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ANTIBACTERIAL ACTIVITIES AND BRINE SHRIMP LETHALITY BIOASSAY OF THE CHLOROFORM EXTRACT OF STEM BARK OF CRATAEVA NURVALA BUCH HAM
Antibacterial and cytotoxic activities of the chloroform extract of the stem bark of Crataeva nurvala (Bengali name- Borun; Family- Capparidaceae) were studied. Antibacterial activity was determined against two Gram positive (Bacillus cereus, Bacillus megaterium,) and four Gram negative (Escherichia coli, Shigella dysenteriae, Shigella sonnei, Shigella boydii) human pathogenic bacteria by disc d...
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DEVELOPMENT AND EVALUATION OF MELT- IN- MOUTH TABLETS BY SUBLIMATION TECHNIQUE
In the present study Rizatriptan benzoate, which is the bitter drug requires taste, masking. β- Cyclodextrin is used in taste masking, which improves the patient compliance and also increases the rate of dissolution. Solid dispersion of drug and β- Cyclodextrin were prepared which was optimised in 1: 8 ratios, which gave satisfactory results for taste masking. This was then characterised using D...
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SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTICANCER EVALUATION OF BIS-[1,5]-BENZOTHIAZEPINES AGAINST HUMAN BREAST CANCER CELL LINE MCF-7
Bis-[1,5]-benzothiazepines (3a-i) containing two 1,5-benzothiazepine nuclei in a single molecule were synthesized by cyclocondensation reaction of bis-chalcones (1a-i) with two equivalent of 2-aminobenzenethiol (2). All the synthesized compounds were characterized by IR, 1H NMR,13C NMR and mass spectral analysis. Anticancer activity of the synthesized compounds against human breast cancer cell lin...
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COMPARATIVE ANTIBACTERIAL STUDY OF DIFFERENT EXTRACT OF CLAVERIA ROSEA FRIES AGAINST GRAM NEGATIVE AND GRAM POSITIVE PATHOGENS
Objective: To compare the antibacterial activity of different solvent extract of Clavaria rosea. Method: Different solvent extract of Claveria rosea was prepared. Standard cultures of Escherichia coli (MTCC-1698), Klebsiella pneumoniae (MTCC-7028), Pseudomonas aeuroginosa (MTCC-1934), Salmonella typhi (MTCC-733), Xanthomonas campestris (MTCC-2286), Pseudomonas syringae (MTCC-1604) and Agrobacte...
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PROTECTIVE ACTIVITY OF SEMECARPUS ANACARDIUM FRUIT EXTRACTS AGAINST PARACETAMOL INDUCED HEPATIC DAMAGE IN WISTAR RATS
The objective of the present investigation of hepatoprotective activity of various Fruit extract of Semecarpus anacardium in paracetamol induced liver damage model in Wistar rats. Liver damage was produced by paracetamol (2gm/kg, p. o.) in 1% CMC. The Plant extracts (200mg/kg, p. o.) were administered every 24 hrs for seven days, while standard group received N-acetyl l- cysteine. At the end of th...
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AGGREGATES OF ALTERNATE AMPHIPHILC POLYANION TO CARRY ZWITTERIONIC DRUG IN AQUEOUS MEDIA
The effect of amphiphilic polyanion Poly(maleic acid-alt-octadecene)sodium salt on solubility of a zwitterionic drug (ampicillin trihydrate) in aqueous media was evaluated. This polymeric salt was obtained by an equimolar reaction of parent copolymer poly Poly(maleic acid-alt-octadecene)with an aqueous solution of NaOH. The obtained amphiphilic polyanion was purified by dialysis and lyophilization...
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ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF AQUA FORM OF CAESALPINIA BONDUCELLA SEED IN RATS
The objective of this study is to evaluate the analgesic and anti-inflammatory activities of the Caesalpinia bonducella in animals. The analgesic action was evaluated in rats using the acetic acid-induced writhing test and the hot-plate test. The anti-inflammatory activity was estimated using carrageenan-induced paw edema in rats. Caesalpinia bonducella strikingly and dose-dependently suppressed c...
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PREPARATION AND EVALUATION OF HPMC-ALGINATE MUCOADHESIVE MICROCAPSULES OF DICLOFENAC FOR CONTROLLED RELEASE
A new, novel promising technology for obtaining controlled release and enhancing the bioavailability is a combination of mucoadhesion principle and microencapsulation to result in mucoadhesive microcapsules. Mucoadhesive microcapsules consist of either entirely of a mucoadhesive polymer or having an outer coating enclosing the drug particles. They facilitate an intimate and prolonged contact with ...
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CHEMOPREVENTIVE ACTION OF EMBLICA OFFICINALIS AGAINST RADIATION AND CADMIUM INDUCED HEPATIC LESIONS IN SWISS ALBINO MICE.
In the present study an attempt has been made to explore radiation and cadmium induced histological alterations in mice liver and their modulation by Emblica officinalis fruit Extract (EOE). For this purpose mice were selected from Inbred colony and divided into five different groups. Group: Ι (Sham-irradiated group) considered as normal; II (cadmium chloride treated group) in this group animals ...
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EXPLORING THE PATH OF NIRYASA (EXUDATES): AN OVERVIEW
Ayurveda (Indian system of medicine) chikitsapaddhati treats the patient with herbal, animal, and mineral drugs. Among the three, plant-based products acquire prime importance because of their wide utility and negligible side effects. Various parts of the plant are used solely or in different formulations. Niryasaor exudate broadly includes all types of secretory products like gum, resins and some...
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