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CIGARETTE SMOKE EXTRACTS INDUCE AND REPRESS GENES IN HUMAN EMBRYONIC LUNG CELLS
Disastrous effects of tobacco consumption on health remain in the focus of preclinical and clinical research. Exposures to tobacco smoke are closely connected to acute and chronic smoke lung dysfunctions and the effects are not restricted to airway inflammation processes. The facts that smoke exposure result in aberrant gene expression and changes in cellular phenotype resulting in clinical patter...
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COLON SPECIFIC DRUG DELIVERY SYSTEM: REVIEW ON NOVEL APPROACHES
Article reviews the research focus on potential opportunities and challenges available in new area of colon targeted drug delivery system. Colon was considered as “BLACK BOX” as, most of drugs are absorbed from upper part of GIT tract. Targeted drug delivery to the colon would ensure direct treatment at the disease site, lowering of dose and lesser systemic side effects. In addition, the colon...
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SYNTHESIS AND IN- VITRO ANTIOXIDANT ACTIVITY OF SOME NEW 2, 5-DISUBSTITUTED-1, 3, 4-OXADIAZOLES CONTAINING FURAN MOIETY
A series of five membered heterocyclics was synthesized by the reaction between refluxing 2 - furoic acid with ethanol and conc. H2SO4. The obtained ester (2) with hydrazine hydrate and ethanol was refluxed to give hydrazides (3). Reaction of hydrazides (3) with different aromatic acids using phosphorousoxy trichloride (POCl3) lead to the formation of 2-Aryl -5-furyl -1, 3, 4-oxadiazoles [DM (1-...
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2007
QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP AND MOLECULAR DOCKING ANALYSIS OF CHOLESTEROL INHIBITORS AGAINST NIEMANN-PICK C2 TARGET GENE (NPC2)
In an effort to develop new targets with enhanced antihyperlipidemic activity, seven new inhibitors such as beta-sitosterol, cholesterol, cholesterol sulfate, desmosterol, lathosterol, stigmasterol and cholesterol acetate was targeted using in silico docking experiments with the modeled structure of the Niemann-Pick C2 target gene (NPC2). Quantitative structure–activity relationship models (QSAR...
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DEVELOPMENT AND OPTIMIZATION OF CHITOSAN-CA-PECTINATE BEADS OF AMORPHOUS CELECOXIB BY RESPONSE SURFACE METHODOLOGY
The aim of the present work was to develop a new microbeads system for colon-targeted delivery of celecoxib. The ternary system were develop using PVP (polyvinylpyrrolidone) and hydroxypropyl-β-cyclodextrin (HPB) to increase solubility of celecoxib. DSC and XRD results confirmed formation of amorphous celecoxib complex with HPB. Chitosan and pectin were used for the development of microbeads of...
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1565
IN VITRO EVALUATION OF ANTIBACTERIAL AND ANTIFUNGAL PROPERTIRS OF TERMINALIA BELERICA
The research work was conducted with the fruits of Terminalia belerica (Fam: Combretaceae) to investigate antibacterial & antifungal activities. The fruits of the plant were successively extracted by cold extraction process by using two solvents namely ethanol and acetone. Antimicrobial activities of the extracts of both solvents were investigated by a simple agar diffusion method using ten pa...
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SIMULTANEOUS ESTIMATION OF HYDROCORTISONE AND KETOCONAZOLE IN PHARMACEUTICAL DOSAGE FORM BY RP-HPLC METHOD
A simple, selective, rapid, precise and economical reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of hydrocortisone and ketoconazole from pharmaceutical formulation. The method was carried out on a C18 (25 cm × 4.6 mm i.d., 5 μ) column with a mobile phase consisting of methanol: water (adjusted to pH 3.0 using triethylamine) in the...
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SYNTHESIS, CHARACTERIZATION, THERMAL AND KINETIC STUDIES OF LANTHANUM (III), THORIUM (IV) AND DIOXOURANIUM (VI) CHELATES WITH MULTIDENTATE LIGAND AND ITS IN VITRO ANTIBACTERIAL ANALYSIS
Metal Complexes of lanthanum (III), Thorium (IV) and dioxouranium (VI) with Schiff base ligand ethyl 2-{[(2E, 3Z)-4-hydroxypent-3-en-2-ylidene] amino}-4, 5, 6, 7-tetrahydro-1-benzothio-phene-3-carboxylate were prepared. All synthesized complexes were identified and confirmed by elemental analysis, molar conductance measurements and spectral analysis (UV-visible, IR and 1H NMR). The conductance mea...
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1963
ANTIPYRETIC ACTIVITY OF THESPESIA POPULNEA FRUITS
In the present study, the alcoholic and aqueous extracts of Thespesia populnea were investigated for their antipyretic activity. Suspension of subcutaneous administration of brewer’s yeast in albino rat leads to pyrexia. Oral administration of extracts at a dose of 500 mg/kg body weight significantly reduced the elevated body temperature of rat. This antipyretic effect has been compared with ant...
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CAUSE OF ANTIRETROVIRAL DRUG CHANGES AMONG PATIENTS ON ANTIRETROVIRAL THERAPY AT THE ART CENTER IN DESSEI REGIONAL REFERRAL HOSPITAL, ETHIOPIA
Background: Beside the fact of poor adherence to antiretroviral drugs in resource limited country, serious adverse effects of the drugs and treatment failure complicate the whole management of antiretroviral therapy. Consequently, treatment modification and discontinuation of therapy has become a common phenomenon and hence limitation of treatment option has turn out the major concern of the futur...
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