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ROLE OF THE INCRETINS IN HYPOGLYCEMIC EFFECT OF PHLOGACANTHUS THYRSIFLORUS NEES IN CHEMICALLY INDUCED DIABETIC MICE
Objective: This study was aimed to evaluate the role of GLP-1, GIP in the hypoglycemic activity of Phlogacanthus thyrsiflorus Nees. Materials and Methods: We have evaluated the influence of Phlogacanthus thyrsiflorus Nees, a traditionally used antidiabetic medicinal plant on some metabolic parameters, glucose homeostasis, insulin production, glucagon like peptide 1 (GLP1) and gastric Inhibitory Po...
4037
2019
FLAVONOIDS OF BOERHAVIA DIFFUSA – GC-MS ANALYSIS AND INHIBITORY ACTIVITY AGAINST PATHOGENIC MICROBES
Boerhavia diffusa is a species of flowering plant in the four o'clock family, Boerhavia belongs to family Nyctaginaceae the plant holds the tremendous potential of medicinal value and has been traditionally used in various ailments like syphilis, leukoderma, blood disorders to name a few. The present study focuses on the GC-MS analysis of extracts of all the plant parts of B. diffusa which reveal...
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1882
SYNTHESIS AND SPECTRAL STUDIES OF Ni(II) COMPLEXES WITH 2-HEPTANONESEMICARBAZONE AND 2-HETANONETHIOSEMICABAZONE
Complexes of Nickel(II) with 2-heptanonesemicarbazone (hsc) and 2-heptanonethiosemicabazone (htc) have been synthesized and characterized by elemental analysis, molar conductance measurements, magnetic moments, mass, IR and electronic/spectral studies. Synthesized complexes were found to have a general composition of Ni(L)2X2 (where X=Cl-, 1/2SO42-, NO3-, ClO4-, NCS-, CH3COO- and L=hsc or htc). Mo...
4036
1723
LIPID PROFILE VARIABLES AND PREDICTION OF THE SEVERITY OF CORONARY ARTERY DISEASE IN TUNISIAN TYPE 2 DIABETIC PATIENTS
DM is characterized by insulin resistance and dyslipidemia, in particular, high levels of total cholesterol, triglycerides and LDL, and low levels of HDL-C, wich confer increased risk for CAD. Our study aimed to evaluate lipid profile in type 2 diabetic (T2DM) patients with coronary artery disease (CAD) in Tunisian population. Plasma levels of lipid profile variables were determined in 148 CAD pat...
4036
1453
EFFECTIVENESS OF ANTIBIOTICS IN INCREASING THE FUNCTIONAL CAPACITY AND REDUCING THE ECONOMIC BURDEN IN FEMALE URINARY TRACT INFECTION PATIENTS
Background: Urinary tract infection is a common medical problem for women throughout their lifetime. Recurrence after urinary tract infection (rUTI) is common in adult women. The majority of recurrences are believed to be reinfection from extra urinary sources such as rectum or vagina. The treatment of recurrent urinary tract infection also inflicts an economic burden on the patient’s life. Henc...
4035
1496
FORMULATION AND IN-VITRO EVALUATION OF ACECLOFENAC ORODISPERSIBLE TABLETS
The object of the study was to formulate and evaluate Aceclofenac orodispersible tablets (ODT) by wet granulation method using different super disintegrants in different concentrations. Orodispersible tablets produce rapid dissolution of drug and absorption thereby producing rapid onset of action. Five batches (AFD1, AFD2, AFD3, AFD4, AFD5) of Aceclofenac orodispersible tablets were prepared and c...
4034
1757
CURCUMIN CONSUMPTION AND COGNITIVE FUNCTION IN ELDERLY
Cognitive impairment in elderly is a growing public health concern, and is mainly caused by dementia of various etiologies. Hence, it is important to explore possible measures to mitigate the risk of dementia. Curcumin, active ingredient of turmeric (Curcuma longa) is used in curry and has shown protective effect on cognition. This study aims to explore the association between curcumin consumption...
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1642
FLAVONOIDS IMPACT ON PREVENTION AND TREATMENT OF OBESITY AND RELATED METABOLIC RISK FACTORS
Metabolic syndrome, the most prevailing health concern worldwide, and their incidences are increasing at a very high rate, resulting in enormous social costs. Obesity is a measure risk factor for non-communicable disease such as cardiovascular diseases, diabetes, cancer, and inflammation-based diseases. Therapeutic strategies for managing this syndrome include synthetic drugs and surgery, which en...
4034
1951
INCREASED PROPERTIES AND CITOCOMPATIBILITY OF ZINC OXIDE-MAGNESIUM CEMENT
Zinc oxide-magnesium has been used in dentistry with limitations especially related to its high acidity and low biocompatibility. The objective of this study was to develop cement based on nano-hydroxyapatite (nHA), chitosan as more biocompatibility agents to increase zinc oxide-magnesium cito-compatibility. The formulations prepared were: 1. Complete cement (HCP) with nHA, zinc oxide-magnesium, a...
4034
1586
STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF PROCESS IMPURITIES AND DEGRADATION PRODUCTS OF LEVOLEUCOVORIN CALCIUM FOR INJECTION
Levoleucovorin calcium contains amide and aldehyde groups which makes it vulnerable to degradation. Stability indicating method for determination of all seven process-related impurities and degradation impurities in Fusilev® 50 mg/mL injection was developed with the help of RP-HPLC. A Forced degradation study supports method development to ensure stability indicating conditions. Solutions of the ...
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3283