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VALIDATION FOR QUANTITATIVE DETERMINATION OF AZTREONAM IN SIMULATED LUNG FLUID BY UV SPECTROSCOPY METHOD
Aztreonam, a synthetic beta-lactam antibiotic is widely used for the treatment of infections in lungs, meninges, bladder, etc. Its potential use in the treatment of pneumonia and cystic fibrosis has been established. Recently FDA has approved Cayston® for inhalation therapy of Aztreonam in lungs infection. Many studies have been reported on the quantitative determination of Aztreonam by UV spectr...
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META-ANALYSIS OF HERBAL CURE FOR PITYRIASIS VERSICOLOR: A CASE REPORT
Background: Pityriasis Versicolor (PV) is a cutaneous fungal infection of the skin revealed by changes in skin pigmentation due to colonization by a dimorphic lipophilic fungus of the skin, known as Malassezia furfur. There is an impact on the psychological status of patients resulting in anxiety or depression. This disease is predominant in warm and hot climates. Currently, no ideal drug of choic...
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BIOSORPTION OF As (III) BY ASPERGILLUS NIGER X300 USING COMPLEX NUTRIENT MEDIUM
An experimental study was carried out to select a suitable complex nutrient medium for growth and As(III) biosorption by an As(III) resistant strain Aspergillus niger X300 .For this purpose different complex nutrient were examined one by one. The recommended complex nutrients (gm%) were corn steep liquir, 20; rice bran extract, 10; paddy soak liquir, 10; wheat bran extract, 15 beef extract, 30, me...
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FORMULATION DEVELOPMENT AND EVALUATION OF MUCOADHESIVE MICRO-SPHERES OF SALBUTAMOL SULPHATE BY USING A NATURAL POLYMER
Salbutamol sulphate (SS) loaded microspheres were prepared by solvent evaporation method with combination of Sterculia foetida gum in various proportions. A total of eighteen formulations were prepared in different oil phases i.e., liquid paraffin and sunflower oil. Those prepared from liquid paraffin L1-L9 and those...
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COMPARATIVE STUDY OF PHENOLICS AND ANTIOXIDANT ACTIVITY OF PHYTOCHEMICALS OF T.CHEBULA EXTRACTED USING MICROWAVE AND ULTRASONICATION
The extraction of active compounds from plants is one of the most critical steps in the commercial development of natural products for medicinal and health benefits. In view of the large number of plant species potentially available for study, it is essential to have efficient systems for the rapid and efficient extraction of phytochemicals for further investigation on their properties. The presen...
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PHYSICAL, CHEMICAL AND PHYSICO-CHEMICAL CONTROL OF HELIOTROPIUM INDICUM LINN., BORAGINACEAE, POWDER AND TINCTURE
The quality control of herbal drugs and their extracts is essential when they are used as raw material for the development of herbal medicines. In this work, several techniques (pharmacopoeial and non-pharmacopoeial) were performed, aiming at establishing quality control parameters of the leaves of Heliotropium indicum L. (Boraginaceae), a shrub popularly known as stinker (fedegoso) in Brazilian n...
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GC MS ANALYSIS AND ANTIMICROBIAL ACTIVITY OF SEED OIL OF BROUSSONETIA PAPYRIFERA (L.) VENT
The current study focuses on evaluating chemical composition and antimicrobial activity of seed oil of Broussonetia papyrifera; a widely used Chinese medicinal plant. The chemical constituents of the oil were evaluated by GC‑MS analysis. Antimicrobial activity and minimum inhibitory concentrations were determined by disk diffusion and agar dilution methods. The seed oil contains 46 different p...
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ANTI-ULCER EFFECT ON THE ETHANOL EXTRACT OF THE BARK & ROOT OF FICUS RELIGOISA LINN. IN DIFFERENT EXPERIMENTAL ULCER MODELS IN RATS
Ficus religiosa L (Moraceae) is widely distributed in northern part of India has traditionally been used in India as medicinal plant for the treatment of diarrhoea and dysentery. In the present study ethanolic extract of Ficus religiosa L was used for investigation of antiulcer activity by using pylorus ligation as antisecretory model and ethanol induced ulceration models as cytoprotective model. ...
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SUBTRACTIVE GENOMICS APPROACH FOR IN SILICO IDENTIFICATION OF NOVEL DRUG TARGETS AND EPITOPES FOR VACCINE DESIGN IN TREPONEMA PALLIDUM SUBSP. PALLIDUM STR. NICHOLS
In silico differential genomics helps to identify genes that encode for unique metabolism with relation to human. The genomic database provides a vast amount of useful information for the drug target identification. The subtractive dataset obtained comparatively between the human and the pathogen genome, differentially provides information about the genes that are likely to be essential to the pat...
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DEVELOPMENT AND VALIDATION OF NEW RP-HPLC ASSAY METHOD FOR VALSARTAN IN PURE AND IN FORMULATIONS
An isocratic, reversed phase HPLC method was developed, using an Inertsil ODS C8 (100 x 4.6) mm,5u column and the mobile phase containing an homogenous mixture of buffer and acetonitrile (65:35,v/v). The flow rate of the mobile phase was maintained at 1.0ml/min and the detection was carried out at wavelength 250 nm. The developed method was validated with respect to linearity, accuracy (recovery),...
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