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EFFECT OF XYLIA DOLABRIFORMIS LEAVES EXTRACT ON HIGH FRUCTOSE DIET INDUCED C57BL/6J OB/OB DIABETIC MICE
The objective of the present study was to investigate anti-diabetic and nephroprotective and cardioprotective activity of Xylia dolabriformis leaves extract, using High Fructoseinduced diabetic C57BL/6Job/ob mice as model for clinical type-2 diabetic. At a regular interval of an experimental protocol blood glucose, urinary creatinine, total proteins, insulin resistance, total β-cell count, LDL, H...
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SURVEILLANCE AND ASSESSMENT OF ADVERSE DRUG REACTIONS AND COMPARISON WITH THE RETROSPECTIVE STUDIES IN A SECONDARY CARE HOSPITAL
Adverse drug reactions are considered to be among the leading causes of morbidity and mortality. Approximately 5-25% of hospital admissions are due to ADR’s, and 6-15% of hospitalized patients experience serious adverse drug reactions (SADR’s), causing significant prolongation of hospital stay. The adverse drug reactions reported were classified based on Wills and Brown classification, Causali...
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BRINE SHRIM LETHALITY BIOASSAY OF METHANOLIC CRUDE EXTRACTS OF TERMINALIA ARJUNA
The aim of this work is to determine the cytotoxic activities of Terminalia arjuna (Family: Combretaceae) by brine shrimp lethality bioassay. The leaves of Terminalia arjuna were extracted with methanol and the methanolic extract was fractionated into three fractions by using organic solvents like n-hexane, ethyl acetate and chloroform. The n-hexane, ethyl acetate and chloroform soluble fractions ...
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IDENTIFICATION AND HPLC QUANTIFICATION OF AFLATOXINS IN GROUNDNUT (ARACHIS HYPOGAEA L.) SAMPLES COLLECTED IN RAYALASEEMA AREA, ANDHRA PRADESH
The present investigation reports the fungal Aflatoxins contamination in groundnut samples collected in different locations in the Rayalaseema area, Andhra Pradesh, India. Aflatoxins were extracted by liquid-liquid extraction method using chloroform solvent. The qualitative and quantitative analysis of aflatoxins present in the samples was done using TLC and HPLC techniques. Among the eight sample...
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MORPHO-ANATOMIC INVESTIGATION OF VEGETATIVE ORGANS OF WATER AVENS (GEUM RIVALE L.)
Species of Geum L. genus (avens) of Rosaсeae L. family belong to perspective sources of medicinal plant raw material for obtaining medicines with the anti-microbic and anti-inflammatory action. They are characterized by such an important feature as the presence of biologically active substances, particularly the polyphenol compounds. According to the aim of present work, morphologic and anatomic...
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SALICYLIC ACID AND CHITOSAN MEDIATED ABIOTIC STRESS IN CELL SUSPENSION CULTURE OF ANDROGRAPHIS PANICULATA (BURM.F.) NEES. FOR ANDRO-GRAPHOLIDE SYNTHESIS
Quantitative and qualitative improvement of rare and valuable bioactive plant products is promisingly possible using In-vitro cell culture techniques. The present investigation was conducted with the aim to elicit the synthesis ofandrographolide by subjecting cultured cells of Andrographis paniculata to Salicylic acid (SA) and Chitosan mediated abiotic stressCell suspension culture of Andrographis...
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BINDING EFFICACY AND ELUCIDATION OF QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP OF ACETANILIDE AND ITS DERIVATIVES WITH BOVINE SERUM ALBUMIN AND THEIR INHIBITION AGAINST COX1
Serum albumins are the most abundant proteins in plasma with many physiological functions. Among them, BSA has a wide range of functions involving the binding, transport and delivery of fatty acids, porphyrins, bilirubin, steroids, etc and it is home to specific binding sites for metals, pharmaceuticals and dyes. Recently, nanotechnology has become a popular term in the current science and technol...
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CHARACTERIZATION OF ENDOGLIN GENE USING IN SILICO TOOLS
Diabetic retinopathy (DR) is a micro vascular disorder affecting the retina of the eye. Many genes have been identified for its pathogenesis. Endoglin (ENG) is one of the candidate gene involved in DR. Several literature studies helped us understand that the in vitro and in vivo studies of these candidate genes had demonstrated the role of a new gene called endoglin (ENG) capable of inhibiting ang...
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METABOLIC SYNDROME: PREVALENCE (IDF & NCEP-ATP III) IN UDHAMPUR, JAMMU CITY
Aim: To determine the prevalence of metabolic syndrome in Udhampur, J & K population according to two different criteria’s (IDF & NCEP-ATP III). Methods: A cross-sectional survey was conducted for the prevalence of metabolic syndrome among 210 participants. A pre-designed questionnaire was used to collect data, including demographic information; physical activity and biochemical paramete...
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SYNTHESIS OF THIAZOLIDINONE AND AZETIDINONE DERIVATIVES OF BENZOXAZOLINONE AS ANTIMICROBIAL AGENTS
The present investigation is concerned with synthesis of new substituted benzoxazolinone derivatives (1-18) with the objective of discovering novel and potent antimicrobial agents. The structure of all the synthesized compounds were elucidated by elemental (C, H, N) and spectral (IR, 1HNMR and mass) analysis. The purity of the synthesized compounds was checked by thin layer chromatography (TLC). T...
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