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COMPARATIVE ANALYSIS OF CHEMICAL AND PHYTOCHEMICAL COMPOSITIONS OF FOUR SELECTED MEDICINAL PLANTS AND EVALUATION OF ANTIDIABETIC PROPERTIES OF AQUEOUS EXTRACTS OF TRIGONELLA FOENUM-GRAECUM AND COMBINATION OF TRIGONELLA FOENUM-GRAECUM – MOMORDICA CHARANTIA
The present study was designed to compare the chemical and phytochemical compositions of Momordica charantia, Azadira chtaindica, Trigonella foenum-graecum and Phyllanthus emblica and subsequently, antidiabetic activities of T. foenum-graecum and a combination of polyherbal extract of T. foenum-graecum and M. charantia were evaluated on alloxan induced diabetic mice. The proximate and phytochemica...
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HPTLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF OXYCLOZANIDE AND LEVAMISOLE HYDROCHLORIDE IN TABLET DOSAGE FORM
This paper describes a new, simple, precise, and accurate HPTLC method for simultaneous estimation of Oxyclozanide and Levamisole hydrochloride as the bulk drug and in tablet dosage forms. Chromatographic separation of the drugs was performed on aluminium plates pre-coated with silica gel 60 F254 as the stationary phase and the solvent system consisted of Toluene: acetone: ammonia (5:5:0.04 v/v/v)...
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STABILITY INDICATING ASSAY METHOD DEVELOPMENT AND VALIDATION OF EDOXABANTOSYLATE MONOHYDRATE: A COMPREHENSIVE STUDY INVOLVING IMPURITIES ISOLATION, IDENTIFICATION AND DEGRADATION KINETICS DETERMINATION IN VARIOUS CONDITIONS
Objective: State of the art, robust and environmentally benign stability indicating assay method (SIAM) has been developed for model drug Edoxabantosylate (EDO) Methods: Successful RP-HPLC chromatographic method was accomplished on a CHROMBUDGET® 100-5-C18 column (250 mm × 4.6 mm, 5 μ) column using methanol and acetate buffer in the ratio of 53:47 having 2.9 pH and 10mM buffer strength. The deg...
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ASYSTASIA GANGETICA: A BIBLIOMETRIC ASSESSMENT OF GLOBAL PUBLICATIONS OUTPUT DURING 1960-2020
There has been an exponential growth in plant-based products during the last few decades for the treatment of various ailments. According to literature, about 25% of prescribed drugs are of plant origin globally. One such important plant is Asystasia gangetica, also known as ‘Chinese violet’ or ‘Ganges primrose’ is an ornamental, scattering, groundcover herb. The plant is about 0.30 to 0.6...
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EVALUATION OF EFFECTS OF PARTHENIUM HYSTEROPHORUS L., LEAVES EXTRACTS AGAINST MILK-INDUCED EOSINOPHILIA IN MICE
Parthenium hysterophorus L., compositae, also known as congress weed, carrot weed, star weed, reaching a height of 2 m in weeks of germination, is believed to have entered India accidentally in the mid 1950's and is now available abundantly all over the India. Leaves are traditionally used in the treatment of asthma and allergy, leavas of the plant were extracted successively using aqueous and...
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ANTI-ULCEROGENIC EFFECTS OF ARECA CATECHU L. IN SPRAGUE DAWLEY RATS
The aim of this study was to evaluate the anti-ulcerogenic activity of aqueous extract of Areca catechu L in ethanol induced ulcer model in Sprague Dawley Rats. For possible mechanism of anti-ulcerogenic potential, determination of ulcer index was done using the Merazzi-Uberti and Turba method. Also, analytical method was used to test the 10% homogenate preparation of mucosa of the glandular stoma...
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VALIDATED HPTLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF EMTRICITABINE AND TENOFOVIR IN DRUG FORMULATION
A simple, precise, specific and accurate high-performance thin-layer chromatographic method has been developed for the simultaneous determination of Emtricitabine (EMB) and Tenofovir (TEN) in pharmaceutical dosage form. The separation was carried out on Merck HPTLC aluminum plates of silica gel 60 F254, (20×10 cm) with 250 μm thickness using toluene: ethylacetate: methanol in the ratio (2:8:1 v/...
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GABA-AT INHIBITORY ACTIVITY OF BENZOTHIAZOLE – GABA ANALOGS: IN-SILICO APPROACH FOR ANTIEPILEPTIC PROFILE
Estimation of binding affinity of receptor – ligand complex in docking study of small molecules plays an Important role in structure based drug development process. The γ-amino-butyric acid amino-transferase (GABA-AT) exhibits a catalytic role in regulating γ-amino -butyric acid (GABA) level in brain and responsible for many physiological and pathological changes. Here, in – silico study o...
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MULTI DIMENSION PROTEIN IMPACT MATRIX BASED PROTEIN SEQUENCE PREDICTION USING DATA MINING
Proteins are the most essential and versatile macromolecules of life, and the knowledge of their functions is a crucial link in the development of new drugs, better crops, and even the development of synthetic biochemicals such as biofuels. Experimental procedures for protein function prediction are inherently low throughput and are thus unable to annotate a non-trivial fraction of proteins that a...
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THE ANTIOXIDANT EFFECTS OF IPB-3S STRAIN ORYZA SATIVA BRAN EXTRACT TOWARDS MALONDIALDEHYDE AND GLUTATHIONE PEROXIDASE LEVELS IN RAT BRAIN INDUCED BY CARBON TETRACHLORIDE
IPB-3S Strain Oryza sativa bran, a high-antioxidant food, was expected to protect the brain as a susceptible organ from oxidative damage. This study was conducted to analyze the effect of rice bran extract on malondialdehyde (MDA) and glutathione peroxidase (GSH) levels in the brain induced by carbon tetrachloride (CCl4). A total of 24 Sprague-Dawley male rats was divided into 6 groups, including ...
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