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MULTI DIMENSION PROTEIN IMPACT MATRIX BASED PROTEIN SEQUENCE PREDICTION USING DATA MINING
Proteins are the most essential and versatile macromolecules of life, and the knowledge of their functions is a crucial link in the development of new drugs, better crops, and even the development of synthetic biochemicals such as biofuels. Experimental procedures for protein function prediction are inherently low throughput and are thus unable to annotate a non-trivial fraction of proteins that a...
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STABILITY INDICATING ASSAY METHOD DEVELOPMENT AND VALIDATION OF EDOXABANTOSYLATE MONOHYDRATE: A COMPREHENSIVE STUDY INVOLVING IMPURITIES ISOLATION, IDENTIFICATION AND DEGRADATION KINETICS DETERMINATION IN VARIOUS CONDITIONS
Objective: State of the art, robust and environmentally benign stability indicating assay method (SIAM) has been developed for model drug Edoxabantosylate (EDO) Methods: Successful RP-HPLC chromatographic method was accomplished on a CHROMBUDGET® 100-5-C18 column (250 mm × 4.6 mm, 5 μ) column using methanol and acetate buffer in the ratio of 53:47 having 2.9 pH and 10mM buffer strength. The deg...
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CIGARETTE SMOKE EXTRACTS INDUCE AND REPRESS GENES IN HUMAN EMBRYONIC LUNG CELLS
Disastrous effects of tobacco consumption on health remain in the focus of preclinical and clinical research. Exposures to tobacco smoke are closely connected to acute and chronic smoke lung dysfunctions and the effects are not restricted to airway inflammation processes. The facts that smoke exposure result in aberrant gene expression and changes in cellular phenotype resulting in clinical patter...
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EVALUATION OF RATIONAL USAGE OF ANTIMICROBIAL AGENTS IN THE MEDICINE DEPARTMENT AT TERTIARY TEACHING CARE HOSPITAL, GUJRAT
Background: Prescription of drugs which needs to be continuously assessed and refined according to disease progression. It is not only reflects the physician’s knowledge about drugs but also know the pathophysiology of diseases and attitude towards rational prescribing. Methods-: Retrospective study was carried out by collecting 350 prescriptions containing antimicrobial agents of the indoor ...
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FLAVONE AND FLAVONE GLYCOSIDE FROM CICHORIUM INTYBUS LINN
Cichorium intybus Linn (Compositae) contains UV-absorbing metabolites. Studies on methanol extract of Cichorium intybus Linn by means of HPLC-UV, NMR, HPLC-MS resulted in isolation and identification of three previously unknown flavones glycosides: 5, 6, 7, 3′, 4′, 7′-hexahydroxy flavones-7-O-β-D-glucopyranoside (1), 3, 5, 7 – trihydroxy-3′,4′-dimethoxy-flavone-7-O-β-D-galactopyranos...
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EVALUATION OF EFFECTS OF PARTHENIUM HYSTEROPHORUS L., LEAVES EXTRACTS AGAINST MILK-INDUCED EOSINOPHILIA IN MICE
Parthenium hysterophorus L., compositae, also known as congress weed, carrot weed, star weed, reaching a height of 2 m in weeks of germination, is believed to have entered India accidentally in the mid 1950's and is now available abundantly all over the India. Leaves are traditionally used in the treatment of asthma and allergy, leavas of the plant were extracted successively using aqueous and...
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A COMPARATIVE AND CORRELATIVE STUDY BETWEEN BLOOD AND SALIVARY GLUCOSE WITH BLOOD HbA1c IN TYPE 2 DIABETES
Diabetes is a non-communicable disease characterized by increased blood glucose. As regular monitoring of glucose and glycated hemoglobin (HbA1c) levels in diabetic individual’s blood causes psychological stress, development of a non-invasive technique to quantify glucose and HbA1c are essential. This study was carried out to compare and correlate the blood and salivary glucose and blood HbA1c l...
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BIOFILM INFECTIONS: A NEW THERAPEUTIC CHALLENGE
Biofilms are multicellular communities of bacteria. The ability to form biofilm is a universal attribute of bacteria and as bacteria can form biofilm in medical, industrial and environmental settings, it impacts human lives in many different ways. Bacteria undergo profound physiologic, morphologic and genetic changes as the transit from planktonic (free swimming, non-biofilm) form to surface attac...
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FORMULATION AND OPTIMIZATION OF FAST DISSOLVING TABLETS OF OLANZAPINE USING VACUUM DRYING TECHNIQUE BY 22 FACTORIAL DESIGN
The purpose of this research was to develop fast dissolving tablets of olanzapine and to optimize the processing variables. Tablets containing olanzapine, camphor, crosscarmellose, and directly compressible lactose were prepared by direct compression technique. The tablets were compressed and later exposed to vacuum. Sublimation of camphor from tablets resulted in superior fast dissolving tablets....
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GC–MS ANALYSIS AND IN-VITRO CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACT OF ANTIGONON LEPTOPUS FLOWERS
The present study has been designed to evaluate the bioactive compounds and cytotoxic activity from the n-hexane fraction of methanolic extract of Antigonon leptopus flowers. The n-hexane fraction was analysed by GC-MS (Thermo GC-TRACE ultra ver.: 5.0, Thermo MS DSQ II) which revealed the presence of many diversified compounds including flavonoids, Vitamin D2 derivative, carbohydrates, amino acids...
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