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SUB-ACUTE CHLOROQUINE TOXICITY ON TESTIS OF SWISS ALBINO MICE AND ITS AMELIORATION BY CURCUMIN
The objective of the present study is to investigate the adverse effect of chloroquine (CQ) toxicity on reproductive tissues and its attenuation by curcumin. Chloroquine (CQ) has been used widely as an antimalarial drug due to its quick action on blood schizontocide of different malarial parasite species for prophylaxis and treatment of malaria. Thirty-six male mice were divided into six experimen...
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DEVELOPMENT AND VALIDATION OF A HPLC METHOD WITH UV DETECTOR FOR QUANTIFICATION OF GEMIFLOXACIN IN HUMAN PLASMA: APPLICATION TO BIOEQUIVALENCE STUDY
A simple, sensitive, high throughput and specific HPLC method with UV detection was developed and validated to according to the FDA guideline for quantification of gemifloxacin in human plasma. The bioanalytical method consists of liquid-liquid extraction and quantification by UV detection. The analyte was separated isocratically on a Cyano column (250 X 4.6 mm, 5µ particle size) with a mobile ph...
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2033
RENO-HEPATOPROTECTIVE EFFECTS OF MURRAYA KOENIGII LEAVES CHLOROFORM EXTRACT (MKCE) AGAINST LEAD-INDUCED OXIDATIVE STRESS IN MICE
Lead induced oxidative stress implies morphological dysfunctions and physiological deformation in the liver. The aim of present study was to establish the protective effect of chloroform extract of Murraya koenigii leaves against the lethal effects of lead on the antioxidant status of mice. Murraya koenigii Chloroform Extract (MKCE) was prepared by maceration. Male Swiss albino mice were divided i...
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1993
A COMPARISON BETWEEN WELLS’ SCORE AND MODIFIED DOPPLER ULTRASOUND IN THE DIAGNOSIS OF DEEP VENOUS THROMBOSIS OF THE LOWER LIMB
The assessment of the probability of occurrence of deep vein thrombosis played a very important part in making a correct diagnosis and modified Wells’ score is a widely used prediction rule for pre-test probability assessment. We aimed to evaluate the diagnostic accuracy of the modified Wells’ score in the diagnosis of lower extremity deep vein thrombosis compared to Doppler ultrasound study. ...
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DETERMINATION OF LAFUTIDINE THROUGH OXIDATIVE COUPLING REACTION IN BULK SAMPLE AND DOSAGE FORMS- A NEW APPROACH
A simple, sensitive, highly accurate method has been developed for the determination of Lafutidine in bulk sample and dosage forms. This method is based on the oxidative coupling reaction of drug with 3-methyl-2-benzothialinone hydrazine hydrochloride (MBTH) reagent in the presence of ferric chloride to form green colored chromogen exhibiting maximum absorption at 630 nm. Beer’s law was obeyed a...
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ALLIUM SATIVUM REGULATES LIPID METABOLISM IN ALLOXAN INDUCED DIABETIC RATS
Allium sativum (A. sativum), commonly known as garlic, is a species in the onion genus, Allium. The hypolipidemic activity of A. Sativum (Family: Amaryllidaceae) extract have been studied in alloxan-induced diabetic rats. In this model oral administration of extract (500mg/kg bw., p.o.) for 15 days in diabetic-dyslipidemic rats exerted significant lipid lowering effect as assessed by the reversal ...
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ESTIMATION OF QUERCETIN BY HIGH PERFORMANCE CHROMATOGRAPHY AND ANTIFUNGAL ACTIVITY OF MOSS PHILONOTIS REVOLUTA
Bryophytes- the small, slow growing group of plants is stockroom of naturally occurring materials. They contain a high number of biologically active compounds, however their use as a natural fungicides is negligible. In the recent years bryophytes has emerged as a potential biopharming tool for production of complex biopharmaceutiticals. In order to evaluate potential use of bryophytes as an antif...
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1837
ANTIFUNGAL ACTIVITIES OF PANGIUM EDULE REINW SEED EXTRACTS INHIBIT THE GROWTH OF ASPERGILLUS FLAVUS, PRODUCER OF AFLATOXINS, THROUGH THE IN-VITRO TEST
Aspergillus flavus is a famous fungus that produces aflatoxins. Aflatoxins are the most well known toxic and carcinogenic chemical prominent produced in nature. The fungus and aflatoxins are the main concern of the corn consumer. Pangi (Pangium edule Reinw) is a potential native plant to reduce infestation of the fungus A. flavus to prevent fungal contamination of food or feed. The research was un...
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ESTIMATION OF PERINDOPRIL ARGININE, INDAPAMIDE AND AMLODIPINE IN BULK AND FIXED DOSE COMBINATION USING STABILITY INDICATING REVERSE PHASE HIGH-PRESSURE LIQUID CHROMATOGRAPHY
A simple, accurate, and precise stability-indicating reverse phase high pressure liquid chromatographic method was developed and validated for the estimation of Perindopril arginine, Indapamide, and Amlodipine in the bulk and pharmaceutical dosage form. Chromatographic separation was carried out on ZORBAX RX C8 (250 mm × 4.6 mm, 5 µm) as a stationary phase with a mobile phase of gradient system ...
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EX-VIVO PENETRATION OF NANOMETRIC ZnO and TiO2 ACROSS ACTINICALLY DAMAGED PORCINE SKIN: DEVELOPMENT OF AN ALBINISTIC SKIN PROTECTION TREATMENT
The skin penetration and safety of nanometric zinc oxide and titanium dioxide incorporated in a cosmeceutical cream, specifically designed to retard skin actinic damage in tropical Oculocutaneous albinism was investigated ex-vivo through simulated actinically damaged porcine skin. Franz diffusion cells were used in an experiment modeled in line with related work done by Diembeck et al (1999); the ...
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2061