Most Popular
EXPERIMENTAL MODELS FOR ALZHEIMER’S DISEASE: A MECHANISTIC VIEW
Alzheimer’s disease (AD) is a leading cause of morbidity and mortality and its prevalence is continuously increasing. AD is characterized to varying degrees by Amyloid β, neurofibrillary tangles, gliosis, synaptic and neuronal loss leading to a decline in memory & apraxia agnosia and several neuropsychiatric changes like anxiety and depression etc. Increased age, oxidative stress and neuroi...
3922
1922
EFFECT OF EUGENOL EMULSION ON SHELF LIFE OF GRAPES AND STRAWBERRY
In present study, eugenol (major functional component of essential oil of Syzygium aromaticum (clove), at 2% level (v/v) was incorporated in peanut oil based coating to get antimicrobial emulsion. Eugenol emulsion thus prepared was applied on grapes and strawberries. After applying emulsion, reference fruits were kept in corrugated fiber boxes for 8 days for shelf life studies under ambient condit...
3922
1480
COMPARISON OF INCIDENCE, RISK FACTORS, OUTCOME AND ANTIFUNGAL SUSCEPTIBILITY BETWEEN CANDIDA ALBICANS AND NON-ALBICANS CANDIDA SPECIES IN PATIENTS OF CANDIDEMIA IN INTENSIVE CARE SETTING
Candidemia is associated with a high mortality. The most common cause of candidemia is Candida albicans, though infections by non-albicans Candida are being increasingly reported. The present study was conducted to determine the incidence of candidemia, the risk factors and antifungal susceptibility in intensive care unit (ICU). This study was conducted from January 2012 to June 2013 and prospecti...
3922
1478
INCIDENCE AND PATTERN OF ADVERSE DRUG REACTIONS (ADRs) IN PATIENTS TREATED FOR TUBERCULOSIS UNDER DOTS AT A TERTIARY CARE HOSPITAL OF NORTHERN INDIA
Background: WHO statistics for 2015 give an estimated incidence figure of 2.2 million cases of TB for India out of a global incidence of 9 million thus making India accountable for almost one-third of the global TB burden. The first-line antitubercular drugs include H (Isoniazid), R (Rifampicin), Z (Pyrazinamide), E (Ethambutol) and S (Streptomycin). The treatment of tuberculosis being of longer d...
3922
1598
PTEN-A REVIEW
PTEN (phosphatase and tension homolog deleted on chromosome 10) is an important key factor in regulating intracellular for cell growth and proliferation by blocking the phosphatidylinositol -3kinase/ AKT protein kinase B (PI3K/Akt) pathway alteration in PTEN is concomitant with many diseases. PTEN is recurrently mutated in several pathological diseases which indicate its significance in general ph...
3922
1306
PERMEATION ENHANCERS COMPATIBLE WITH TRANSDERMAL DRUG DELIVERY SYSTEMS OVERCOMING THE SKIN BARRIER FUNCTIONS: CURRENT AND FUTURE PROSPECTS
Transdermal drug delivery system (TDDS) provides a leading edge over injectables and oral routes by increasing patient compliance and avoiding the first-pass metabolism respectively. Transdermal delivery not only provides controlled, constant administration of the drug, but also allows continuous input of drugs with short biological half-lives and eliminates pulsed entry into the systemic circulat...
3921
1704
PREPARATION, CHARACTERIZATION AND EVALUATION OF ANTIFUNGAL ACTIVITY OF CLOTRIMAZOLE NANOSTRUCTURED LIPID CARRIERS
Objectives: The aim of this work was the preparation of Clotrimazole (CM) loaded nanostructured lipid carriers (CM-NLC) and the examination of in-vitro antifungal activity of prepared formula. Methods: High shear hot homogenization method was used for CM-NLC preparation. Different ratios of Compritol AT 888 and Labrasol were used and combined with two types of surfactants: Kolliphor P188 or Kollip...
3921
1744
VALIDATION FOR QUANTITATIVE DETERMINATION OF AZTREONAM IN SIMULATED LUNG FLUID BY UV SPECTROSCOPY METHOD
Aztreonam, a synthetic beta-lactam antibiotic is widely used for the treatment of infections in lungs, meninges, bladder, etc. Its potential use in the treatment of pneumonia and cystic fibrosis has been established. Recently FDA has approved Cayston® for inhalation therapy of Aztreonam in lungs infection. Many studies have been reported on the quantitative determination of Aztreonam by UV spectr...
3920
1523
PHARMACOGNOSTICAL EVALUATION AND ANTHELMENTIC ACTIVITY OF SWERTIA ALATA ROYLE
Objective: In the present investigation, pharmacognostical, physicochemical characteristics, thin layer chromatography and anthelmintic activity of different extracts of Swertia alata Royle were studied. Methods: Different types of preliminary and phytochemical analysis and quantitative estimation have been done along with HPTLC fingerprinting. Two concentrations (30 mg/mL and 60 mg/mL) of differe...
3919
1489
PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIOXIDANT ACTIVITY OF EVOLVULUS ALSINOIDES EXTRACTS
Free radicals are atoms or groups of atoms with an unpaired number of electrons and can be formed when oxygen interacts with certain molecules. Once formed these highly reactive radicals can start a chain reaction, like dominoes. These free radicals become more lethal when they react with important cellular components such as DNA, or the cell membrane. Cells may function poorly or die if this occu...
3919
1441