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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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31.

DESIGN OF EXPERIMENT IN THE BIO-ANALYTICAL DETERMINATION OF QUETIAPINE FUMARATE IN HUMAN PLASMA BY A RP-HPLC METHOD

A new, simple, sensitive, accurate and precise RP-HPLC method was developed for the estimation of quetiapine fumarate in human plasma. Full factorial design was used for the optimization of an extraction method. The main effect of volume of deproteinating agent, speed of centrifugation, time of centrifugation and temperature of centrifugation was found to be significant at P<0.0001 on all the r...

S. D. Dalvi *, R. K. Nanda and S. S. Chitlange

Department of Pharmaceutical Chemistry, Marathwada Mitramandal’s College of Pharmacy, Kalewadi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(7).2875-82

2875-2882

3888

1587

67.

FORMULATION AND EVALUATION OF PROGRAMMED RELEASE OCULAR INSERTS OF MIZOLASTINE

The main objective of this study was to prepare controlled release matrix type ocular inserts of mizolastine for the treatment of seasonal allergic conjunctivitis.The films were prepared by solvent casting technique using Eudragit RL100 and RS100 in different ratios with dibutylphthalate as the plasticizer. The films were evaluated for the physicochemical parameters. In-vitro studies were carried ...

Hema Bansal, Sadhna Khatry* and Sandeep Arora

Chitkara College of Pharmacy, Chitkara University, Rajpura-140401, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).497-01

497-501

3887

1723

47.

ANTI- CONVULSANT PROFILE OF AQUEOUS EXTRACT OF SAPINDUS LAURIFOLIA IN EXPERIMENTAL ANIMALS

Objective: The aim of the present study was to evaluatethe anti convulsant property of aqueous extract of Sapindus laurifolia in Pentylenetetrazole (PTZ) and MES induced convulsions in experimental models. Materials & Methods: The purpose of this study is to explore the anticonvulsant activity of ethanolic extract of Momordica tuberosa using Pentylenetetrazole and maximal electric shock induce...

N. Siva Kumar *, N. Raveendra Kumar and Parabattula B. Gangadhar

Associate Professor, Alluri Sitaramaraju Academy of Medical Sciences (ASRAM), Eluru, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1968-72

1968-1972

3887

1787

40.

ANTIPYRETIC ACTIVITY OF AQUEOUS AND ALCOHOLIC EXTRACTS OF NONI ON YEAST INDUCED PYREXIA IN RATS

Numerous herbal agents have been claimed to having antipyretic property. One up-coming botanical fruit of Morinda citrifolia, whose Polynesian name is Noni, is unique in view of the large number of medical indications that characterize claims for its efficacy. Researchers at an independent research facility found that Noni was a selective inhibitor of COX-2 enzyme. The analgesic efficacy of the No...

Bharti Jethani , R. K. Sharma*, M. Raipuria , Hemlata Jain

Associate Professor, Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Mhow, Madhya Pradesh, India

DOI: 40. http://dx.doi.org/10.13040/IJPSR.0975-8232.2(7).1850-54

1850-1854

3886

1617

16.

IN-VITRO ASSESSMENT, ISOLATION AND SPECTRAL ANALYSIS OF THE CHLOROFORM FRACTION OF DIOSPYROS KAKI FRUIT

Persimmon (Diospyros kaki Linn.), which belongs to the Ebenaceae family, have numerous bioactive compounds such as polyphenols, dietary fiber, carotenoids and minerals. This fruit possesses hypolipidemic and antioxidant properties and can be used in anti-atherosclerosis diets. The present paper reveals the phytochemical screening, Antioxidant, Anti-inflammatory activity and GC-MS Spectral analysis...

B. Vanitha *and B. Duraisamy

Department of Pharmacognosy and Phytopharmacy, JSS College of Pharmacy, Ooty, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(1).140-49

140-149

3885

1763

48.

ATTENUATION OF HYPERGLYCEMIA AND OXIDATIVE STRESS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS BY AQUEOUS EXTRACT OF AVERRHOA BILIMBI LINN FRUITS

In the present study, the antidiabetic and antioxidant effect of aqueous extract of Averrhoa bilimbi Linn (ABAE) fruits were evaluated. Diabetes mellitus was induced in male Sprague Dawley rats by a single intraperitoneal injection of streptozotocin (40 mg/kg body weight). Oral administration of aqueous extract of Averrhoa bilimbi Linn (ABAE) (50mg/kg body weight) and metformin (100 mg/kg body wei...

Surya B. Kurup* and S Mini

Department of Biochemistry, University of Kerala, Kariavattom, Trivandrum, Kerala, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(11).4979-86

4979-4986

3884

1756

5.

NOVEL NUCLEAR RECEPTOR SUPER FAMILY DATABASE

The objective of the project is to develop a comprehensive database of Nuclear Receptor (NR) Superfamily-Ligand. Nuclear Receptor Superfamily represents one of the most important families of drug targets in pharmaceutical development. Nuclear Receptor) Superfamily-Ligand is a novel public NR-related chemical genomic database that is primarily focused on the correlation of information between NRs a...

Akshay A. Bhat, Vinay Sridhar, Hemanth Kumar K., Abhilash M.*

UST Global, Technopark, Trivandrum, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).41-49

41-49

3884

1477

28.

NON-TARGETED ANALYSIS AND CYTOTOXIC ACTIVITY OF HAMELIA PATENS JACQ.

In the present study we have done non-targeted analysis of extract from Hamelia patens Jacq. by GC/MS and estimated the inhibitory concentration (IC50) of the extract in three human tumor cell lines MCF-7, H-460 and SF-268. Hamelia patens is an herbaceous perennial plant of family Rubiaceae. Parts of the plant are used in Peruvian and Mexican folk-medicine. Dried leaves of Hamelia patens were extr...

S. Kumar, R. Bodla*and R. Kant

Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1093-99

1093-1099

3883

1595

45.

DEVELOPMENT OF A POLYHERBAL CAPSULE FOR THE TREATMENT OF HYPERLIPIDAEMIA

Hyperlipidaemia is mentioned as one of the life-style-related diseases as much as so for diabetes. In the present study an attempt was made to develop herbal capsules, which are containing the extract of Murraya koenigii and Achyranthus aspera. One of the major concerns in designing new formulation is that the active ingredient should be compatible with all the excipients and packaging material co...

P. K. Sharma *, R. P. Singh and S. Jain

Department of Pharmaceutical Sciences, Suresh Gyan Vihar University, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.9(6).2500-06

2500-2506

3883

1420

52.

COMPARATIVE STUDY OF HEPATOPROTECTIVE EFFECT PRODUCED BY CUMINUM CYMINUM AND NIGELLA SATIVA AGAINST CISPLATIN-INDUCED HEPATOTOXICITY; WITH HISTOPATHOLOGICAL STUDIES

Cisplatin is a cytotoxic drug which induced the hepatotoxicity in the albino mice when intra-peritoneally administered at the dose of 10 mg/kg. Administration of cisplatin raised the level of LFT’s enzymes and also reduced the level of antioxidant enzymes in the liver of the mice. Administration of Cuminum cyminum and Nigella sativa extract and silymarin remarkably showed the hepatoprotective ef...

N. Abbas*, L. Alyousef, E. M. E. Agabien, E. S. Ahmed, A. S. Ahmed and A. Begum

Department of Medicinal Chemistry, Qassim University, Qassim, KSA.

DOI: 10.13040/IJPSR.0975-8232.9(1).393-01

393-401

3882

1487