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EFFECT OF TRANS – ESTERIFICATION OF OIL ON NANOEMULSION GEL FOR TOPICAL DRUG DELIVERY
The research investigated the modification of nano-emulsion by using transesterfied soyabean oil, to enhanced solubility and diffusion of voriconazole. Ternary phase diagrams of soyabean oil, acid / base esters of soyabean oil, Tween 80: PEG 400 (S/CoS) and water were developed. Ester value of soyabean oil increased from 214.04 to 261.5mg KOH/1g for acid ester and 293.58mg KOH/1g for base ester co...
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VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DAUNORUBICIN AND CYTARABINE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM
This paper describes a new validated Reverse-Phase High-Performance Liquid Chromatography (HPLC) method for the simultaneous determination of two anti-cancer drugs, Daunorubicin and Cytarabine (Ara-C). A simultaneous determination method saves cost and time as both drugs can be injected into a single HPLC system without the need to change or re-equilibrate with a new mobile phase. The objective of...
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BIOCHEMICAL ESTIMATION OF PRIMARY METABOLITES OF PHYLA NODIFLORA L. GREENE
Phyla nodiflora is an evergreen perennial herb found near the water bodies. It belongs to family Verbenaceae. It is commonly known as frog fruit or turkey tangle. The present investigation is the estimation of primary metabolite content in various plant parts. The investigation revealed that maximum amount of soluble sugar was found in stem, maximum amount of starch found in stems, leaves showed t...
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DEVELOPMENT OF QUALITY STANDARDS OF VATARI CHURNA: A POLYHERBAL FORMULATION
India is a landmark for traditional system of medicine from past few centuries. Most of the medicines are effective but only one major drawback is lack of standardization. So, there is a need to develop a standardization technique to mingle this system of medicine in the main stream of health science. Standardization of herbal formulations is essential in order to assess the quality of drugs, base...
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ISOLATION OF TRITERPENES FROM FIORIA VITIFOLIA (L.) AND IT’S ANTIOXIDANT ACTIVITY
Fioria vitifolia L. (Linn.),(Malvacae) has been extensively used in folk medicine for the treatment of common cold, flu, and upper respiratory infections and also used as an immune system booster. The methanolic extract of whole plant of Fioria vitifolia was taken underphytochemical investigation. The methanolic extract was partitioned with different solvent system by increasing their polarities u...
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VALIDATION OF A NOVEL RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF AMLODIPINE BESYLATE AND NEBIVOLOL HYDROCHLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORMS
This experimental work present the development and validation of a simple, rapid, accurate and precise RP-HPLC method for the simultaneous estimation of amlodipine besylate (AMB) and nebivolol hydrochloride (NBH) in bulk drug and pharmaceutical dosage forms. The chromatographic separation was carried out with AGILENT 1120 liquid chromatograph in an isocratic mode using Kromasil ODS column (250 x 4...
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COMPARATIVE STUDY OF PHENOLICS AND ANTIOXIDANT ACTIVITY OF PHYTOCHEMICALS OF T.CHEBULA EXTRACTED USING MICROWAVE AND ULTRASONICATION
The extraction of active compounds from plants is one of the most critical steps in the commercial development of natural products for medicinal and health benefits. In view of the large number of plant species potentially available for study, it is essential to have efficient systems for the rapid and efficient extraction of phytochemicals for further investigation on their properties. The presen...
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SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME NEW 2, 3-DIHYDRO-1, 5-BENZODIAZEPINE DERIVATIVES
A series of some New 2, 3-dihydro-1, 5-benzodiazepines has been synthesized using condensation reaction of o-phenylenediamine and various substituted chalcones in presence of DMF as solvent and screening of antibacterial and antifungal activities of synthesized compounds....
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ISOLATION, PURIFICATION AND CHARACTERIZATION OF ANTIBACTERIAL PROTEINS FROM INDUCED LARVAE OF ANTHEREAE MYLITTA DRURY (DABA TV)
Antibacterial proteins are evolutionarily ancient, effect or molecules of innate immune defense and are ubiquitously found in all kingdoms. The present study deals with the induction of antibacterial proteins in the haemolymph of Anthereae mylitta drury (Daba TV) by injecting non-pathogenic Pseudomonas DAS-01. Purified protein fraction obtained on ammonium sulphate precipitation followed by ion ex...
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MICROWAVE IRRADIATED SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDIES OF 3-((SUBSTITUTED-BENZO[D]THIAZOL-2-YLAMINO)METHYL)-5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOLE-2(3H)-THIONE
A series of new Mannich base derivatives were designed, synthesized by conventional and non-conventional microwave method, compared and evaluated for their antimicrobial and anti-mycobacterial activity. Structures of the newly synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral studies. The bioactive assay showed that Mannich base derivativ...
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