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EVALUATION OF HEPATOPROTECTIVE AND ANTI-OXIDANT ACTIVITY OF ROOT EXTRACTS OF AEGLE MARMELOS IN CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY WISTAR ALBINO RATS
Herbal medicines are effective in the treatment of various ailments. Very often these drugs are unscientifically exploited and / or improperly used. Therefore plant drugs deserve detailed studies in the light of modern science. The detailed investigation and documentation of plants used in local health traditions and pharmacological evaluation of these plants and their taxonomical relatives can le...
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2043
DETERMINATION OF LAFUTIDINE THROUGH OXIDATIVE COUPLING REACTION IN BULK SAMPLE AND DOSAGE FORMS- A NEW APPROACH
A simple, sensitive, highly accurate method has been developed for the determination of Lafutidine in bulk sample and dosage forms. This method is based on the oxidative coupling reaction of drug with 3-methyl-2-benzothialinone hydrazine hydrochloride (MBTH) reagent in the presence of ferric chloride to form green colored chromogen exhibiting maximum absorption at 630 nm. Beer’s law was obeyed a...
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RENO-HEPATOPROTECTIVE EFFECTS OF MURRAYA KOENIGII LEAVES CHLOROFORM EXTRACT (MKCE) AGAINST LEAD-INDUCED OXIDATIVE STRESS IN MICE
Lead induced oxidative stress implies morphological dysfunctions and physiological deformation in the liver. The aim of present study was to establish the protective effect of chloroform extract of Murraya koenigii leaves against the lethal effects of lead on the antioxidant status of mice. Murraya koenigii Chloroform Extract (MKCE) was prepared by maceration. Male Swiss albino mice were divided i...
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1993
SUB-ACUTE CHLOROQUINE TOXICITY ON TESTIS OF SWISS ALBINO MICE AND ITS AMELIORATION BY CURCUMIN
The objective of the present study is to investigate the adverse effect of chloroquine (CQ) toxicity on reproductive tissues and its attenuation by curcumin. Chloroquine (CQ) has been used widely as an antimalarial drug due to its quick action on blood schizontocide of different malarial parasite species for prophylaxis and treatment of malaria. Thirty-six male mice were divided into six experimen...
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1604
ESTIMATION OF QUERCETIN BY HIGH PERFORMANCE CHROMATOGRAPHY AND ANTIFUNGAL ACTIVITY OF MOSS PHILONOTIS REVOLUTA
Bryophytes- the small, slow growing group of plants is stockroom of naturally occurring materials. They contain a high number of biologically active compounds, however their use as a natural fungicides is negligible. In the recent years bryophytes has emerged as a potential biopharming tool for production of complex biopharmaceutiticals. In order to evaluate potential use of bryophytes as an antif...
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A COMPARISON BETWEEN WELLS’ SCORE AND MODIFIED DOPPLER ULTRASOUND IN THE DIAGNOSIS OF DEEP VENOUS THROMBOSIS OF THE LOWER LIMB
The assessment of the probability of occurrence of deep vein thrombosis played a very important part in making a correct diagnosis and modified Wells’ score is a widely used prediction rule for pre-test probability assessment. We aimed to evaluate the diagnostic accuracy of the modified Wells’ score in the diagnosis of lower extremity deep vein thrombosis compared to Doppler ultrasound study. ...
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1324
ESTIMATION OF PERINDOPRIL ARGININE, INDAPAMIDE AND AMLODIPINE IN BULK AND FIXED DOSE COMBINATION USING STABILITY INDICATING REVERSE PHASE HIGH-PRESSURE LIQUID CHROMATOGRAPHY
A simple, accurate, and precise stability-indicating reverse phase high pressure liquid chromatographic method was developed and validated for the estimation of Perindopril arginine, Indapamide, and Amlodipine in the bulk and pharmaceutical dosage form. Chromatographic separation was carried out on ZORBAX RX C8 (250 mm × 4.6 mm, 5 µm) as a stationary phase with a mobile phase of gradient system ...
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3174
DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF ABACAVIR AND ZIDOVUDINE TABLET IN COMBINATION
The present study outlines a systematic approach for Formulation and Evaluation of Immediate release Tablets of Abacavir and Zidovudine tablet. Combination of anti retiro-viral creates multiple obstacles to HIV replication to keep the number of off springs low, reduce the possibility of superior mutations, decrease viral load and potentiate synergistic activity with one another, combining two ...
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EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF DROSERA SPATULATA
The aim of the present study is to investigate and evaluate analgesic and anti-inflammatory potential of aqueous and methanolic extracts of Drosera spatulata using different models in rats. The aqueous and methanolic extracts of D. spatulata (at the doses of 3, 4, 5, 8 and 10 mg/Kg body weight) investigated for anti-inflammatory and analgesic activities using various experimental models. Analgesic...
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SOFT CHEMICAL SYNTHESIS OF Ag DOPED ZnO NANOPARTICLES: ANTIMICROBIAL ACTIVITY AND IN VIVO ACUTE NANOTOXICOLOGICAL IMPACT ON SWISS ALBINO MICE
In this research work Zn1-xAgxO1-δ (where x = 0.05, 0.10, 0.15 and 0.20) nano powders were synthesized via simple soft chemical method using corresponding metal nitrates and alkali precipitant. Sodium hydroxide was used as a precipitant during the synthesis. The prepared samples were characterized using X-ray diffraction, FTIR spectroscopy, particle size analysis, SEM, EDAX analysis and TEM. The ...
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