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SYNTHESIS, CHARACTERIZATION AND IN-VITRO ANTICANCER EVALUATION OF NOVEL BENZO[D]IMIDAZOLE DERIVATIVES
The novel benzimidazole derivatives were synthesized by 2-acetyl benzimidazole consent to react with various substituted aromatic aldehyde (2a–e) to obtain preferred intermediate chalcones (3a–j), these intermediates are undergo the cyclocondensation with guanidine hydrochloride and phenyl hydrazine yielded benzimidazole derivatives (4a–j and 5a–j respectively). The synthesized compounds w...
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COMPARATIVE ANTI-ANXIETY POTENTIAL OF DIFFERENT PARTS OF VITEX NEGUNDO LINN.
Vitex negundo, commonly called Nirgundi, is one of the widely investigated medicinal plants of India. The present study were planned to compare different parts, i.e. leaves, stems and roots of V. negundo for antianxiety activity using elevated plus maze model. Petroleum ether (60 - 80 °C), chloroform, ethanol and aqueous extracts of these parts were prepared and evaluated for anti-anxiety activit...
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MEMBRANE STABILIZING ACTIVITY AND ANTIOXIDANT EFFECT OF SIDA CORDATA (BURM F.) BIOSS AND RHODODENDRON ARBOREUM SM. LEAVES
Purpose: To investigate membrane stabilizing activity and antioxidant activity off different extracts of leaves of Sida cordata and Rhododendron arboreum. Methods: Preliminary phytochemical analysis of different extracts of leaves of Sida cordata and Rhododendron arboreum were performed for presence of phytoconstituents. In vitro membrane stabilizing activity was done by using RBC membrane stab...
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NEUROPROTECTIVE ROLE OF HERB ECLIPTA ALBA LINN. ON ACUTE AND CHRONIC UNPREDICTABLE STRESS INDUCED BEHAVIORAL, BIOCHEMICAL AND NEURO-TRANSMITTER ALTERATION IN WISTAR MALE ALBINO RAT BRAIN
Chronic stress is a risk factor for the development of many psychopathological conditions in humans, including major depression and anxiety disorders and cognitive dysfunction. It is therefore important to focus on identifying possible mechanism to prevent these stress-induced disorders. Therefore, current study was designed to investigate the effect of Eclipta alba on chronic unpredicted stress (...
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FORMULATION OF GEL KEFIR PRODUCT OF MILK FERMENTATION AND ANTIBACTERIAL ACTIVITY TESTS AGAINST PROPIONIBACTERIUM ACNES
Propionibacterium acnes is one of the bacteria that causes acne. One of the natural ingredients that potentially as anti acne is kefir. Kefir is a product of fermented milk with starter kefir grain. The fermented kefir is incorporated into the gel product for acne treatment. The purpose of this study was to formulate the fermented kefir in the gel product and to test the antibacterial activity aga...
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APPLICATIONS OF CE-MS IN PHARMACEUTICAL FIELD
Capillary Electrophoresis–Mass Spectroscopy (CE-MS) is a hyphenated technique as it combines the advantages of both CE and MS. It provides high-resolution separations with high detection selectivity and sensitivity, which allows detailed characterization of many biomolecules in a single analysis. CE-MS improves the ability to deal with the analysis of complex biological samples containing trace ...
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PHARMACOGNOSTICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL INVESTIGATION ON LEAVES OF TRIDAX PROCUMBENS LINN.
The study is aimed at development of physicochemical parameters and to investigate the active principle present in Tridax procumbens Linn. Tridax procumbens Linn. (Asteraceae) commonly known as Coat Buttons is an important plant used against various disorders in indigenous system of medicine such as Wound-Healing, Hepatoprotective, Anti-Inflammatory, Anti-diabetic and Immunomodulatory activities. ...
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PHARMACOGNOSTIC STUDIES ON LEAF AND STEM OF CRESSA CRETICA LINN.
Cressa cretica is halophytic plant belongs to family Convolvulaceae, growing extensively all over India. The entire plant is medicinally important and used extensively in traditional system of medicine. The present work attempted to summarize the macroscopic characters of the plant Cressa cretica. The microscopic characters, physical constant values, extractive values, fluorescent analysis of the ...
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EFFECT OF CEFTRIAXONE ON ISOLATED GASTROINTESTINAL, TRACHEAL AND UTERINE SMOOTH MUSCLES
The pharmacodynamic effect of ceftriaxone on smooth muscles was investigated in isolated organs. Maximum stimulation of isolated guinea pig's ileum, rabbit's duodenum and rat's fundic strip was achieved by addition of 1024 µg of ceftriaxone/ml bath. While in isolated rat's colon, it was achieved by 512 µg of ceftriaxone/ml bath. The effect of graded increased concentrations of ceftriaxone on i...
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EXPERIMENTAL DESIGN APPROACH TO OPTIMIZATION OF THE NEW COMMERCIAL RP-HPLC DISCRIMINATION CONDITIONS FOR THE ESTIMATION OF PARACETAMOL AND ZALTAPROFEN IN PHARMACEUTICAL FORMULATION
A simple, rapid, RP-HPLC method developed for the simultaneous estimation of paracetamol and zaltaprofen in commercial pharmaceutical formulation by applying Derringer’s desirability function. The dependent variables such as Capacity factor of first peak, α value and retention time of tR3 as the responses with three important independent factors of organic phase composition, pH of mobile phase ...
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