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ASSESSMENT OF OXIDATIVE STRESS, ANTIOXIDANT ENZYMES AND LIPID PROFILE IN THE SUBJECTS OF CORONARY ARTERY DISEASE (CAD)
Coronary artery disease (CAD) is the major cause of mortality and morbidity worldwide. The incident of CAD is rising and they are predicted to be the biggest causes of death by 2020 in India. Therefore, the aim of the present study was to assess the association of oxidative stress, antioxidant enzyme and lipid status parameters in CAD patients and to compare the results age- sex matched healthy co...
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IDENTIFICATION OF SIGNIFICANT PATHWAYS RESPONSIBLE FOR AUTISM THROUGH MOLECULAR NETWORK ANALYSIS
Autism is a spectrum of developmental disorders characterized by impairments in social interaction, communication, often accompanied by stereotypical or repetitive behaviours. There are numerous hypotheses holding to the etiology and pathology of Autism but actual mechanism of the ailment is still unknown. Although a number of rare mutations and dosage abnormalities are specific to autism, these e...
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CAUSE OF ANTIRETROVIRAL DRUG CHANGES AMONG PATIENTS ON ANTIRETROVIRAL THERAPY AT THE ART CENTER IN DESSEI REGIONAL REFERRAL HOSPITAL, ETHIOPIA
Background: Beside the fact of poor adherence to antiretroviral drugs in resource limited country, serious adverse effects of the drugs and treatment failure complicate the whole management of antiretroviral therapy. Consequently, treatment modification and discontinuation of therapy has become a common phenomenon and hence limitation of treatment option has turn out the major concern of the futur...
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SCREENING OF ANTI-HYPERLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF LAGERSTROEMIA SPECIOSA (LINN.) PERS. LEAVES
The present study was designed to investigate the hypolipidemic activity of the methanolic leaf extract of Lagerstroemia speciosa Linn. Plant extract was tested in fat diet induced hyperlipidemic rat models. Methanolic extracts of leaves of Lagerstroemia speciosa Linn. were administered in doses of 250mg/kg and 500mg/kg/day for one week. The obtained results reveal that methanolic leaf extract (LM...
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ANTI-INFLAMMATORY ACTIVITY OF WHOLE PLANT OF BELOPERONE PLUMBAGINIFOLIA (ACANTHACEAE)
In the present study anti-inflammatory activity of ethanol extract of Beloperone plumbaginifolia whole plant were investigated. The anti-inflammatory activity of ethanol extract of whole plant of B.plumbaginifolia were evaluated by carageenan induced rat paw edema to determine its effect on acute phase of inflammation models in rats. The phytochemical screening of ethanol extract of whole plant of...
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IN VITRO PROPHYLACTIC CATARACT PREVENTION STUDY ON GLUCOSE INDUCED CATARACT BY QUERCETIN AND ALPHA- TOCOPHEROL
The antioxidants such as quercetin and alpha- tocopherol were subjected for in vitro prophylactic cataract prevention study on glucose induced cataract model. Goat lenses were incubated in artificial aqueous humor containing 55 mM glucose with test drugs in different concentrations at room temperature for 72 h. Biochemical parameters studied in the lens were electrolytes (Na+, K+), Na+- K+- ATPase...
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ANTI- CONVULSANT PROFILE OF AQUEOUS EXTRACT OF SAPINDUS LAURIFOLIA IN EXPERIMENTAL ANIMALS
Objective: The aim of the present study was to evaluatethe anti convulsant property of aqueous extract of Sapindus laurifolia in Pentylenetetrazole (PTZ) and MES induced convulsions in experimental models. Materials & Methods: The purpose of this study is to explore the anticonvulsant activity of ethanolic extract of Momordica tuberosa using Pentylenetetrazole and maximal electric shock induce...
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DESIGN OF EXPERIMENT IN THE BIO-ANALYTICAL DETERMINATION OF QUETIAPINE FUMARATE IN HUMAN PLASMA BY A RP-HPLC METHOD
A new, simple, sensitive, accurate and precise RP-HPLC method was developed for the estimation of quetiapine fumarate in human plasma. Full factorial design was used for the optimization of an extraction method. The main effect of volume of deproteinating agent, speed of centrifugation, time of centrifugation and temperature of centrifugation was found to be significant at P<0.0001 on all the r...
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THE POSSIBLE PROTECTIVE EFFECT OF FRESH BEETROOT JUICE AGAINST PARACETAMOL INDUCED HEPATOXICITY IN ADULT ALBINO RATS
Hepatotoxicity in the form of acute liver failure is a serious side effect of several drugs most importantly paracetamol. Beetroot main ingredients are nitrate, betalains, phenolics and ascorbic acid, which are responsible for its protective against oxidative stress and inflammation. Aim: This study assessed the possible protective effect of beetroot against liver toxicity induced by paracetamol. ...
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SYNTHESIS, CHARACTERIZATION, THERMAL AND KINETIC STUDIES OF LANTHANUM (III), THORIUM (IV) AND DIOXOURANIUM (VI) CHELATES WITH MULTIDENTATE LIGAND AND ITS IN VITRO ANTIBACTERIAL ANALYSIS
Metal Complexes of lanthanum (III), Thorium (IV) and dioxouranium (VI) with Schiff base ligand ethyl 2-{[(2E, 3Z)-4-hydroxypent-3-en-2-ylidene] amino}-4, 5, 6, 7-tetrahydro-1-benzothio-phene-3-carboxylate were prepared. All synthesized complexes were identified and confirmed by elemental analysis, molar conductance measurements and spectral analysis (UV-visible, IR and 1H NMR). The conductance mea...
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