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ANTIBACTERIAL ACTIVITY OF THE CRUDE EXTRACTS OF B. SUBTILIS FROM SML
The rise of antibiotic-resistant pathogens leads to the development of new antibiotics and drugs. Natural products capture the attention of the researchers for such drug discovery. Apart from medicinal plants, many microorganisms also play a great role in the discovery of antibiotics. In this context, bacteria from Sea surface microlayer (SML) are also investigated nowadays. The secondary metaboli...
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ANTI- INFLAMMATORY, ANALGESIC & ULCEROGENIC ACTIVITY OF KETOPROFEN GLUCOPYRANOSIDE CONJUGATES
Ketoprofen is a non-steroidal anti-inflammatory drug. Glucopyranoside Conjugates of Ketoprofen have been synthesized and evaluated for anti- inflammatory, analgesic and ulcerogenic activities. In vivo biological screening in mice and rats indicated that conjugates improved analgesic and anti-inflammatory activities with significantly reduced ulcerogenicity compared to the parent drug....
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DEVELOPMENT AND VALIDATIONOF OF STABILITY INDICATING HPLC METHOD FOR DETERMINATION OF ACOTIAMIDE HYROCHLORIDE
A simple and rapid stability indicating HPLC method for acotiamide hydrochloride was developed and validated. The stationary phase used was thermo gold cyno (250 × 4.6 mm) 5 μ with a mobile phase consisting of mixture of acetonitrile and 10 mM KH2PO4 in water in the ratio of 80:20 v/v at a flow rate of 0.8ml/min. Detection was carried at 284 nm. The retention time observed was 8.1 ± 0.2 min. Th...
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ANTIOXIDANT ACTIVITY OF PLANTS AT CHINNATIRUPATHI, SALEM, TAMIL NADU, INDIA
This study was carried out during March - April 2013. The fresh leaves collected were extracted with water and used for antioxidant assay. Nitric oxide scavenging activity, Reducing power assay, Metal chelating activity, Phosphomolybdenum activity was assayed and also secondary metabolites such as phenol, flavonoid was estimated. These metabolites play a major role in antioxidant activity. Here,...
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DEVELOPMENT OF NOVEL INJECTABLE FORMULATION OF CLOPIDOGREL BY QbD APPROACH
Clopidogrel, a poorly water-soluble drug, has been the mainstay of platelet management in acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI) for over a decade. Since Clopidogrel is a prodrug and requires hepatic metabolism for activation, it exhibits a slower onset of action upon oral administration. This time-lag before the onset on the action is highly undesirable for the ...
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COMPARISON OF SURGICAL SITE INFECTION RATE BETWEEN ANTIBACTERIAL COATED SURGICAL SUTURE AND CONVENTIONAL SUTURE: A RANDOMIZED CONTROLLED SINGLE CENTRE STUDY FOR PREVENTIVE MEASURE OF POSTOPERATIVE INFECTION
The main objective of this study is to compare the reduction rate of surgical site infection (SSI) between Triclosan coated (TC) and conventional surgical (CS) suture postoperatively. Surgical site infection (SSI) can be presented as a major challenge for people in the sense of mortality and morbidity mostly in developing countries. The result of SSI with antibacterial suture in developed countrie...
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EVALUATION OF ANTIMICROBIAL ACTIVITIES AND DNA-BINDING PROPERTIES OF MOLYBDENUM COMPLEXES
Molybdenum is a trace element distributed widely in nature which plays an important role in plant and animal nutrition and in our industrial society. Molybdenum is essentially present in the enzymes nitrogenase, Xanthine-oxidase, sulphite oxidas, nitrate reductase, formate dehydrogenase and aldehyde oxidase. These enzymes are responsible for a number of catalytic reactions of redox nature. M...
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EFFECTS OF CADMIUM STRESS ON ANTIOXIDANT ENZYMES IN VIGNA RADIATA ROOTS
A brief study to analyze oxidative stress and antioxidant response of cadmium stress was carried out. The plant chosen Vigna radiata (var. SML-668) was hydroponically grown in 0, 50µM, 100µM and 150µM, cadmium chloride. The roots were taken from hydroponic culture at 6 days of growth for various enzymatic and metabolic estimations. Among the antioxidant enzymes, root catalase and ascorbate pe...
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SYNTHESIS, CHARACTERISATION AND BIOLOGICAL SCREENING OF Cu (II) COMPLEXES OF PINCER LIGANDS
The ligands bis-(benzimidazolyl)pyridine (BBIP) and bis-(benzimidazolyl)benzene (BBIB) have been used to synthesize Copper(II) complexes [Cu(BBIP)2]Cl2 and [Cu(BBIB)2]Cl2 respectively. The complexes are characterized by analytical and spectral (FTIR, 1H NMR and electronic) techniques. IR spectra of complexes show that the tertiary nitrogens in the ligand are involved in the co-ordination to the me...
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PHYTO-FABRICATION OF SILVER NANOPARTICLES BY DIFFERENT PHYSICO-CHEMICAL PARAMETRES USING PETREA VOLUBILIS L. LEAF BROTH AND EVALUATION OF THEIR ANTI-MICROBIAL ACTIVITY
The present study instantiates the phyto-fabrication of silver nanoparticles by utilizing Petrea volubilis L. leaf broth which were instantaneously synthesised, eco-friendly, and cost-effective. The influence of physico-chemical parameters viz. contact time, leaf broth quantity, pH, temperature, and silver nitrate concentration were investigated and optimised to engineer infinitesimal nanopartic...
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