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DESIGN OF EXPERIMENT IN THE BIO-ANALYTICAL DETERMINATION OF QUETIAPINE FUMARATE IN HUMAN PLASMA BY A RP-HPLC METHOD
A new, simple, sensitive, accurate and precise RP-HPLC method was developed for the estimation of quetiapine fumarate in human plasma. Full factorial design was used for the optimization of an extraction method. The main effect of volume of deproteinating agent, speed of centrifugation, time of centrifugation and temperature of centrifugation was found to be significant at P<0.0001 on all the r...
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FORMULATION AND EVALUATION OF PROGRAMMED RELEASE OCULAR INSERTS OF MIZOLASTINE
The main objective of this study was to prepare controlled release matrix type ocular inserts of mizolastine for the treatment of seasonal allergic conjunctivitis.The films were prepared by solvent casting technique using Eudragit RL100 and RS100 in different ratios with dibutylphthalate as the plasticizer. The films were evaluated for the physicochemical parameters. In-vitro studies were carried ...
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ANTI- CONVULSANT PROFILE OF AQUEOUS EXTRACT OF SAPINDUS LAURIFOLIA IN EXPERIMENTAL ANIMALS
Objective: The aim of the present study was to evaluatethe anti convulsant property of aqueous extract of Sapindus laurifolia in Pentylenetetrazole (PTZ) and MES induced convulsions in experimental models. Materials & Methods: The purpose of this study is to explore the anticonvulsant activity of ethanolic extract of Momordica tuberosa using Pentylenetetrazole and maximal electric shock induce...
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ANTIPYRETIC ACTIVITY OF AQUEOUS AND ALCOHOLIC EXTRACTS OF NONI ON YEAST INDUCED PYREXIA IN RATS
Numerous herbal agents have been claimed to having antipyretic property. One up-coming botanical fruit of Morinda citrifolia, whose Polynesian name is Noni, is unique in view of the large number of medical indications that characterize claims for its efficacy. Researchers at an independent research facility found that Noni was a selective inhibitor of COX-2 enzyme. The analgesic efficacy of the No...
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IN-VITRO ASSESSMENT, ISOLATION AND SPECTRAL ANALYSIS OF THE CHLOROFORM FRACTION OF DIOSPYROS KAKI FRUIT
Persimmon (Diospyros kaki Linn.), which belongs to the Ebenaceae family, have numerous bioactive compounds such as polyphenols, dietary fiber, carotenoids and minerals. This fruit possesses hypolipidemic and antioxidant properties and can be used in anti-atherosclerosis diets. The present paper reveals the phytochemical screening, Antioxidant, Anti-inflammatory activity and GC-MS Spectral analysis...
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ATTENUATION OF HYPERGLYCEMIA AND OXIDATIVE STRESS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS BY AQUEOUS EXTRACT OF AVERRHOA BILIMBI LINN FRUITS
In the present study, the antidiabetic and antioxidant effect of aqueous extract of Averrhoa bilimbi Linn (ABAE) fruits were evaluated. Diabetes mellitus was induced in male Sprague Dawley rats by a single intraperitoneal injection of streptozotocin (40 mg/kg body weight). Oral administration of aqueous extract of Averrhoa bilimbi Linn (ABAE) (50mg/kg body weight) and metformin (100 mg/kg body wei...
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NOVEL NUCLEAR RECEPTOR SUPER FAMILY DATABASE
The objective of the project is to develop a comprehensive database of Nuclear Receptor (NR) Superfamily-Ligand. Nuclear Receptor Superfamily represents one of the most important families of drug targets in pharmaceutical development. Nuclear Receptor) Superfamily-Ligand is a novel public NR-related chemical genomic database that is primarily focused on the correlation of information between NRs a...
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NON-TARGETED ANALYSIS AND CYTOTOXIC ACTIVITY OF HAMELIA PATENS JACQ.
In the present study we have done non-targeted analysis of extract from Hamelia patens Jacq. by GC/MS and estimated the inhibitory concentration (IC50) of the extract in three human tumor cell lines MCF-7, H-460 and SF-268. Hamelia patens is an herbaceous perennial plant of family Rubiaceae. Parts of the plant are used in Peruvian and Mexican folk-medicine. Dried leaves of Hamelia patens were extr...
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DEVELOPMENT OF A POLYHERBAL CAPSULE FOR THE TREATMENT OF HYPERLIPIDAEMIA
Hyperlipidaemia is mentioned as one of the life-style-related diseases as much as so for diabetes. In the present study an attempt was made to develop herbal capsules, which are containing the extract of Murraya koenigii and Achyranthus aspera. One of the major concerns in designing new formulation is that the active ingredient should be compatible with all the excipients and packaging material co...
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COMPARATIVE STUDY OF HEPATOPROTECTIVE EFFECT PRODUCED BY CUMINUM CYMINUM AND NIGELLA SATIVA AGAINST CISPLATIN-INDUCED HEPATOTOXICITY; WITH HISTOPATHOLOGICAL STUDIES
Cisplatin is a cytotoxic drug which induced the hepatotoxicity in the albino mice when intra-peritoneally administered at the dose of 10 mg/kg. Administration of cisplatin raised the level of LFT’s enzymes and also reduced the level of antioxidant enzymes in the liver of the mice. Administration of Cuminum cyminum and Nigella sativa extract and silymarin remarkably showed the hepatoprotective ef...
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