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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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2.

EXPERIMENTAL MODELS FOR ALZHEIMER’S DISEASE: A MECHANISTIC VIEW

Alzheimer’s disease (AD) is a leading cause of morbidity and mortality and its prevalence is continuously increasing. AD is characterized to varying degrees by Amyloid β, neurofibrillary tangles, gliosis, synaptic and neuronal loss leading to a decline in memory & apraxia agnosia and several neuropsychiatric changes like anxiety and depression etc. Increased age, oxidative stress and neuroi...

Vivek Kumar Sharma

Department of Pharmacology, Govt. College of Pharmacy, Rohru, Shimla, Himachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8).13-22

13-22

3922

1922

58.

EFFECT OF EUGENOL EMULSION ON SHELF LIFE OF GRAPES AND STRAWBERRY

In present study, eugenol (major functional component of essential oil of Syzygium aromaticum (clove), at 2% level (v/v) was incorporated in peanut oil based coating to get antimicrobial emulsion. Eugenol emulsion thus prepared was applied on grapes and strawberries. After applying emulsion, reference fruits were kept in corrugated fiber boxes for 8 days for shelf life studies under ambient condit...

Mamta Bhatia* and Alka Sharma

Department of Food Technology, Guru Jambheshwar University of Science and Technology, Hisar-125 001, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2280-82

2280-2282

3922

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49.

COMPARISON OF INCIDENCE, RISK FACTORS, OUTCOME AND ANTIFUNGAL SUSCEPTIBILITY BETWEEN CANDIDA ALBICANS AND NON-ALBICANS CANDIDA SPECIES IN PATIENTS OF CANDIDEMIA IN INTENSIVE CARE SETTING

Candidemia is associated with a high mortality. The most common cause of candidemia is Candida albicans, though infections by non-albicans Candida are being increasingly reported. The present study was conducted to determine the incidence of candidemia, the risk factors and antifungal susceptibility in intensive care unit (ICU). This study was conducted from January 2012 to June 2013 and prospecti...

N.Tejan*, N. Singla, V. Guglani, S. Gombar and J. Chander

Department of Microbiology, SGPGIMS, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(11).4891-98

4891-4898

3922

1478

60.

INCIDENCE AND PATTERN OF ADVERSE DRUG REACTIONS (ADRs) IN PATIENTS TREATED FOR TUBERCULOSIS UNDER DOTS AT A TERTIARY CARE HOSPITAL OF NORTHERN INDIA

Background: WHO statistics for 2015 give an estimated incidence figure of 2.2 million cases of TB for India out of a global incidence of 9 million thus making India accountable for almost one-third of the global TB burden. The first-line antitubercular drugs include H (Isoniazid), R (Rifampicin), Z (Pyrazinamide), E (Ethambutol) and S (Streptomycin). The treatment of tuberculosis being of longer d...

S. Tutu *, S. Kant, A. K. Verma, A. K. Sachan, R. Nath, N. Kumar, A. Singh and R. K. Dixit

Department of Pharmacology and Therapeutics, King George’s Medical University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(11).4950-55

4950-4955

3922

1598

4.

PTEN-A REVIEW

PTEN (phosphatase and tension homolog deleted on chromosome 10) is an important key factor in regulating intracellular for cell growth and proliferation by blocking the phosphatidylinositol -3kinase/ AKT protein kinase B (PI3K/Akt) pathway alteration in PTEN is concomitant with many diseases. PTEN is recurrently mutated in several pathological diseases which indicate its significance in general ph...

M. Mayuri and G. V. N. Kumar *

Department of Pharmacology, Drug Standardization Unit, Dr. D. P. Rastogi Central Research Institute for Homeopathy, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(1).35-40

35-40

3922

1306

6.

PERMEATION ENHANCERS COMPATIBLE WITH TRANSDERMAL DRUG DELIVERY SYSTEMS OVERCOMING THE SKIN BARRIER FUNCTIONS: CURRENT AND FUTURE PROSPECTS

Transdermal drug delivery system (TDDS) provides a leading edge over injectables and oral routes by increasing patient compliance and avoiding the first-pass metabolism respectively. Transdermal delivery not only provides controlled, constant administration of the drug, but also allows continuous input of drugs with short biological half-lives and eliminates pulsed entry into the systemic circulat...

A. D. Paul, C. Prasanthi *, N. Sumiya, P. V. Prasad and J. V. Kumar

SVU College of Pharmaceutical Sciences, SV University, Tirupathi, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2143-55

2143-2155

3921

1704

14.

PREPARATION, CHARACTERIZATION AND EVALUATION OF ANTIFUNGAL ACTIVITY OF CLOTRIMAZOLE NANOSTRUCTURED LIPID CARRIERS

Objectives: The aim of this work was the preparation of Clotrimazole (CM) loaded nanostructured lipid carriers (CM-NLC) and the examination of in-vitro antifungal activity of prepared formula. Methods: High shear hot homogenization method was used for CM-NLC preparation. Different ratios of Compritol AT 888 and Labrasol were used and combined with two types of surfactants: Kolliphor P188 or Kollip...

A. Gardouh, H. Abou-Taleb * and S. Solyman

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef, Egypt.

DOI: 10.13040/IJPSR.0975-8232.10(12).5362-69

5362-5369

3921

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22.

VALIDATION FOR QUANTITATIVE DETERMINATION OF AZTREONAM IN SIMULATED LUNG FLUID BY UV SPECTROSCOPY METHOD

Aztreonam, a synthetic beta-lactam antibiotic is widely used for the treatment of infections in lungs, meninges, bladder, etc. Its potential use in the treatment of pneumonia and cystic fibrosis has been established. Recently FDA has approved Cayston® for inhalation therapy of Aztreonam in lungs infection. Many studies have been reported on the quantitative determination of Aztreonam by UV spectr...

S. Bhattacharyya* and B. S. Sogali

Department of Pharmaceutics, Krupanidhi College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(1).222-26

222-226

3920

1523

14.

PHARMACOGNOSTICAL EVALUATION AND ANTHELMENTIC ACTIVITY OF SWERTIA ALATA ROYLE

Objective: In the present investigation, pharmacognostical, physicochemical characteristics, thin layer chromatography and anthelmintic activity of different extracts of Swertia alata Royle were studied. Methods: Different types of preliminary and phytochemical analysis and quantitative estimation have been done along with HPTLC fingerprinting. Two concentrations (30 mg/mL and 60 mg/mL) of differe...

S. Bajaj* and S. Wakode

Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, Pusph Vihar, Sector III, Mehrauli - Badarpur Road, New Delhi, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3315-24

3315-3324

3919

1489

50.

PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIOXIDANT ACTIVITY OF EVOLVULUS ALSINOIDES EXTRACTS

Free radicals are atoms or groups of atoms with an unpaired number of electrons and can be formed when oxygen interacts with certain molecules. Once formed these highly reactive radicals can start a chain reaction, like dominoes. These free radicals become more lethal when they react with important cellular components such as DNA, or the cell membrane. Cells may function poorly or die if this occu...

M. K. Yadav *, S. K. Singh, J. S. Tripathi and Y. B. Tripathi

Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1247-50

1247-1250

3919

1441