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ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF ORAL DECOCTION OF PTEROCARPUS SANTALINUS BARK WOOD POWDER IN ACUTE INFLAMMATION MODEL
Background: Raktachandan / Pterocarpus santalinus is mentioned to have edema reducing property in Ayurvedic literature. Studies have been performed using its methanolic extract for anti-inflammatory, analgesic and antioxidant activities. Since, Ayurveda advises to use it as a decoction, we planned to study the acute anti-inflammatory activity of decoction prepared from Pterocarpus santalinus bark-...
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VIRTUAL SCREENING OF NOVEL HIV-RT NNRT INHIBITORS USING ZINC DATABASE
Non-nucleoside reverse transcriptase inhibitors (NNRTI) are a group of small hydrophobic compounds with diverse structure that specifically inhibit HIV-1 reverse transcriptase (RT) by allosteric bind to change its conformation. NNRTIs interact with HIV-1 RT by binding to a single site on the p66 subunit of the p66/p51 heterodimeric enzyme, termed the NNRTI-binding pocket (NNRTI-BP), binding intera...
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IN VITRO ANTIMICROBIAL ACTIVITY NUTRITIONAL PROFILE OF MEDICINAL PLANT OF GARHWAL, HIMALAYA
The present study is aimed at evaluating the in vitro antibacterial and antifungal activities of petroleum ether, chloroform, ethyl acetate, acetone, methanol, ethanol and water extracts of medicinal plant, Pyrus pashia were tested against (different gram positive and gram negative) ten bacterial strains and three fungal strains using by disc diffusion method. The different fractions of bark, frui...
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BIOSURFACTANT MEDIATED SYNTHESIS OF SILVER NANOPARTICLES USING LACTOBACILLUS BREVIS (MTCC 4463) AND THEIR ANTIMICROBIAL STUDIES
Biosurfactants are surface active, amphiphilic biochemical compounds containing both hydrophobic and hydrophilic moieties produced by microorganisms. They are produced by a variety of microorganisms mainly fungi, bacteria, and yeasts on their cell surface or extracellularly secreted. Biosurfactant mediated synthesis of nanoparticles has now emerged as a green alternative for enhancing both nanopar...
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FORMULATION AND EVALUATION OF ORODISPERSIBLE DOSAGE FORMS INCORPORATING DRUG NANOPARTICLES CONTAINING CLOPIDOGREL BISULPHATE
Clopidogrel bisulphate (CB) is the rate of dissolution often controls a sparingly soluble orally administered drug and the rate of absorption. Reports suggest that the drug has poor water solubility which may be challenging for developing liquid dosage forms of Clopidogrel bisulphate. Hence in the present study, we sought to develop orodispersible nanoparticles to enhance the solubility by an anti...
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COMPARATIVE SYNTHESIS AND PHYSICOCHEMICAL CHARACTERIZATION OF SUBSTITUTED 2-METHYLQUINOLIN- 4(1H)-ONE BY VARIOUS CONVENTIONAL AND MICROWAVE METHODS
In the present work various conventional methods and microwave method for synthesis of substituted quinolone reported. Substituted anilines were taken as a starting material and reacted with ethyl acetoacetate in presence of catalytic amount of acid and cyclized by various cyclisation agents that give the title compounds which differ in its color intensity, reaction time as well in %yield. Based o...
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ANTI-ULCEROGENIC EFFECTS OF ARECA CATECHU L. IN SPRAGUE DAWLEY RATS
The aim of this study was to evaluate the anti-ulcerogenic activity of aqueous extract of Areca catechu L in ethanol induced ulcer model in Sprague Dawley Rats. For possible mechanism of anti-ulcerogenic potential, determination of ulcer index was done using the Merazzi-Uberti and Turba method. Also, analytical method was used to test the 10% homogenate preparation of mucosa of the glandular stoma...
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ANTIOXIDANT POTENTIAL FRACTIONATION FROM METHANOL EXTRACT OF AERIAL PARTS OF RUELLIA PROSTRATA POIR (ACANTHACEAE)
Aerial parts of Ruellia prostrata were subjected to extraction and further fractionation to obtain antioxidant rich fraction. Different concentrations of methanolic extract and its n-butanolic fraction were subjected to antioxidant assay by DPPH method, Nitric oxide scavenging activity and reducing power assay. The fractions showed dose dependent free radical scavenging property in all the models....
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STUDIES ON LINEARTY AND ASSAY USING RP-HPLC AND UV-VISIBLE SPECTROSCOPY FOR THE DRUGS OXCARBAZEPINE AND PIOGLITAZONE BEFORE AND AFTER EXPIRY PERIOD
The standard for stability and quality of drugs for approval of marketing, are assured by testing and systematic evaluation using different analytical techniques. The drugs are tested in pharma analytical lab involving analysts associated spectra, chromatogram etc , and the results are analyzed leading to fixation of expiry dates. Once the drug crosses its expiry period, its potency is lost and it...
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SUGGESTED VENOUS THROMBOEMBOLISM (VTE) RISK STRATIFICATION SHEET FOR ORTHOPEDIC SURGERIES
Background: Major orthopedic surgeries are divided into 3 major surgeries: total or partial hip replacement (TPHR), total knee replacement (TKR), and hip fracture surgeries (HFS), these surgeries are considered as high-risk surgeries for the development of venous thromboembolism (VTE) which includes deep vein thrombosis (DVT) and pulmonary embolism (PE). In general there are several factors that i...
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