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RIFAMPICIN AND ISONIAZID MICROCAPSULES FOR TREATMENT OF TUBERCULOSIS
Rifampicin and Isoniazid microcapsules were prepared by phase seperation coacervation method for inclusion in suspension formulations. Ethyl cellulose was used as the coating material for microencapsulation. Developed microcapsules were characterized for visual appearance, photomicrography, sieve analysis, drug content, bulk density, ethyl cellulose content and drug release studies. Microcapsules ...
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RP-HPLC METHOD FOR THE DETERMINATION OF 5-FLUROURACIL IN PHARMACEUTICAL FORMULATIONS AND SPIKED HUMAN PLASMA
A simple, rapid and accurate reverse phase high-performance liquid chromatographic method for the determination of 5-Flurouracil (5-FU) in pharmaceutical formulations and human plasma samples has been developed and validated. The assay of the drug was performed on a CLC C18 (5 μm, 25 cm 4.6 mm i.d.) with UV detection at 266 nm. The mobile phase consisted of methanol-water mixture in the ratio...
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ALLEVIATION OF ARSENIC INDUCED LUNG TOXICITY BY OCIMUM SANCTUM IN MURINE MODEL
Arsenic is a well known pulmonary irritant and has been found associated with lung cancer in smelter workers exposed to arsenic via inhalation. The recent findings suggest the involvement of reactive oxygen species (ROS), generated during arsenic metabolism in inducing arsenic toxicity. Thus present work was designed to establish a correlation between arsenic induced oxidative stress, histopatholo...
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NEW INSIGHTS INTO LATENT TUBERCULOSIS: A PERSISTING GLOBAL HEALTH CHALLENGE
After more than a century, tuberculosis (TB) is still a formidable public health challenge as it contributes considerably to illness and death worldwide, irrespective of continuous advancement in technology and in depth understanding of molecular biology concepts. Mycobacterium tuberculosis persist for longer period in human and animal host in latent state without causing active disease and may re...
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EVALUATION OF ANTIADIPOGENESIS ACTIVITIES OF SELECTED SPECIES OF CARALLUMA R. BR., BOUCEROSIA WIGHT & ARN. AND PREGNANE STEROID ON CELL LINES.
Back ground: The study was designed to determine antiadipogenesis properties of crude methanolic extracts from four species of Caralluma R.Br. such as Caralluma adscendens (Roxb.) R. Brown var. attenuata (Wight) Grav. & Mayur. (CAA), Caralluma adscendens (Roxb.) R. Brown var. fimbriata (Wall.) Gravely & Mayur. (CAF), Caralluma stalagmifera C.E.C. Fisch. (CS) and Caralluma stalagmifera C.E....
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CHEMICALLY FABRICATED SILVER NANOPARTICLES ENHANCES THE ACTIVITY OF ANTIBIOTICS AGAINST SELECTED HUMAN BACTERIAL PATHOGENS
Due to the outbreak of infectious diseases caused by different pathogenic bacteria and the development of antibiotic resistance, the pharmaceutical companies and the researchers are now searching for new unconventional antibacterial agents. Nanotechnology represents a modern and innovative approach to develop new formulations based on metallic nanoparticles with antimicrobial properties. The pot...
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PARKINSONISM: A GENERAL MOTOR DISABILITY
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders in the population above 60 years of age. The movement abnormalities in PD are credited due to an imbalance between the acetylcholine and dopamine which results in uncontrolled movements. It is characterized using resting tremor, postural impairment, bradykinesia, and rigidity. The degeneration of midbrain dopaminergic...
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SEASONAL COMPARATIVE STUDY OF KANOI PAPER MILL EFFLUENT IN REFERENCE OF PHYSICO-CHEMICAL AND HEAVY METALS
In order to ascertain the degree of various pollutants in Kanoi Paper mill effluent of Bilaspur district (C.G.) India. We have taken minor research project. For attained to this purpose, we have selected eight sampling sites; Four SW and four GW sources. Collected samples (Premonsoon, Monsoon and Postmonsoon 2012) were analyzed for physico-chemical special chloride and phenolic compounds and heavy...
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STRUCTURAL DYNAMICS OF LACTOBACILLUS RHAMNOSUS PROTEINS UNDER COPPER SULPHATE AND ZINC CHLORIDE STRESS
Lactobacillus rhamnosus plays an important role as probiotic often associated with beneficial health effects. Although copper and zinc are trace metals, they are toxic at high concentrations. In this paper, bioinformatic tools and molecular modeling approach was adopted to explore the structure of L. rhamnosus under copper sulfate and zinc chloride stress. The differentially expressed proteins un...
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ANTIDIARRHOEAL ACTIVITY, NITRIC OXIDE SCAVENGING AND TOTAL TANNIN CONTENT FROM THE BARK OF CERIOPS DECANDRA (GRIFF.) DING HOU
The present study was designed to investigate the antidiarrhoeal, nitric oxide scavenging and total tannin content from the ethanolic extract of the bark of Ceriops decandra (Griff.) Ding Hou (Family: Rhizophoraceae). The ethanol extract at graded doses (200 & 400 mg/kg body weight) was investigated for antidiarrhoeal activity in term of reduction in the rate of defecation and consistency of f...
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