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PREPARATION AND PROPERTIES OF MACROCYCLIC LIGAND AND ITS COMPLEXES DERIVED FROM TRIMETHOPRIM AND DIETHYL PHTHALATE
Macrocyclic complexes of MnII, CoII, NiII and CuII using a macrocyclic ligand derived by the condensation of Trimethoprim and diethyl phthalate have been prepared and characterized by electronic, IR and NMR spectral studies as well as magnetic moment and conductivity. On the basis of spectral studies, an octahedral geometry has been proposed for all the complexes....
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PRELIMINARY TOXICITY STUDY, ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY PROPERTIES OF EXTRACTS FROM SIDA RHOMBIFOLIA L. (MALVACEAE)
Background: Sida rhombifolia L. (Malvaceae) is in flora of Asian medicinal herbs and used traditionally in West of Burkina Faso for the treatment of inflammatory diseases, fever, pain and possesses analgesic properties. The aim of the study was to access the biological activities of extract (acetone/water extract) and alkaloid extracts from Sida rhombifolia L. (Malvaceae) in the carrageenan-induce...
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APPROPRIATE USE OF ANTIBIOTICS FOR THE MANAGEMENT OF SEPSIS IN NEONATES
Neonatal sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolongation of hospital stay. Clinical features of sepsis are non-specific in neonates and a high index of suspicion is required for timely diagnosis. Antibiotics are a very important group of drugs for the sick neonate and have undoubtedly played a role in their improved survival. But...
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TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL: AN EMERGING TARGET FOR PAIN
Pain perception begins with the activation of primary sensory nociceptors. Over the past decade, flourishing research has revealed that members of the Transient Receptor Potential (TRP) ion channel family are fundamental molecules that detect noxious stimuli and transduce a diverse range of physical and chemical energy into action potentials in somatosensory nociceptors. Here we highlight the role...
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ANTIOXIDANT AND ANTICANCER ACTIVITIES OF ETHANOLIC EXTRACT OF FICUS GLOMERATA ROXB. IN DMBA INDUCED RATS
The present study was designed to evaluate the antioxidant and anticancer activities of the ethanolic leaf extract of Ficus glomerata Roxb. on the basis of enzymatic and non-enzymatic antioxidants, xenobiotic enzymes and histopathological parameters in 7, 12- dimethylbenz(a)anthracene (DMBA) induced mammary carcinoma in rats. F. glomerata is large evergreen tree, found all over India and South Eas...
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SYNTHESIS, CHARACTERISATION AND BIOLOGICAL EVALUATION OF NOVEL OXADIAZOLE DERIVATIVES
New 5- phenyl- 1, 3, 4- oxadiazole- 2- thiol derivative was synthesized by the ring closure reactions of benzohydrazides with carbon disulphide in presence of ethanolic KOH followed by substitution with secondary amines at 2nd position. All the newly synthesized compounds were characterized by IR, NMR and LC-MASS spectral data. Most of them were tested for their anti-inflammatory and antibacte...
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EXPLORATION OF HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACT OF SOLANUM NIGRUM – AN EXPERIMENTAL STUDY
Introduction: Solanum nigrum (S. nigrum) has been shown to be hepatoprotective by Ayurvedic physicians but has not been scientifically evaluated so far. So, the present study was undertaken to explore the hepatoprotective activity of S. nigrum against experimentally induced hepatotoxicity in albino rats. Aim of the study: To explore the hepatoprotective activity of S. nigrum. Materials and M...
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PHARMACOKINETIC STUDIES OF SECNIDAZOLE IN THE PRESENCE OF PIPERINE AND ITS SYNTHETIC DERIVATIVE
Piperine has been widely used as a bioenhancer. Secnidazole is a long-acting 5-nitroimidazole analog. It is used in the treatment of amoebiasis, giardiasis, trichomoniasis and anaerobic bacterial infection. In this study derivative of piperine was synthesized and studied for its bio enhancing the effect and this effect was compared with the bioenhancing effect of piperine. The pharmacokinetic prof...
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INFLUENCE OF LEVETIRACETAM ON AGGRAVATION OF MEMORY IMPAIRMENT BY VALPROATE: A STUDY ON PILOCARPINE MOUSE MODEL OF TEMPORAL LOBE EPILEPSY
Association of memory impairment (MI) with epilepsy, majorly in temporal lobe epilepsy (TLE) is considerably a tricky condition where existing treatment options involving the administration of anti-epileptic drugs (AED’s) tend to worsen the stated incidence. This study evaluates the aggravating effect of valproate (VAL) at normal and reduced doses on MI associated with TLE and additionally asses...
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THERAPEUTIC AND PHARMACOLOGICAL POTENTIAL OF PRUNUS DOMESTICA: A COMPREHENSIVE REVIEW
Prune is a dry form of plum fruit; its botanical name is Prunus domestica characterized by unique nutrients and dietary bioactive profile. Prunes have wide application in traditional medicine and are known for their beneficial role as a laxative in management of non-communicable diseases and bone health. Researches have proved their antioxidant, anticancer, antihyperglycemic, anti-hyperlipidemic, ...
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