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ANTIMICROBIAL PROFILE OF RHODOCOCCUS ERYTHROPOLIS VL-RK_05 ISOLATED FROM MANGO ORCHARDS
The aim of the present study was to isolate, identify and to analyze the phylogenetic characteristics of the potent actinobacterial strain VL-RK_05 isolated from Mango orchards of Vissannapet, Krishna Dist, Andhra Pradesh. Soil samples collected were pre treated with calcium carbonate and used for isolation of potent Actinobacterial strain designated as VL-RK_05. Identification of the strain was c...
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AQUEOUS ROOT EXTRACT OF THE ANTIMALARIAL HERBAL CRYPTOLEPIS SANGUINOLENTA (LINDL.) SCHLTR DELAYS THE DEVELOPMENT OF PHYSICAL LANDMARKS AND SENSORIMOTOR SYSTEMS IN MICE
We demonstrated previously that the aqueous root extract of Cryptolepis sanguinolenta (cryptolepis), with cryptolepine as the major constituent adversely affect reproduction and foetal development in mice. However, very little is known on the effect of prenatal exposure of cryptolepis on the post-natal life of surviving animals. Using murine models, we report here, the effects of prenatal exposu...
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IN VITRO ANTIBACTERIAL ACTIVITY AND CALLUOGENESIS OF BRYONIA LACINIOSA
Interest in medicinal plant as a re-emerging health aid has been fuelled by the rising cost of prescription drug in the maintenance of personal health. In present work an attempt has been made to carry out antimicrobial activity of bryonia laciniosa plant, used in Indian folk medicine. The aim of the study was to grow in vitro callus from bryonia laciniosa from leaf explants and its microbial acti...
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DEVELOPMENT OF FELODIPINE LOADED SMEDDS FOR IMPROVING ORAL BIOAVAILABILITY
Felodipine is a poorly water soluble drug having 15% oral bioavailability. In the present study Self micro emulsifying drug delivery system of felodipine was developed to improve its solubility and bioavailability. SMEDDS were prepared by phase titration method and ternary phase diagram was constructed using Chemix software. Based on solubility of drug in the excipients, capmul MCM, oleic acid, Tw...
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FORMULATION AND EVALUATION OF MUCOADHESIVE IN-SITU NASAL GEL OF CYCLOBENZAPRINE HYDROCHLORIDE
Cyclobenzaprine hydrochloride (CBZ) is a muscle relaxant. It has 33% bioavailability due to its first pass effect and hence posses problems in the development of oral sustained release formulations. Mucoadhesive thermo reversible in-situ nasal gel of Cyclobenzaprine HCl was designed and developed to sustain its release due to the increased nasal residence time of the formulation. Poloxamer 407 (PF...
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DEVELOPMENT AND EVALUATION OF FAST DISINTEGRATING TABLETS OF SALBUTAMOL SULPHATE BY SUPERDISINTEGRATING AGENTS
The purpose of this research was to develop fast disintegrating tablets of Salbutamol Sulphate using superdisintegrating agents. Recently fast disintegrating drug delivery system have started gaining popularity and acceptance as new drug delivery system, because they are easy to administer and lead to better patient compliance. Salbutamol Sulphate is a selective β2 receptor agonist widely used as...
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ANTIDIABETIC ACTIVITY OF METHANOLIC LEAVES EXTRACTS OF TRANSFORMED SOYBEAN IN 3T3-L1 PRE-ADIPOCYTES CELL LINE
The present study was initiated to quantify the Isoflavones content that accumulated in soybean transgenics with RnPPARγ gene by using high performance liquid chromatography. The effects of methanolic leaves extract of transformed soybean in 3T3-L1 adipocyte cell line. The RnPPARγ transgenic soybean variety JS335 was developed and transgenics were confirmed by PCR and Southern blot techniques. T...
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ANTIOXIDANT CHANGES IN WISTAR ALBINO RATS AFTER ACUTE HEAT STRESS
Introduction: Global warming is one of the major issues in the current scenario. Heat stress is known to affect both physical and mental task. Imbalance in the maintenance of temperature leads to oxidative stress and damage to the body systems. Several studies have been documented on various stressors and its impact on antioxidant status. Aim: The present study was done to evaluate the antioxidant...
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SUCCESS AND FAILURE WITH INTRALESIONAL 3% SODIUM TETRADECYL SULFATE SCLEROSING AGENT IN TWO CASES OF INTRAORAL HEMANGIOMA
Vascular malformations are one of the most common lesions of the oral cavity. The lesion may be a congenital malformation observed in neonates or arteriovenous malformation observed in adults. The treatment of these lesions includes surgical excision, cryotherapy, selective embolization and treatment with intralesional sclerosing agents. We present two cases of benign oral vascular lesions treated...
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RECENT TRENDS IN CHALLENGES AND OPPORTUNITIES OF PHARMACOGENOMICS
Pharmacogenomics is the branch of pharmacology and genomics that deals with the influence of genetic variation on drug response in patients by correlating molecular expressions and single-nucleotide polymorphisms with a drug's efficacy or toxicity. Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with mi...
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