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EVALUATION OF ANTHELMINTIC ACTIVITY OF DALBERGIA SISSOO ROXB.
The ethanolic extract of bark of Dalbergia sissoo Roxb. was investigated for its activity against Indian earthworms Pheretima posthuma and nematode Ascardi galli. Various concentrations (10, 20, 50 mg/ml) of ethanolic extract were tested, which involved determination of time of paralysis and time of death of the worms. It was compared with Piperazine citrate (15 mg/ml) and Albendazole (20 mg/ml) a...
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METAL COMPLEXES OF HETEROCYCLIC UNSATURATED 1, 3- DIKETONES
The present investigation is mainly on the synthesis, characterization and anti-microbial screening of certain new curcuminoid analogues containing imidazole, pyrrole and thiophene rings and their metal complexes. The ability of such heterocyclic β-dicarbonyl compounds and their metal ions to influence many of complex reaction upon which the vital processes of micro-organisms depends is the motiv...
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PHYTOCHEMICAL SCREENING AND IN-VITRO ANTICANCER ACTIVITY OF EXTRACTS OF TECTARIA CICUTARIA
The rhizome of Tectaria cicutaria has been used in Indian traditional medicine for the treatment of various disorders. Different extracts of the rhizomes of Tectaria cicutaria were subjected to phytochemical analysis, anti-microbial activity and in-vitro anticancer activity. The in-vitro anticancer activity was performed using Sulforhodamine B (SRB) assay against various cancer cell lines namely H...
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A VALIDATED RP- HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND NAPROXEN IN TABLET FORMULATION
The study describes a validated reverse-phase HPLC method for the simultaneous estimation of paracetamol and naproxen in bulk and in tablet formulation. The proposed RP-HPLC method utilizes Eclipse XDB C18 column (150 ×4.6 mm i.d., 5 µm), optimum mobile phase consisted of gradient run of initial ratio of water (pH-2.5 adjusted with orthophosphoric acid): acetonitrile (87:13) with the effluent fl...
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SYNTHESIS AND CHARACTERISATION OF CHALCONE BASED COPOLYESTERS AND THEIR ANTICANCER ACTIVITY
Breast cancer is one of the most common causes of death in women. Chalcone exhibit chemopreventive and antitumor effects. As a part of proactive approach in the fight against breast cancer, two copolyesters using varying chalcone diols as monomer and varying aliphatic and aromatic acid chlorides were synthesised by solution polycondensation method. The two copolyest...
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BIOCHEMICAL STUDIES ON THE EFFECT OF ETHANOLIC EXTRACTS OF TRICHOSANTHES DIOICA AND CLITORIA TERNATEA IN STREPTOZOTOCIN INDUCED DIABETIC MALE WISTAR RATS
To investigate the effect of ethanolic extracts of leaf and fruit of Trichosanthe dioica (T. dioica) and leaf of Clitoria ternatea (C. ternatea) on the biochemical parameters in streptozotocin (STZ) induced diabetic Wistar albino rats. Healthy male adult Albino rats of Wistar strain were randomly divided into eleven groups of six rats each were assigned into normal and diabetic groups (Group I to ...
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FORMULATION DESIGN, IN-VITRO AND BIOLOGICAL CORRELATION OF SITE SPECIFIC DRUG DELIVERY SYSTEM FOR DISTAL GASTRO-INTESTINAL TRACT
In the present studies was designed to evaluate oral compression coated tablet formulation to achieve time and site specific drug release system to target lower GIT. A pectin based compression coated tablet formulation of different ratios and concentration of ethyl cellulose and cellulose acetate phthalate were designed and evaluated physico chemical parameters and for tinidazole release, compress...
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EFFECT OF COMBINATION THERAPY USING COW (BOS INDICUS) URINE DISTILLATE AND SOME INDIAN MEDICINAL PLANTS AGAINST SELECTIVE PATHOGENIC GRAM-NEGATIVE BACTERIA
Inconsequential use of broad-spectrum antibiotics results in the evolution of multiple drug resistant pathogenic gram-negative bacterial strains which is a global health threat and is responsible for high morbidity and mortality rates. This necessitated the search for new effective and safe treatment strategies. One such successful treatment strategy is combination therapy which comprises cow urin...
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BIOFILM INFECTIONS: A NEW THERAPEUTIC CHALLENGE
Biofilms are multicellular communities of bacteria. The ability to form biofilm is a universal attribute of bacteria and as bacteria can form biofilm in medical, industrial and environmental settings, it impacts human lives in many different ways. Bacteria undergo profound physiologic, morphologic and genetic changes as the transit from planktonic (free swimming, non-biofilm) form to surface attac...
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RESPONSES OR EFFECT OF CEREBRAL MALARIA ON PLATELET COUNT, PLATELET FACTOR – 3 AND PLATELET AGGREGATE AVAILABILITY IN CHILDREN
Background and Objective: Malaria, a formidable global parasitic infection represent a major health problem in tropical countries in terms of geographical spread, high morbidity, severe mortality especially among children. This study investigated platelet function’s role and its strength to make platelet factor 3 (PF-3) available for coagulation in children with cerebral malaria. Subjects and...
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