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ANTIDIABETIC ACTIVITY OF METHANOLIC LEAVES EXTRACTS OF TRANSFORMED SOYBEAN IN 3T3-L1 PRE-ADIPOCYTES CELL LINE
The present study was initiated to quantify the Isoflavones content that accumulated in soybean transgenics with RnPPARγ gene by using high performance liquid chromatography. The effects of methanolic leaves extract of transformed soybean in 3T3-L1 adipocyte cell line. The RnPPARγ transgenic soybean variety JS335 was developed and transgenics were confirmed by PCR and Southern blot techniques. T...
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EVALUATION OF RATIONAL USAGE OF ANTIMICROBIAL AGENTS IN THE PAEDIATRIC DEPARTMENT AT TERTIARY TEACHING CARE HOSPITAL, GUJRAT
Background: Prescription of drugs which needs to be continuously assessed and refined according to disease progression. It not only reflects the physician’s knowledge about drugs but also know the pathophysiology of diseases and attitude towards rational prescribing. Methods: Retrospective study was carried out by collecting 350 prescriptions containing antimicrobial agents of the indoor patie...
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ANTI-INFLAMMATORY ACTIVITY OF SAMADERA INDICA LEAVES BY MEMBRANE STABILIZATION
The present work aims at evaluating the anti-inflammatory activity of Samadera indica by HRBC membrane stabilization. The prevention of hypotonicity induced HRBC membrane lysis was taken as a measure of the anti-inflammatory activity. The anti-inflammatory activity of the crude ethanol extract, aqueous extract of leaves part of Samadera indica were compared to that of the standard drug diclofenac....
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DEVELOPMENT AND EVALUATION OF FAST DISINTEGRATING TABLETS OF SALBUTAMOL SULPHATE BY SUPERDISINTEGRATING AGENTS
The purpose of this research was to develop fast disintegrating tablets of Salbutamol Sulphate using superdisintegrating agents. Recently fast disintegrating drug delivery system have started gaining popularity and acceptance as new drug delivery system, because they are easy to administer and lead to better patient compliance. Salbutamol Sulphate is a selective β2 receptor agonist widely used as...
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EFFECTS OF SURFACTANT TYPE ON RETENTION OF BIOACTIVE COMPOUNDS OF SYZYGIUM AROMATICUM IN SPRAY DRIED LIPID BASED SYSTEMS
This work investigates the effects of the surfactant system used and of spray drying temperature in physicochemical properties and retention of bioactive compounds of lipid based systems loaded with bioactive compounds of Syzygium aromaticum. Seven formulations were prepared, containing Compritol 888 ato and buriti oil as lipids and maltodextrin DE10 as wall material. The surfactants Poloxamer 188...
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SCREENING OF ANTIMICROBIAL PROPERTIES OF PHENOL SCHIFF BASES
In their fight for supremacy and survival, microorganisms have been developing and devising various methods to inactivate the action of antibiotics. The numbers of drug resistant microorganisms with reduced susceptibility to various antibiotics are increasing. Therefore, new infection-fighting strategies are required to control microbial infections. The interaction between potent chemicals and liv...
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RECENT TRENDS IN CHALLENGES AND OPPORTUNITIES OF PHARMACOGENOMICS
Pharmacogenomics is the branch of pharmacology and genomics that deals with the influence of genetic variation on drug response in patients by correlating molecular expressions and single-nucleotide polymorphisms with a drug's efficacy or toxicity. Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with mi...
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HERBAL-DERIVED ANTICANCER PHYTOCONSTITUENTS: TRADITION TO MOLECULAR MECHANISMS
This article reveals a detailed review of important constitutes of herbal drugs which will be useful to treat various types of cancer. Cancer is the second leading cause of death in both developed and developing countries as the number of mortalities is increasing day-by-day and year after year. Herbal drugs have contributed for the discovery of new anticancer drugs due to conventional cancer ther...
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DEVELOPMENT AND EVALUATION OF NATURAL ANTI-DANDRUFF SHAMPOO
The objective of this study is to develop and assess an herbal anti-dandruff shampoo that emphasizes safety and efficacy through the use of natural ingredients. Recognizing that healthy, vibrant hair is a key element of beauty, this shampoo is designed to effectively cleanse dirt and dandruff, promote hair growth, enhance lustre, and strengthen and darken the hair. Given the shampoo sector's signi...
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DESIGN AND DEVELOPMENT OF ANTI-DIABETIC TABLET FORMULATION CONTAINING SPRAY DRIED EXTRACT OF MULBERRY LEAVES
Diabetes is a group of metabolic disorders characterized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. The chronic hyperglycemia in diabetes is associated with long term damage, dysfunction, failure of kidney, nerves and blood vessel. Nowadays, herbal treatments available for diabetics are eroding the share of allopathic formulations. Cur...
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