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SCREENING OF PLANTS FOR ANTI DERMATOPHYTE ACTIVITY
Mycotic infections of skin are caused by dermatophytes. Screening of plants for anti dermatophyte activity was carried out based on the literature search done. Native plants of Maharashtra (India) were screened for anti dermatophyte activity. Various plant parts from different regions were collected and then extracted with three different solvents viz. alcohol, hydro-alcohol and aqueous. The obtai...
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EVALUATION OF HEPATOPROTECTIVE AND ANTI-OXIDANT ACTIVITY OF ROOT EXTRACTS OF AEGLE MARMELOS IN CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY WISTAR ALBINO RATS
Herbal medicines are effective in the treatment of various ailments. Very often these drugs are unscientifically exploited and / or improperly used. Therefore plant drugs deserve detailed studies in the light of modern science. The detailed investigation and documentation of plants used in local health traditions and pharmacological evaluation of these plants and their taxonomical relatives can le...
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ANTIOXIDANT ANALYSIS AND ENZYME INHIBITION ASSAY OF PLANTS OF APOCYNACEAE FAMILY FOR ULCERS
Different plants of the Apocynaceae family viz. Alstonia scholaris, Calotropis procera, Rauvolfia serpentine, Hemidesmus indicus and Calotropis gigantean are traditionally being reported in ulcers treatments. The present study was aimed to validate the authenticity of correlationship of various phytoconstituents concentrations, antioxidant activity and urease inhibitory potential of the same. Vari...
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FAMILY SELF MEDICATION IN CHILDREN ATTENDING A TERTIARY CARE HOSPITAL IN NORTHEAST INDIA
This study was undertaken to determine the prevalence and determinants of family self-medication in children in northeast India. A validated structured interview schedule was used in 487 caregivers of children attending the out-patient department and in-patient ward of the department of pediatrics, Regional Institute of Medical Sciences, Imphal, India. The study schedule included questions related...
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EFFECT OF CEFTRIAXONE ON ISOLATED GASTROINTESTINAL, TRACHEAL AND UTERINE SMOOTH MUSCLES
The pharmacodynamic effect of ceftriaxone on smooth muscles was investigated in isolated organs. Maximum stimulation of isolated guinea pig's ileum, rabbit's duodenum and rat's fundic strip was achieved by addition of 1024 µg of ceftriaxone/ml bath. While in isolated rat's colon, it was achieved by 512 µg of ceftriaxone/ml bath. The effect of graded increased concentrations of ceftriaxone on i...
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SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF CEFUROXIME SODIUM AND SULBACTAM SODIUM IN INJECTON
Cefuroxime is a 2nd-generation cephalosporin and Sulbactam is a β-Lactamase inhibitor. The combination formulation is used for the treatment of lower respiratory tract infection. Two new, simple, accurate and precise UV spectrophotometric methods have been developed and validated for the simultaneous determination of Cefuroxime Sodium (CEF) and Sulbactam Sodium (SUL) in their combined dosage form...
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EVALUATION OF CNS DEPRESSANT AND ANALGESIC ACTIVITIES OF THE METHANOL EXTRACT OF PIPER LONGUM LINN. LEAVES
Present study reports CNS depressant and analgesic activities of methanol extract obtained from the leaves of Piper longum L (MEPL). CNS depressant activity was evaluated by using open field and hole cross tests at doses of 250 and 500 mg/kg body weight while peripheral analgesic activity was evaluated by using acetic acid induced writhing method and formalin test respectively in rat model at 100 ...
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DETERMINATION OF LAFUTIDINE THROUGH OXIDATIVE COUPLING REACTION IN BULK SAMPLE AND DOSAGE FORMS- A NEW APPROACH
A simple, sensitive, highly accurate method has been developed for the determination of Lafutidine in bulk sample and dosage forms. This method is based on the oxidative coupling reaction of drug with 3-methyl-2-benzothialinone hydrazine hydrochloride (MBTH) reagent in the presence of ferric chloride to form green colored chromogen exhibiting maximum absorption at 630 nm. Beer’s law was obeyed a...
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SOFT CHEMICAL SYNTHESIS OF Ag DOPED ZnO NANOPARTICLES: ANTIMICROBIAL ACTIVITY AND IN VIVO ACUTE NANOTOXICOLOGICAL IMPACT ON SWISS ALBINO MICE
In this research work Zn1-xAgxO1-δ (where x = 0.05, 0.10, 0.15 and 0.20) nano powders were synthesized via simple soft chemical method using corresponding metal nitrates and alkali precipitant. Sodium hydroxide was used as a precipitant during the synthesis. The prepared samples were characterized using X-ray diffraction, FTIR spectroscopy, particle size analysis, SEM, EDAX analysis and TEM. The ...
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EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF DROSERA SPATULATA
The aim of the present study is to investigate and evaluate analgesic and anti-inflammatory potential of aqueous and methanolic extracts of Drosera spatulata using different models in rats. The aqueous and methanolic extracts of D. spatulata (at the doses of 3, 4, 5, 8 and 10 mg/Kg body weight) investigated for anti-inflammatory and analgesic activities using various experimental models. Analgesic...
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