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FORMULATION AND DEVELOPMENT OF FAST DISINTEGRATING FELODIPINE TABLETS: FUNCTIONALITY OF SUPERDISINTEGRANTS
Felodipine, a calcium channel blocker, is used for hypertension and angina pectoris. Felodipine fast- disintegrating tablets (FDT) have been prepared by direct compression method. Effect of superdisintegrants (like crosspovidone, croscarmellose sodium and sodium starch glycolate) on wetting time, disintegrating time, drug content, in vitro release and stability parameter has been studied. Disinteg...
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DEVELOPMENT OF ANALYTICAL TECHNIQUES FOR IDENTIFICATION OF PHYTOCHEMICALS IN SELECTED HERBAL DRUGS
The present work attempted to identify and standardize the different phytochemical by modern analytical techniques and to summarize the UV, TLC, FTIR characters of the plants; Eugenia caryophyllus (clove), Acorus Calamus (vekhand), Myristica fragrans (Nutmeg) and Citrus aurantium(Orange peel) which ultimately results in compilation of analytical data for these crude drugs which are very much used ...
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BIOSURFACTANT MEDIATED SYNTHESIS OF SILVER NANOPARTICLES USING LACTOBACILLUS BREVIS (MTCC 4463) AND THEIR ANTIMICROBIAL STUDIES
Biosurfactants are surface active, amphiphilic biochemical compounds containing both hydrophobic and hydrophilic moieties produced by microorganisms. They are produced by a variety of microorganisms mainly fungi, bacteria, and yeasts on their cell surface or extracellularly secreted. Biosurfactant mediated synthesis of nanoparticles has now emerged as a green alternative for enhancing both nanopar...
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FAMILY SELF MEDICATION IN CHILDREN ATTENDING A TERTIARY CARE HOSPITAL IN NORTHEAST INDIA
This study was undertaken to determine the prevalence and determinants of family self-medication in children in northeast India. A validated structured interview schedule was used in 487 caregivers of children attending the out-patient department and in-patient ward of the department of pediatrics, Regional Institute of Medical Sciences, Imphal, India. The study schedule included questions related...
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IDENTIFICATION AND CHARACTERIZATION OF E, Z ISOMERS FOR ACID DEGRADENTS OF SECONDARY ALCOHOL IN API BY HS/GC/ EI-MS
2º alcohols under acidic conditions (such as sulphuric acid) undergo degradation into E & Z isomers. There are many drug substances with sulphate as salt, and sulphuric acid is used for the preparation of sulphate of drug substance. Also, sulphuric acid is widely used in synthetic process for many drug substances. 2º alcohols are widely used as process solvents and as crystallization solvent...
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1807
CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF CORIANDRUM SATIVUM LINN.
The ethanolic extract of whole plant of Coriandrum sativum Linn., family: Umbelliferae, was assessed for its possible analgesic, antidiarrhoeal, antimicrobial and cytotoxic activity. Preliminary phytochemical screening of the ethanolic extract revealed the presence of alkaloids, tannins, glycosides, and gums. In acetic acid induced writhing in mice, the ethanolic extract (250 and 500 mg/kg) exhibi...
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IN VITRO ANTIBACTERIAL ACTIVITY AND CALLUOGENESIS OF BRYONIA LACINIOSA
Interest in medicinal plant as a re-emerging health aid has been fuelled by the rising cost of prescription drug in the maintenance of personal health. In present work an attempt has been made to carry out antimicrobial activity of bryonia laciniosa plant, used in Indian folk medicine. The aim of the study was to grow in vitro callus from bryonia laciniosa from leaf explants and its microbial acti...
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1841
PHARMACOGNOSTIC STUDIES ON LEAF AND STEM OF CRESSA CRETICA LINN.
Cressa cretica is halophytic plant belongs to family Convolvulaceae, growing extensively all over India. The entire plant is medicinally important and used extensively in traditional system of medicine. The present work attempted to summarize the macroscopic characters of the plant Cressa cretica. The microscopic characters, physical constant values, extractive values, fluorescent analysis of the ...
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FORMULATION AND EVALUATION OF MUCOADHESIVE IN-SITU NASAL GEL OF CYCLOBENZAPRINE HYDROCHLORIDE
Cyclobenzaprine hydrochloride (CBZ) is a muscle relaxant. It has 33% bioavailability due to its first pass effect and hence posses problems in the development of oral sustained release formulations. Mucoadhesive thermo reversible in-situ nasal gel of Cyclobenzaprine HCl was designed and developed to sustain its release due to the increased nasal residence time of the formulation. Poloxamer 407 (PF...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF BINUCLEAR Fe(III), Co(II), Ni(II), Cu(II) AND Zn(II) COMPLEXES WITH SCHIFF BASE (E)-4-[(HYDROXYL PHENYLIMINO)METHYL]BENZENE-1, 2-DIOL
Schiff base ligand (E)-4-[(hydroxyl phenylimino)methyl]benzene-1, 2-diol (H3L) was prepared from the condensation reaction of Protochatechu aldehyde (3, 4-dihydroxybenzaldhyde) with 2-amino phenol. From the direct reaction of the ligand (H3L) with Co(II), Ni(II) and Cu(II) chlorides and Fe(III) and Zn(II) nitrates in 2M:1L molar ratio, the five new neutral complexes were prepared. The characteriza...
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