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INCIDENCE AND PATTERN OF ADVERSE DRUG REACTIONS (ADRs) IN PATIENTS TREATED FOR TUBERCULOSIS UNDER DOTS AT A TERTIARY CARE HOSPITAL OF NORTHERN INDIA
Background: WHO statistics for 2015 give an estimated incidence figure of 2.2 million cases of TB for India out of a global incidence of 9 million thus making India accountable for almost one-third of the global TB burden. The first-line antitubercular drugs include H (Isoniazid), R (Rifampicin), Z (Pyrazinamide), E (Ethambutol) and S (Streptomycin). The treatment of tuberculosis being of longer d...
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PREPARATION, CHARACTERIZATION AND EVALUATION OF ANTIFUNGAL ACTIVITY OF CLOTRIMAZOLE NANOSTRUCTURED LIPID CARRIERS
Objectives: The aim of this work was the preparation of Clotrimazole (CM) loaded nanostructured lipid carriers (CM-NLC) and the examination of in-vitro antifungal activity of prepared formula. Methods: High shear hot homogenization method was used for CM-NLC preparation. Different ratios of Compritol AT 888 and Labrasol were used and combined with two types of surfactants: Kolliphor P188 or Kollip...
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NOVEL METHOD FOR SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN HYDROCHLORIDE AND OFLOXACIN BY REVERSE PHASE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (RP-HPLC)
A novel method was developed for the determination of fluoroquinolones such as ciprofloxacin hydrochloride (CPL) and ofloxacin (OFX) by isocratic reverse phase-high performance liquid chromatography (RP-HPLC) coupled with UV detection. The developed method was rapid, accurate, reproducible, economical and sensitive for the simultaneous estimation of ciprofloxacin hydrochloride and ofloxacin. Fluor...
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HEPATOPROTECTIVE POTENTIAL OF AQUEOUS AND ETHANOLIC STEM-BARK EXTRACTS OF PONGAMIA PINNATA AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN RATS
Introduction: Pongamia pinnata is commonly known as karanja. In Ayurvedic and Unani system of medicine, it has been used as anti-inflammatory, antiplasmodial, anti-nociceptive, anti-hyperglycaemic, anti-lipid oxidative, anti-diarrheal, anti-ulcer, anti-hyperammonemic, antioxidant, etc. Moreover, it has been used traditionally in the treatment of liver disorders. However, there are no scientific ba...
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PHARMACOGNOSTICAL EVALUATION AND ANTHELMENTIC ACTIVITY OF SWERTIA ALATA ROYLE
Objective: In the present investigation, pharmacognostical, physicochemical characteristics, thin layer chromatography and anthelmintic activity of different extracts of Swertia alata Royle were studied. Methods: Different types of preliminary and phytochemical analysis and quantitative estimation have been done along with HPTLC fingerprinting. Two concentrations (30 mg/mL and 60 mg/mL) of differe...
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COMPARISON OF INCIDENCE, RISK FACTORS, OUTCOME AND ANTIFUNGAL SUSCEPTIBILITY BETWEEN CANDIDA ALBICANS AND NON-ALBICANS CANDIDA SPECIES IN PATIENTS OF CANDIDEMIA IN INTENSIVE CARE SETTING
Candidemia is associated with a high mortality. The most common cause of candidemia is Candida albicans, though infections by non-albicans Candida are being increasingly reported. The present study was conducted to determine the incidence of candidemia, the risk factors and antifungal susceptibility in intensive care unit (ICU). This study was conducted from January 2012 to June 2013 and prospecti...
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PERMEATION ENHANCERS COMPATIBLE WITH TRANSDERMAL DRUG DELIVERY SYSTEMS OVERCOMING THE SKIN BARRIER FUNCTIONS: CURRENT AND FUTURE PROSPECTS
Transdermal drug delivery system (TDDS) provides a leading edge over injectables and oral routes by increasing patient compliance and avoiding the first-pass metabolism respectively. Transdermal delivery not only provides controlled, constant administration of the drug, but also allows continuous input of drugs with short biological half-lives and eliminates pulsed entry into the systemic circulat...
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PTEN-A REVIEW
PTEN (phosphatase and tension homolog deleted on chromosome 10) is an important key factor in regulating intracellular for cell growth and proliferation by blocking the phosphatidylinositol -3kinase/ AKT protein kinase B (PI3K/Akt) pathway alteration in PTEN is concomitant with many diseases. PTEN is recurrently mutated in several pathological diseases which indicate its significance in general ph...
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EXPLORING THE MEDICINAL PROPERTIES, THERAPEUTIC USES, AND ECO-FRIENDLY WATER FILTRATION POTENTIAL OF TULSI (HOLY BASIL): A COMPREHENSIVE REVIEW
In this comprehensive review, the medicinal properties of Tulsi are thoroughly explored, highlighting its esteemed therapeutic uses that are widely regarded as safe, cost-effective and efficacious owing to its abundant availability. Tulsi a member of the genus Ocimum and a revered medicinal plant native to India has garnered significant recognition and reverence for its profound healing capabiliti...
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PREVALENCE OF ANEMIA AND ITS ASSOCIATED FACTORS AMONG PREGNANT WOMEN ATTENDING ANTENATAL CENTER IN SHARJAH, UAE
Anemia during pregnancy is a common complication which can involve a mother’s health, baby’s health, or both. Socioeconomic status is affecting the prevalence of maternal anemia, which is varied substantially across regions and countries. Although, the prevalence of maternal anemia in UAE has not yet been well documented nationwide. Therefore, knowledge of the prevalence and determinants of lo...
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