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PRELIMINARY PHYTOCHEMICAL, ANTI-BACTERIAL, ANALGESIC, ANTI-DIARRHOEAL AND CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACT OF POLYALTHIA SUBEROSA LEAVES
The MeOH extract of leaves of Polyalthia suberosa Roxb. (Annonaceae) was screened for its antibacterial, analgesic, Antidiarrhoeal and cytotoxic activities. The extract showed moderate anti-bacterial activity against Vibrio cholerae, Sheigella sonnei, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus saprophyticus. It also produced significant (P<0.01) writhing inhibition in a...
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IMMUNOHISTOCHEMICAL DETECTION OF CASPASE 8 EXPRESSION AND APOPTOTIC INDEX ACTIVITIES OF CALVATIA CRANIIFORMIS CRUDE EXTRACT IN BALB/C MICE INOCULATED WITH H22 CELLS
Objectives: To identify Immunomodulatory, apoptosis induction and anticancer activities of aqueous and alcoholic extracts of Calvatia craniiformis regarding the size of tumor mass and immunohistochemical detection of caspase 8 expressions and apoptotic index in mice inoculated with H22 mouse hepatocellular carcinoma cells as therapeutic experimental system for human hepatocellular carcinom...
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FORMULATION AND EVALUATION OF ANTIHYPERTENSIVE BILAYER TABLET
The present research work was carried out to Formulate and evaluation of bilayer tablet dosage form for the treatment of Hypertension. The objective of this study to compare the specific characteristics of Olmesartan Midoxomil [Angiotensin II receptor antagonist] and Hydrochlorothiazide [Thiazide Diuretics] in order to design stable formulation. It can be concluded that Olmesartan Midoxomil [Angio...
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DESIGN AND FABRICATION OF GASTRORETENTIVE BILAYER FLOATING TABLET OF PROPRONOLOL HCl USING NATURAL POLYMER
The purpose of this study is to prepare a bilayer gastro retentive tablet of Propranolol HCl using direct compression technology and optimize the type and concentration of polymer to give maximum retentive effect with good drug release profile. Propranolol hydrochloride, a nonselective β-adrenergic blocker having short half-life (3-4 hr)and first pass metabolism favors for sustained release dosag...
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MICROWAVE IRRADIATED SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDIES OF 3-((SUBSTITUTED-BENZO[D]THIAZOL-2-YLAMINO)METHYL)-5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOLE-2(3H)-THIONE
A series of new Mannich base derivatives were designed, synthesized by conventional and non-conventional microwave method, compared and evaluated for their antimicrobial and anti-mycobacterial activity. Structures of the newly synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral studies. The bioactive assay showed that Mannich base derivativ...
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COMPARATIVE STUDY OF PHENOLICS AND ANTIOXIDANT ACTIVITY OF PHYTOCHEMICALS OF T.CHEBULA EXTRACTED USING MICROWAVE AND ULTRASONICATION
The extraction of active compounds from plants is one of the most critical steps in the commercial development of natural products for medicinal and health benefits. In view of the large number of plant species potentially available for study, it is essential to have efficient systems for the rapid and efficient extraction of phytochemicals for further investigation on their properties. The presen...
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QSAR STUDY TO PREDICT ANTI-AMOEBIC ACTIVITIES OF PYRAZOLINE AND DIOXAZOLE DERIVATIVES WITH THE HELP OF PM5-BASED DESCRIPTORS
In quest of better anti-amoebic agents, quantitative structure-activity relationship (QSAR) studies were performed on a series of pyrazoline & dioxazoles derivatives with the help of PM5 calculations and geometry optimizations using CAChe software. Multiple Linear Regression (MLR) analysis was performed to derive QSAR models using the descriptors, molecular weight (MW), conformation minimum en...
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OPTIMIZATION OF TETRABENAZINE TABLET FORMULATION TO MEET THE REQUIRED DISSOLUTION PROFILE AND CONTENT UNIFORMITY
An approach to determine the relationship between independent process variables and their two level four factor partial factorial design was adopted, composite of experiment design was applied to optimize a tablet formulation of Tetrabenazine (TBZ) Tablets 25mg containing high percentage of Lactose Anhydrous, Sodium starch Glycolate, Magnesium Stearate and Starch / Lactose Ratio. The particle size...
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GASTRIC ULCER PROTECTIVE EFFECT OF MADHUCA LATIFOLIA ROXB BARK IN WISTAR RATS
The present study was carried out to investigate the protective effect of ethanolic extract of Madhuca latifolia (Roxb.) bark (MLE) and aqueous extract of Madhuca latifolia (Roxb.) bark (MLA) in aspirin-induced gastric ulcer. In both extract, acute toxicity performed according to guidelines for the selection of doses. The oral administration (400 mg/kg) of MLE & MLA extract reduced the ulcer i...
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EVALUATION OF CARDIOPROTECTIVE EFFECTS OF CAMELLIA SINENSIS ON ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION
Background: Black tea is rich in polyphenols which are antioxidants. The most abundant polyphenolic compounds are flavonols and catechins. Black tea antioxidants showed protective actions against chronic diseases like cardiovascular diseases due to their antioxidant action. Objective: The present study was conducted to evaluate the cardioprotective effects of Camellia sinensis on isoproterenol ...
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