF LEAF EXTRACTS OF WATTAKAKA VOLUBILIS LINN. (STAPF) BY GC-MS METHOD
The aim of the study was to investigate the phytochemical compounds of Wattakaka volubilis ethanolic leaf extracts. The phytochemical compounds were screened by GC-MS method. The ethanolic leaf extracts presented 32 bioactive compounds. The identification of phytochemical compounds is based on the peak area, molecular weight and molecular formula. Diethyl phthalate C12H14O4 has peak area 37.31, 2-...
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VALIDATED HPTLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF EMTRICITABINE AND TENOFOVIR IN DRUG FORMULATION
A simple, precise, specific and accurate high-performance thin-layer chromatographic method has been developed for the simultaneous determination of Emtricitabine (EMB) and Tenofovir (TEN) in pharmaceutical dosage form. The separation was carried out on Merck HPTLC aluminum plates of silica gel 60 F254, (20×10 cm) with 250 μm thickness using toluene: ethylacetate: methanol in the ratio (2:8:1 v/...
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MULTI DIMENSION PROTEIN IMPACT MATRIX BASED PROTEIN SEQUENCE PREDICTION USING DATA MINING
Proteins are the most essential and versatile macromolecules of life, and the knowledge of their functions is a crucial link in the development of new drugs, better crops, and even the development of synthetic biochemicals such as biofuels. Experimental procedures for protein function prediction are inherently low throughput and are thus unable to annotate a non-trivial fraction of proteins that a...
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