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OPTIMIZATION OF INFLUENZA A AND B VIRUSES CULTIVATION CONDITIONS FOR PREPARATION OF TRIVALENT SEASONAL INFLUENZA SPLIT VACCINE
This article presents the results of studies on determination of optimal parameters of recombinant strains A/NYMC X-217 (H3N2) and B/NYMC BX-49 of influenza virus cultivation in chicken embryos. It is found that a maximum virus accumulation is formed under the following cultivation conditions: age of chicken embryos is 9-11 days in case of inoculation of the allantoic cavity, inoculated virus dose...
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GABA-AT INHIBITORY ACTIVITY OF BENZOTHIAZOLE – GABA ANALOGS: IN-SILICO APPROACH FOR ANTIEPILEPTIC PROFILE
Estimation of binding affinity of receptor – ligand complex in docking study of small molecules plays an Important role in structure based drug development process. The γ-amino-butyric acid amino-transferase (GABA-AT) exhibits a catalytic role in regulating γ-amino -butyric acid (GABA) level in brain and responsible for many physiological and pathological changes. Here, in – silico study o...
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STUDY OF THE ENZYME-SUBSTRATE BY MOLECULAR MODELING INTERACTION; CASES OF THE DISEASE OF CANCER
This study was carried out with goal to predict the inhibition of Aurora Kinase B by a series of Oleocanthal by molecular modeling. During last year’s Kinases Aurora were emerged like one of the important targets of drug in several pharmaceutical companies and industries of research and it plays a main function in the regulation of the mitosis and the cytocinèse 1 and for this reason one inhibi...
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THE ANTIOXIDANT EFFECTS OF IPB-3S STRAIN ORYZA SATIVA BRAN EXTRACT TOWARDS MALONDIALDEHYDE AND GLUTATHIONE PEROXIDASE LEVELS IN RAT BRAIN INDUCED BY CARBON TETRACHLORIDE
IPB-3S Strain Oryza sativa bran, a high-antioxidant food, was expected to protect the brain as a susceptible organ from oxidative damage. This study was conducted to analyze the effect of rice bran extract on malondialdehyde (MDA) and glutathione peroxidase (GSH) levels in the brain induced by carbon tetrachloride (CCl4). A total of 24 Sprague-Dawley male rats was divided into 6 groups, including ...
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PHARMACOGENOMIC STUDIES OF CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) GENOTYPES IN SUSPECTED CAD PATIENTS
Recent studies have attempted to identify specific genes that contribute to cardiovascular health and disease. Response to various drugs like statins differs from individual to individual, due to polymorphic variations in drug metabolizing genes related to pharmacogenomics of the diseases. The aim of this study was to find out the association of Cholesteryl ester transfer protein (CETP) gene polym...
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EVALUATION OF EFFECTS OF PARTHENIUM HYSTEROPHORUS L., LEAVES EXTRACTS AGAINST MILK-INDUCED EOSINOPHILIA IN MICE
Parthenium hysterophorus L., compositae, also known as congress weed, carrot weed, star weed, reaching a height of 2 m in weeks of germination, is believed to have entered India accidentally in the mid 1950's and is now available abundantly all over the India. Leaves are traditionally used in the treatment of asthma and allergy, leavas of the plant were extracted successively using aqueous and...
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A VALIDATED LC-MS/MS METHOD FOR PHARMACOKINETIC STUDY OF AFATINIB IN HEALTHY RABBITS
A liquid chromatography-tandem mass spectrophotometric (LC–MS/MS) method was developed for quantification of Afatinib in rabit plasma employing Solid Phase Extraction (SPE) technique. Developed method was validated for specificity, precision, accuracy, recovery, and stability characteristics. Chromatographic separation was achieved on Gemini, 5µ C18, 50 × 4.60 mm with 30:70 v/v of 10 mM ammoni...
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EFFECT OF XYLIA DOLABRIFORMIS LEAVES EXTRACT ON HIGH FRUCTOSE DIET INDUCED C57BL/6J OB/OB DIABETIC MICE
The objective of the present study was to investigate anti-diabetic and nephroprotective and cardioprotective activity of Xylia dolabriformis leaves extract, using High Fructoseinduced diabetic C57BL/6Job/ob mice as model for clinical type-2 diabetic. At a regular interval of an experimental protocol blood glucose, urinary creatinine, total proteins, insulin resistance, total β-cell count, LDL, H...
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GC–MS ANALYSIS AND IN-VITRO CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACT OF ANTIGONON LEPTOPUS FLOWERS
The present study has been designed to evaluate the bioactive compounds and cytotoxic activity from the n-hexane fraction of methanolic extract of Antigonon leptopus flowers. The n-hexane fraction was analysed by GC-MS (Thermo GC-TRACE ultra ver.: 5.0, Thermo MS DSQ II) which revealed the presence of many diversified compounds including flavonoids, Vitamin D2 derivative, carbohydrates, amino acids...
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GLYCINE AND GOLD NANOPARTICLES FOR THE ELECTROCHEMICAL DETERMINATION OF AN ANTI-PARKINSON’S DRUG IN A TERTIARY MIXTURE
A sensitive sensor for the electrochemical determination of anti-Parkinson’s disease drug; entacapone (EN) was constructed using carbon paste electrode modified via electro-polymerization of glycine (GL) incorporate gold nanoparticles (GNP) and sodium dodecyl sulphate (SDS). Different voltammetric techniques, electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM) te...
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