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SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF SOME PHENYL URENYL CHALCONES
Despite significant progress made in the treatment of infectious diseases, caused by bacteria and fungi, it remains a major worldwide health problem due to rapid development of resistance against the existing antimicrobial drugs. In the present investigation, a novel series of chalcones 2a–2h were synthesized by the clasein-schmidt condensation of various aldehydes with methyl ketone in the pres...
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ASSESSMENT OF NUTRITIONAL CONSTITUENTS AND IN VITRO ANTIOXIDANT CAPACITY OF METHANOLIC STEM EXTRACT OF CARALLUMA ATTENUATA
The main objective of the present study includes the assessment of nutritional constituents and anti-oxidant activity of methanolic stem extract of Caralluma attenuata by in-vitro methods. In the present investigation the author has identified the phytochemical constituents which have nutritional importance by specific chemical tests, thin layer chromatography, atomic absorption spectroscopy for C...
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FORMULATION AND EVALUATION OF LORNOXICAM MOUTH DISSOLVING TABLET BY USING NATURAL SUPERDISINTEGRANTS
The concept of fast dissolving drug delivery system emerged from the desire to provide patients with more convenient means of taking their medication. It is difficult for many patients to swallow tablets and hard gelatin capsules. The main objective of the study is to develop a reproducible formulation of fast dissolving tablets of Lornoxicam already used the therapeutic molecule to enhance effect...
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THERAPEUTIC APPLICATIONS OF MUSHROOMS AND ITS COMPOSITIONAL ANALYSIS BY HIGH THROUGHPUT SCREENING TECHNIQUES
Mushrooms can be considered as a prolific resource for drugs as per previous literature surveys. Their constituent bioactive components are broadly classified such as phenols, flavonoids, triterpenoids, saponins. Whole mushrooms or mainly fruiting bodies extracts and compounds isolated from their mycelium are of immense pharmacological importance. Extraction employing suitable solvents leads to th...
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DIURETIC ACTIVITY OF METHANOLIC RHIZOME EXTRACT OF PICRORRHIZA KURROA ROYLE EX. BENTH.
Kidneys are the excretory organs of our body that serves the important functions such as elimination of waste products, regulation of fluid volume and electrolyte content of the extracellular fluid. Picrorrhiza kurroa (Scrophulariaceae) is a small perennial herb growing in the hilly parts of the north-Western Himalayas region in India and Nepal. The objective of the present study was to evaluate a...
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MICROWAVE ASSISTED ISOLATION OF MUCILAGE FROM THE TRICHOSANTHES DIOICA FRUIT
A microwave assisted extraction technique was developed to optimize the extraction of mucilage from the fruits of Trichosenthes dioica plant. Materials and Methods: the plant has been extracted by conventional and microwave assisted methods for the isolation of mucilage. Results and Discussion: Microwave extraction at 320 W intensity and 20 min heating duration, 84.92% increase in the yield of muc...
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X-RAY DIFFRACTION STUDY OF A PANCHAVAKTRA RAS
Analytical monitoring of Pharmaceutical products is necessary to ensure its safety and efficacy throughout all phases of the drug. A systematic approach should be adapted to the presentation and evaluation of stable information, which should include, as necessary, physical, chemical, biological and microbiological test characteristics. Indian System of Medicine (ISM) frequently uses metal/mineral ...
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ASSESSMENT OF CYTOTOXICITY, ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITIES OF THE ETHYLACETATE EXTRACT OF CALLIANDRA PORTORICENSIS ROOT BARK
Calliandra portoricensis a medicinal plant, is widely use in the treatment/management of various diseases in Nigeria. The ethyl acetate extract of the Calliandra portoricensis root bark were tested to evaluate the cytotoxicity, antioxidant (in vitro) and free radical scavenging activity. The different assay methods, including total antioxidant activity, free radical (nitric oxide, hydroxyl radical...
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SEPARATION OF STARCH FROM ZINGIBER OFFICINALE (GINGER) AND STUDY IT’S CHARACTERIZATION
Zingiber officinalis belonging to family Zingiberaceae is a plant of ancient cultivation that is traditionally used in several disorders. The principal components of ginger reported are gingerols, shogaols, and high content of starch (40 to 60 %). Not much work has been done on the separation of starch from ginger and its characterization. The main objective of this study was to investigate the po...
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SOLUBILITY ENHANCEMENT OF BCS CLASS II DRUGS
One of the major barriers in the development of oral dosage form is poor solubility. Poor water solubility obstructs drug bioavailability and decreases its pharmaceutical development. Many drugs are in the pipeline to enhance solubility to formulate dosage form to be taken by the most preferred route of administration that is the oral route. Etodolac is nonsteroidal anti-inflammatory drug having a...
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